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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185.
- 2025-06-03
- RCT
- Journal of biomedical science 32(1)
- - Yao-Jong Yang
  - Chung-Tai Wu
  - Hsiu-Chi Cheng
  - Wei-Ying Chen
  - Joseph T Tseng
  - Wei-Lun Chang
  - Bor-Shyang Sheu
- PubMed: 40462044
- DOI: 10.1186/s12929-025-01149-3
1 Insight on
- Improved Intestinal Metaplasia Regression
- High evidence
Incorporating Postbiotics into Intervention for Managing Obesity.
- 2025-06-03
- Review
- International journal of molecular sciences 26(11)
- - Emília Hijová
  - Izabela Bertková
  - Jana Štofilová
- PubMed: 40508171
- DOI: 10.3390/ijms26115362
1 Insight on
- Improved Weight Management
- Moderate evidence
- Rigorous Journal
Lactobacillus GG and other probiotics in pediatric food allergy treatment: a network meta-analysis.
- 2025-06-03
- Systematic Review · n = 502
- Frontiers in nutrition 12
- - Li Xiaohua
  - Du Yiting
  - Li Qin
  - Zhai Yang
  - Wu Shumao
  - Peng Li
  - Pan Yi
  - Chen Lingmei
  - Liao Wenge
  - Li Maoxia
- PubMed: 40529417
- DOI: 10.3389/fnut.2025.1565436
7 Insights on
- High evidence
Randomized Controlled Trials for Oral Leukoplakia.
- 2025-06-02
- Review · n = 7
- Oral diseases 31(11)
- - Michele Lodolo
  - Michele Lodolo
  - Jack Valor
  - Alessandro Villa
- PubMed: 40457716
- DOI: 10.1111/odi.15399
4 Insights on
- Low evidence
Microbiome Engineering for Biotherapeutic in Alzheimer's Disease Through the Gut-Brain Axis: Potentials and Limitations.
- 2025-06-02
- Review
- International journal of molecular sciences 26(11)
- - Editha Renesteen
  - Jacqueline L Boyajian
  - Paromita Islam
  - Amal Kassab
  - Ahmed Abosalha
  - Stephanie Makhlouf
  - Madison Santos
  - Hongmei Chen
  - Cedrique Shum-Tim
  - Satya Prakash
- PubMed: 40508160
- DOI: 10.3390/ijms26115351
4 Insights on
- Moderate evidence
- Rigorous Journal
Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis.
- 2025-06-02
- Meta-Analysis
- Nutrients 17(11)
- - Chen Ee Low
  - Nicole Shi Min Chew
  - Sean Loke
  - Jia Yang Tan
  - Shayne Phee
  - Ainsley Ryan Yan Bin Lee
  - Cyrus Su Hui Ho
- PubMed: 40507181
- DOI: 10.3390/nu17111911
2 Insights on
- Reduced Suicide Attempt
- Reduced Suicide Ideation
- High evidence
- Rigorous Journal
Efficacy and safety of Saccharomyces boulardii as adjunct therapy with Vancomycin in treating Clostridioides difficile infection: A randomized controlled trial.
- 2025-06-02
- RCT
- Scientific reports 15(1)
- - Taned Chitapanarux
  - Umaporn Wiracha
  - Poramed Winichakoon
  - Parichat Salee
  - Patrinee Traisathit
- PubMed: 40457042
- DOI: 10.1038/s41598-025-04986-2
9 Insights on
- High evidence
- Rigorous Journal
Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet.
- 2025-06-01
- n = 49
- Iranian journal of microbiology 17(3)
- - Sahar Fouladi
  - Elham Moazamian
- PubMed: 40612728
- DOI: 10.18502/ijm.v17i3.18826
8 Insights on
- Low evidence
Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.
- 2025-06-01
- RCT
- Journal of sports science & medicine 24(2)
- - Yongliang Wang
  - Yanyan Wang
  - Kun Qian
- PubMed: 40469872
- DOI: 10.52082/jssm.2025.258
7 Insights on
- High evidence
Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency.
- 2025-05-30
- RCT · n = 44
- European journal of nutrition 64(5)
- - Xiaoyun Shan
  - Wenxuan Wu
  - Jingxin Yang
  - Yang Cao
  - Yuting Li
  - Yichun Hu
  - Rui Wang
  - Lichen Yang
- PubMed: 40445221
- DOI: 10.1007/s00394-025-03723-9
4 Insights on
- High evidence
- Rigorous Journal
Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Supplementation: An Exploratory, Randomized, Placebo-Controlled Trial of Endocannabinoid and Inflammatory Responses in Female Dancers.
- 2025-05-30
- Clinical Trial
- Microorganisms 13(6)
- - Jakub Wiącek
  - Karolina Skonieczna-Żydecka
  - Igor Łoniewski
  - Chariklia K Deli
  - Ioannis G Fatouros
  - Athanasios Z Jamurtas
  - Dominika Moszczyńska
  - Joanna Karolkiewicz
- PubMed: 40572172
- DOI: 10.3390/microorganisms13061284
1 Insight on
- No Significant Change in Endocannabinoid or Inflammatory Biomarkers
- Moderate evidence
Vitamin C in Allergy Mechanisms and for Managing Allergic Diseases: A Narrative Review.
- 2025-05-30
- Review
- Children (Basel, Switzerland) 12(6)
- - Chiara Trincianti
  - Matteo Naso
  - Maria Angela Tosca
  - Giorgio Ciprandi
- PubMed: 40564676
- DOI: 10.3390/children12060718
5 Insights on
- Low evidence
Fruit and Vegetable Juices as Functional Carriers for Probiotic Delivery: Microbiological, Nutritional, and Sensory Perspectives.
- 2025-05-30
- Review
- Microorganisms 13(6)
- - Renata Žvirdauskienė
  - Vesta Jonikė
  - Loreta Bašinskienė
  - Dalia Čižeikienė
- PubMed: 40572160
- DOI: 10.3390/microorganisms13061272
3 Insights on
- Low evidence
A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune Response in Subjects Recovering from Respiratory Viral Infection: A Randomized, Double-Blind Clinical Study Using Vitamin C as a Positive Control.
- 2025-05-29
- RCT · n = 28
- International journal of molecular sciences 26(11)
- - Bruno Fink
  - John M Hunter
  - Zbigniew Pietrzkowski
  - Richard Fink
  - Coy Brunssen
  - Henning Morawietz
  - Boris Nemzer
- PubMed: 40508019
- DOI: 10.3390/ijms26115209
3 Insights on
- High evidence
- Rigorous Journal
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- High evidence
Bifidobacterium animalis subsp. lactis modulates early-life immune response and gut metabolism.
- 2025-05-28
- Animal models and experimental medicine 8(6)
- - Haoming Du
  - Yiran Cai
  - Lulu Shen
  - Yuxing Zheng
  - Lingling Zhao
  - Ruibiao Hu
  - Shan Jiang
  - Jiajia Yuan
  - Chengming Hu
  - Qi Deng
  - Jiaoyan Huang
  - Jingbo Hu
  - Yuexiang Wang
  - Jing Tan
  - Jiahui Chen
  - Feitong Liu
  - Yuanyuan Duan
  - Haitao Niu
- PubMed: 40437776
- DOI: 10.1002/ame2.70034
2 Insights on
- Improved Immune Organ Development
- Increased Levels of Beneficial Metabolites
- Low evidence
- Animal Study
Managing pediatric metabolic syndrome: a systematic review of current approaches.
- 2025-05-28
- Systematic Review
- BMC pediatrics 25(1)
- - Kasra Talebi Anaraki
  - Motahar Heidari-Beni
  - Mehrnoosh Arefian
  - Roya Kelishadi
- PubMed: 40437390
- DOI: 10.1186/s12887-025-05759-6
1 Insight on
- Improved Metabolic Health
- High evidence
Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota.
- 2025-05-28
- Journal of microbiology and biotechnology 35
- - Eoun Ho Nam
  - Minjee Lee
  - Donggyu Kim
  - Young Hoon Jung
  - Jungwoo Yang
  - Minhye Shin
- PubMed: 40443239
- DOI: 10.4014/jmb.2502.02045
2 Insights on
- Increased Gut Microbial Growth
- Increased Folate Production
- Low evidence
The Effect of Probiotics on Health in Pregnancy and Infants: A Randomized, Double-Blind, Placebo-Controlled Trial.
- 2025-05-28
- RCT
- Nutrients 17(11)
- - Sylvie Binda
  - Mélanie Chow-Shi-Yée
  - Saly El Salti
  - Noémie Auclair-Ouellet
  - Marie-Laure Oula
  - Thomas Carton
  - Sébastien Leuillet
  - Diego Tomassi
  - Robert Hemmings
  - Isaac-Jacques Kadoch
- PubMed: 40507094
- DOI: 10.3390/nu17111825
7 Insights on
- High evidence
- Rigorous Journal
The impact of probiotics on pulmonary, gastrointestinal, and growth outcomes in pediatric cystic fibrosis: a randomized controlled trial.
- 2025-05-28
- RCT · n = 55
- BMC pediatrics 25(1)
- - Parisa Rahmani
  - Pejman Rohani
  - Arian Kariman
  - Farzaneh Motamed
  - Mohammad Reza Modaresi
  - Kambiz Eftekhari
  - Mehri Ayati
  - Mohammad Hassan Sohouli
- PubMed: 40437397
- DOI: 10.1186/s12887-025-05789-0
6 Insights on
- High evidence
Effects of berry consumption on cardiometabolic risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomised controlled trials.
- 2025-05-28
- Meta-Analysis · n = 50
- International journal of food sciences and nutrition 76(5)
- - Mohammad Amin Mohammadi
  - Ali Ebrahimi Dabagh
  - Shirin Hassanizadeh
  - Gholamreza Askari
  - Mohammad Bagherniya
  - Amirhossein Sahebkar
- PubMed: 40436036
- DOI: 10.1080/09637486.2025.2510358
5 Insights on
- High evidence
Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial.
- 2025-05-28
- RCT · n = 55
- 3 Biotech 15(6)
- - Wei-Ju Chen
  - Lavanya Ajay Sharma
  - Peng Shao
  - Tia Griffith
  - Robert Love
  - Rohit Jain
  - John Hale
  - Ajay Sharma
- PubMed: 40443548
- DOI: 10.1007/s13205-025-04363-w
7 Insights on
- High evidence
Circadian Disruption and Sleep Disorders in Astronauts: A Review of Multi-Disciplinary Interventions for Long-Duration Space Missions.
- 2025-05-28
- Review
- International journal of molecular sciences 26(11)
- - Hongjie Zong
  - Yifei Fei
  - Ningang Liu
- PubMed: 40507991
- DOI: 10.3390/ijms26115179
2 Insights on
- Improved Sleep Quality
- Reduced Circadian Sleep Disturbance
- Moderate evidence
- Rigorous Journal
Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.
- 2025-05-27
- Review
- International journal of molecular sciences 26(11)
- - Zofia Gorzelanna
  - Aleksandra Mamrot
  - Daria Będkowska
  - Joanna Bubak
  - Marta Miszczak
- PubMed: 40507953
- DOI: 10.3390/ijms26115143
8 Insights on
- Moderate evidence
- Rigorous Journal
Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.
- 2025-05-27
- RCT · n = 43
- Nutrients 17(11)
- - Yingxuan Tao
  - Murong Wu
  - Boyao Su
  - Heng Lin
  - Qianzi Li
  - Tian Zhong
  - Ying Xiao
  - Xi Yu
- PubMed: 40507089
- DOI: 10.3390/nu17111821
2 Insights on
- Improved Sleep Quality
- Reduced Perceived Stress
- High evidence
- Rigorous Journal
COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADE compliant meta-analysis of randomized controlled trials with molecular docking and dynamics simulation studies with Mpro of SARS-CoV-2.
- 2025-05-26
- Meta-Analysis · n = 1,125
- Cellular and molecular biology (Noisy-le-Grand, France) 71(5)
- - Seshadri Reddy Varikasuvu
  - Munikumar Manne
  - Subodh Kumar
  - Shiv Kumar Mudgal
  - Vikash Raj
  - Saurabh Varshney
  - Pratima Gupta
  - Ashoo Grover
  - Chanchal Goyal
  - Vanita Lal
  - Harminder Singh
  - Mona Lisa
  - Saransh Workshop Members
- PubMed: 40418545
- DOI: 10.14715/cmb/2025.71.5.13
2 Insights on
- Reduced Mortality Risk
- Improved Recovery Rate
- High evidence
Plant-Derived Natural Products for Dietary Intervention in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis.
- 2025-05-26
- Review · n = 2,513
- Phytotherapy research : PTR 39(6)
- - Elvan Wiyarta
  - Refael Alfa Budiman
  - Devina Ravelia Tiffany Subroto
  - Moon Nyeo Park
  - Nelly Mayulu
  - Nurpudji Astuti Taslim
  - Raymond Rubianto Tjandrawinata
  - Trina Ekawati Tallei
  - Hardinsyah Hardinsyah
  - Fahrul Nurkolis
  - Bonglee Kim
- PubMed: 40420357
- DOI: 10.1002/ptr.8490
7 Insights on
- High evidence
Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine.
- 2025-05-25
- Scientific reports 15(1)
- - Ruth Dudek-Wicher
  - Malwina Brożyna
  - Justyna Paleczny
  - Beata Mączyńska
  - Bartłomiej Dudek
  - Paweł Migdał
  - Arleta Dołowacka-Jóźwiak
  - Jędrzej Fischer
  - Adam Junka
- PubMed: 40414916
- DOI: 10.1038/s41598-025-01852-z
1 Insight on
- Increased Cytotoxicity and Mucosal Damage Risk
- Low evidence
- Rigorous Journal
The Impact of Flaxseed (Linum usitatissimum L.) Oil Supplementation on Human Health: A Human-Centric Evidence-Graded Approach.
- 2025-05-25
- Review
- Nutrients 17(11)
- - Ying Nie
  - Yuchen Wang
  - Ju Hui
  - Danqing Shao
  - Ran Chen
  - Qianchun Deng
  - Yashu Chen
  - Xiangyu Wang
  - Dazhou Zhu
- PubMed: 40507062
- DOI: 10.3390/nu17111791
7 Insights on
- Moderate evidence
- Rigorous Journal
Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets.
- 2025-05-24
- Microbiome 13(1)
- - Ryoga Hashimoto
  - Keita Nishiyama
  - Fu Namai
  - Kasumi Suzuki
  - Taiga Sakuma
  - Itsuko Fukuda
  - Yuta Sugiyama
  - Kenji Okano
  - Takafumi Shanoh
  - Eita Toyoshi
  - Ryusuke Ohgi
  - Sudeb Saha
  - Sae Tsuchida
  - Eri Nishiyama
  - Takao Mukai
  - Mutsumi Furukawa
  - Tomonori Nochi
  - Julio Villena
  - Wakako Ikeda-Ohtsubo
  - Gou Yoshioka
  - Eri Nakazaki
  - Yoshihito Suda
  - Haruki Kitazawa
- PubMed: 40413516
- DOI: 10.1186/s40168-025-02129-3
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study