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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

GABA-Producing Capabilities of Lactococcus lactis PL186 in Murine and Human.
- 2026-03-20
- Journal of microbiology and biotechnology 36
- - Jennifer Jaemin Paek
  - Hyungwon Yang
  - Kyung Soo Paek
  - Yeonhee Lee
- PubMed: 41866909
- DOI: 10.4014/jmb.2512.12040
2 Insights on
- Increased Systemic GABA Levels
- Increased Brain GABA Levels
- Low evidence
Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization.
- 2026-03-20
- Foods (Basel, Switzerland) 15(6)
- - Bista Sunita
  - Yuxing Liu
  - Hanwei Zheng
  - Yue Su
  - Mingyue Liu
  - Linfeng Xu
  - Ikram Alouk
  - Zhiqing Liu
  - Wenyong Lou
- PubMed: 41897819
- DOI: 10.3390/foods15061096
1 Insight on
- Reduced Inflammation
- Low evidence
The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review.
- 2026-03-19
- Systematic Review · n = 1,063
- Nutrients 18(6)
- - Batoul Jaafar
  - Nour Chami
  - Mohamad Tlais
  - Maria Matar
  - Nazih Obeid
  - Nadia Taha
  - Karim El Haddad
  - Jessica Abou Chaaya
  - Sami Azar
- PubMed: 41901143
- DOI: 10.3390/nu18060968
7 Insights on
- High evidence
- Rigorous Journal
Radiomitigators: Breakthroughs in Post-Radiation Recovery.
- 2026-03-18
- Review
- Antioxidants (Basel, Switzerland) 15(3)
- - Elena Obrador
  - José M Estrela
  - Rafael López-Blanch
  - Paz Moreno-Murciano
  - Alegría Montoro
  - María Oriol-Caballo
- PubMed: 41897526
- DOI: 10.3390/antiox15030381
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Effect of sesame oil and Nigella sativa oil on the prevention of amiodarone-induced phlebitis: a randomized controlled trial.
- 2026-03-18
- RCT · n = 108
- Explore (New York, N.Y.) 22(3)
- - Burcu Nal
  - Dilek Sari
  - Mehmet Ali Astarcioğlu
  - İsmail Şen
- PubMed: 41880716
- DOI: 10.1016/j.explore.2026.103403
2 Insights on
- Reduced Phlebitis Severity
- Reduced Phlebitis Incidence
- High evidence
- Large Human Trial
The role of vitamin K in the prognosis of patients with hepatocellular carcinoma: a systematic review and meta-analysis.
- 2026-03-18
- Systematic Review · n = 688
- Frontiers in oncology 16
- - Lang Guo
  - Yaqiong Wang
  - Zhenkun Tan
  - Tingli Lu
  - Zha Peng
  - Hai Huang
- PubMed: 41930200
- DOI: 10.3389/fonc.2026.1765445
3 Insights on
- High evidence
Effects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study.
- 2026-03-18
- Clinical Trial
- JBMR plus 10(5)
- - Sharon H Chou
  - Nancy Cook
  - Eunjung Kim
  - Gregory Kotler
  - David A Ganz
  - Peggy M Cawthon
  - Allison Clar
  - Aladdin H Shadyab
  - JoAnn E Manson
  - Howard D Sesso
  - Carolyn J Crandall
  - Meryl LeBoff
- PubMed: 42004609
- DOI: 10.1093/jbmrpl/ziag041
6 Insights on
- High evidence
Membrane Vesicles from Lactobacillus acidophilus Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages.
- 2026-03-18
- International journal of molecular sciences 27(6)
- - Cristal Dafne Lonngi Sosa
  - Francisco Rodolfo González Díaz
  - Hugo Ramírez Álvarez
  - Alejandro Vargas Ruiz
  - Rosa Isabel Higuera Piedrahita
  - Héctor Alejandro de la Cruz Cruz
  - Jorge Alfredo Cuéllar Ordaz
  - Gerardo Ramírez-Rico
  - Erasmo Negrete Abascal
  - Magda Reyes López
  - Cynthia González Ruíz
- PubMed: 41898624
- DOI: 10.3390/ijms27062764
2 Insights on
- Enhanced Innate Immune Function
- Balanced Cytokine Response
- Low evidence
- Rigorous Journal
- Animal Study
A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.
- 2026-03-18
- Gut microbes 18(1)
- - Michele Biagioli
  - Cristina Di Giorgio
  - Silvia Marchianò
  - Benedetta Sensini
  - Ginevra Urbani
  - Eleonora Giannelli
  - Ginevra Lachi
  - Carmen Massa
  - Maria Rosaria Sette
  - Francesca Paniconi
  - Elva Morretta
  - Maria Chiara Monti
  - Angela Zampella
  - Eleonora Distrutti
  - Stefano Fiorucci
- PubMed: 41851067
- DOI: 10.1080/19490976.2026.2645125
2 Insights on
- Reduced Intestinal Inflammation
- Reduced Intestinal Fibrosis
- Low evidence
Coffee and Tea Intake, Dementia Risk, and Cognitive Function.
- 2026-03-17
- Observational · n = 821
- JAMA 335(11)
- - Yu Zhang
  - Yuxi Liu
  - Yanping Li
  - Yuhan Li
  - Xiao Gu
  - Jae H Kang
  - A Heather Eliassen
  - Molin Wang
  - Eric B Rimm
  - Walter C Willett
  - Frank B Hu
  - Meir J Stampfer
  - Dong D Wang
- PubMed: 41661604
- DOI: 10.1001/jama.2025.27259
4 Insights on
- High evidence
- Rigorous Journal
Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.
- 2026-03-17
- Review
- Antonie van Leeuwenhoek 119(4)
- - Tsachi Tsadok Perets
  - Rachel Gingold-Belfer
  - Ram Dickman
- PubMed: 41843249
- DOI: 10.1007/s10482-026-02278-x
3 Insights on
- Low evidence
Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible.
- 2026-03-17
- Case Report
- Pediatrics 157(4)
- - Tomás Woodgate
  - Jay Patel
  - Thomas Day
  - Brodie Knight
  - Adriani Spanaki
  - Alistair Calder
  - Shahin Moledina
  - Sadia Quyam
- PubMed: 41839225
- DOI: 10.1542/peds.2025-073645
3 Insights on
- Low evidence
Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies.
- 2026-03-17
- Review
- Frontiers in microbiology 17
- - Chao Niu
  - Jing Wang
  - Xinping Lu
  - Yongduo Yu
- PubMed: 41924481
- DOI: 10.3389/fmicb.2026.1787284
1 Insight on
- Reduced Ulcerative Colitis Symptoms
- Low evidence
The Effect of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers, Tumor Necrosis Factor-α Gene Expression, and DNA Damage in Subjects with Metabolic Syndrome: a Randomized Placebo-Controlled Clinical Trial.
- 2026-03-17
- RCT · n = 48
- Biological trace element research 204(6)
- - Behrooz Ebrahimzadehkour
  - Sara Jambarsang
  - Farzad Karimpour
  - Seyyed Ebrahim Hosseini
  - Vahid Ramezani
  - Mohammad-Reza Jowshan
  - Hassan Mozaffari-Khosravi
- PubMed: 41840296
- DOI: 10.1007/s12011-025-04950-1
9 Insights on
- High evidence
Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose-response meta-analysis of randomized controlled trials.
- 2026-03-17
- Systematic Review · n = 962
- Frontiers in nutrition 13
- - Hsuan-Hsien Liu
  - Ting-Hui Liu
  - Chia-Yu Liu
  - Jheng-Yan Wu
  - Chien-Ho Lin
  - Chih-Cheng Lai
- PubMed: 41923913
- DOI: 10.3389/fnut.2026.1772451
6 Insights on
- High evidence
Vitamin D and Hemopoietic Stem Cell Transplantation: Clinical Guidance for GVHD Management and Post-Transplant Outcomes.
- 2026-03-17
- Review
- Cancers 18(6)
- - Manlio Fazio
  - Maria Elisa Nasso
  - Sebastiano Gangemi
  - Adele Bottaro
  - Luca Gammeri
  - Fabio Stagno
  - Alessandro Allegra
- PubMed: 41899574
- DOI: 10.3390/cancers18060972
7 Insights on
- Low evidence
Post spike syndrome (PSS): Simple solution leading to resolving results, five cases report.
- 2026-03-16
- Case Report
- IDCases 41
- - Roberto S Zeballos
  - Mariely Fernanda da Silva Helbingen
  - Paulo Macio Porto Melo
  - Francisco Eduardo Cardoso Alves
  - Caio Roberto Salvino
  - Ewerton Paes Seródio
  - Edimilson Ramos Migowski de Carvalho
- PubMed: 40671933
- DOI: 10.1016/j.idcr.2025.e02278
4 Insights on
- Low evidence
New and emerging treatments for anxiety disorders.
- 2026-03-16
- Review
- BMJ (Clinical research ed.) 392
- - Tomislav D Zbozinek
  - Sahib S Khalsa
  - Michelle G Craske
- PubMed: 41839508
- DOI: 10.1136/bmj-2024-083441
1 Insight on
- Reduced Anxiety
- Low evidence
Lacticaseibacillus rhamnosus CRL1505 Ameliorates Liver Injury and Inflammation in Poly(I:C)-Induced Acute Hepatitis.
- 2026-03-16
- Foods (Basel, Switzerland) 15(6)
- - María José Lorenzo Pisarello
  - Ayelen Antonella Baillo
  - Mariano Elean
  - Leonardo Albarracín
  - Luciano Arellano-Arriagada
  - Yoshihito Suda
  - Haruki Kitazawa
  - Julio Villena
- PubMed: 41897754
- DOI: 10.3390/foods15061034
1 Insight on
- Improved Antiviral Immune Response
- Low evidence
Production of Xylooligosaccharides (XOSs) with Anti-inflammatory and Prebiotic Activities Using Recombinant Endo-1,4-β-xylanases from Bacillus subtilis.
- 2026-03-16
- Journal of agricultural and food chemistry 74(11)
- - Nguyen Cao Cuong
  - Dietmar Haltrich
  - Apichat Boontawan
  - Montarop Yamabhai
- PubMed: 41838424
- DOI: 10.1021/acs.jafc.5c13633
2 Insights on
- Reduced Inflammation
- Enhanced Prebiotic Activity
- Low evidence
- Rigorous Journal
Immunonutritional effects elicited by a novel multicomponent food supplement in children with cow's milk allergy: results from a randomized, placebo-controlled trial.
- 2026-03-16
- Clinical Trial
- Frontiers in allergy 7
- - Laura Carucci
  - Erika Caldaria
  - Franca Oglio
  - Raffaele Federico Iorio
  - Vittoria Mauriello
  - Antonio Masino
  - Serena Coppola
- PubMed: 41918962
- DOI: 10.3389/falgy.2026.1760231
11 Insights on
- High evidence
Enhanced Quality and Metabolic Profile of Fermented Milk Through Fucose Supplementation with Lactobacillus helveticus.
- 2026-03-16
- Molecules (Basel, Switzerland) 31(6)
- - Shunyu Wang
  - Hongchao Wang
  - Yurong Zhao
  - Zhangming Pei
  - Wenwei Lu
  - Jianxin Zhao
  - Shourong Lu
- PubMed: 41900089
- DOI: 10.3390/molecules31060990
1 Insight on
- Increased Levels of Beneficial Metabolites
- Low evidence
- Animal Study
Lactobacillus acidophilus alleviates slow transit constipation by modulating 5-HT pathway and gut microbial composition.
- 2026-03-16
- Frontiers in nutrition 13
- - Yunhe Fan
  - Hao Qin
  - Jiayao Liu
  - Mureed Abbas
  - Chuanli Yang
  - Haixia Cheng
  - Xiushan Dong
- PubMed: 41919078
- DOI: 10.3389/fnut.2026.1775405
4 Insights on
- Low evidence
Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase.
- 2026-03-16
- Journal of nanobiotechnology 24(1)
- - Yuefeng Zhang
  - Qian Zhang
  - Yue Luo
  - Xiaohan Li
  - Ruirui Zhao
  - Yaning Xu
  - Saixuan Zhang
  - Xinyu Bai
  - Haopeng Chen
  - Hao Li
  - Yanjun Hong
  - Zhiyong Xie
- PubMed: 41840625
- DOI: 10.1186/s12951-026-04275-8
3 Insights on
- Low evidence
Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.
- 2026-03-16
- RCT
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 25(5)
- - Aheen Faisal
  - C M Lerche
  - T Douki
  - P A Philipsen
  - C Pihl
  - T Gregersen
  - J R Granborg
  - P Bjerring
  - M Haedersdal
  - S R Wiegell
- PubMed: 41838346
- DOI: 10.1007/s43630-026-00884-2
3 Insights on
- High evidence
The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trial.
- 2026-03-16
- RCT
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 34(4)
- - Azad Rahmani
  - Zohreh Sanaat
  - Hosein Nazemiyeh H
  - Afzal Shamsi
  - Musab Ghaderi
- PubMed: 41838185
- DOI: 10.1007/s00520-026-10398-3
5 Insights on
- High evidence
Early modulatory effects of Porphyromonas gingivalis and Lactobacillus salivarius on oncogenic processes in dysplastic oral keratinocytes.
- 2026-03-16
- Molecular biology reports 53(1)
- - Umme Samia
  - Tamara Vlajic Tovilovic
  - Ilinka Pecinar
  - Milena Radunovic
  - Sanja Petrovic
  - Milos Lazarevic
  - Dijana Mitic
  - Milica Jaksic Karisik
  - Nadja Nikolic
  - Jelena Carkic
  - Maria Cristina Curia
  - Jelena Milasin
- PubMed: 41838299
- DOI: 10.1007/s11033-026-11667-4
1 Insight on
- Modulated Oral Cancer-Related Signaling
- Low evidence
Assessing the impact of Spirulina supplementation on the growth of children and adolescents: a systematic review and meta-analysis.
- 2026-03-16
- Systematic Review
- Frontiers in nutrition 13
- - Bijaya Kumar Mishra
  - Jaya Singh Kshatri
  - Bharati Kulkarni
  - Swagatika Pati
  - Harshita Dhusiya
  - Pritimayee Sethy
  - Tanveer Rehman
  - Aparna Mukherjee
  - Srikanta Kanungo
  - Sanghamitra Pati
- PubMed: 41919083
- DOI: 10.3389/fnut.2026.1779491
2 Insights on
- Reduced Body Weight
- Increased Weight
- High evidence
Microbial Fermentation as a Tool to Improve the Antioxidant and Functional Value of Milk Products.
- 2026-03-15
- Review
- Foods (Basel, Switzerland) 15(6)
- - Sion Seol
  - JuDong Yeo
- PubMed: 41897746
- DOI: 10.3390/foods15061024
2 Insights on
- Improved Antioxidant Activity
- Improved Functional Properties of Food
- Low evidence
Valorization of stale bread into protein-rich biomass: an optimized Rhizopus oryzae fermentation strategy and characterization study.
- 2026-03-14
- Letters in applied microbiology 79(4)
- - Burcu Kaya
  - Özlem Şahiner
  - Gökçe Örüntaş
  - Erol Kestek
  - Harun Efe Bozaslan
  - Seda Savranoğlu Kulabaş
  - Tugba Boyunegmez Tumer
  - Onur Güneşer
  - Yonca Karagül Yüceer
- PubMed: 41830919
- DOI: 10.1093/lambio/ovag034
1 Insight on
- Improved Cell Compatibility
- Low evidence