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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Rice flour fermented with Lactobacillus paracasei CBA L74 in the treatment of atopic dermatitis in infants: A randomized, double- blind, placebo- controlled trial.
- 2021-01
- RCT
- Pharmacological Research 163
- - E. D’Auria
  - S. Panelli
  - L. Lunardon
  - M. Pajoro
  - L. Paradiso
  - S. Beretta
  - C. Loretelli
  - D. Tosi
  - Matteo Perini
  - G. Bedogni
  - A. Abdelsalam
  - P. Fiorina
  - C. Bandi
  - G. Zuccotti
- PubMed: 33157233
- DOI: 10.1016/j.phrs.2020.105284
13 Insights on
- High evidence
- Rigorous Journal
Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet.
- 2021-01
- Clinical Trial
- Food Research International 139
- - Xu-Cong Lv
  - Min Chen
  - Zi-Rui Huang
  - Wei-ling Guo
  - Lian-zhong Ai
  - Weidong Bai
  - Xiao-Dan Yu
  - Ying-Li Liu
  - P. Rao
  - Li Ni
- PubMed: 33509508
- DOI: 10.1016/j.foodres.2020.109956
10 Insights on
- Low evidence
- Animal Study
Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12
- 2021-01
- Clinical Trial
- OncoImmunology 10(1)
- - Qingxiang Li
  - Yuke Li
  - Yifei Wang
  - Le Xu
  - Yuxing Guo
  - Yixiang Wang
  - Lin Wang
  - Chuanbin Guo
- PubMed: 33537172
- DOI: 10.1080/2162402X.2020.1868122
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials.
- 2021-01
- Meta-Analysis · n = 23
- BioMed research international 2021(1)
- - Yayun Weng
  - Shuo Zhang
  - Wei Huang
  - Xianze Xie
  - Zhiyuan Ma
  - Qiaomei Fan
- PubMed: 33521132
- DOI: 10.1155/2021/9491615
6 Insights on
- High evidence
Effect of active dry yeast on lactation performance, methane production, and ruminal fermentation patterns in early-lactating Holstein cows.
- 2021-01
- RCT · n = 60
- Journal of Dairy Science 104(1)
- - Yan Li
  - Yizhao Shen
  - J. Niu
  - Yanfei Guo
  - Mirielle L Pauline
  - Xiaojing Zhao
  - Qiufeng Li
  - Yufeng Cao
  - Chongliang Bi
  - Xiujiang Zhang
  - Zhonghua Wang
  - Yanxia Gao
  - Jianguo Li
- PubMed: 33272580
- DOI: 10.3168/jds.2020-18594
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effect of feeding Bacillus subtilis on rumen fermentation, blood metabolites, nutrient digestibility, and energy and nitrogen balances in non-lactating crossbred cows.
- 2021-01
- RCT · n = 4
- Animal Science Journal 92(1)
- - Daisuke Kawauchi
  - W. Angthong
  - O. Keaokliang
  - T. Ishida
  - Toshihiro Takahashi
  - T. Kawashima
- PubMed: 33638258
- DOI: 10.1111/asj.13531
2 Insights on
- Reduced Plasma Non-Esterified Fatty Acid Concentrations
- Increased Heat Production
- Low evidence
- Animal Study
Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro
- 2021-01
- 3 Biotech 11(1)
- - Anuradha Barigela
  - Bhima Bhukya
- PubMed: 33442521
- DOI: 10.1007/s13205-020-02570-1
1 Insight on
- Reduced Cancer Activity
- Low evidence
Fewer Community-Acquired Colds with Daily Consumption of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2. A Randomized, Placebo-Controlled Clinical Trial
- 2021-01
- RCT · n = 898
- The Journal of Nutrition 151(1)
- - I. L. Ahrén
  - M. Hillman
  - E. Nordström
  - N. Larsson
  - T. Niskanen
- PubMed: 33296464
- DOI: 10.1093/jn/nxaa353
11 Insights on
- High evidence
- Large Human Trial
Effect of long-term dietary probiotic Lactobacillus reuteri 1 or antibiotics on meat quality, muscular amino acids and fatty acids in pigs.
- 2021-01
- Clinical Trial
- Meat Science 171
- - Z. Tian
  - Yiyan Cui
  - Huijie Lu
  - Gang Wang
  - Xianyong Ma
- PubMed: 32906013
- DOI: 10.1016/j.meatsci.2020.108234
3 Insights on
- Low evidence
- Animal Study
The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson's Disease.
- 2021-01
- Oxidative medicine and cellular longevity 2021(1)
- - Ovidiu-Dumitru Ilie
  - Emanuela Paduraru
  - Madalina-Andreea Robea
  - Ioana-Miruna Balmus
  - Roxana Jijie
  - Mircea Nicoara
  - Alin Ciobica
  - Ilinca-Bianca Nita
  - Romeo Dobrin
  - Bogdan Doroftei
- PubMed: 34691361
- DOI: 10.1155/2021/9629102
3 Insights on
- Low evidence
Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators.
- 2021-01
- Mediators of inflammation 2021(1)
- - Shotaro Isozaki
  - Hiroaki Konishi
  - Mikihiro Fujiya
  - Hiroki Tanaka
  - Yuki Murakami
  - Shin Kashima
  - Katsuyoshi Ando
  - Nobuhiro Ueno
  - Kentaro Moriichi
  - Toshikatsu Okumura
- PubMed: 33859537
- DOI: 10.1155/2021/5582943
3 Insights on
- Low evidence
- Animal Study
High protein yogurt with addition of Lactobacillus helveticus: Peptide profile and angiotensin-converting enzyme ACE-inhibitory activity.
- 2020-12
- Food Chemistry 333
- - Flávia Giacometti Cavalheiro
  - Débora Parra Baptista
  - Bruno Domingues Galli
  - F. Negrão
  - Marcos Nogueira Eberlin
  - Mirna Lúcia Gigante
- PubMed: 32659671
- DOI: 10.1016/j.foodchem.2020.127482
1 Insight on
- Increased ACE Inhibitor Activity
- Low evidence
Probiotic characteristics of Lactobacillus strains isolated from cheese and their antibacterial properties against gastrointestinal tract pathogens
- 2020-12
- Saudi Journal of Biological Sciences 27(12)
- - Xiao Zhang
  - Galal Ali Esmail
  - Abdulaziz Fahad Alzeer
  - M. Valan Arasu
  - P. Vijayaraghavan
  - Ki Choon Choi
  - N. Abdullah Al-Dhabi
- PubMed: 33304162
- DOI: 10.1016/j.sjbs.2020.10.022
2 Insights on
- Reduced Intestinal Pathogens
- Increased Production of Bioactive Metabolites
- Low evidence
Effects of Bacillus subtilis on growth performance, serum parameters, digestive enzyme, intestinal morphology, and colonic microbiota in piglets
- 2020-12
- RCT · n = 72
- AMB Express 10(1)
- - B. Deng
  - Jie Wu
  - Xiaohui Li
  - Cheng Zhang
  - X. Men
  - Ziwei Xu
- PubMed: 33263814
- DOI: 10.1186/s13568-020-01150-z
12 Insights on
- Low evidence
- Animal Study
Evaluation of nebulized N-acetyl cysteine in outcome of esophageal atresia with tracheoesophegeal fistula.
- 2020-12
- Clinical Trial · n = 30
- Journal of pediatric surgery 55(12)
- - Gurmeet Singh
  - Anand Pandey
  - Gaurav Shandilya
  - Archika Gupta
  - J D Rawat
  - Ashish Wakhlu
  - S N Kureel
- PubMed: 32467034
- DOI: 10.1016/j.jpedsurg.2020.04.013
3 Insights on
- High evidence
Dietary supplementation with L-carnosine improves patient-reported outcomes, autonomic nervous system performance, and brain metabolism in 3 adult patients with multiple sclerosis.
- 2020-12
- Clinical Trial
- Nutrition research (New York, N.Y.) 84
- - Dragana Zanini
  - Tatjana Jezdimirovic
  - Valdemar Stajer
  - Jelena Ostojic
  - Nebojsa Maksimovic
  - Sergej M Ostojic
- PubMed: 33189432
- DOI: 10.1016/j.nutres.2020.09.008
9 Insights on
- Moderate evidence
Fermented milk containing a potential probiotic Lactobacillus rhamnosus SD11 with maltitol reduces Streptococcus mutans: A double-blind, randomized, controlled study
- 2020-12
- RCT · n = 123
- Journal of Dental Sciences 15(4)
- - Nuntiya Pahumunto
  - S. Piwat
  - S. Chanvitan
  - Wiboon Ongwande
  - Supansa Uraipan
  - R. Teanpaisan
- PubMed: 33505609
- DOI: 10.1016/j.jds.2020.03.003
3 Insights on
- High evidence
- Rigorous Journal
Lactobacillus reuteri DSM 17938 is effective in the treatment of functional abdominal pain in children: Results of the double-blind randomized study.
- 2020-12
- RCT · n = 147
- Clinical Nutrition 39(12)
- - O. Jadrešin
  - Sara Sila
  - I. Trivić
  - Z. Mišak
  - S. Kolaček
  - I. Hojsak
- PubMed: 32362486
- DOI: 10.1016/j.clnu.2020.04.019
7 Insights on
- High evidence
Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial.
- 2020-12
- RCT
- Journal of the American College of Surgeons 231(6)
- - Koya Yasukawa
  - Akira Shimizu
  - Takahide Yokoyama
  - Koji Kubota
  - Tsuyoshi Notake
  - Hitoshi Seki
  - Akira Kobayashi
  - Yuji Soejima
- PubMed: 32927075
- DOI: 10.1016/j.jamcollsurg.2020.08.761
2 Insights on
- Reduced Nonalcoholic Fatty Liver Disease Incidence
- Improved Nonalcoholic Fatty Liver Disease
- High evidence
Effect of Lactobacillus rhamnosus on growth of Listeria monocytogenes and Staphylococcus aureus in a probiotic Minas Frescal cheese.
- 2020-12
- Food Microbiology 92
- - L. Prezzi
  - S. Lee
  - V. M. Nunes
  - C. Corassin
  - T. C. Pimentel
  - R. Rocha
  - G. L. Ramos
  - J. Guimarães
  - C. Balthazar
  - M. Duarte
  - M. Q. Freitas
  - E. Esmerino
  - M. C. Silva
  - A. Cruz
  - C. Oliveira
- PubMed: 32950151
- DOI: 10.1016/j.fm.2020.103557
2 Insights on
- Reduced Risk of Listeria Monocytogenes Infection
- No Effect on Staphylococcus aureus
- Low evidence
Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)
- 2020-11
- RCT · n = 120
- Neurobiology of Stress 13
- - E. Patterson
  - Síle M. Griffin
  - A. Ibarra
  - E. Ellsiepen
  - J. Hellhammer
- PubMed: 33385020
- DOI: 10.1016/j.ynstr.2020.100277
10 Insights on
- High evidence
Effect of Bacillus subtilis on growth performance, bone mineralization, and bacterial population of broilers fed with different protein sources
- 2020-11
- RCT · n = 40
- Poultry Science 99(11)
- - G. Ciurescu
  - M. Dumitru
  - A. Gheorghe
  - A. Untea
  - R. Drăghici
- PubMed: 33142513
- DOI: 10.1016/j.psj.2020.08.075
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Milk fermented with Lactobacillus rhamnosus R0011 induces a regulatory cytokine profile in LPS-challenged U937 and THP-1 macrophages
- 2020-11
- Current Research in Food Science 3
- - M. Jeffrey
  - H. Jones Taggart
  - J. Strap
  - Gibran Edun
  - J. Green-Johnson
- PubMed: 32914120
- DOI: 10.1016/j.crfs.2020.02.002
4 Insights on
- Low evidence
Probiotic characterization of Pediococcus strains isolated from Iranian cereal-dairy fermented product: Interaction with pathogenic bacteria and the enteric cell line Caco-2.
- 2020-11
- Journal of Bioscience and Bioengineering 130(5)
- - A. Vasiee
  - F. Falah
  - B. A. Behbahani
  - Farideh Tabatabaee-Yazdi
- PubMed: 32753308
- DOI: 10.1016/j.jbiosc.2020.07.002
7 Insights on
- Low evidence
Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice.
- 2020-11
- RCT
- International Immunopharmacology 88
- - Miao Liu
  - Wenjie Xie
  - X. Wan
  - T. Deng
- PubMed: 32771947
- DOI: 10.1016/j.intimp.2020.106862
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effects of Probiotic (Bacillus subtilis) Supplementation During Offseason Resistance Training in Female Division I Athletes.
- 2020-11
- RCT · n = 23
- Journal of Strength and Conditioning Research 34(11)
- - Jeremy C Toohey
  - Jeremy R. Townsend
  - Sean B Johnson
  - Ann M. Toy
  - William C. Vantrease
  - David Bender
  - Chelsea C Crimi
  - Kathleen L. Stowers
  - M. D. Ruiz
  - Trisha A. VanDusseldorp
  - Y. Feito
  - G. Mangine
- PubMed: 33105368
- DOI: 10.1519/JSC.0000000000002675
4 Insights on
- High evidence
Synergistic effects of the early administration of Lactobacillus kefiranofaciens DN1 and Kluyveromyces marxianus KU140723-05 on the inhibition of Salmonella Enteritidis colonization in young chickens
- 2020-11
- RCT · n = 108
- Poultry Science 99(11)
- - Dongryeoul Bae
  - Dong‐Hyeon Kim
  - Jung-Whan Chon
  - K. Song
  - K. Seo
- PubMed: 33142518
- DOI: 10.1016/j.psj.2020.07.032
2 Insights on
- Reduced Salmonella enteritidis Colonization
- Prolonged Inhibition of SE Colonization
- Low evidence
- Rigorous Journal
- Animal Study
Evaluation of the fate of Lactobacillus crispatus BC4, carried in Squacquerone cheese, throughout the simulator of the human intestinal microbial ecosystem (SHIME).
- 2020-11
- Food Research International 137
- - F. Patrignani
  - C. Parolin
  - M. D’Alessandro
  - L. Siroli
  - B. Vitali
  - R. Lanciotti
- PubMed: 33233191
- DOI: 10.1016/j.foodres.2020.109580
7 Insights on
- Low evidence
The effects of Bacillus coagulans supplementation in patients with non-alcoholic fatty liver disease: A randomized, placebo-controlled, clinical trial.
- 2020-10
- RCT · n = 53
- Clinical Nutrition ESPEN 39
- - K. Abhari
  - Saeede Saadati
  - Zahra Yari
  - H. Hosseini
  - M. Hedayati
  - S. Abhari
  - S. Alavian
  - A. Hekmatdoost
- PubMed: 32859329
- DOI: 10.1016/j.clnesp.2020.06.020
12 Insights on
- High evidence
Anti-obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high-fat diet-induced C57BL/6 mice.
- 2020-10
- Clinical Trial
- Journal of Food Biochemistry 44(12)
- - Y. Gan
  - Ming-Wei Tang
  - Fang Tan
  - Xianrong Zhou
  - Ling Fan
  - Yu-Xin Xie
  - Xin Zhao
- PubMed: 33006202
- DOI: 10.1111/jfbc.13491
6 Insights on
- Low evidence
- Animal Study