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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

L-citrulline Enriched Fermented Milk with Lactobacillus helveticus Attenuates Dextran Sulfate Sodium (DSS) Induced Colitis in Mice.
- 2022-01
- RCT · n = 6
- The Journal of Nutritional Biochemistry 99
- - Sze Wing Ho
  - H. El‐Nezami
  - H. Corke
  - C. Ho
  - N. Shah
- PubMed: 34587540
- DOI: 10.1016/j.jnutbio.2021.108858
12 Insights on
- Low evidence
- Animal Study
Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.
- 2022-01
- Review
- Journal of evidence-based integrative medicine 27
- - Tomas Koltai
  - Larry Fliegel
- PubMed: 35018864
- DOI: 10.1177/2515690x211068826
1 Insight on
- Reduced Hepatitis C Progression
- Low evidence
Complete genome analysis of Lactobacillus fermentum YLF016 and its probiotic characteristics.
- 2022-01
- Microbial Pathogenesis 162
- - Li-hong Zhang
  - Hong-Bo Ma
  - M. F. Kulyar
  - Huachun Pan
  - Kewei Li
  - Aoyun Li
  - Q. Mo
  - Yaping Wang
  - Hailong Dong
  - Yuhua Bao
  - Jia-kui Li
- PubMed: 34597776
- DOI: 10.1016/j.micpath.2021.105212
5 Insights on
- Low evidence
Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways.
- 2022-01
- Research (Washington, D.C.) 2022
- - Da Hyun Kim
  - Minju Jeong
  - Jae Hwan Kim
  - Joe Eun Son
  - John J Y Lee
  - Sang-Jun Park
  - Juyeon Lee
  - Minwoo Kim
  - Jong-Won Oh
  - Myeong Soo Park
  - Sanguine Byun
- PubMed: 39290965
- DOI: 10.34133/research.0007
5 Insights on
- Low evidence
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial.
- 2022-01
- RCT
- Oxidative medicine and cellular longevity 2022(1)
- - Mehrdokht Mazdeh
  - Parnaz Abolfathi
  - Maryam Sabetghadam
  - Younes Mohammadi
  - Maryam Mehrpooya
- PubMed: 35936217
- DOI: 10.1155/2022/2493053
10 Insights on
- High evidence
Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives.
- 2022-01
- Review
- Oxidative medicine and cellular longevity 2022(1)
- - Prabhakar Semwal
  - Sakshi Painuli
  - Tareq Abu-Izneid
  - Abdur Rauf
  - Anshu Sharma
  - Sevgi Durna Daştan
  - Manoj Kumar
  - Mohammed M Alshehri
  - Yasaman Taheri
  - Rajib Das
  - Saikat Mitra
  - Talha Bin Emran
  - Javad Sharifi-Rad
  - Daniela Calina
  - William C Cho
- PubMed: 35677108
- DOI: 10.1155/2022/1035441
2 Insights on
- Improved Cognitive Function
- Improved Menopause Symptom
- Low evidence
The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
- 2022-01
- RCT · n = 149
- The American journal of clinical nutrition 115(1)
- - Jamie W Bellinge
  - Roslyn J Francis
  - Sing C Lee
  - Nicola P Bondonno
  - Marc Sim
  - Joshua R Lewis
  - Gerald F Watts
  - Carl J Schultz
- PubMed: 34637494
- DOI: 10.1093/ajcn/nqab306
1 Insight on
- Reduced Arterial Calcifying Lesion Development
- High evidence
- Large Human Trial
Beneficial effects of a combination of Clostridium cochlearium and Lactobacillus acidophilus on body weight gain, insulin sensitivity, and gut microbiota in high-fat diet-induced obese mice.
- 2022-01
- RCT · n = 36
- Nutrition 93
- - Fei Yang
  - Wenjun Zhu
  - Paba Edirisuriya
  - Qing Ai
  - Kai Nie
  - Xiang Ji
  - Yong Li
  - K. Zhou
- PubMed: 34507264
- DOI: 10.1016/j.nut.2021.111439
5 Insights on
- Low evidence
- Animal Study
Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review.
- 2022-01
- Systematic Review
- International journal of clinical practice 2022(1)
- - Roghayeh Afifirad
  - Amir Darb Emamie
  - Rezvan Golmoradi Zadeh
  - Parisa Asadollahi
  - Roya Ghanavati
  - Atieh Darbandi
- PubMed: 35685517
- DOI: 10.1155/2022/4774783
5 Insights on
- High evidence
Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson's Disease Patients.
- 2022-01
- RCT
- Contrast media & molecular imaging 2022(1)
- - Jiaojiao Li
  - Pin Meng
  - Jianyu Zhang
  - Mingli He
- PubMed: 35685661
- DOI: 10.1155/2022/8381870
3 Insights on
- High evidence
Watermelon and L-Citrulline in Cardio-Metabolic Health: Review of the Evidence 2000-2020.
- 2021-12
- Review
- Current atherosclerosis reports 23(12)
- - Britt Burton-Freeman
  - Morganne Freeman
  - Xuhuiqun Zhang
  - Amandeep Sandhu
  - Indika Edirisinghe
- PubMed: 34894302
- DOI: 10.1007/s11883-021-00978-5
1 Insight on
- Reduced Blood Pressure
- Low evidence
Bacteriocins: Properties and potential use as antimicrobials.
- 2021-12
- Review
- Journal of clinical laboratory analysis 36(1)
- - Atieh Darbandi
  - Arezoo Asadi
  - Marzieh Mahdizade Ari
  - Elnaz Ohadi
  - Malihe Talebi
  - Masoume Halaj Zadeh
  - Amir Darb Emamie
  - Roya Ghanavati
  - Maryam Kakanj
- PubMed: 34851542
- DOI: 10.1002/jcla.24093
1 Insight on
- Reduced Foodborne Pathogens
- Moderate evidence
- Highly Cited
Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e -GLP-1 in monkey model
- 2021-12
- Clinical Trial
- Synthetic and Systems Biotechnology 6(4)
- - Jie Luo
  - Hongfei Zhang
  - Jiachen Lu
  - Chaolin Ma
  - Tingtao Chen
- PubMed: 34584995
- DOI: 10.1016/j.synbio.2021.09.009
4 Insights on
- Low evidence
- Animal Study
The divergent roles of sortase in the biology of Gram-positive bacteria.
- 2021-12
- Review
- Cell surface (Amsterdam, Netherlands) 7
- - Aliyath Susmitha
  - Harsha Bajaj
  - Kesavan Madhavan Nampoothiri
- PubMed: 34195501
- DOI: 10.1016/j.tcsw.2021.100055
2 Insights on
- Improved Immunomodulation
- Improved Whole Gut Transit Time
- Low evidence
The effects of Cuminum cyminum on glycemic parameters: A systematic review and meta-analysis of controlled clinical trials.
- 2021-12
- Meta-Analysis
- Journal of ethnopharmacology 281
- - Omid Mohammad Tavakoli-Rouzbehani
  - Amir Hossein Faghfouri
  - Maryam Anbari
  - Shahab Papi
  - Farid Salimi Shojaei
  - Mehdi Ghaffari
  - Mohammad Alizadeh
- PubMed: 34371114
- DOI: 10.1016/j.jep.2021.114510
6 Insights on
- High evidence
Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis.
- 2021-12
- Meta-Analysis · n = 536
- Phytomedicine : international journal of phytotherapy and phytopharmacology 93
- - Nahdiya Sha'ari
  - Luke Sy-Cherng Woon
  - Hatta Sidi
  - Srijit Das
  - Chad A Bousman
  - Suriati Mohamed Saini
- PubMed: 34638031
- DOI: 10.1016/j.phymed.2021.153760
4 Insights on
- High evidence
Probiotic properties of Lactobacillus casei – MYSRD 108 and Lactobacillus plantarum-MYSRD 71 with potential antimicrobial activity against Salmonella paratyphi
- 2021-12
- Biotechnology Reports 32
- - S. Divyashree
  - P. Anjali
  - Rakesh Somashekaraiah
  - M. Sreenivasa
- PubMed: 34540599
- DOI: 10.1016/j.btre.2021.e00672
1 Insight on
- Reduced Salmonella Paratyphi Growth
- Low evidence
Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis.
- 2021-12
- Meta-Analysis
- Complementary Therapies in Medicine 63
- - Angela Pierina Dos Reis Buzzo Zermiani
  - Ana Luiza Pelissari Peçanha de Paula Soares
  - Bárbara Leticia da Silva Guedes de Moura
  - Edson Roberto Arpini Miguel
  - Luciana Dias Ghiraldi Lopes
  - N. Santana
  - T. Da Silva Santos
  - I. G. Demarchi
  - Jorge Juarez Teixeira
- PubMed: 34627993
- DOI: 10.1016/j.ctim.2021.102781
7 Insights on
- High evidence
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.
- 2021-12
- Meta-Analysis
- Journal of the International Society of Sports Nutrition 18(1)
- - Noah M A d'Unienville
  - Henry T Blake
  - Alison M Coates
  - Alison M Hill
  - Alison M Hill
  - Maximillian J Nelson
  - Jonathan D Buckley
- PubMed: 34965876
- DOI: 10.1186/s12970-021-00472-y
1 Insight on
- Improved Endurance Exercise Performance
- High evidence
Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system.
- 2021-11
- Food Research International 149
- - M. Marzorati
  - P. van den Abbeele
  - Sarah S Bubeck
  - Thomas Bayne
  - K. Krishnan
  - Aicacia Young
- PubMed: 34600678
- DOI: 10.1016/j.foodres.2021.110676
5 Insights on
- Low evidence
Beta-alanine fails to improve on 5000 m running time despite increasing PAT1 expression in long-distance runners.
- 2021-11
- RCT · n = 16
- The Journal of sports medicine and physical fitness 61(12)
- - Gabriel S Franco
  - Natália Y Noronha
  - Bruno A Oliveira
  - Flávia C Ferreira
  - Ana P Pinto
  - Camila F Brandao
  - Marcelo Papoti
  - Carla B Nonino
- PubMed: 33305552
- DOI: 10.23736/s0022-4707.20.11946-7
1 Insight on
- Improved 5000 m Running Time
- High evidence
Assessment of Lactobacillus casei rhamnosus (LGG) therapy in children with biliary atresia - Randomized placebo controlled trial.
- 2021-11
- RCT · n = 16
- Clinics and research in hepatology and gastroenterology 45(6)
- - Ewa Orłowska
  - Piotr Czubkowski
  - Katarzyna Wołochowska
  - Dorota Jarzębicka
  - Ilona Motyl
  - Piotr Socha
- PubMed: 34311135
- DOI: 10.1016/j.clinre.2021.101753
3 Insights on
- High evidence
Treatment with L-Citrulline in patients with post-polio syndrome: A single center, randomized, double blind, placebo-controlled trial.
- 2021-11
- RCT
- Neuromuscular disorders : NMD 31(11)
- - Niveditha Putananickal
  - Anna-Lena Orsini
  - Simone Schmidt
  - Vanya Gocheva
  - Daniela Rubino
  - Tanja Haas
  - Sabine Schädelin
  - Xeni Deligianni
  - Oliver Bieri
  - Dirk Fischer
  - Patricia Hafner
- PubMed: 34711479
- DOI: 10.1016/j.nmd.2021.08.011
3 Insights on
- High evidence
In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA.
- 2021-11
- Journal of Ethnopharmacology 280
- - Liliane Laure Toukam
  - Bertrand Tatsinkou Fossi
  - G. S. Taiwé
  - Raymond Bess Bila
  - David Denis Feugaing Sofeu
  - Enyong Peter Ivo
  - E. Achidi
- PubMed: 34303805
- DOI: 10.1016/j.jep.2021.114448
4 Insights on
- Low evidence
Oral administration of Lactobacillus crispatusM247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial.
- 2021-11
- Clinical Trial · n = 35
- Minerva Obstetrics and Gynecology 73(5)
- - F. Di Pierro
  - A. Criscuolo
  - Anna Dei Giudici
  - R. Senatori
  - F. Sesti
  - M. Ciotti
  - E. Piccione
- PubMed: 33876901
- DOI: 10.23736/S2724-606X.21.04752-7
3 Insights on
- High evidence
Lactobacillus johnsonii Attenuates Citrobacter rodentium-Induced Colitis by Regulating Inflammatory Responses and Endoplasmic Reticulum Stress in Mice.
- 2021-11
- RCT · n = 36
- The Journal of Nutrition 151(11)
- - Yunchang Zhang
  - Tianqi Mu
  - Ying Yang
  - Jinhua Zhang
  - F. Ren
  - Zhenlong Wu
- PubMed: 34383918
- DOI: 10.1093/jn/nxab250
10 Insights on
- Low evidence
- Animal Study
Comparing the Effectiveness of Herbal and Conventional Dentifrices in Reducing Dental Plaque and Gingivitis: A Systematic Review.
- 2021-11
- Review
- Journal of International Society of Preventive & Community Dentistry 11(6)
- - Sushanthi Suresh
  - Indiran Meignana Arumugham
  - Srisakthi Doraikannan
  - Pradeep Kumar Rathinavelu
  - Jayashri Prabakar
  - Arthi Balasubramaniam
- PubMed: 35036369
- DOI: 10.4103/jispcd.jispcd_171_21
2 Insights on
- Reduced Formation of Dental Plaque
- Reduced Gingivitis Severity
- Low evidence
Probiotic, Lactobacillus pentosus BD6 boost the growth and health status of white shrimp, Litopenaeus vannamei via oral administration.
- 2021-10
- Fish & Shellfish Immunology 117
- - Shieh-Tsung Chiu
  - T. Chu
  - Tohap Simangunsong
  - Rolissa Ballantyne
  - Chiu-Shia Chiu
  - Chun‐Hung Liu
- PubMed: 34343542
- DOI: 10.1016/j.fsi.2021.07.024
4 Insights on
- Low evidence
Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract.
- 2021-10
- Review
- Pharmacology research & perspectives 9(5)
- - María Elena Fátima Nader-Macías
  - Priscilla Romina De Gregorio
  - Jessica Alejandra Silva
- PubMed: 34609059
- DOI: 10.1002/prp2.787
4 Insights on
- Low evidence
Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract
- 2021-10
- Clinical Trial
- Saudi Journal of Biological Sciences 28(10)
- - M. A. Correa Deza
  - A. Rodríguez de Olmos
  - N. Suárez
  - G. Font de Valdez
  - S. Salva
  - C. L. Gerez
- PubMed: 34588880
- DOI: 10.1016/j.sjbs.2021.06.010
3 Insights on
- Low evidence
- Animal Study