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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Exploring the Diversity and Applications of Lactic Acid Bacteria from Tunisian Traditional Fermented Foods.
- 2026-02-05
- Review
- Microorganisms 14(2)
- - Sabrine Alebidi
  - Hana Mallek
  - Mariagiovanna Fragasso
  - Vittorio Capozzi
  - Ferid Abidi
  - Ines Essid
  - Giuseppe Spano
  - Hiba Selmi
- PubMed: 41753670
- DOI: 10.3390/microorganisms14020383
1 Insight on
- Not Assessable From Provided Abstract
- Low evidence
Changes of Swede Score in Low-Grade Cervical Precancerous Lesions After Administration of Coriolus versicolor Vaginal Gel: A Prospective Single-Arm Pilot Study in Indonesia.
- 2026-02-05
- Observational
- International journal of women's health 18
- - Sulaeman Andrianto Susilo
  - Ali Budi Harsono
- PubMed: 41883943
- DOI: 10.2147/ijwh.s572630
2 Insights on
- Reduced Swede Score
- Reduced VIA Positivity
- Low evidence
Fermentation of Fruit By-Products as a Tool for Nutritional and Environmental Sustainability.
- 2026-02-05
- Review
- Foods (Basel, Switzerland) 15(3)
- - Doheon Kim
  - Uyory Choe
  - Young-Jin Park
- PubMed: 41683164
- DOI: 10.3390/foods15030578
7 Insights on
- Low evidence
Combined fortification of yogurt with grape pomace pectic oligosaccharides and encapsulated probiotics.
- 2026-02-05
- Scientific reports 16(1)
- - Mohamad Savarolyia
  - Sara Amiri Samani
  - Mina Ghorbani
  - Maedeh Khezri
  - Milad Kazemi
  - Manochehr Momeni Shahraki
  - Faramarz Khodaiyan
  - Seyed Saeid Hosseini
- PubMed: 41644652
- DOI: 10.1038/s41598-026-35862-2
1 Insight on
- Improved Antioxidant Activity
- Low evidence
- Rigorous Journal
Ginkgo biloba for cognitive impairment and dementia.
- 2026-02-05
- Meta-Analysis · n = 9,783
- The Cochrane database of systematic reviews 2026(2)
- - Lisa S Wieland
  - Emilie Ludeman
  - Yuan Chi
  - Termeh M Feinberg
  - I-Hui Chen
  - Kee-Hsin Chen
  - Yanan Zhu
  - Emma Wolverson
  - Hakima Amri
- PubMed: 41641880
- DOI: 10.1002/14651858.cd013661.pub2
3 Insights on
- High evidence
Serrapeptase After Liposuction for Lipedema: Limited Evidence for Antifibrotic Efficacy.
- 2026-02-05
- Observational · n = 25
- Aesthetic plastic surgery 50(9)
- - Agostino Bruno
  - Valerio Saccoccio
- PubMed: 41642311
- DOI: 10.1007/s00266-026-05638-0
4 Insights on
- Low evidence
Microstructural and Rheological Properties of Camel and Bovine Milk Fermented with Five Lactic Acid Bacteria Strains.
- 2026-02-04
- Foods (Basel, Switzerland) 15(3)
- - Sifatun Nesa Ali
  - Syed Muhammad Asim
  - Nadiya Samad
  - Mutamed Ayyash
  - Afaf Kamal-Eldin
- PubMed: 41683133
- DOI: 10.3390/foods15030546
1 Insight on
- Increased Proteolysis
- Low evidence
The Protective Effect of Vitamin C Targeting Oxidative Stress on Renal Function in Patients with Septic Acute Kidney Injury: A Prospective, Randomized Controlled, Pilot Study.
- 2026-02-04
- RCT · n = 40
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 96(1)
- - Yu Chen
  - Min Lu
  - Xuee Shi
  - Fang Feng
  - Jinquan Zhou
- PubMed: 41873106
- DOI: 10.31083/ijvnr38770
5 Insights on
- High evidence
The Role of Probiotics Limosilactobacillus reuteri, Ligilactobacillus salivarius, and Lactobacillus johnsonii in Inhibziting Pathogens, Maintaining Gut Health, and Improving Disease Outcomes.
- 2026-02-04
- Review
- International journal of molecular sciences 27(3)
- - Li Li
  - Xiangqi Qiu
  - Shengyong Lu
  - Haitao Yu
  - Panpan Lu
  - Sumei Zeng
  - Aihua Deng
  - Min Zhu
  - E Xu
  - Jin Niu
- PubMed: 41683964
- DOI: 10.3390/ijms27031545
8 Insights on
- Moderate evidence
- Rigorous Journal
Efficacy and safety of probiotic/synbiotic supplementation for osteoporosis: a meta-analysis of randomized controlled trials.
- 2026-02-03
- Systematic Review · n = 732
- Frontiers in medicine 13
- - Xinyu Wang
  - Lei Zhou
  - Xingming Yu
  - Qiang Hou
  - Chenglong Wang
  - Wei Cui
  - Yuheng Hu
  - Xiumei Wang
  - Zhuangchen Zhu
- PubMed: 41709910
- DOI: 10.3389/fmed.2026.1731528
4 Insights on
- High evidence
Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy.
- 2026-02-03
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(19)
- - Haodong Ge
  - Chengsheng Ding
  - Xiao Yang
  - Si Gao
  - Changjie Yang
  - Yuchen Hou
  - Hongye Wang
  - Linke Bian
  - Hao Zhong
  - Yifan Qu
  - Luyang Zhang
  - Junjun Ma
  - Zhengwei Cai
  - Wenguo Cui
  - Minhua Zheng
- PubMed: 41632211
- DOI: 10.1002/advs.202517989
2 Insights on
- Reduced Tumor Growth
- Increased Intratumoral Accumulation
- Low evidence
Targeted Lipidomics and Lipid Metabolism Elucidate Anti-Obesity Effects of Lactic Acid Bacteria-Fermented Purple Sweet Potato Tainung No. 73 Extract in Obese Mice.
- 2026-02-03
- International journal of molecular sciences 27(3)
- - Hsien-Yi Yang
  - Chien-Hsun Huang
  - Shang-Tse Ho
  - Hsin-Hui Su
  - Yen-Po Chen
  - Yung-Tsung Chen
- PubMed: 41683924
- DOI: 10.3390/ijms27031489
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Therapeutic Interventions to Manage Oral Mucositis and Their Impact on Quality of Life in Cancer Patients: An Umbrella Review.
- 2026-02-03
- Systematic Review
- Pain research & management 2026
- - Joatan Lucas de Sousa Gomes Costa
  - Leonardo Díaz
  - Alain Chaple Gil
  - Gonzalo Rodríguez Martínez
  - Rodrigo Cabello Ibacache
  - Cristian Bersezio Miranda
  - Alfredo Von Marttens
  - Javier Basualdo
  - Eduardo Fernández Godoy
  - Milton Carlos Kuga
- PubMed: 41647299
- DOI: 10.1155/prm/3601001
3 Insights on
- High evidence
Topical probiotic Lactobacillus lactis treatment in atopic dermatitis: a placebo-controlled pilot study on tolerability and efficacy.
- 2026-02-03
- Clinical Trial · n = 13
- Frontiers in medicine 13
- - Ville Salo
  - Anita Remitz
  - Antti Lauerma
  - Alexander Salava
- PubMed: 41709889
- DOI: 10.3389/fmed.2026.1694229
8 Insights on
- Moderate evidence
Effects of Oral Probiotics on Streptococcus mutans in Children: A Systematic Review and Meta-Analysis.
- 2026-02-03
- Review · n = 1,362
- Dentistry journal 14(2)
- - Andrea Caiza-Rennella
  - Andrea Ordoñez-Balladares
  - Rosangela Caicedo-Quiroz
  - Indira Gómez-Capote
  - Zuilen Jiménez-Quintana
- PubMed: 41744926
- DOI: 10.3390/dj14020087
2 Insights on
- Reduced Streptococcus Mutans Levels
- Reduced Salivary Streptococcus mutans Level
- High evidence
Bio-Functional Properties of Lactic Acid Bacteria in Functional Foods.
- 2026-02-03
- Review
- Foods (Basel, Switzerland) 15(3)
- - Svetoslav Dimitrov Todorov
- PubMed: 41683114
- DOI: 10.3390/foods15030528
8 Insights on
- Low evidence
Effect of a gut commensal Lactobacillus strain Limosilactobacillus caviae JL20 on leptospiral whole-cell inactivated vaccine in hamsters.
- 2026-02-03
- PLoS neglected tropical diseases 20(2)
- - Shilei Zhang
  - Lianjie Ma
  - Qi Cao
  - Meijing Zhang
  - Guixin Yan
  - Wanqi Jiang
  - Xufeng Xie
  - Wenlong Zhang
  - Yongguo Cao
- PubMed: 41632794
- DOI: 10.1371/journal.pntd.0013951
5 Insights on
- Low evidence
- Animal Study
Probiotics as emerging adjuncts in metabolic associated fatty liver disease therapy-a systemic review.
- 2026-02-03
- Systematic Review
- BMC gastroenterology 26(1)
- - Radha Samyuktha Reddy Narem
  - Vani Mathakala
  - Sri Tejaswi Sallabathula
  - Vijaya Lakshmi Peddiboyina
  - Uma Maheswari Devi Palempalli
- PubMed: 41634593
- DOI: 10.1186/s12876-026-04618-7
5 Insights on
- High evidence
Proteomic antibacterial characterization of flavonoid xanthohumol and probiotic Clostridium butyricum on pathogenic Clostridioides difficile.
- 2026-02-03
- Chinese medicine 21(1)
- - Shenkun Wei
  - Guorong Li
  - Qiong Yang
  - Xinping Zhu
  - Junjie Liang
  - Mengyi Liu
  - Zijian Chen
  - Xia Liu
  - Jun-Yu Xu
  - Wei Chen
- PubMed: 41634763
- DOI: 10.1186/s13020-026-01343-x
2 Insights on
- Reduced Bacterial Toxin Production
- Reduced Clostridium difficile Cytotoxicity
- Low evidence
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
- 2026-02-02
- Review · n = 2,643
- Journal of clinical medicine 15(3)
- - Roman Maslennikov
  - Eva Gosteeva
  - Vera Ananeva
  - Lada Korshunova
  - Anastasya Kravtsowa
  - Elena Poluektova
  - Anatoly Ulyanin
  - Alexey Sigidaev
  - Patimat Kikhasurova
  - Vladimir Ivashkin
- PubMed: 41682832
- DOI: 10.3390/jcm15031152
3 Insights on
- High evidence
Design and immunogenicity of a recombinant Saccharomyces boulardii secreting the P2-VP8 subunit rotavirus vaccine.
- 2026-02-02
- Clinical Trial
- Scientific reports 16(1)
- - Ibrahim Farhani
  - Ahad Yamchi
  - Hadi Razavi Nikoo
  - Fatemeh T Shamsabadi
  - Shahriyar Abdoli
  - R Holland Cheng
  - Majid Shahbazi
- PubMed: 41629582
- DOI: 10.1038/s41598-026-37374-5
2 Insights on
- Immune Response to Rotavirus Vaccine Antigen
- Reduced Immunogenicity After Oral Vaccination
- High evidence
- Rigorous Journal
Gut Microbiota and Exercise-Induced Fatigue: A Narrative Review of Mechanisms, Nutritional Interventions, and Future Directions.
- 2026-02-02
- Review
- Nutrients 18(3)
- - Zhengxin Zhao
  - Shengwei Zhao
  - Wenli Li
  - Zheng Lai
  - Yang Zhou
  - Feng Guan
  - Xu Liang
  - Jiawei Zhang
  - Linding Wang
- PubMed: 41683324
- DOI: 10.3390/nu18030502
3 Insights on
- Moderate evidence
- Rigorous Journal
Protective activity of galacto-oligosaccharides against intestinal damage and inflammation induced by enterotoxigenic Escherichia coli F4+ and evaluation of prebiotic potential.
- 2026-02-02
- Frontiers in veterinary science 12
- - Barbara Guantario
  - Sofie Tanghe
  - Alberto Finamore
  - Bert Devriendt
  - Chiara Devirgiliis
  - Stefanie Verstringe
  - Enya Rooyackers
  - Maartje De Vos
  - Jan Vande Ginste
  - Marianna Roselli
- PubMed: 41705115
- DOI: 10.3389/fvets.2025.1740099
1 Insight on
- Improved Prebiotic Support for Lactobacillus amylovorus
- Low evidence
Immunomodulatory effects and gut microbiota modulation by brewer's yeast mannatide in cyclophosphamide-induced immunosuppression mice.
- 2026-02-02
- Archives of microbiology 208(4)
- - Shuang Zhao
  - Haidi Wang
  - Shuo Zhao
  - Jia Yu
  - Yuxi Wei
- PubMed: 41627476
- DOI: 10.1007/s00203-026-04725-9
3 Insights on
- Low evidence
- Animal Study
Magnesium Supplementation and Tachyarrhythmias: A Nonrandomized Clinical Trial.
- 2026-02-01
- Clinical Trial · n = 478
- JAMA internal medicine 186(2)
- - Robert Goulden
  - Michal Abrahamowicz
  - Erin Strumpf
  - Robyn Tamblyn
- PubMed: 41359319
- DOI: 10.1001/jamainternmed.2025.6572
3 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
The Combined Use of Hydroxymethylbutyrate and Branched-Chain Amino Acids to Counteract Uremic Sarcopenia.
- 2026-02-01
- RCT
- Nutrients 18(3)
- - Giulia Marrone
  - Manuela Di Lauro
  - Kevin Cornali
  - Sabri Shamsan Hassan
  - Gabriele D'Urso
  - Luca Di Marco
  - Sara Dominijanni
  - Roberto Palumbo
  - Anna Paola Mitterhofer
  - Annalisa Noce
- PubMed: 41683304
- DOI: 10.3390/nu18030483
3 Insights on
- High evidence
- Rigorous Journal
Efficacy of a Naturally Calcium and Magnesium-Rich Mineral Water on Musculoskeletal Fragility: A Randomized, Double-Blind Controlled Trial.
- 2026-01-31
- RCT · n = 98
- Nutrients 18(3)
- - Antimo Moretti
  - Sara Liguori
  - Marco Paoletta
  - Francesca Gimigliano
  - Giovanni Iolascon
- PubMed: 41683292
- DOI: 10.3390/nu18030470
2 Insights on
- Reduced Fall Incidence
- Improved Muscle Mass
- High evidence
- Rigorous Journal
Folate and global health umbrella review series, part 1: methodological framework and syntheses on anaemia and neural tube defects.
- 2026-01-30
- Systematic Review
- Journal of global health 16
- - Samantha Yoo
  - Azita Montazeri
  - Derrick Bennett
  - Yacong Bo
  - Peizhan Chen
  - Susan Duthie
  - Natalie Jensen
  - Atipatsa Kaminga
  - Jun-Shi Lai
  - Xue Li
  - Amanda J MacFarlane
  - Homero Martinez
  - Helene McNulty
  - Franco Momoli
  - Peter Mossey
  - Patrick Mullie
  - Ron Munger
  - Rajendra Prasad Parajuli
  - Monique Potvin Kent
  - Michele Rubini
  - Marjanne Senekal
  - Lindsey Sikora
  - Alain Stintzi
  - Evropi Theodoratou
  - Hui Wang
  - Chittaranjan Yajnik
  - Ann Yaktine
  - Julian Little
- PubMed: 41612855
- DOI: 10.7189/jogh.16.04014
2 Insights on
- Reduced Obesity
- Reduced Risk of Megaloblastic Anemia
- High evidence
The Effect of Oral Supplementation with a Multi-Strain Probiotic Preparation on Group B Streptococcus (GBS) Carriage in Pregnant Women-A Pilot Study.
- 2026-01-30
- Clinical Trial · n = 46
- Journal of clinical medicine 15(3)
- - Katarzyna Zych-Krekora
  - Oskar Sylwestrzak
  - Michał Krekora
- PubMed: 41682795
- DOI: 10.3390/jcm15031113
2 Insights on
- Reduced Group B Streptococcus Colonization
- Well Tolerated
- High evidence
Rhodotorula mucilaginosa ZTHY2 as a promising antibiotic alternative in Leizhou black ducks: impact on growth, meat quality, intestinal health, and microbiota composition.
- 2026-01-30
- RCT · n = 150
- BMC veterinary research 22(1)
- - Jiang Wu
  - Namula Zhao
  - Wei Yang
  - Yingxin Hu
  - Zhibao Chen
- PubMed: 41612385
- DOI: 10.1186/s12917-026-05292-3
1 Insight on
- Improved Growth Performance
- High evidence