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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk.
- 2010-06-15
- RCT · n = 352
- Clinical Infectious Diseases 50(12)
- - Rebeca Arroyo
  - V. Martín
  - Antonio Maldonado
  - E. Jiménez
  - L. Fernández
  - J. M. Rodríguez
- PubMed: 20455694
- DOI: 10.1086/652763
2 Insights on
- Reduced Milk Bacterial Counts
- Improved Mastitis Symptoms
- High evidence
- Large Human Trial
- Highly Cited
Caries Inhibition by and Safety of Lactobacillus paracasei DSMZ16671
- 2010-06-02
- RCT
- Journal of Dental Research 89(9)
- - J. Tanzer
  - A. Thompson
  - C. Lang
  - B. Cooper
  - L. Hareng
  - A. Gamer
  - A. Reindl
  - M. Pompejus
- PubMed: 20519491
- DOI: 10.1177/0022034510369460
5 Insights on
- Low evidence
- Animal Study
Alpha-lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal tolerance.
- 2010-06-02
- RCT · n = 66
- European journal of clinical nutrition 64(7)
- - C Dupont
  - M Rivero
  - C Grillon
  - N Belaroussi
  - A Kalindjian
  - V Marin
- PubMed: 20517331
- DOI: 10.1038/ejcn.2010.81
3 Insights on
- High evidence
- Rigorous Journal
Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model.
- 2010-06-01
- Beneficial Microbes 1(2)
- - H. Mäkivuokko
  - S. Forssten
  - M. Saarinen
  - A. Ouwehand
  - N. Rautonen
- PubMed: 21840801
- DOI: 10.3920/BM2009.0033
3 Insights on
- Low evidence
Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora
- 2010-05-26
- RCT · n = 78
- Clinical Oral Investigations 15(4)
- - L. Chuang
  - Chiung-Shing Huang
  - L. Ou-Yang
  - Shiao-Yu Lin
- PubMed: 20502929
- DOI: 10.1007/s00784-010-0423-9
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly.
- 2010-05-23
- RCT
- Bioscience, biotechnology, and biochemistry 74(5)
- - Kazuyoshi Namba
  - Michiko Hatano
  - Tomoko Yaeshima
  - Mitsunori Takase
  - Kunihiko Suzuki
- PubMed: 20460726
- DOI: 10.1271/bbb.90749
5 Insights on
- High evidence
Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1
- 2010-05-21
- Meta-Analysis
- British Journal of Nutrition 104(7)
- - Seiya Makino
  - S. Ikegami
  - Akinori Kume
  - H. Horiuchi
  - H. Sasaki
  - Naoki Orii
- PubMed: 20487575
- DOI: 10.1017/S000711451000173X
4 Insights on
- High evidence
- Highly Cited
Extended Safety Data for the Oral Cavity Probiotic Streptococcus salivarius K12
- 2010-05-19
- Clinical Trial · n = 880
- Probiotics and Antimicrobial Proteins 2(3)
- - Jeremy P. Burton
  - C. Chilcott
  - P. Wescombe
  - J. Tagg
- PubMed: 26781236
- DOI: 10.1007/s12602-010-9045-4
4 Insights on
- High evidence
- Large Human Trial
The hypocholesterolaemic effects of Lactobacillus acidophilus American Type Culture Collection 4356 in rats are mediated by the down-regulation of Niemann-Pick C1-Like 1
- 2010-05-05
- Clinical Trial
- British Journal of Nutrition 104(6)
- - Ying Huang
  - Jinfeng Wang
  - Yi Cheng
  - Yong-chen Zheng
- PubMed: 20441669
- DOI: 10.1017/S0007114510001285
5 Insights on
- Low evidence
- Animal Study
Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome.
- 2010-04-20
- RCT · n = 61
- Methods and Findings in Experimental and Clinical Pharmacology 31(10)
- - Dolin Bj
- PubMed: 20140275
- DOI: 10.1358/mf.2009.31.10.1441078
1 Insight on
- Reduced Bowel Movements
- High evidence
- Highly Cited
Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects.
- 2010-04-12
- RCT · n = 12
- British journal of clinical pharmacology 69(5)
- - Mohi Iqbal Mohammed Abdul
  - Xuemin Jiang
  - Kenneth M Williams
  - Richard O Day
  - Basil D Roufogalis
  - Winston S Liauw
  - Hongmei Xu
  - Anita Matthias
  - Reginald P Lehmann
  - Andrew J McLachlan
- PubMed: 20573086
- DOI: 10.1111/j.1365-2125.2010.03620.x
2 Insights on
- Reduced International Normalized Ratio
- Inhibited Platelet Aggregation
- High evidence
Beneficial effects of probiotic and food borne yeasts on human health.
- 2010-04-01
- Review
- Nutrients 2(4)
- - Saloomeh Moslehi-Jenabian
  - Line Lindegaard Pedersen
  - Lene Jespersen
- PubMed: 22254033
- DOI: 10.3390/nu2040449
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Estimation of combined effects of carbon and nitrogen sources on the growth and bacteriocin production of Lactobacillus salivarius from human source
- 2010-03-31
- Journal of Basic Microbiology 50(2)
- - M. S. J. Tomás
  - E. Bru
  - M. E. Nader-Macías
- PubMed: 20082367
- DOI: 10.1002/jobm.200900122
1 Insight on
- Reduced Urogenital Infections
- Low evidence
GanedenBC30™ cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro
- 2010-03-24
- BMC Immunology 11(1)
- - G. Jensen
  - K. Benson
  - Steve G. Carter
  - J. Endres
- PubMed: 20331905
- DOI: 10.1186/1471-2172-11-15
9 Insights on
- Low evidence
- Highly Cited
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
- 2010-03-10
- RCT · n = 87
- European Journal of Clinical Nutrition 64(6)
- - Y. Kadooka
  - M. Sato
  - K. Imaizumi
  - A. Ogawa
  - Ken Ikuyama
  - Y. Akai
  - M. Okano
  - M. Kagoshima
  - T. Tsuchida
- PubMed: 20216555
- DOI: 10.1038/ejcn.2010.19
11 Insights on
- High evidence
- Highly Cited
Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour.
- 2010-03-02
- British Journal of Nutrition 104(2)
- - M. Yazdi
  - M. M. Soltan Dallal
  - Z. Hassan
  - M. Holakuyee
  - S. Agha Amiri
  - M. Abolhassani
  - M. Mahdavi
- PubMed: 20193099
- DOI: 10.1017/S0007114510000516
8 Insights on
- Moderate evidence
Survival and metabolic activity of the GanedenBC30 strain of Bacillus coagulans in a dynamic in vitro model of the stomach and small intestine.
- 2010-03-01
- Beneficial Microbes 1(1)
- - A. Maathuis
  - D. Keller
  - S. Farmer
- PubMed: 21831748
- DOI: 10.3920/BM2009.0009
3 Insights on
- Low evidence
- Highly Cited
Clinical efficacy comparison of Saccharomyces boulardii and yogurt fluid in acute non-bloody diarrhea in children: a randomized, controlled, open label study.
- 2010-03-01
- RCT · n = 55
- The American Journal of Tropical Medicine and Hygiene 82(3)
- - M. Eren
  - E. Dinleyici
  - Y. Vandenplas
- PubMed: 20207879
- DOI: 10.4269/ajtmh.2010.09-0529
2 Insights on
- Reduced Duration of Diarrhea
- Resolution of Diarrhea
- High evidence
- Rigorous Journal
Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial
- 2010-01-12
- RCT · n = 45
- BMC Complementary and Alternative Medicine 10(1)
- - D. Mandel
  - K. Eichas
  - J. Holmes
- PubMed: 20067641
- DOI: 10.1186/1472-6882-10-1
13 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms
- 2009-11-18
- RCT · n = 61
- BMC Gastroenterology 9(1)
- - D. Kalman
  - H. Schwartz
  - Patricia Álvarez
  - S. Feldman
  - J. Pezzullo
  - D. Krieger
- PubMed: 19922649
- DOI: 10.1186/1471-230X-9-85
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Exopolysaccharides produced by Bifidobacterium longum IPLA E44 and Bifidobacterium animalis subsp. lactis IPLA R1 modify the composition and metabolic activity of human faecal microbiota in pH-controlled batch cultures.
- 2009-11-15
- International Journal of Food Microbiology 135(3)
- - N. Salazar
  - P. Ruas-Madiedo
  - S. Kolida
  - M. Collins
  - R. Rastall
  - G. Gibson
  - C. G. de los Reyes-Gavilán
- PubMed: 19735956
- DOI: 10.1016/j.ijfoodmicro.2009.08.017
4 Insights on
- Low evidence
- Highly Cited
Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia—a five-year retrospective review
- 2009-11-15
- Observational · n = 205
- European Journal of Clinical Microbiology & Infectious Diseases 29(1)
- - S. J. Mcbride
  - A. Upton
  - Sally A. Roberts
- PubMed: 19916034
- DOI: 10.1007/s10096-009-0830-5
3 Insights on
- High evidence
- Highly Cited
Administration of Bacillus coagulans in calves: recovery from faecal samples and evaluation of functional aspects of spores
- 2009-09-18
- Veterinary Research Communications 33(8)
- - B. Ripamonti
  - A. Agazzi
  - A. Baldi
  - C. Balzaretti
  - C. Bersani
  - S. Pirani
  - R. Rebucci
  - G. Savoini
  - S. Stella
  - A. Stenico
  - C. Domeneghini
- PubMed: 19763863
- DOI: 10.1007/s11259-009-9318-0
2 Insights on
- Increased Fecal Spore Counts
- Maintained Digestive Function
- Low evidence
Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial
- 2009-09-14
- RCT · n = 1,072
- British Journal of Nutrition 103(1)
- - E. Guillemard
  - F. Tondu
  - F. Lacoin
  - J. Schrezenmeir
- PubMed: 19747410
- DOI: 10.1017/S0007114509991395
2 Insights on
- Reduced Upper Respiratory Infections
- Reduced Duration of Infectious Diseases
- High evidence
- Large Human Trial
- Highly Cited
Effects of date ( Phoenix dactylifera L., Medjool or Hallawi Variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: a pilot study.
- 2009-09-09
- Clinical Trial · n = 10
- Journal of Agricultural and Food Chemistry 57(17)
- - Wasseem Rock
  - M. Rosenblat
  - H. Borochov-Neori
  - N. Volkova
  - Sylvie Judeinstein
  - M. Elias
  - M. Aviram
- PubMed: 19681613
- DOI: 10.1021/jf901559a
4 Insights on
- High evidence
- Highly Cited
Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.
- 2009-08-20
- RCT · n = 6
- Carcinogenesis 31(2)
- - R. L. Le Leu
  - Ying Hu
  - I. Brown
  - R. Woodman
  - G. Young
- PubMed: 19696163
- DOI: 10.1093/carcin/bgp197
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Probiotic effects on cold and influenza-like symptom incidence and duration in children.
- 2009-08-01
- RCT · n = 112
- Pediatrics 124(2)
- - Gregory J Leyer
  - Shuguang Li
  - Mohamed E Mubasher
  - Cheryl Reifer
  - Arthur C Ouwehand
- PubMed: 19651563
- DOI: 10.1542/peds.2008-2666
8 Insights on
- High evidence
- Large Human Trial
- Highly Cited
Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori.
- 2009-08-01
- Journal of Medical Microbiology 58(8)
- - K. Ryan
  - A. M. O'Hara
  - Jan-Peter van Pijkeren
  - François P Douillard
  - P. O’Toole
- PubMed: 19528183
- DOI: 10.1099/jmm.0.009407-0
2 Insights on
- Reduced IL-8 Production in Gastric Epithelial Cells
- Reduced Expression of Cag Pathogenicity Island Genes in H. pylori
- Low evidence
- Highly Cited
Heterologous expression and secretion of Lactobacillus amylovorus alpha-amylase in Leuconostoc citreum.
- 2009-07-18
- Biotechnology letters 31(11)
- - Hyun-Ju Eom
  - Jin-Seok Moon
  - Eun-Young Seo
  - Nam Soo Han
- PubMed: 19618275
- DOI: 10.1007/s10529-009-0079-1
1 Insight on
- Heterologous Protein Secretion
- Low evidence
Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial.
- 2009-05-18
- RCT · n = 66
- Journal of Clinical Periodontology 36(6)
- - G. Mayanagi
  - Moto Kimura
  - S. Nakaya
  - H. Hirata
  - M. Sakamoto
  - Y. Benno
  - H. Shimauchi
- PubMed: 19453574
- DOI: 10.1111/j.1600-051X.2009.01392.x
5 Insights on
- High evidence
- Highly Cited