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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Lactobacillus plantarum L-137 and/or β-glucan impacted the histopathological, antioxidant, immune-related genes and resistance of Nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila.
- 2020-06
- RCT
- Research in Veterinary Science 130
- - M. Dawood
  - E. Moustafa
  - Z. Elbialy
  - F. Farrag
  - Emad. E. Lolo
  - Hanaa A Abdel-Daim
  - Mohamed M. Abdel-Daim
  - Hien Van Doan
- PubMed: 32203766
- DOI: 10.1016/j.rvsc.2020.03.019
14 Insights on
- Low evidence
- Animal Study
The efficacy of L-carnitine in improving malnutrition in patients on maintenance hemodialysis: a meta-analysis.
- 2020-06
- Meta-Analysis
- Bioscience reports 40(6)
- - Jianwei Zhou
  - Tubao Yang
- PubMed: 32490516
- DOI: 10.1042/bsr20201639
4 Insights on
- High evidence
Structural characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus helveticus LZ-R-5.
- 2020-05
- Carbohydrate Polymers 235
- - Xiu You
  - Zhi Li
  - Kai Ma
  - Changliang Zhang
  - Xiaohong Chen
  - Guangxian Wang
  - Lin Yang
  - Mingsheng Dong
  - X. Rui
  - Qiuqin Zhang
  - Wei Li
- PubMed: 32122508
- DOI: 10.1016/j.carbpol.2020.115977
1 Insight on
- Improved Immune Response
- Low evidence
Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism.
- 2020-05
- RCT · n = 7
- The Journal of Nutritional Biochemistry 79
- - A. U. Din
  - Adil Hassan
  - Yuan Zhu
  - Kun Zhang
  - Yi Wang
  - Tianhan Li
  - Yang Wang
  - Guixue Wang
- PubMed: 32145470
- DOI: 10.1016/j.jnutbio.2020.108353
15 Insights on
- Low evidence
- Animal Study
Synbiotic Alters Fecal Microbiomes, but not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Non-alcoholic Fatty Liver Disease.
- 2020-05
- RCT · n = 104
- Gastroenterology 158(6)
- - E. Scorletti
  - P. Afolabi
  - E. Miles
  - Debbie E. Smith
  - Amal Almehmadi
  - Albandri Alshathry
  - C. Childs
  - S. Del Fabbro
  - Josh Bilson
  - H. Moyses
  - G. Clough
  - Jaswinder K. Sethi
  - J. Patel
  - M. Wright
  - D. Breen
  - C. Peebles
  - A. Darekar
  - R. Aspinall
  - A. Fowell
  - J. Dowman
  - V. Nobili
  - G. Targher
  - N. Delzenne
  - L. Bindels
  - P. Calder
  - C. Byrne
- PubMed: 31987796
- DOI: 10.1053/j.gastro.2020.01.031
2 Insights on
- Reduced Liver Fat Content
- Changes in Liver Fibrosis Markers
- High evidence
- Highly Cited
S-layer protein 2 of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens.
- 2020-05
- International Journal of Biological Macromolecules 150
- - V. Abramov
  - I. Kosarev
  - T. Priputnevich
  - A. Machulin
  - V. Khlebnikov
  - S. Pchelintsev
  - R. Vasilenko
  - V. Sakulin
  - N. Suzina
  - I. Chikileva
  - Evgenia I Derysheva
  - V. Melnikov
  - I. N. Nikonov
  - V. A. Samoilenko
  - Eduard E Svetoch
  - G. Sukhikh
  - V. Uversky
  - A. V. Karlyshev
- PubMed: 32045605
- DOI: 10.1016/j.ijbiomac.2020.02.065
16 Insights on
- Low evidence
Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice
- 2020-05
- Clinical Trial
- Neurobiology of Stress 12
- - Peijun Tian
  - Kenneth J. O'Riordan
  - Yuan-Kun Lee
  - Gang Wang
  - Jianxin Zhao
  - Hao Zhang
  - J. Cryan
  - Wei Chen
- PubMed: 32258258
- DOI: 10.1016/j.ynstr.2020.100216
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Lactobacillus paracasei as a protective factor of obesity induced by an unhealthy diet in children.
- 2020-05
- Observational · n = 1,111
- Obesity Research & Clinical Practice 14(3)
- - A. C. Castañeda-Márquez
  - C. E. Díaz-Benítez
  - M. Bahena-Román
  - Guadalupe Evelin Campuzano-Benítez
  - Marcia V Galván-Portillo
  - J. Campuzano-Rincón
  - A. Lagunas-Martínez
  - V. Bermúdez-Morales
  - Y. C. Orbe-Orihuela
  - Jesús Peralta-Romero
  - M. Cruz
  - A. Burguete-García
- PubMed: 32518007
- DOI: 10.1016/j.orcp.2020.04.005
1 Insight on
- Reduced Obesity
- High evidence
Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine.
- 2020-05
- RCT · n = 6
- The Journal of Nutrition 150(5)
- - Jiangdi Mao
  - Siri Qi
  - Yanjun Cui
  - Xiaoxiao Dou
  - Xin M. Luo
  - Jianxin Liu
  - T. Zhu
  - Yanfei Ma
  - Haifeng Wang
- PubMed: 32027752
- DOI: 10.1093/jn/nxaa009
9 Insights on
- Low evidence
- Animal Study
A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial.
- 2020-05
- RCT · n = 80
- Digestive and Liver Disease 52(5)
- - S. Sadrin
  - S. Sennoune
  - B. Gout
  - S. Marque
  - J. Moreau
  - Karim Zinoune
  - J. Grillasca
  - O. Pons
  - J. Maixent
- PubMed: 31952938
- DOI: 10.1016/j.dld.2019.12.009
13 Insights on
- High evidence
Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial.
- 2020-05
- RCT · n = 219
- European journal of cancer (Oxford, England : 1990) 130
- - Jin Won Kim
  - Sae Won Han
  - Jae Yong Cho
  - Ik-Joo Chung
  - Jong Gwang Kim
  - Kyung Hee Lee
  - Keon Uk Park
  - Sun Kyung Baek
  - Sang Cheul Oh
  - Myung Ah Lee
  - Doyeun Oh
  - Byoungyong Shim
  - Joong Bae Ahn
  - Dongbok Shin
  - Jae Won Lee
  - Yeul Hong Kim
- PubMed: 32172198
- DOI: 10.1016/j.ejca.2020.02.018
6 Insights on
- High evidence
- Large Human Trial
Lactobacillus fermentum CECT5716 supplementation in rats during pregnancy and lactation affects breast milk composition.
- 2020-04
- Journal of Dairy Science 103(4)
- - Ignasi Azagra-Boronat
  - A. Tres
  - M. Massot-Cladera
  - À. Franch
  - M. Castell
  - F. Guardiola
  - F. Pérez-Cano
  - M. J. Rodríguez-Lagunas
- PubMed: 32008776
- DOI: 10.3168/jds.2019-17384
13 Insights on
- Low evidence
- Rigorous Journal
Effects of dietary probiotic (Pediococcus acidilactici) supplementation on productive performance, egg quality, and body composition in laying hens fed diets varying in energy density
- 2020-04
- Poultry Science 99(4)
- - D. Mikulski
  - J. Jankowski
  - M. Mikulska
  - V. Demey
- PubMed: 32241513
- DOI: 10.1016/j.psj.2019.11.046
5 Insights on
- Low evidence
- Rigorous Journal
Effects of recombinant Lactobacillus casei on growth performance, immune response and disease resistance in crucian carp, Carassius auratus.
- 2020-04
- Clinical Trial
- Fish & Shellfish Immunology 99
- - Yi‐di Kong
  - Min Li
  - Jiaxin Tian
  - Linhui Zhao
  - Yuanhuan Kang
  - Lei Zhang
  - Guiqin Wang
  - Xiaofeng Shan
- PubMed: 32032762
- DOI: 10.1016/j.fsi.2020.02.008
4 Insights on
- Low evidence
- Animal Study
Oral intake of Streptococcus thermophilus improves knee osteoarthritis degeneration: A randomized, double-blind, placebo-controlled clinical study
- 2020-04
- RCT · n = 80
- Heliyon 6(4)
- - Jianwei Lyu
  - Ting-Ming Wang
  - Yen-Hao Chen
  - Shu-Xuan Chang
  - Ming-Shiang Wu
  - Yung-Hao Lin
  - Yung-Hsiang Lin
  - Chen-Meng Kuan
- PubMed: 32368640
- DOI: 10.1016/j.heliyon.2020.e03757
5 Insights on
- High evidence
L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
- 2020-04
- RCT
- Journal of affective disorders 267
- - Behin Araminia
  - Mohammadreza Shalbafan
  - Amirhosein Mortezaei
  - Elham Shirazi
  - Salomeh Ghaffari
  - Erfan Sahebolzamani
  - Seyyed Hosein Mortazavi
  - Behnam Shariati
  - Mehrdad Eftekhar Ardebili
  - Ali Aqamolaei
  - Sina Naderi
  - Shahin Akhondzadeh
- PubMed: 32063564
- DOI: 10.1016/j.jad.2020.02.020
3 Insights on
- High evidence
Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway
- 2020-03
- Clinical Trial
- Experimental & Molecular Medicine 52(3)
- - J. Choi
  - C. Moon
  - Tae-Seop Shin
  - Eun Kyoung Kim
  - Andrea McDowell
  - Min-Kyung Jo
  - Y. Joo
  - Seong-Eun Kim
  - Hye-Kyung Jung
  - K. Shim
  - S. Jung
  - Yoon-Keun Kim
- PubMed: 32123288
- DOI: 10.1038/s12276-019-0359-3
15 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Studies on characteristics and anti-diabetic and -nephritic effects of polysaccharides isolated from Paecilomyces hepiali fermentation mycelium in db/db mice.
- 2020-03
- Clinical Trial
- Carbohydrate Polymers 232
- - Wenji Hu
  - Juan Wang
  - Weiying Guo
  - Yange Liu
  - Z. Guo
  - Y. Miao
  - Di Wang
- PubMed: 31952583
- DOI: 10.1016/j.carbpol.2019.115766
5 Insights on
- Low evidence
- Animal Study
Effects of dietary Pediococcus acidilactici GY2 single or combined with Saccharomyces cerevisiae or/and β-glucan on the growth, innate immunity response and disease resistance of Macrobrachium rosenbergii.
- 2020-03
- RCT · n = 5
- Fish & Shellfish Immunology 98
- - Shuyan Miao
  - B. Han
  - Chenze Zhao
  - Juntao Hu
  - Jinyu Zhu
  - Xin Zhang
  - Longsheng Sun
- PubMed: 31857226
- DOI: 10.1016/j.fsi.2019.12.038
12 Insights on
- Low evidence
- Animal Study
Exopolysaccharides of Bacillus amyloliquefaciens modulate glycemic level in mice and promote glucose uptake of cells through the activation of Akt.
- 2020-03
- Clinical Trial
- International Journal of Biological Macromolecules 146
- - Yo-Chia Chen
  - Shen-Da Huang
  - Jing-Hong Tu
  - Jyun-Sian Yu
  - Annisa Oktafianti Nurlatifah
  - Wen‐Chin Chiu
  - Yu-Han Su
  - Hsuan-Lun Chang
  - Diwyacitta Antya Putri
  - Hsueh-Ling Cheng
- PubMed: 31887379
- DOI: 10.1016/j.ijbiomac.2019.12.217
3 Insights on
- Low evidence
- Animal Study
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial.
- 2020-03
- RCT · n = 50
- Complementary therapies in medicine 49
- - Amir Hadi
  - Arman Arab
  - Hossein Hajianfar
  - Behrouz Talaei
  - Maryam Miraghajani
  - Siavash Babajafari
  - Wolfgang Marx
  - Rahele Tavakoly
- PubMed: 32147060
- DOI: 10.1016/j.ctim.2020.102315
10 Insights on
- High evidence
Metabolic activity of Bacillus coagulans R11 and the health benefits of and potential pathogen inhibition by this species in the intestines of laying hens under lead exposure.
- 2020-03
- Clinical Trial
- Science of The Total Environment 709
- - Sicheng Xing
  - J. Mi
  - Jing-Yuan Chen
  - Jiaxin Hu
  - Xin-Di Liao
- PubMed: 31881475
- DOI: 10.1016/j.scitotenv.2019.134507
4 Insights on
- Low evidence
- Animal Study
Effect of vitamin K1 on survival of patients with chronic liver failure: A retrospective cohort study.
- 2020-03
- Observational · n = 80
- Medicine 99(13)
- - Zhuang Xiong
  - Yangyang Liu
  - Tianying Chang
  - Xiaohao Xu
  - Shaokai Huo
  - Houbo Deng
  - Tiejun Liu
  - Yan Leng
- PubMed: 32221088
- DOI: 10.1097/md.0000000000019619
2 Insights on
- Reduced Mortality Rate
- Reduced International Normalized Ratio
- Moderate evidence
Effect of Lactobacillus Plantarum Containing Probiotics on Blood Pressure: A systematic review and meta-analysis.
- 2020-03
- Meta-Analysis
- Pharmacological Research 153
- - Anne-Mary Lewis-Mikhael
  - Amirhossein Davoodvandi
  - S. Jafarnejad
- PubMed: 31987993
- DOI: 10.1016/j.phrs.2020.104663
3 Insights on
- High evidence
- Rigorous Journal
Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice.
- 2020-03
- Clinical Trial
- Chinese Journal of Natural Medicines 18(3)
- - H. Yi
  - Xiaoxiao Zhu
  - Xiao-Li Huang
  - Yupei Lai
  - Yue Tang
- PubMed: 32245586
- DOI: 10.1016/s1875-5364(20)30018-2
7 Insights on
- Low evidence
- Animal Study
Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women.
- 2020-03
- The Journal of Nutrition 150(3)
- - A. Kojima
  - S. Ikehara
  - K. Kamiya
  - E. Kajita
  - Yuho Sato
  - K. Kouda
  - J. Tamaki
  - S. Kagamimori
  - M. Iki
- PubMed: 31825069
- DOI: 10.1093/jn/nxz292
1 Insight on
- Reduced Risk of Osteoporotic Fractures
- Moderate evidence
Orodispersible lozenges containing a combination of Lactobacillus reuteri DSM 17938 and Lactobacillus reuteri ATCC PTA 5289 and normal gum function: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
- 2020-03
- EFSA Journal 18(3)
- - D. Turck
  - J. Castenmiller
  - S. de Henauw
  - Karen Ildico Hirsch‐Ernst
  - J. Kearney
  - H. Knutsen
  - A. Maciuk
  - I. Mangelsdorf
  - H. Mcardle
  - A. Naska
  - C. Peláez
  - K. Pentieva
  - F. Thies
  - S. Tsabouri
  - M. Vinceti
  - J. Bresson
  - Yolanda Sanz
  - A. Siani
- PubMed: 32874242
- DOI: 10.2903/j.efsa.2020.6004
3 Insights on
- Low evidence
Comparison of Serenoa repens With Tamsulosin in the Treatment of Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis.
- 2020-03
- Meta-Analysis · n = 80
- American journal of men's health 14(2)
- - Tong Cai
  - Yuanshan Cui
  - Shaoxia Yu
  - Qian Li
  - Zhongbao Zhou
  - Zhenli Gao
- PubMed: 32274957
- DOI: 10.1177/1557988320905407
6 Insights on
- High evidence
Probiotic Properties of Lactobacillus brevis KU200019 and Synergistic Activity with Fructooligosaccharides in Antagonistic Activity against Foodborne Pathogens
- 2020-03
- Food Science of Animal Resources 40(2)
- - K. M. G. M. M. Kariyawasam
  - Seo-Jin Yang
  - N. Lee
  - H. Paik
- PubMed: 32161924
- DOI: 10.5851/kosfa.2020.e15
9 Insights on
- Low evidence
Physicochemical, bioactive and rheological properties of an exopolysaccharide produced by a probiotic Pediococcus pentosaceus M41.
- 2020-02
- Carbohydrate Polymers 229
- - M. Ayyash
  - B. Abu-Jdayil
  - A. Olaimat
  - G. Esposito
  - P. Itsaranuwat
  - T. Osaili
  - R. Obaid
  - Jaleel Kizhakkayil
  - Shaoquan Liu
- PubMed: 31826478
- DOI: 10.1016/j.carbpol.2019.115462
5 Insights on
- Low evidence
- Highly Cited