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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.
- 2016-06
- RCT · n = 51
- Nutrition 32(6)
- - L. J. Bernini
  - A. Simão
  - D. Alfieri
  - M. A. Lozovoy
  - Naiara Lourenço Mari
  - C. H. B. de Souza
  - I. Dichi
  - G. N. Costa
- PubMed: 27126957
- DOI: 10.1016/j.nut.2015.11.001
11 Insights on
- High evidence
- Highly Cited
Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers - Randomized, double blind, placebo-controlled study.
- 2016-06
- RCT · n = 210
- Clinical Nutrition 35(3)
- - I. Hojsak
  - Ana Močić Pavić
  - T. Kos
  - J. Dumančić
  - S. Kolaček
- PubMed: 26031908
- DOI: 10.1016/j.clnu.2015.05.004
7 Insights on
- High evidence
Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed.
- 2016-05
- Fish & Shellfish Immunology 52
- - Xia Guo
  - Dan-Dan Chen
  - K. Peng
  - Zheng-Wei Cui
  - Xu-Jie Zhang
  - Shun Li
  - Yong‐An Zhang
- PubMed: 26988285
- DOI: 10.1016/j.fsi.2016.03.017
3 Insights on
- Low evidence
- Highly Cited
A double-blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I-745 in formula-fed preterm infants.
- 2016-05
- RCT · n = 125
- Jornal de Pediatria 92(3)
- - Ling-fen Xu
  - Yun Wang
  - Yang Wang
  - Jianhua Fu
  - Mei Sun
  - Zhi-qin Mao
  - Y. Vandenplas
- PubMed: 26946967
- DOI: 10.1016/j.jped.2015.08.013
5 Insights on
- High evidence
High-Dose Probiotic Supplementation Containing Lactobacillus casei for 7 Days Does Not Enhance Salivary Antimicrobial Protein Responses to Exertional Heat Stress Compared With Placebo.
- 2016-04
- RCT · n = 8
- International Journal of Sport Nutrition and Exercise Metabolism 26(2)
- - S. Gill
  - A. Teixeira
  - F. Rosado
  - Martin Cox
  - R. Costa
- PubMed: 26479711
- DOI: 10.1123/ijsnem.2015-0171
3 Insights on
- High evidence
Fermented milk with probiotic Lactobacillus rhamnosus S1K3 (MTCC5957) protects mice from salmonella by enhancing immune and nonimmune protection mechanisms at intestinal mucosal level.
- 2016-04
- Clinical Trial
- The Journal of Nutritional Biochemistry 30
- - T. S. Kemgang
  - S. Kapila
  - V. P. Shanmugam
  - S. Reddi
  - R. Kapila
- PubMed: 27012622
- DOI: 10.1016/j.jnutbio.2015.11.018
14 Insights on
- Low evidence
- Animal Study
Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens.
- 2016-04
- RCT
- Poultry Science 95(4)
- - Q. Peng
  - X. Zeng
  - Jinlong Zhu
  - Siyuan Wang
  - X. Liu
  - C. Hou
  - P. Thacker
  - S. Qiao
- PubMed: 26772658
- DOI: 10.3382/ps/pev435
18 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Antagonistics against pathogenic Bacillus cereus in milk fermentation by Lactobacillus plantarum ZDY2013 and its anti-adhesion effect on Caco-2 cells against pathogens.
- 2016-04
- Journal of Dairy Science 99(4)
- - Zhihong Zhang
  - X. Tao
  - N. Shah
  - Hua Wei
- PubMed: 26830743
- DOI: 10.3168/jds.2015-10587
2 Insights on
- Reduced Pathogenic Bacillus Cereus Levels
- Reduced Enterotoxin-Producing Bacillus Cereus Adhesion
- Low evidence
- Rigorous Journal
Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults.
- 2016-03
- RCT · n = 30
- Molecular Nutrition & Food Research 60(5)
- - Huicui Meng
  - Yujin Lee
  - Zhaoyong Ba
  - Jiayu Peng
  - Junli Lin
  - Alexander S Boyer
  - J. Fleming
  - E. Furumoto
  - R. Roberts
  - P. Kris-Etherton
  - C. Rogers
- PubMed: 26821116
- DOI: 10.1002/mnfr.201500665
14 Insights on
- High evidence
- Rigorous Journal
Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5(1A).
- 2016-03
- Clinical Trial
- Microbes and Infection 18(3)
- - A. T. Vieira
  - V. Rocha
  - L. Tavares
  - Cristiana C Garcia
  - M. Teixeira
  - S. Oliveira
  - G. Cassali
  - C. Gamba
  - F. Martins
  - J. Nicoli
- PubMed: 26548605
- DOI: 10.1016/j.micinf.2015.10.008
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Evaluation of probiotic properties of Lactobacillus plantarum WLPL04 isolated from human breast milk.
- 2016-03
- Journal of Dairy Science 99(3)
- - Meiling Jiang
  - Fen Zhang
  - C. Wan
  - Yonghua Xiong
  - N. Shah
  - Hua Wei
  - X. Tao
- PubMed: 26805974
- DOI: 10.3168/jds.2015-10434
10 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Effects of dietary supplementation of Lactobacillus rhamnosus or/and Lactococcus lactis on the growth, gut microbiota and immune responses of red sea bream, Pagrus major.
- 2016-02
- RCT
- Fish & Shellfish Immunology 49
- - M. Dawood
  - S. Koshio
  - M. Ishikawa
  - S. Yokoyama
  - M. F. El Basuini
  - Md. Sakhawat Hossain
  - Truong H. Nhu
  - Serge Dossou
  - Amina S. Moss
- PubMed: 26766177
- DOI: 10.1016/j.fsi.2015.12.047
23 Insights on
- High evidence
- Highly Cited
Effectiveness of Lactobacillus reuteri DSM 17938 for the Prevention of Nosocomial Diarrhea in Children: A Randomized, Double-blind, Placebo-controlled Trial
- 2016-02
- RCT · n = 184
- Pediatric Infectious Disease Journal 35(2)
- - M. Urbańska
  - D. Gieruszczak-Bialek
  - H. Szymański
  - H. Szajewska
- PubMed: 26551445
- DOI: 10.1097/INF.0000000000000948
2 Insights on
- Reduced Nosocomial Diarrhea Incidence
- Increased Adverse Effects
- High evidence
Use of the dynamic gastro-intestinal model TIM to explore the survival of the yogurt bacterium Streptococcus thermophilus and the metabolic activities induced in the simulated human gut.
- 2016-02
- Food Microbiology 53
- - O. Uriot
  - W. Galia
  - A. A. Awussi
  - C. Perrin
  - S. Denis
  - S. Chalancon
  - Emilie Lorson
  - C. Poirson
  - M. Junjua
  - Y. Le Roux
  - M. Alric
  - A. Dary
  - S. Blanquet-Diot
  - Y. Roussel
- PubMed: 26611166
- DOI: 10.1016/j.fm.2015.05.007
2 Insights on
- Improved Survival Rate
- Improved Gastrointestinal Survival
- Low evidence
Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto.
- 2016-02
- Clinical Trial
- Food and Chemical Toxicology 88
- - Bradley J. Lampe
  - J. Caroline English
- PubMed: 26740078
- DOI: 10.1016/j.fct.2015.12.025
3 Insights on
- Low evidence
- Animal Study
Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial
- 2016-02
- RCT · n = 1,315
- The Lancet 387(10019)
- - K. Costeloe
  - P. Hardy
  - E. Juszczak
  - M. Wilks
  - M. Millar
- PubMed: 26628328
- DOI: 10.1016/S0140-6736(15)01027-2
12 Insights on
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
Extraction, characterization and antioxidant activity of mycelial polysaccharides from Paecilomyces hepiali HN1.
- 2016-02
- Carbohydrate Polymers 137
- - Zhongwei Wu
  - Mingxia Zhang
  - Minhao Xie
  - Zhuqing Dai
  - Xiaoqing Wang
  - Bing Hu
  - Hong Ye
  - Xiaoxiong Zeng
- PubMed: 26686161
- DOI: 10.1016/j.carbpol.2015.11.010
1 Insight on
- Reduced Hepatic Oxidative Stress
- Low evidence
Biofilms of Lactobacillus plantarum and Lactobacillus fermentum: Effect on stress responses, antagonistic effects on pathogen growth and immunomodulatory properties.
- 2016-02
- Food Microbiology 53
- - N. Aoudia
  - A. Rieu
  - R. Briandet
  - J. Deschamps
  - J. Chluba
  - G. Jego
  - C. Garrido
  - J. Guzzo
- PubMed: 26611169
- DOI: 10.1016/j.fm.2015.04.009
1 Insight on
- Reduced TNF Production
- Low evidence
- Highly Cited
Association of Lactobacillus crispatus with fructo-oligosaccharides and ascorbic acid in hydroxypropyl methylcellulose vaginal insert.
- 2016-01
- Carbohydrate Polymers 136
- - B. Vitali
  - A. Abruzzo
  - C. Parolin
  - R. A. Ñ. Palomino
  - F. Dalena
  - F. Bigucci
  - T. Cerchiara
  - B. Luppi
- PubMed: 26572459
- DOI: 10.1016/j.carbpol.2015.10.035
3 Insights on
- Low evidence
The Influence of Probiotic Lactobacillus casei in Combination with Prebiotic Inulin on the Antioxidant Capacity of Human Plasma
- 2016-01
- RCT · n = 32
- Oxidative Medicine and Cellular Longevity 2016
- - P. Kleniewska
  - Arkadiusz Hoffmann
  - E. Pniewska
  - R. Pawliczak
- PubMed: 27066188
- DOI: 10.1155/2016/1340903
4 Insights on
- High evidence
Clostridium butyricum: from beneficial to a new emerging pathogen.
- 2016-01
- Clinical Microbiology and Infection 22(1)
- - N. Cassir
  - S. Benamar
  - B. Scola
- PubMed: 26493849
- DOI: 10.1016/j.cmi.2015.10.014
4 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Anti-colon cancer and antioxidant activities of bovine skim milk fermented by selected Lactobacillus helveticus strains.
- 2016-01
- Journal of Dairy Science 99(1)
- - KR Elfahri
  - T. Vasiljevic
  - Thomas R. Yeager
  - O. Donkor
- PubMed: 26601580
- DOI: 10.3168/jds.2015-10160
6 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
A novel consortium of Lactobacillus rhamnosus and Streptococcus thermophilus for increased access to functional fermented foods
- 2015-12
- Microbial Cell Factories 14(1)
- - R. Kort
  - Nieke Westerik
  - L. M. Serrano
  - François P Douillard
  - W. Gottstein
  - I. M. Mukisa
  - C. Tuijn
  - L. Basten
  - B. Hafkamp
  - W. Meijer
  - B. Teusink
  - W. Vos
  - W. Vos
  - G. Reid
  - G. Reid
  - W. Sybesma
- PubMed: 26643044
- DOI: 10.1186/s12934-015-0370-x
1 Insight on
- Alleviated Diarrhea
- Low evidence
- Highly Cited
Dietary Bacillus subtilis FPTB13 and chitin, single or combined, modulate systemic and cutaneous mucosal immunity and resistance of catla, Catla catla (Hamilton) against edwardsiellosis.
- 2015-12
- Clinical Trial
- Comparative Immunology, Microbiology and Infectious Diseases 43
- - T. Sangma
  - D. Kamilya
- PubMed: 26616655
- DOI: 10.1016/j.cimid.2015.09.003
6 Insights on
- Low evidence
- Animal Study
Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro.
- 2015-12
- International Journal of Medical Microbiology 305(8)
- - A. Rizzo
  - M. Fiorentino
  - E. Buommino
  - G. Donnarumma
  - A. Losacco
  - N. Bevilacqua
- PubMed: 26372530
- DOI: 10.1016/j.ijmm.2015.07.005
7 Insights on
- Low evidence
Probiotics and gut health in infants: A preliminary case-control observational study about early treatment with Lactobacillus reuteri DSM 17938.
- 2015-12
- Observational · n = 60
- Clinica Chimica Acta 451
- - F. Savino
  - Stefania Fornasero
  - Simone Ceratto
  - A. De Marco
  - N. Mandras
  - J. Roana
  - V. Tullio
  - G. Amisano
- PubMed: 25704298
- DOI: 10.1016/j.cca.2015.02.027
4 Insights on
- Moderate evidence
Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study
- 2015-12
- RCT · n = 100
- Immunity & Ageing 12(1)
- - Marie Lefevre
  - S. Racedo
  - Gabrielle Ripert
  - B. Housez
  - M. Cazaubiel
  - C. Maudet
  - Peter Jüsten
  - P. Marteau
  - M. Urdaci
- PubMed: 26640504
- DOI: 10.1186/s12979-015-0051-y
6 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial
- 2015-12
- RCT
- Nutrition Journal 15(1)
- - M. Pakdaman
  - J. Udani
  - J. Molina
  - M. Shahani
- PubMed: 27207411
- DOI: 10.1186/s12937-016-0172-y
11 Insights on
- High evidence
Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study
- 2015-12
- RCT · n = 36
- Nutrition Journal 15(1)
- - M. Majeed
  - K. Nagabhushanam
  - Sankaran Natarajan
  - A. Sivakumar
  - Furqan Ali
  - A. Pande
  - Shaheen Majeed
  - S. K. Karri
- PubMed: 26922379
- DOI: 10.1186/s12937-016-0140-6
11 Insights on
- High evidence
- Highly Cited
Safety and acceptability of Lactobacillus reuteri DSM 17938 and Bifidobacterium longum subspecies infantis 35624 in Bangladeshi infants: a phase I randomized clinical trial.
- 2015-12
- RCT · n = 160
- BMC complementary and alternative medicine 16(1)
- - Yana Emmy Hoy-Schulz
  - Kaniz Jannat
  - Thomas Roberts
  - Saira Husain Zaidi
  - Leanne Unicomb
  - Stephen Luby
  - Julie Parsonnet
- PubMed: 26832746
- DOI: 10.1186/s12906-016-1016-1
3 Insights on
- High evidence
- Large Human Trial