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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
- 2026-03-31
- RCT · n = 32
- East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan 36(1)
- - A S Walyddaini
  - S T Lisal
  - Ilhamuddin
  - A A Zainuddin
  - A J Tanra
  - Y Widianingsih
  - S Syamsuddin
- PubMed: 41916937
- DOI: 10.12809/eaap25122
1 Insight on
- Improved Depressive Symptoms
- High evidence
Tart cherry supplementation for exercise recovery: an evidence-informed narrative review and applied monitoring framework.
- 2026-03-31
- Review
- Physical activity and nutrition 30(1)
- - Jooyoung Kim
- PubMed: 41956499
- DOI: 10.20463/pan.2026.0009
6 Insights on
- Low evidence
Encapsulation of probiotics to improve their survival: A focus on Bifidobacterium animalis subsp. lactis BB-12.
- 2026-03-30
- Review
- Food chemistry: X 35
- - Defeng Shu
  - Tianning Zhang
  - Yajie Dong
  - Jinlong Xu
  - Yongkai Yuan
- PubMed: 41994549
- DOI: 10.1016/j.fochx.2026.103802
2 Insights on
- Improved Gastrointestinal Transit
- Improved Food Matrix Resistance
- Low evidence
Effect of Probiotic and Synbiotic Oral Supplementation in Autoimmune Diseases: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-03-30
- Meta-Analysis · n = 703
- Nutrients 18(7)
- - Yuan-Yow Chiou
  - Tsu-Yun Chiu
  - Mei-Ju Chen
- PubMed: 41978157
- DOI: 10.3390/nu18071107
3 Insights on
- High evidence
- Rigorous Journal
Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.
- 2026-03-29
- Review
- Gut microbes 18(1)
- - Solveiga Samulėnaitė
  - Jan Rodriguez Parkitna
  - Daiva Baltriukienė
  - Elena Martín-García
  - Rafael Maldonado
  - Aurelijus Burokas
- PubMed: 41906418
- DOI: 10.1080/19490976.2026.2647535
4 Insights on
- Low evidence
Lactobacillus acidophilus Postbiotics Differentially Modulate Nutrient Sensing, Intestinal Barrier Integrity, and Inflammatory Signaling in Broiler.
- 2026-03-29
- RCT · n = 400
- Comprehensive Physiology 16(2)
- - Meng Yu
  - Zhiyun Qin
  - Atique Ahmed Behan
  - Shabbir Ahmed
  - Muhammad Asif Arain
  - Nazrin Malikli
  - Jameel Ahmed Budar
  - Hesham Hassanien
- PubMed: 41905960
- DOI: 10.1002/cph4.70139
6 Insights on
- Low evidence
- Animal Study
Efficacy and potential pharmacological mechanisms of total glucosides of paeony in treating ankylosing spondylitis in Asian populations: a meta-analysis, network pharmacology, and molecular dynamics simulation.
- 2026-03-27
- Systematic Review · n = 130
- Frontiers in nutrition 13
- - Wenjun Mu
  - Jianhui Ma
  - Xudong Zhang
  - Jun Su
  - Xiang Wang
  - Cong Huang
- PubMed: 41971360
- DOI: 10.3389/fnut.2026.1738150
1 Insight on
- Reduced Inflammatory Response
- High evidence
Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis.
- 2026-03-27
- Review
- Frontiers in microbiology 17
- - Natarajan Sisubalan
  - Periyanaina Kesika
  - Bhagavathi Sundaram Sivamaruthi
  - Chaiyavat Chaiyasut
- PubMed: 41971341
- DOI: 10.3389/fmicb.2026.1804560
7 Insights on
- Low evidence
Dietary Bacillus subtilis PB6 Enhances Reproductive Performance by Modulating Gut Microbiota, Barrier Function, and Inflammation in Clostridium perfringens Type A-Infected Sows.
- 2026-03-27
- Animals : an open access journal from MDPI 16(7)
- - Mengran Zhang
  - Aohang Yu
  - Chihao Wang
  - Chaojie Chen
  - Chenchen Wu
- PubMed: 41976011
- DOI: 10.3390/ani16071032
3 Insights on
- Low evidence
N-Acetylcysteine in Neurological Disorders: A Systematic Review of Clinical and Translational Evidence Across Seven Disorders.
- 2026-03-27
- Systematic Review
- International journal of molecular sciences 27(7)
- - Robert Mîndreanu
  - Irina Camelia Chiș
  - Alexandra Sevastre-Berghian
  - Cezar Login
  - Adina Stan
  - Teodora Stan
  - Simona Clichici
  - Șoimița Suciu
- PubMed: 41977262
- DOI: 10.3390/ijms27073076
4 Insights on
- High evidence
- Rigorous Journal
Differential and Dose-Dependent Redistribution of Vitamin D Metabolites After Acute High-Intensity Exercise in Mixed Martial Arts Athletes and Untrained Men: Pilot Study.
- 2026-03-26
- RCT
- Nutrients 18(7)
- - Katarzyna Patrycja Dzik
  - Katarzyna Jagłowska
  - Miłosz Palicki
  - Sylwester Kujach
  - Piotr Sawicki
  - Konrad Kowalski
  - Jan Jacek Kaczor
- PubMed: 41978112
- DOI: 10.3390/nu18071061
4 Insights on
- High evidence
- Rigorous Journal
Effects of probiotic and metformin co-administration versus metformin monotherapy on anthropometric measurements, hormones, and glucolipid profile in women with polycystic ovary syndrome: a systematic review and meta-analysis.
- 2026-03-26
- Meta-Analysis
- Frontiers in endocrinology 17
- - Mohammed Hamsho
  - Wijdan Shkorfu
  - Meriem Bensaoua
  - Carlos Eduardo Carvalho Martins
  - Hale Hacıbayram
  - Abdulmannan Fadel
  - Yazan Ranneh
- PubMed: 41970993
- DOI: 10.3389/fendo.2026.1802369
4 Insights on
- High evidence
Probiotic Lactic Acid Bacteria-Fermented Beverages from Bambara Groundnut and Cowpea Sprouts Modulate Gut Microbiota and Short-Chain Fatty Acids.
- 2026-03-26
- Foods (Basel, Switzerland) 15(7)
- - Nobahle Pretty Cele
  - Yusuf Olamide Kewuyemi
  - Oladipupo Adiamo
  - Eshetu Mulisa Bobasa
  - Jiale Zhang
  - Maral Seididamyeh
  - Yasmina F Sultanbawa
  - Dharini Sivakumar
- PubMed: 41976435
- DOI: 10.3390/foods15071141
1 Insight on
- Increased Short-Chain Fatty Acid Production
- Low evidence
Maternal probiotic supplementation and offspring health: an umbrella review with re-analysis of systematic reviews and meta-analyses.
- 2026-03-26
- Systematic Review
- Frontiers in nutrition 13
- - Wenrui Sun
  - Yu Cao
  - Shumin Li
  - Liping Sun
  - Yuexia Liao
- PubMed: 41971379
- DOI: 10.3389/fnut.2026.1764109
2 Insights on
- Reduced Pathogenic Bacterial Abundance
- Reduced Offspring Eczema Risk
- High evidence
Role of Bifidobacterium breve PRL2020 in reducing symptoms of antibiotic-associated diarrhea in children.
- 2026-03-26
- Clinical Trial
- Frontiers in pediatrics 14
- - Alexander Bertuccioli
  - Annalisa Belli
  - Davide Sisti
  - Marco Bruno Luigi Rocchi
  - Chiara Maria Palazzi
  - Giordano Bruno Zonzini
  - Filippo Boccellari
  - Roberto Sacchetti
  - Francesco Di Pierro
  - Giuseppe Gregori
- PubMed: 41971733
- DOI: 10.3389/fped.2026.1726821
2 Insights on
- Reduced Antibiotic-Associated Diarrhea
- Reduced Abdominal Pain
- Moderate evidence
The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses.
- 2026-03-26
- Review
- Frontiers in oral health 7
- - Zhen Tang
  - Yunzhen Deng
  - Gang Guo
  - LiLi Zhou
- PubMed: 41969406
- DOI: 10.3389/froh.2026.1768508
3 Insights on
- Low evidence
Crystal structure of PM1Pgh, a poly-γ-glutamate hydrolase from Bacillus phage PM1.
- 2026-03-25
- Acta crystallographica. Section F, Structural biology communications 82(4)
- - Kyoko Abe
  - Kenji Fukui
  - Yasunori Ogura
- PubMed: 41879646
- DOI: 10.1107/s2053230x26002189
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Probiotics in atherosclerosis: mechanisms, efficacy and future directions - a review study.
- 2026-03-25
- Review
- Frontiers in immunology 17
- - Yue Cai
- PubMed: 41958663
- DOI: 10.3389/fimmu.2026.1722134
7 Insights on
- Low evidence
Association between probiotic intervention and sleep quality in the general adult population: a systematic review and meta-analysis.
- 2026-03-25
- Systematic Review · n = 890
- Frontiers in nutrition 13
- - Tingjing Ren
  - Yilin Wang
  - Bingnan Zhang
  - Haiyan Du
  - Huixia Ren
  - Naijin Zhang
  - Hongwu Wang
  - Yuanyuan Guan
- PubMed: 41958906
- DOI: 10.3389/fnut.2026.1795450
2 Insights on
- Reduced Insomnia
- Improved Sleep Quality
- High evidence
Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis.
- 2026-03-25
- Meta-Analysis
- Nutrients 18(7)
- - Iván Cavero-Redondo
  - Alicia Saz-Lara
  - Andrea Del Saz-Lara
  - Óscar Martínez-Cifuentes
  - Iris Otero-Luis
  - Ana González-Collado
  - Juan Pablo Rey-López
- PubMed: 41978094
- DOI: 10.3390/nu18071043
1 Insight on
- Reduced Carotid Intima-Media Thickness
- High evidence
- Rigorous Journal
Modulation of Glucose Homeostasis, Metabolic Endotoxemia and Circulating Short-Chain Fatty Acids Following Multi-Species Probiotic Supplementation: Findings from a 12-Week Randomised Placebo-Controlled Trial.
- 2026-03-24
- RCT · n = 39
- Nutrients 18(7)
- - George Moschonis
  - Pauline Dacaya
  - Thy T Truong
  - Angela Amoruso
  - Marco Pane
- PubMed: 41978077
- DOI: 10.3390/nu18071025
6 Insights on
- High evidence
- Rigorous Journal
Assessment of genome evolution in Bifidobacterium adolescentis indicates genetic adaptation to the human gut.
- 2026-03-24
- Observational
- mSystems 11(3)
- - Emanuele Selleri
  - Chiara Tarracchini
  - Silvia Petraro
  - Leonardo Mancabelli
  - Christian Milani
  - Francesca Turroni
  - Yan Shao
  - Hilary P Browne
  - Trevor D Lawley
  - Douwe van Sinderen
  - Marco Ventura
  - Gabriele Andrea Lugli
- PubMed: 41649278
- DOI: 10.1128/msystems.01173-25
1 Insight on
- Genetic Adaptation to the Human Gut
- Moderate evidence
- Rigorous Journal
Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.
- 2026-03-24
- Review
- Frontiers in immunology 16
- - Mohamed T El-Saadony
  - Ahmed M Saad
  - Mahmoud Sitohy
  - Samar Sami Alkafaas
  - Mthokozisi Dladla
  - Soumya Ghosh
  - Dina Mostafa Mohammed
  - Essam H Ibrahim
  - Mohamed A Fahmy
  - Amr Elkelish
  - Synan F AbuQamar
  - Khaled A El-Tarabily
- PubMed: 41953220
- DOI: 10.3389/fimmu.2025.1713426
10 Insights on
- Low evidence
CNDP1 and Diabetic Kidney Disease: From Genetic Susceptibility to Therapeutic Targeting.
- 2026-03-24
- Review
- Genes 17(4)
- - Bulent Tolga Delibasi
  - Michael Ismail Sarisen
  - Matthew Thomas Belitsos
  - Halil Kutlu Erol
  - Tuncay Delibasi
- PubMed: 42074485
- DOI: 10.3390/genes17040367
2 Insights on
- Reduced Oxidative Stress Markers
- Improved Albuminuria
- Low evidence
Time-dependent efficacy of zinc supplements in preventing oral mucositis after chemoradiotherapy: a meta-analysis.
- 2026-03-24
- Meta-Analysis · n = 1,076
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 34(4)
- - Jiale Wang
  - Jianyu Hu
  - Yongshi Luo
  - Jinfeng Nie
  - Mangui Deng
  - Zhihong Wang
- PubMed: 41872524
- DOI: 10.1007/s00520-026-10572-7
5 Insights on
- High evidence
Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.
- 2026-03-24
- RCT
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(28)
- - Grith Højfeldt
  - Joris Michaud
  - Ann Damgaard
  - Karoline Karlog
  - Eugenia Migliavacca
  - Sonia Karaz
  - Elham Pazirandeh-Micol
  - Odd E Johansen
  - Leonidas G Karagounis
  - Bjørk W Helge
  - William Hagemann
  - Michael Kjaer
  - Jerome N Feige
  - Pascal Stuelsatz
  - Abigail L Mackey
- PubMed: 41874466
- DOI: 10.1002/advs.202518471
4 Insights on
- High evidence
The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes.
- 2026-03-24
- Systematic Review · n = 196
- Amino acids 58(1)
- - Imran Mohammed
  - Yasimin Nankya
  - U Teng Hong
  - Amy Kan
  - Alya Masoud Abdelhafid
  - Gladys O Latunde-Dada
- PubMed: 41874704
- DOI: 10.1007/s00726-026-03513-5
1 Insight on
- Improved Non-Motor Symptoms
- High evidence
Correction: Protective effects of engineered Lactobacillus crispatus on intrauterine adhesions in mice via delivering CXCL12.
- 2026-03-24
- Frontiers in immunology 17
- - Yao Kong
  - Zhaoxia Liu
  - Qin Xiao
  - Fei Wu
  - Lijuan Hu
  - Xiaorong Deng
  - Tingtao Chen
- PubMed: 41953017
- DOI: 10.3389/fimmu.2026.1794467
1 Insight on
- Reduced Intrauterine Adhesions
- Low evidence
Engineered Lactobacillus casei targets the IgT-pIgR axis to confer mucosal protection against Aeromonas veronii in snakehead (Channa argus).
- 2026-03-23
- Frontiers in immunology 17
- - Kui-Peng Gao
  - Jian-Ran Dou
  - Bing-Bing Ma
  - Tian-Bao Ma
  - Na Li
  - Ai-Dong Qian
  - Xiao-Feng Shan
  - Wu-Wen Sun
  - Lei Zhang
  - Di Zhang
  - Chun-Feng Wang
  - Dong-Xing Zhang
- PubMed: 41948342
- DOI: 10.3389/fimmu.2026.1759765
3 Insights on
- Low evidence
- Animal Study
Impact of thiamin supplementation on thiamin pyrophosphate effect and cardiac function in pediatric heart disease patients on diuretics: a randomized controlled trial.
- 2026-03-23
- RCT · n = 45
- Scientific reports 16(1)
- - Rathaporn Sumboonnanonda
  - Chodchanok Vijarnsorn
  - Puthita Saengpanit
  - Chatchawan Srisawat
  - Kwanjai Chotipanang
  - Sarawut Junnu
  - Supawan Kunnangja
  - Hathaichanok Rukprayoon
  - Phakkanan Phuangphan
  - Bordeesuda Suiwongsa
  - Sompong Liammongkolkul
  - Phakwan Laohathai
  - Narumon Densupsoontorn
- PubMed: 41872295
- DOI: 10.1038/s41598-026-45100-4
2 Insights on
- Improved Left Ventricular Ejection Fraction
- Reduced Thiamin Pyrophosphate Effect
- High evidence
- Rigorous Journal