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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Dose-dependent effect of coconut oil supplementation on obesity indices: a systematic review and dose-response meta-analysis of clinical trials.
- 2025-06-06
- Systematic Review · n = 620
- BMC nutrition 11(1)
- - Zahra Gaeini
  - Zahra Bahadoran
  - Hanieh Malmir
  - Parvin Mirmiran
- PubMed: 40481535
- DOI: 10.1186/s40795-025-01090-6
3 Insights on
- High evidence
Bifidobacterium longum subsp. longum dipro-O: a potential therapeutic agent for ameliorating metabolic disorders in high-fat diet-induced obesity mouse model.
- 2025-06-06
- Frontiers in endocrinology 16
- - Ning Xu
  - Jiang Luo
  - Weiyang Chen
  - Weiwei Xiang
  - Yue Zhai
  - Wei Jiang
  - Junlin Wu
  - Yanqing Hao
  - Meiru Chen
  - Qinghua Yu
- PubMed: 40547525
- DOI: 10.3389/fendo.2025.1519058
5 Insights on
- Low evidence
- Animal Study
Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice.
- 2025-06-06
- Probiotics and antimicrobial proteins 18(1)
- - P P An
  - X Y Liang
  - X Y Yao
  - Z H Liao
  - Y C Tang
  - N Cao
  - Z Wang
  - W Wang
  - H Y Niu
  - C X Tang
  - J Chen
- PubMed: 40478433
- DOI: 10.1007/s12602-025-10576-5
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Impacts of Milk Protein Supplementation on Lipid Profile, Blood Pressure, Oxidative Stress, and Liver Enzymes: A Systematic Review and Meta-analysis.
- 2025-06-05
- Meta-Analysis
- Nutrition reviews 84(4)
- - Shooka Mohammadi
  - Damoon Ashtary-Larky
  - Mahya Beyki
  - Narges Kouhi Sough
  - Navid Alaghemand
  - Niusha Amirani
  - Hossein Salehi Omran
  - Sina Dolatshahi
  - Omid Asbaghi
- PubMed: 40471664
- DOI: 10.1093/nutrit/nuaf068
2 Insights on
- Reduced Triglyceride Levels
- Reduced Blood Cholesterol
- High evidence
Vitamin C as an Adjuvant Analgesic Therapy in Postoperative Pain Management.
- 2025-06-05
- Review · n = 14
- Journal of clinical medicine 14(11)
- - Wioletta Mędrzycka-Dąbrowska
  - Sandra Lange
  - Sebastian Dąbrowski
  - Klaudia Długoborska
  - Renata Piotrkowska
- PubMed: 40507754
- DOI: 10.3390/jcm14113994
2 Insights on
- Reduced Pain Intensity
- Reduced Opioid Consumption
- Low evidence
Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial.
- 2025-06-05
- RCT
- Journal of the International Society of Sports Nutrition 22(1)
- - Davoud Bayat
  - Mohammad Azizi
  - Naser Behpour
  - Grant M Tinsley
- PubMed: 40470618
- DOI: 10.1080/15502783.2025.2513944
7 Insights on
- High evidence
The role of fermented foods in maternal health during pregnancy and infant health during the first 1,000 days of life.
- 2025-06-05
- Review
- Frontiers in nutrition 12
- - Arun Pandiyan
  - Manoj Gurung
  - Bharath Kumar Mulakala
  - Sathish Kumar Ponniah
  - Laxmi Yeruva
- PubMed: 40538587
- DOI: 10.3389/fnut.2025.1581723
2 Insights on
- Improved Immune Function
- Improved Brain Health
- Low evidence
An In Vitro Gut-Liver-Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic-Polycosanol Combination.
- 2025-06-05
- Foods (Basel, Switzerland) 14(11)
- - Simone Mulè
  - Rebecca Galla
  - Francesca Parini
  - Mattia Botta
  - Sara Ferrari
  - Francesca Uberti
- PubMed: 40509530
- DOI: 10.3390/foods14112003
6 Insights on
- Low evidence
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
- 2025-06-05
- Systematic Review
- Frontiers in pharmacology 16
- - Qin Xu
  - Hua Lian
  - Rui Zhou
  - Zhenzhen Gu
  - Jiao Wu
  - Yu Wu
  - Zhongyu Li
- PubMed: 40538540
- DOI: 10.3389/fphar.2025.1601204
16 Insights on
- High evidence
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters.
- 2025-06-04
- RCT
- Gut microbes reports 2(1)
- - Monica Ramakrishnan
  - Tzu-Wen L Cross
  - Anna Clapp Organski
  - Sindusha Mysore Saiprasad
  - Abigayle M R Simpson
  - Daniel J Tancredi
  - Mallory J Van Haute
  - Chloe M Christensen
  - Zachery T Lewis
  - Thomas A Auchtung
  - Jens Walter
  - Robert Hutkins
  - Dennis A Savaiano
- PubMed: 41909904
- DOI: 10.1080/29933935.2025.2508199
3 Insights on
- High evidence
Efficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.
- 2025-06-04
- Meta-Analysis · n = 1,125
- Frontiers in cellular and infection microbiology 15
- - Lynne V McFarland
  - Tong Li
- PubMed: 40535538
- DOI: 10.3389/fcimb.2025.1587792
5 Insights on
- High evidence
The effect of Nigella Sativa emulgel on episiotomy wound healing and pain intensity in primiparous women: A triple-blind randomized controlled trial.
- 2025-06-04
- RCT
- PloS one 20(6)
- - Mahsa Maghalian
  - Afsaneh Alizadeh
  - Fatemeh Raphi
  - Ziba Islambulchilar
  - Laleh Khodaie
  - Mahsan Nabighadim
  - Simin Taghavi
  - Mojgan Mirghafourvand
- PubMed: 40465634
- DOI: 10.1371/journal.pone.0325112
2 Insights on
- Improved Wound Healing
- Reduced Pain Intensity
- High evidence
Lactobacillus GG and other probiotics in pediatric food allergy treatment: a network meta-analysis.
- 2025-06-03
- Systematic Review · n = 502
- Frontiers in nutrition 12
- - Li Xiaohua
  - Du Yiting
  - Li Qin
  - Zhai Yang
  - Wu Shumao
  - Peng Li
  - Pan Yi
  - Chen Lingmei
  - Liao Wenge
  - Li Maoxia
- PubMed: 40529417
- DOI: 10.3389/fnut.2025.1565436
7 Insights on
- High evidence
Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185.
- 2025-06-03
- RCT
- Journal of biomedical science 32(1)
- - Yao-Jong Yang
  - Chung-Tai Wu
  - Hsiu-Chi Cheng
  - Wei-Ying Chen
  - Joseph T Tseng
  - Wei-Lun Chang
  - Bor-Shyang Sheu
- PubMed: 40462044
- DOI: 10.1186/s12929-025-01149-3
1 Insight on
- Improved Intestinal Metaplasia Regression
- High evidence
Incorporating Postbiotics into Intervention for Managing Obesity.
- 2025-06-03
- Review
- International journal of molecular sciences 26(11)
- - Emília Hijová
  - Izabela Bertková
  - Jana Štofilová
- PubMed: 40508171
- DOI: 10.3390/ijms26115362
1 Insight on
- Improved Weight Management
- Moderate evidence
- Rigorous Journal
Oral administration of Lactiplantibacillus plantarum GKK1 ameliorates atopic dermatitis in a mouse model.
- 2025-06-03
- Frontiers in microbiology 16
- - Tzu-Chun Lin
  - Yu-Chieh Wu
  - You-Shan Tsai
  - Shih-Wei Lin
  - Chin-Chu Chen
  - Ming-Ju Chen
  - Yen-Po Chen
- PubMed: 40529585
- DOI: 10.3389/fmicb.2025.1566594
6 Insights on
- Low evidence
Microbiome Engineering for Biotherapeutic in Alzheimer's Disease Through the Gut-Brain Axis: Potentials and Limitations.
- 2025-06-02
- Review
- International journal of molecular sciences 26(11)
- - Editha Renesteen
  - Jacqueline L Boyajian
  - Paromita Islam
  - Amal Kassab
  - Ahmed Abosalha
  - Stephanie Makhlouf
  - Madison Santos
  - Hongmei Chen
  - Cedrique Shum-Tim
  - Satya Prakash
- PubMed: 40508160
- DOI: 10.3390/ijms26115351
4 Insights on
- Moderate evidence
- Rigorous Journal
Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis.
- 2025-06-02
- Meta-Analysis
- Nutrients 17(11)
- - Chen Ee Low
  - Nicole Shi Min Chew
  - Sean Loke
  - Jia Yang Tan
  - Shayne Phee
  - Ainsley Ryan Yan Bin Lee
  - Cyrus Su Hui Ho
- PubMed: 40507181
- DOI: 10.3390/nu17111911
2 Insights on
- Reduced Suicide Attempt
- Reduced Suicide Ideation
- High evidence
- Rigorous Journal
Efficacy and safety of Saccharomyces boulardii as adjunct therapy with Vancomycin in treating Clostridioides difficile infection: A randomized controlled trial.
- 2025-06-02
- RCT
- Scientific reports 15(1)
- - Taned Chitapanarux
  - Umaporn Wiracha
  - Poramed Winichakoon
  - Parichat Salee
  - Patrinee Traisathit
- PubMed: 40457042
- DOI: 10.1038/s41598-025-04986-2
9 Insights on
- High evidence
- Rigorous Journal
Randomized Controlled Trials for Oral Leukoplakia.
- 2025-06-02
- Review · n = 7
- Oral diseases 31(11)
- - Michele Lodolo
  - Michele Lodolo
  - Jack Valor
  - Alessandro Villa
- PubMed: 40457716
- DOI: 10.1111/odi.15399
4 Insights on
- Low evidence
Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet.
- 2025-06-01
- n = 49
- Iranian journal of microbiology 17(3)
- - Sahar Fouladi
  - Elham Moazamian
- PubMed: 40612728
- DOI: 10.18502/ijm.v17i3.18826
8 Insights on
- Low evidence
Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.
- 2025-06-01
- RCT
- Journal of sports science & medicine 24(2)
- - Yongliang Wang
  - Yanyan Wang
  - Kun Qian
- PubMed: 40469872
- DOI: 10.52082/jssm.2025.258
7 Insights on
- High evidence
Fruit and Vegetable Juices as Functional Carriers for Probiotic Delivery: Microbiological, Nutritional, and Sensory Perspectives.
- 2025-05-30
- Review
- Microorganisms 13(6)
- - Renata Žvirdauskienė
  - Vesta Jonikė
  - Loreta Bašinskienė
  - Dalia Čižeikienė
- PubMed: 40572160
- DOI: 10.3390/microorganisms13061272
3 Insights on
- Low evidence
Vitamin C in Allergy Mechanisms and for Managing Allergic Diseases: A Narrative Review.
- 2025-05-30
- Review
- Children (Basel, Switzerland) 12(6)
- - Chiara Trincianti
  - Matteo Naso
  - Maria Angela Tosca
  - Giorgio Ciprandi
- PubMed: 40564676
- DOI: 10.3390/children12060718
5 Insights on
- Low evidence
Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency.
- 2025-05-30
- RCT · n = 44
- European journal of nutrition 64(5)
- - Xiaoyun Shan
  - Wenxuan Wu
  - Jingxin Yang
  - Yang Cao
  - Yuting Li
  - Yichun Hu
  - Rui Wang
  - Lichen Yang
- PubMed: 40445221
- DOI: 10.1007/s00394-025-03723-9
4 Insights on
- High evidence
- Rigorous Journal
Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Supplementation: An Exploratory, Randomized, Placebo-Controlled Trial of Endocannabinoid and Inflammatory Responses in Female Dancers.
- 2025-05-30
- Clinical Trial
- Microorganisms 13(6)
- - Jakub Wiącek
  - Karolina Skonieczna-Żydecka
  - Igor Łoniewski
  - Chariklia K Deli
  - Ioannis G Fatouros
  - Athanasios Z Jamurtas
  - Dominika Moszczyńska
  - Joanna Karolkiewicz
- PubMed: 40572172
- DOI: 10.3390/microorganisms13061284
1 Insight on
- No Significant Change in Endocannabinoid or Inflammatory Biomarkers
- Moderate evidence
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- High evidence
A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune Response in Subjects Recovering from Respiratory Viral Infection: A Randomized, Double-Blind Clinical Study Using Vitamin C as a Positive Control.
- 2025-05-29
- RCT · n = 28
- International journal of molecular sciences 26(11)
- - Bruno Fink
  - John M Hunter
  - Zbigniew Pietrzkowski
  - Richard Fink
  - Coy Brunssen
  - Henning Morawietz
  - Boris Nemzer
- PubMed: 40508019
- DOI: 10.3390/ijms26115209
3 Insights on
- High evidence
- Rigorous Journal
Bifidobacterium animalis subsp. lactis modulates early-life immune response and gut metabolism.
- 2025-05-28
- Animal models and experimental medicine 8(6)
- - Haoming Du
  - Yiran Cai
  - Lulu Shen
  - Yuxing Zheng
  - Lingling Zhao
  - Ruibiao Hu
  - Shan Jiang
  - Jiajia Yuan
  - Chengming Hu
  - Qi Deng
  - Jiaoyan Huang
  - Jingbo Hu
  - Yuexiang Wang
  - Jing Tan
  - Jiahui Chen
  - Feitong Liu
  - Yuanyuan Duan
  - Haitao Niu
- PubMed: 40437776
- DOI: 10.1002/ame2.70034
2 Insights on
- Improved Immune Organ Development
- Increased Levels of Beneficial Metabolites
- Low evidence
- Animal Study
Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota.
- 2025-05-28
- Journal of microbiology and biotechnology 35
- - Eoun Ho Nam
  - Minjee Lee
  - Donggyu Kim
  - Young Hoon Jung
  - Jungwoo Yang
  - Minhye Shin
- PubMed: 40443239
- DOI: 10.4014/jmb.2502.02045
2 Insights on
- Increased Gut Microbial Growth
- Increased Folate Production
- Low evidence