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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of Lactococcus lactis subsp. lactis JCM5805 on colonization dynamics of gut microbiota and regulation of immunity in early ontogenetic stages of tilapia
- 2019-03
- RCT
- Fish & Shellfish Immunology 86
- - Y. Xia
  - Jianmeng Cao
  - Miao Wang
  - Mai-xin Lu
  - Gang Chen
  - F. Gao
  - Zhigang Liu
  - Defeng Zhang
  - X. Ke
  - Mengmeng Yi
- PubMed: 30428393
- DOI: 10.1016/j.fsi.2018.11.022
1 Insight on
- Enhanced Disease Resistance
- High evidence
Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis.
- 2019-03
- Meta-Analysis · n = 139
- Annals of translational medicine 7(5)
- - Man-Man Han
  - Jin-Fang Sun
  - Xiang-Hui Su
  - You-Fan Peng
  - Hemant Goyal
  - Chun-Hua Wu
  - Xiang-Yun Zhu
  - Ling Li
- PubMed: 31019949
- DOI: 10.21037/atm.2019.01.61
4 Insights on
- High evidence
Bacillus amyloliquefaciens spray improves the growth performance, immune status, and respiratory mucosal barrier in broiler chickens
- 2019-03
- RCT · n = 320
- Poultry Science 98(3)
- - S. Luan
  - Y. Sun
  - Y. Wang
  - R N Sa
  - H F Zhang
- PubMed: 30285152
- DOI: 10.3382/ps/pey478
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Thirty Years of Lactobacillus rhamnosus GG: A Review.
- 2019-03
- Systematic Review
- Journal of Clinical Gastroenterology 53(Supplement 1)
- - L. Capurso
- PubMed: 30741841
- DOI: 10.1097/MCG.0000000000001170
42 Insights on
- High evidence
- Highly Cited
Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis.
- 2019-03
- Meta-Analysis · n = 1,045
- Journal of ethnopharmacology 231
- - Emanuel L Peter
  - Félicien Mushagalusa Kasali
  - Serawit Deyno
  - Andrew Mtewa
  - Prakash B Nagendrappa
  - Casim Umba Tolo
  - Patrick Engeu Ogwang
  - Duncan Sesaazi
- PubMed: 30385422
- DOI: 10.1016/j.jep.2018.10.033
3 Insights on
- High evidence
Lactobacillus johnsonii L531 reduces pathogen load and helps maintain short-chain fatty acid levels in the intestines of pigs challenged with Salmonella enterica Infantis.
- 2019-03
- Clinical Trial
- Veterinary Microbiology 230
- - Ting He
  - Yaohong Zhu
  - Jiao Yu
  - B. Xia
  - Xiao Liu
  - Gui-Yan Yang
  - Jinhui Su
  - Liang Guo
  - Mengling Wang
  - Jiufeng Wang
- PubMed: 30827387
- DOI: 10.1016/j.vetmic.2019.02.003
7 Insights on
- Low evidence
- Animal Study
Exopolysaccharides production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12: Optimization of fermentation variables and characterization of structure and bioactivities.
- 2019-02
- International Journal of Biological Macromolecules 123
- - S. Amiri
  - Reza Rezaei Mokarram
  - M. Sowti Khiabani
  - Mahmoud Rezazadeh Bari
  - Mohammad Alizadeh Khaledabad
- PubMed: 30447370
- DOI: 10.1016/j.ijbiomac.2018.11.084
3 Insights on
- Low evidence
- Highly Cited
Effect of Tribulus terrestris L. on sperm parameters in men with idiopathic infertility: A systematic review.
- 2019-02
- Systematic Review
- Complementary therapies in medicine 42
- - Sima Sanagoo
  - Behnaz Sadeghzadeh Oskouei
  - Nafiseh Gassab Abdollahi
  - Hanieh Salehi-Pourmehr
  - Nazanin Hazhir
  - Azizeh Farshbaf-Khalili
- PubMed: 30670288
- DOI: 10.1016/j.ctim.2018.09.015
4 Insights on
- High evidence
Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets
- 2019-02
- RCT · n = 24
- Journal of Zhejiang University-SCIENCE B 20(2)
- - Yang Wang
  - L. Gong
  - Yan-ping Wu
  - Z. Cui
  - Yong-qiang Wang
  - Yi Huang
  - Xiao-ping Zhang
  - Wei-fen Li
- PubMed: 30666850
- DOI: 10.1631/jzus.B1800022
14 Insights on
- Low evidence
- Animal Study
Lactobacillus rhamnosus GG modulates gastrointestinal absorption, excretion patterns, and toxicity in Holstein calves fed a single dose of aflatoxin B1.
- 2019-02
- RCT
- Journal of Dairy Science 102(2)
- - L. Y. Zhang
  - S. Liu
  - X. Zhao
  - N. Wang
  - X. Jiang
  - H. Xin
  - Y. Zhang
- PubMed: 30594375
- DOI: 10.3168/jds.2018-15444
3 Insights on
- High evidence
- Rigorous Journal
Evaluation of protective effect of Lactobacillus acidophilus La-5 on toxicity and colonization of Clostridium difficile in human epithelial cells in vitro.
- 2019-02
- Anaerobe 55
- - A. Najarian
  - S. Sharif
  - M. Griffiths
- PubMed: 30576791
- DOI: 10.1016/j.anaerobe.2018.12.004
2 Insights on
- Reduced Clostridium difficile Cytotoxicity
- Reduced Clostridium Difficile Adherence
- Low evidence
Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine
- 2019-02
- Clinical Trial
- iScience 12
- - T. Darby
  - Joshua A. Owens
  - B. Saeedi
  - L. Luo
  - J. Matthews
  - B. Robinson
  - C. Naudin
  - Rheinallt M. Jones
- PubMed: 30739017
- DOI: 10.1016/j.isci.2019.01.030
11 Insights on
- Low evidence
- Animal Study
Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study.
- 2019-02
- RCT · n = 40
- Psychoneuroendocrinology 100
- - Leszek Rudzki
  - Lucyna Ostrowska
  - Dariusz Pawlak
  - Aleksandra Małus
  - Krystyna Pawlak
  - Napoleon Waszkiewicz
  - Agata Szulc
- PubMed: 30388595
- DOI: 10.1016/j.psyneuen.2018.10.010
12 Insights on
- High evidence
- Highly Cited
L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-κB pathways.
- 2019-02
- RCT · n = 65
- Toxicology and applied pharmacology 365
- - Rana Yehia
  - Samira Saleh
  - Hanan El Abhar
  - Amr S Saad
  - Mona Schaalan
- PubMed: 30592963
- DOI: 10.1016/j.taap.2018.12.015
7 Insights on
- High evidence
Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study.
- 2019-02
- Journal of Affective Disorders 245
- - R. Okubo
  - Minori Koga
  - N. Katsumata
  - T. Odamaki
  - Shiina Matsuyama
  - Matsuhiko Oka
  - H. Narita
  - N. Hashimoto
  - I. Kusumi
  - Jinzhong Xiao
  - Y. Matsuoka
- PubMed: 30423465
- DOI: 10.1016/j.jad.2018.11.011
8 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Effects of dietary supplementation with Clostridium butyricum on laying performance, egg quality, serum parameters, and cecal microflora of laying hens in the late phase of production
- 2019-02
- RCT · n = 960
- Poultry Science 98(2)
- - H. Zhan
  - X. Dong
  - L. Li
  - Y. X. Zheng
  - Y. Gong
  - X. Zou
- PubMed: 30285187
- DOI: 10.3382/ps/pey436
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model.
- 2019-02
- Clinical Trial
- Journal of Dairy Science 102(2)
- - M. Niibo
  - Bungo Shirouchi
  - Minami Umegatani
  - Yukiko Morita
  - A. Ogawa
  - F. Sakai
  - Y. Kadooka
  - Masao Sato
- PubMed: 30471910
- DOI: 10.3168/jds.2018-15203
2 Insights on
- Improved Insulin Sensitivity
- Improved Insulin Secretion
- Low evidence
- Rigorous Journal
- Animal Study
Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.
- 2019-02
- Archives of Oral Biology 98
- - T. Higuchi
  - N. Suzuki
  - S. Nakaya
  - Sami Omagari
  - M. Yoneda
  - T. Hanioka
  - T. Hirofuji
- PubMed: 30530235
- DOI: 10.1016/j.archoralbio.2018.11.027
4 Insights on
- Low evidence
In vitro and in vivo resistance of Lactobacillus rhamnosus GG carried by a mixed pineapple (Ananas comosus L. Merril) and jussara (Euterpe edulis Martius) juice to the gastrointestinal tract.
- 2019-02
- Clinical Trial
- Food Research International 116
- - Renata Cristina de Almeida Bianchini Campos
  - E. Martins
  - Bruno de Andrade Pires
  - Maria do Carmo Gouveia Pelúzio
  - A. N. da Rocha Campos
  - A. M. Ramos
  - Bruno Ricardo de Castro Leite Júnior
  - Aurélia Dornelas de Oliveira Martins
  - Roselir Ribeiro da Silva
  - M. L. Martins
- PubMed: 30716912
- DOI: 10.1016/j.foodres.2018.10.012
2 Insights on
- Reduced LDL Cholesterol
- Improved Gastrointestinal Resistance
- Low evidence
- Animal Study
Bifidobacterium may benefit the prevention of necrotizing enterocolitis in preterm infants: A systematic review and meta-analysis.
- 2019-01
- Meta-Analysis
- International Journal of Surgery 61
- - Xiu-li Zhu
  - Xiao-Gang Tang
  - Fan Qu
  - Yu Zheng
  - Wenhao Zhang
  - Yu-qiao Diao
- PubMed: 30500473
- DOI: 10.1016/j.ijsu.2018.11.026
6 Insights on
- High evidence
Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage.
- 2019-01
- Journal of Dairy Science 102(1)
- - Tingting Zhou
  - Rui Huo
  - L. Kwok
  - Changkun Li
  - Yuzhu Ma
  - ZhiHui Mi
  - Yongfu Chen
- PubMed: 30343912
- DOI: 10.3168/jds.2018-14602
3 Insights on
- Low evidence
- Rigorous Journal
Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
- 2019-01
- RCT
- Journal of clinical psychopharmacology 39(1)
- - Craig Surman
  - Atilla Ceranoglu
  - Carrie Vaudreuil
  - Brittany Albright
  - Mai Uchida
  - Amy Yule
  - Andrea Spencer
  - Heidi Boland
  - Rebecca Grossman
  - Lauren Rhodewalt
  - Maura Fitzgerald
  - Joseph Biederman
- PubMed: 30566416
- DOI: 10.1097/jcp.0000000000000990
8 Insights on
- High evidence
Lactobacillus plantarum YS2 (yak yogurt Lactobacillus) exhibited an activity to attenuate activated carbon-induced constipation in male Kunming mice.
- 2019-01
- Clinical Trial
- Journal of Dairy Science 102(1)
- - Xin Zhao
  - Y. Qian
  - Guijie Li
  - Ruokun Yi
  - Kun-Young Park
  - Jia-Le Song
- PubMed: 30527985
- DOI: 10.3168/jds.2018-15206
10 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The role of conserved non-aromatic residues in the Lactobacillus amylovorus α-amylase CBM26-starch interaction.
- 2019-01
- International journal of biological macromolecules 121
- - Silvia Armenta
  - Zaira Sánchez-Cuapio
  - Maria Elena Munguia
  - Nancy O Pulido
  - Amelia Farrés
  - Karen Manoutcharian
  - Alejandra Hernandez-Santoyo
  - Silvia Moreno-Mendieta
  - Sergio Sánchez
  - Romina Rodríguez-Sanoja
- PubMed: 30336243
- DOI: 10.1016/j.ijbiomac.2018.10.061
1 Insight on
- Carbohydrate Binding Activity
- Low evidence
Mechanisms of Action of Probiotics.
- 2019-01
- Review
- Advances in nutrition (Bethesda, Md.) 10
- - Julio Plaza-Diaz
  - Francisco Javier Ruiz-Ojeda
  - Mercedes Gil-Campos
  - Angel Gil
- PubMed: 30721959
- DOI: 10.1093/advances/nmy063
4 Insights on
- Moderate evidence
- Highly Cited
Characterization of Bacillus subtilis from gastrointestinal tract of hybrid Hulong grouper (Epinephelus fuscoguttatus × E. lanceolatus) and its effects as probiotic additives.
- 2019-01
- Clinical Trial
- Fish & Shellfish Immunology 84
- - Sheng Zhou
  - D. Song
  - Xiaofeng Zhou
  - Xinliang Mao
  - Xuefeng Zhou
  - Sunli Wang
  - Jingguang Wei
  - Youhua Huang
  - Wenxiong Wang
  - S. Xiao
  - Q. Qin
- PubMed: 30463174
- DOI: 10.1016/j.fsi.2018.10.058
14 Insights on
- Low evidence
- Animal Study
Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis.
- 2019-01
- Journal of Dairy Science 102(1)
- - Ewa Wasilewska
  - D. Złotkowska
  - Barbara Wróblewska
- PubMed: 30343915
- DOI: 10.3168/jds.2018-14520
18 Insights on
- Low evidence
- Rigorous Journal
A dietary pattern rich in calcium, potassium, and protein is associated with tibia bone mineral content and strength in young adults entering initial military training.
- 2019-01
- RCT · n = 401
- The American journal of clinical nutrition 109(1)
- - Anna T Nakayama
  - Laura J Lutz
  - Adela Hruby
  - James P Karl
  - James P McClung
  - Erin Gaffney-Stomberg
- PubMed: 30615068
- DOI: 10.1093/ajcn/nqy199
2 Insights on
- Improved Bone Mineral Content
- Improved Bone Strength
- High evidence
- Large Human Trial
Dietary Lactobacillus plantarum ST-III alleviates the toxic effects of triclosan on zebrafish (Danio rerio) via gut microbiota modulation.
- 2019-01
- Clinical Trial
- Fish & Shellfish Immunology 84
- - Luxiu Zang
  - Yan Ma
  - Wenhao Huang
  - Yuhang Ling
  - Limei Sun
  - Xuedong Wang
  - Aibing Zeng
  - R. Dahlgren
  - Caihong Wang
  - Huili Wang
- PubMed: 30423455
- DOI: 10.1016/j.fsi.2018.11.007
13 Insights on
- Low evidence
- Animal Study
Effects of daily consumption of psyllium, oat bran and polyGlycopleX on obesity-related disease risk factors: A critical review.
- 2019-01
- Review
- Nutrition (Burbank, Los Angeles County, Calif.) 57
- - Monica Jane
  - Jenny McKay
  - Sebely Pal
- PubMed: 30153584
- DOI: 10.1016/j.nut.2018.05.036
4 Insights on
- Low evidence