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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial
- 2020-01-31
- RCT · n = 130
- Nutrients 12(2)
- - T. Toshimitsu
  - A. Gotou
  - T. Sashihara
  - S. Hachimura
  - Nobuhiko Shioya
  - Satoru Suzuki
  - Y. Asami
- PubMed: 32023901
- DOI: 10.3390/nu12020374
3 Insights on
- High evidence
Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial
- 2020-01-30
- RCT · n = 330
- Nutrients 12(2)
- - C. Martoni
  - S. Srivastava
  - G. Leyer
- PubMed: 32019158
- DOI: 10.3390/nu12020363
7 Insights on
- High evidence
- Large Human Trial
Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women
- 2020-01-30
- RCT · n = 86
- Nutrients 12(2)
- - Siwen Yang
  - G. Reid
  - J. Challis
  - G. Gloor
  - E. Asztalos
  - D. Money
  - Shannon Seney
  - A. Bocking
- PubMed: 32019222
- DOI: 10.3390/nu12020368
13 Insights on
- High evidence
GABA potentiate the immunoregulatory effects of Lactobacillus brevis BGZLS10-17 via ATG5-dependent autophagy in vitro
- 2020-01-28
- Scientific Reports 10(1)
- - S. S. Bajić
  - Jelena Đokić
  - M. Dinić
  - S. Tomić
  - N. Popović
  - Emilija Brdarić
  - N. Golić
  - M. Tolinački
- PubMed: 31992761
- DOI: 10.1038/s41598-020-58177-2
4 Insights on
- Low evidence
- Rigorous Journal
Effect of Tart Cherry Concentrate on Endurance Exercise Performance: A Meta-analysis.
- 2020-01-27
- Meta-Analysis
- Journal of the American College of Nutrition 39(7)
- - Ruirui Gao
  - Philip D Chilibeck
- PubMed: 31986108
- DOI: 10.1080/07315724.2020.1713246
1 Insight on
- Improved Endurance Exercise Performance
- High evidence
- Rigorous Journal
Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome
- 2020-01-24
- PLOS ONE 15(1)
- - A. De Cesare
  - C. Sala
  - G. Castellani
  - A. Astolfi
  - V. Indio
  - A. Giardini
  - G. Manfreda
- PubMed: 31978143
- DOI: 10.1371/journal.pone.0228338
6 Insights on
- Low evidence
- Rigorous Journal
The Preliminary Development of an in vitro Poultry Cecal Culture Model to Evaluate the Effects of Original XPCTM for the Reduction of Campylobacter jejuni and Its Potential Effects on the Microbiota.
- 2020-01-23
- Frontiers in microbiology 10
- - Kristina M Feye
  - Peter M Rubinelli
  - William Evan Chaney
  - Hilary O Pavlidis
  - Michael H Kogut
  - Steven C Ricke
- PubMed: 32038534
- DOI: 10.3389/fmicb.2019.03062
1 Insight on
- Reduced Campylobacter jejuni Survival
- Low evidence
Evaluation of urate-lowering therapy in hyperuricemia patients: a systematic review and Bayesian network meta-analysis of randomized controlled trials.
- 2020-01-21
- Systematic Review · n = 401
- Clinical rheumatology 39(5)
- - Yu-Jiun Lin
  - Shiyng-Yu Lin
  - Chang-Hsien Lin
  - Sen-Te Wang
  - Shy-Shin Chang
- PubMed: 31965378
- DOI: 10.1007/s10067-019-04893-8
1 Insight on
- Reduced Adherence Attrition
- High evidence
Restitution of gut microbiota in Ugandan children administered with probiotics (Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12) during treatment for severe acute malnutrition.
- 2020-01-20
- RCT
- Gut microbes 11(4)
- - Josué L Castro-Mejía
  - Sinéad O'Ferrall
  - Łukasz Krych
  - Elaine O'Mahony
  - Hanifa Namusoke
  - Betty Lanyero
  - Witold Kot
  - Nicolette Nabukeera-Barungi
  - Kim Fleischer Michaelsen
  - Christian Mølgaard
  - Henrik Friis
  - Benedikte Grenov
  - Dennis S Nielsen
- PubMed: 31959047
- DOI: 10.1080/19490976.2020.1712982
2 Insights on
- Reduced Diarrhea Incidence
- Improved Gut Microbiota Richness
- High evidence
Regulation of Skeletal Muscle Function by Amino Acids.
- 2020-01-19
- Review
- Nutrients 12(1)
- - Yasutomi Kamei
  - Yukino Hatazawa
  - Ran Uchitomi
  - Ryoji Yoshimura
  - Shinji Miura
- PubMed: 31963899
- DOI: 10.3390/nu12010261
2 Insights on
- Improved Cognitive Function
- Improved Physical Performance
- High evidence
- Highly Cited
- Rigorous Journal
Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.
- 2020-01-16
- Pediatric Research 88(2)
- - Di Meng
  - E. Sommella
  - E. Salviati
  - P. Campiglia
  - K. Ganguli
  - K. Djebali
  - Weishu Zhu
  - W. Walker
- PubMed: 31945773
- DOI: 10.1038/s41390-019-0740-x
3 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial
- 2020-01-15
- RCT · n = 60
- Nutrients 12(1)
- - M. Kubota
  - Kazuya Ito
  - K. Tomimoto
  - Mitsuharu Kanazaki
  - K. Tsukiyama
  - A. Kubota
  - H. Kuroki
  - M. Fujita
  - Y. Vandenplas
- PubMed: 31952280
- DOI: 10.3390/nu12010225
4 Insights on
- High evidence
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity
- 2020-01-15
- RCT · n = 20
- Nutrients 12(1)
- - I. Sergeev
  - Thamer Aljutaily
  - G. Walton
  - E. Huarte
- PubMed: 31952249
- DOI: 10.3390/nu12010222
1 Insight on
- Reduced Blood Glucose Levels
- High evidence
- Highly Cited
Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet.
- 2020-01-15
- Food & Function 10(8)
- - Shuangqiu Li
  - Ce Qi
  - Hualing Zhu
  - R. Yu
  - C. Xie
  - Yuande Peng
  - S. Yin
  - Jianhui Fan
  - Suqing Zhao
  - Jin Sun
- PubMed: 31304501
- DOI: 10.1039/c9fo00417c
17 Insights on
- Low evidence
Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis
- 2020-01-15
- Clinical Trial
- Nutrients 12(1)
- - K. Toda
  - Yuki Yamauchi
  - A. Tanaka
  - T. Kuhara
  - T. Odamaki
  - Shin Yoshimoto
  - J. Xiao
- PubMed: 31952193
- DOI: 10.3390/nu12010219
5 Insights on
- Low evidence
- Animal Study
Dose-Response Recovery of Probiotic Strains in Simulated Gastro-Intestinal Passage.
- 2020-01-13
- Microorganisms 8(1)
- - Sofia Forssten
  - Arthur C Ouwehand
- PubMed: 31941108
- DOI: 10.3390/microorganisms8010112
3 Insights on
- Low evidence
XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products.
- 2020-01-06
- Review
- Marine drugs 18(1)
- - Rui Pedrosa
  - Susana P Gaudêncio
  - Vitor Vasconcelos
- PubMed: 31935809
- DOI: 10.3390/md18010040
1 Insight on
- Improved Gastrointestinal Health
- Low evidence
Effect of dietary supplementation with brewer's yeast hydrolysate on growth performance, faecal microbial counts, diarrhoea score, blood profile, rectal temperature in weanling pigs challenged with lipopolysaccharide.
- 2020-01-03
- RCT · n = 40
- Journal of Animal Physiology and Animal Nutrition 104(2)
- - Jing Hu
  - J. W. Park
  - I. Kim
- PubMed: 31899588
- DOI: 10.1111/jpn.13301
2 Insights on
- Reduced Diarrhea Incidence
- Improved Gain:Feed Ratio
- Low evidence
- Animal Study
Beta alanine supplementation effects on metabolic contribution and swimming performance.
- 2020-01-03
- RCT
- Journal of the International Society of Sports Nutrition 17(1)
- - Matheus Silva Norberto
  - Ricardo Augusto Barbieri
  - Danilo Rodrigues Bertucci
  - Ronaldo Bucken Gobbi
  - Eduardo Zapaterra Campos
  - Alessandrou Moura Zagatto
  - Ellen Cristini De Freitas
  - Marcelo Papoti
- PubMed: 32711541
- DOI: 10.1186/s12970-020-00365-6
4 Insights on
- High evidence
Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
- 2020-01-01
- Meta-Analysis · n = 535
- Journal of evidence-based integrative medicine 25
- - Noriko Shinjyo
  - Guy Waddell
  - Julia Green
- PubMed: 33086877
- DOI: 10.1177/2515690x20967323
1 Insight on
- Reduced Anxiety
- High evidence
Effects of dietary supplementation with Pediococcus acidilactici ZPA017 on reproductive performance, fecal microbial flora and serum indices in sows during late gestation and lactation.
- 2020-01-01
- RCT · n = 94
- Asian-Australasian Journal of Animal Sciences 33(1)
- - Hui Liu
  - Sixin Wang
  - Dongyan Zhang
  - Jing Wang
  - Wei Zhang
  - Yamin Wang
  - H. Ji
- PubMed: 36379222
- DOI: 10.5713/AJAS.18.0764
14 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Lack of effect of tart cherry concentrate dose on serum urate in people with gout.
- 2019-12-31
- RCT
- Rheumatology (Oxford, England) 59(9)
- - Lisa K Stamp
  - Peter Chapman
  - Christopher Frampton
  - Stephen B Duffull
  - Jill Drake
  - Yuqing Zhang
  - Tuhina Neogi
- PubMed: 31891407
- DOI: 10.1093/rheumatology/kez606
3 Insights on
- High evidence
Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy
- 2019-12-31
- Oncotarget 10(68)
- - F. L. R. do Carmo
  - Houem Rabah
  - B. F. Cordeiro
  - S. H. da Silva
  - R. M. Pessoa
  - S. O. Fernandes
  - V. Cardoso
  - V. Gagnaire
  - M. Deplanche
  - Bruna Savassi
  - Alessandra Figueiroa
  - E. Oliveira
  - Caio Fonseca
  - Maria Izabel Alves Queiroz
  - N. M. Rodrigues
  - S. Sandes
  - Á. Nunes
  - Luísa Lemos
  - J. Alves
  - A. C. Faria
  - Ê. Ferreira
  - Y. Le Loir
  - G. Jan
  - V. Azevedo
- PubMed: 31921383
- DOI: 10.18632/oncotarget.27319
4 Insights on
- Low evidence
Pharmacological and Nutritional Modulation of Vascular Calcification.
- 2019-12-30
- Review
- Nutrients 12(1)
- - Liv M Vossen
  - Abraham A Kroon
  - Leon J Schurgers
  - Peter W de Leeuw
- PubMed: 31905884
- DOI: 10.3390/nu12010100
1 Insight on
- Reduced Vascular Calcification
- Moderate evidence
- Rigorous Journal
Probiotic and antioxidant properties of noble Lactobacillus brevis KCCM 12203P isolated from kimchi and evaluation of immune-stimulating activities of its heat-killed cells in RAW 264.7 cells.
- 2019-12-28
- Journal of Microbiology and Biotechnology 29(12)
- - M. Song
  - H. Jang
  - Kee-Tae Kim
  - H. Paik
- PubMed: 31581386
- DOI: 10.4014/jmb.1907.07081
20 Insights on
- Low evidence
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults - A pilot study.
- 2019-12-28
- RCT · n = 10
- Experimental gerontology 131
- - R T Mankowski
  - L You
  - T W Buford
  - C Leeuwenburgh
  - T M Manini
  - S Schneider
  - P Qiu
  - S D Anton
- PubMed: 31891746
- DOI: 10.1016/j.exger.2019.110821
5 Insights on
- High evidence
Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARγ signaling.
- 2019-12-27
- Scientific reports 9(1)
- - Sung-Soo Park
  - Yeon-Joo Lee
  - Hyuno Kang
  - Garam Yang
  - Eun Jeong Hong
  - Jin Yeong Lim
  - Sejong Oh
  - Eungseok Kim
- PubMed: 31882939
- DOI: 10.1038/s41598-019-56817-w
5 Insights on
- Low evidence
- Rigorous Journal
One Week of L-Citrulline Supplementation Improves Performance in Trained Cyclists.
- 2019-12-19
- RCT
- Journal of strength and conditioning research 34(3)
- - Sean T Stanelle
  - Kelsey L McLaughlin
  - Stephen F Crouse
- PubMed: 31860534
- DOI: 10.1519/jsc.0000000000003418
8 Insights on
- High evidence
Comparative Transcriptome Analysis of Thitarodes Armoricanus in Response to the Entomopathogenic Fungi Paecilomyces Hepiali and Ophiocordyceps Sinensis
- 2019-12-19
- Insects 11(1)
- - Zhongchen Rao
  - Li Cao
  - Hua Wu
  - Xue-hong Qiu
  - Guiqing Liu
  - R. Han
- PubMed: 31861642
- DOI: 10.3390/insects11010004
4 Insights on
- Low evidence
- Rigorous Journal
Correction to: Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.
- 2019-12-19
- European journal of nutrition 59(1)
- - Irini Lazou Ahrén
  - Anna Berggren
  - Cristina Teixeira
  - Titti Martinsson Niskanen
  - Niklas Larsson
- PubMed: 31858212
- DOI: 10.1007/s00394-019-02156-5
1 Insight on
- Reduced Cold Symptoms
- Low evidence
- Rigorous Journal