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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice.
- 2014-06-17
- PloS one 9(6)
- - Yen-Wenn Liu
  - Tan-Wei Liao
  - Yu-Han Chen
  - Yi-Chin Chiang
  - Ying-Chieh Tsai
- PubMed: 24936861
- DOI: 10.1371/journal.pone.0100105
3 Insights on
- Low evidence
- Animal Study
In Vitro and In Vivo Survival and Colonic Adhesion of Pediococcus acidilactici MTCC5101 in Human Gut
- 2014-06-11
- BioMed Research International 2013
- - Praveen P. Balgir
  - Baljinder Kaur
  - T. Kaur
  - N. Daroch
  - G. Kaur
- PubMed: 24175293
- DOI: 10.1155/2013/583850
1 Insight on
- Improved Gut Health
- Low evidence
A pilot study of Bifidobacterium breve in neonates undergoing surgery for congenital heart disease
- 2014-06-05
- RCT · n = 21
- Journal of Intensive Care 2(1)
- - T. Umenai
  - N. Shime
  - T. Asahara
  - K. Nomoto
  - T. Itoi
- PubMed: 25960878
- DOI: 10.1186/2052-0492-2-36
12 Insights on
- High evidence
- Rigorous Journal
The effect of five probiotic lactobacilli strains on the growth and biofilm formation of Streptococcus mutans.
- 2014-06-03
- Oral Diseases 21(1)
- - X. Lin
  - X. Chen
  - Y. Chen
  - W. Jiang
  - H. Chen
- PubMed: 24806217
- DOI: 10.1111/odi.12257
1 Insight on
- Reduced Growth of Streptococcus mutans
- Low evidence
Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9.
- 2014-06-01
- Clinical Trial
- American Journal of Physiology-Gastrointestinal and Liver Physiology 306(11)
- - M. Good
  - C. Sodhi
  - J. Ozolek
  - R. Buck
  - Karen C. Goehring
  - Debra L Thomas
  - A. Vikram
  - K. Bibby
  - Michael J. Morowitz
  - B. Firek
  - Peng Lu
  - D. Hackam
- PubMed: 24742987
- DOI: 10.1152/ajpgi.00452.2013
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Lactobacillus acidophilus and Lactobacillus crispatus culture supernatants downregulate expression of cancer-testis genes in the MDA-MB-231 cell line.
- 2014-05-30
- Asian Pacific Journal of Cancer Prevention 15(10)
- - Rosa Azam
  - S. Ghafouri-Fard
  - M. Tabrizi
  - M. Modarressi
  - R. Ebrahimzadeh-Vesal
  - M. Daneshvar
  - M. Mobasheri
  - E. Motevaseli
- PubMed: 24935380
- DOI: 10.7314/APJCP.2014.15.10.4255
1 Insight on
- Decreased Cancer-Testis Antigens
- Low evidence
- Rigorous Journal
Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain ‐ a randomised clinical study
- 2014-05-22
- RCT
- Alimentary Pharmacology & Therapeutics 40(2)
- - T. Ringel-Kulka
  - Jason R. Goldsmith
  - Ian M. Carroll
  - Silvana P. Barros
  - O. Palsson
  - Christian Jobin
  - Christian Jobin
  - Y. Ringel
- PubMed: 24853043
- DOI: 10.1111/apt.12800
1 Insight on
- Improved Symptoms of Functional Bowel Disorders
- High evidence
- Rigorous Journal
The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.
- 2014-05-22
- BMC microbiology 14(1)
- - Massimo Marzorati
  - Barbara Vanhoecke
  - Tine De Ryck
  - Mehdi Sadaghian Sadabad
  - Iris Pinheiro
  - Sam Possemiers
  - Pieter Van den Abbeele
  - Lara Derycke
  - Marc Bracke
  - Jan Pieters
  - Tom Hennebel
  - Hermie J Harmsen
  - Willy Verstraete
  - Tom Van de Wiele
- PubMed: 24884540
- DOI: 10.1186/1471-2180-14-133
2 Insights on
- Reduced IL-8 Production
- Reduced Inflammation
- Low evidence
- Highly Cited
Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on Hepatic Steatosis in Zucker Rats
- 2014-05-22
- RCT
- PLoS ONE 9(5)
- - J. Plaza-Díaz
  - C. Gómez-Llorente
  - F. Abadía-Molina
  - M. J. Sáez-Lara
  - L. Campaña‐Martín
  - S. Muñoz-Quezada
  - F. Romero
  - Á. Gil
  - L. Fontana
- PubMed: 24852284
- DOI: 10.1371/journal.pone.0098401
9 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Vitamin K₂ therapy for postmenopausal osteoporosis.
- 2014-05-16
- Review
- Nutrients 6(5)
- - Jun Iwamoto
- PubMed: 24841104
- DOI: 10.3390/nu6051971
4 Insights on
- Moderate evidence
- Rigorous Journal
Enterococcus faecalis from Healthy Infants Modulates Inflammation through MAPK Signaling Pathways
- 2014-05-15
- PLoS ONE 9(5)
- - Shugui Wang
  - M. Hibberd
  - S. Pettersson
  - Yuan-Kun Lee
- PubMed: 24830946
- DOI: 10.1371/journal.pone.0097523
2 Insights on
- Reduced Inflammation
- Reduced Proinflammatory Cytokine Secretion
- Moderate evidence
- Highly Cited
- Rigorous Journal
The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence
- 2014-05-13
- Systematic Review
- European Journal of Pediatrics 173(10)
- - M. Urbańska
  - H. Szajewska
- PubMed: 24819885
- DOI: 10.1007/s00431-014-2328-0
6 Insights on
- High evidence
- Highly Cited
In vitro and in vivo effects of beneficial vaginal lactobacilli on pathogens responsible for urogenital tract infections.
- 2014-05-01
- Clinical Trial
- Journal of Medical Microbiology 63(5)
- - P. R. De Gregorio
  - M. S. Juárez Tomás
  - M. C. Leccese Terraf
  - M. Nader-Macías
- PubMed: 24523160
- DOI: 10.1099/jmm.0.069401-0
7 Insights on
- Low evidence
- Animal Study
A double blind randomized trial showing probiotics to be ineffective in acute diarrhea in Indonesian children.
- 2014-04-29
- RCT · n = 112
- Indian journal of pediatrics 82(5)
- - Badriul Hegar
  - I Made Indra Waspada
  - Hartono Gunardi
  - Yvan Vandenplas
- PubMed: 24777621
- DOI: 10.1007/s12098-014-1408-5
2 Insights on
- Reduced Diarrhea Rate
- Reduced Defecation Frequency
- High evidence
- Large Human Trial
Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease
- 2014-04-28
- RCT · n = 33
- British Journal of Nutrition 112(1)
- - M. Olivares
  - G. Castillejo
  - V. Varea
  - Y. Sanz
- PubMed: 24774670
- DOI: 10.1017/S0007114514000609
6 Insights on
- High evidence
- Highly Cited
Whey protein delays gastric emptying and suppresses plasma fatty acids and their metabolites compared to casein, gluten, and fish protein.
- 2014-04-21
- RCT
- Journal of proteome research 13(5)
- - Jan Stanstrup
  - Simon S Schou
  - Jens Holmer-Jensen
  - Kjeld Hermansen
  - Lars O Dragsted
- PubMed: 24708224
- DOI: 10.1021/pr401214w
2 Insights on
- Increased Hydroxy Fatty Acid Level
- Increased Dicarboxylic Fatty Acid Level
- High evidence
Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings.
- 2014-04-15
- Review
- BioMed research international 2013
- - Öner Özdemir
  - Azize Yasemin Göksu Erol
- PubMed: 24078929
- DOI: 10.1155/2013/932391
3 Insights on
- Low evidence
Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants
- 2014-04-14
- PLoS ONE 9(4)
- - A. Finamore
  - Marianna Roselli
  - Ambra Imbinto
  - Julie Seeboth
  - I. Oswald
  - E. Mengheri
- PubMed: 24733511
- DOI: 10.1371/journal.pone.0094891
5 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
454 pyrosequencing reveals changes in the faecal microbiota of adults consuming Lactobacillus casei Zhang.
- 2014-04-10
- FEMS Microbiology Ecology 88(3)
- - Jiachao Zhang
  - Lifeng Wang
  - Zhuang Guo
  - Zhihong Sun
  - Qimu Gesudu
  - L. Kwok
  - Menghebilige
  - Heping Zhang
- PubMed: 24702028
- DOI: 10.1111/1574-6941.12328
1 Insight on
- Improved Diversity of Gut Microbiota
- Low evidence
- Rigorous Journal
Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice
- 2014-04-10
- Clinical Trial
- Scientific Reports 4(1)
- - Yosuke Nakayama
  - Tomohiro Moriya
  - F. Sakai
  - N. Ikeda
  - T. Shiozaki
  - T. Hosoya
  - H. Nakagawa
  - T. Miyazaki
- PubMed: 24717726
- DOI: 10.1038/srep04638
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial
- 2014-04-01
- RCT · n = 336
- Pediatrics 133(4)
- - P. Gutiérrez-Castrellón
  - G. López-Velázquez
  - Luisa Díaz-García
  - C. Jiménez-Gutiérrez
  - J. Mancilla-Ramírez
  - Juliana Estevez-Jiménez
  - M. Parra
- PubMed: 24639271
- DOI: 10.1542/peds.2013-0652
17 Insights on
- High evidence
- Large Human Trial
- Highly Cited
Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88.
- 2014-04-01
- Journal of Animal Science 92(4)
- - K. M. Yang
  - Zong-yong Jiang
  - C. Zheng
  - Li Wang
  - X. Yang
- PubMed: 24492550
- DOI: 10.2527/jas.2013-6619
6 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Probiotic Attributes of Autochthonous Lactobacillus rhamnosus Strains of Human Origin
- 2014-03-30
- Applied Biochemistry and Biotechnology 173(1)
- - Sheetal P. Pithva
  - Satyamitra L. Shekh
  - J. Dave
  - B. Vyas
- PubMed: 24682879
- DOI: 10.1007/s12010-014-0839-9
1 Insight on
- Enhanced Antimicrobial Resistance
- Low evidence
The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®
- 2014-03-28
- Review
- Microorganisms 2(2)
- - Mikkel Jungersen
  - A. Wind
  - E. Johansen
  - J. Christensen
  - Birgitte Stuer-Lauridsen
  - D. Eskesen
- PubMed: 27682233
- DOI: 10.3390/microorganisms2020092
15 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Protective effects of probiotic Lactobacillus rhamnosus IMC501 in mice treated with PhIP.
- 2014-03-28
- Clinical Trial
- Journal of Microbiology and Biotechnology 24(3)
- - L. Dominici
  - M. Villarini
  - F. Trotta
  - E. Federici
  - G. Cenci
  - M. Moretti
- PubMed: 24346468
- DOI: 10.4014/JMB.1309.09072
3 Insights on
- Low evidence
- Animal Study
Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
- 2014-03-24
- RCT
- British Journal of Nutrition 111(11)
- - C. Childs
  - H. Röytiö
  - E. Alhoniemi
  - Á. Fekete
  - S. Forssten
  - Natasa Hudjec
  - Ying Ni Lim
  - Cara J Steger
  - P. Yaqoob
  - K. Tuohy
  - R. Rastall
  - A. Ouwehand
  - G. Gibson
- PubMed: 24661576
- DOI: 10.1017/S0007114513004261
5 Insights on
- High evidence
- Highly Cited
Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhoea in hospitalised children.
- 2014-03-24
- RCT · n = 64
- Acta paediatrica (Oslo, Norway : 1992) 103(7)
- - Ener Cagri Dinleyici
  - Yvan Vandenplas
- PubMed: 24579935
- DOI: 10.1111/apa.12617
2 Insights on
- Reduced Diarrhea Rate
- Reduced Hospital Stay
- High evidence
Impact of orally administered lozenges with Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 on the number of salivary mutans streptococci, amount of plaque, gingival inflammation and the oral microbiome in healthy adults.
- 2014-03-18
- RCT · n = 31
- Clinical oral investigations 19(1)
- - Aino Toiviainen
  - Heli Jalasvuori
  - Emilia Lahti
  - Ulvi Gursoy
  - Seppo Salminen
  - Margherita Fontana
  - Susan Flannagan
  - George Eckert
  - Alexis Kokaras
  - Bruce Paster
  - Eva Söderling
- PubMed: 24638207
- DOI: 10.1007/s00784-014-1221-6
2 Insights on
- Reduced Plaque Accumulation
- Reduced Gingival Inflammation
- High evidence
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 improves acute liver injury induced by d-galactosamine in rats
- 2014-03-18
- Clinical Trial
- Applied Microbiology and Biotechnology 98(12)
- - L. Lv
  - Xin-Jun Hu
  - Guiyun Qian
  - Hua Zhang
  - H. Lu
  - Bei-wen Zheng
  - Li Jiang
  - Lan-Juan Li
- PubMed: 24639205
- DOI: 10.1007/s00253-014-5638-2
8 Insights on
- Low evidence
- Animal Study
The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants
- 2014-03-17
- RCT · n = 40
- International Journal of Food Sciences and Nutrition 65(5)
- - F. Garofoli
  - E. Civardi
  - F. Indrio
  - I. Mazzucchelli
  - Micol Angelini
  - C. Tinelli
  - M. Stronati
- PubMed: 24635827
- DOI: 10.3109/09637486.2014.898251
3 Insights on
- High evidence