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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial
- 2015-12
- RCT
- Nutrition Journal 15(1)
- - M. Pakdaman
  - J. Udani
  - J. Molina
  - M. Shahani
- PubMed: 27207411
- DOI: 10.1186/s12937-016-0172-y
11 Insights on
- High evidence
Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study
- 2015-12
- RCT · n = 100
- Immunity & Ageing 12(1)
- - Marie Lefevre
  - S. Racedo
  - Gabrielle Ripert
  - B. Housez
  - M. Cazaubiel
  - C. Maudet
  - Peter Jüsten
  - P. Marteau
  - M. Urdaci
- PubMed: 26640504
- DOI: 10.1186/s12979-015-0051-y
6 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study
- 2015-12
- RCT · n = 36
- Nutrition Journal 15(1)
- - M. Majeed
  - K. Nagabhushanam
  - Sankaran Natarajan
  - A. Sivakumar
  - Furqan Ali
  - A. Pande
  - Shaheen Majeed
  - S. K. Karri
- PubMed: 26922379
- DOI: 10.1186/s12937-016-0140-6
11 Insights on
- High evidence
- Highly Cited
A novel consortium of Lactobacillus rhamnosus and Streptococcus thermophilus for increased access to functional fermented foods
- 2015-12
- Microbial Cell Factories 14(1)
- - R. Kort
  - Nieke Westerik
  - L. M. Serrano
  - François P Douillard
  - W. Gottstein
  - I. M. Mukisa
  - C. Tuijn
  - L. Basten
  - B. Hafkamp
  - W. Meijer
  - B. Teusink
  - W. Vos
  - W. Vos
  - G. Reid
  - G. Reid
  - W. Sybesma
- PubMed: 26643044
- DOI: 10.1186/s12934-015-0370-x
1 Insight on
- Alleviated Diarrhea
- Low evidence
- Highly Cited
Probiotics and gut health in infants: A preliminary case-control observational study about early treatment with Lactobacillus reuteri DSM 17938.
- 2015-12
- Observational · n = 60
- Clinica Chimica Acta 451
- - F. Savino
  - Stefania Fornasero
  - Simone Ceratto
  - A. De Marco
  - N. Mandras
  - J. Roana
  - V. Tullio
  - G. Amisano
- PubMed: 25704298
- DOI: 10.1016/j.cca.2015.02.027
4 Insights on
- Moderate evidence
Dietary Bacillus subtilis FPTB13 and chitin, single or combined, modulate systemic and cutaneous mucosal immunity and resistance of catla, Catla catla (Hamilton) against edwardsiellosis.
- 2015-12
- Clinical Trial
- Comparative Immunology, Microbiology and Infectious Diseases 43
- - T. Sangma
  - D. Kamilya
- PubMed: 26616655
- DOI: 10.1016/j.cimid.2015.09.003
6 Insights on
- Low evidence
- Animal Study
Lactobacillus fermentum CECT 5716 Reduces Staphylococcus Load in the Breastmilk of Lactating Mothers Suffering Breast Pain: A Randomized Controlled Trial.
- 2015-11
- RCT
- Breastfeeding Medicine 10(9)
- - J. Maldonado-Lobón
  - M. A. Díaz-López
  - R. Carputo
  - Pilar Duarte
  - M. Díaz-Ropero
  - A. Valero
  - A. Sañudo
  - Lluis Sempere
  - M. Ruíz-López
  - O. Bañuelos
  - J. Fonollá
  - Mónica Olivares Martín
- PubMed: 26352805
- DOI: 10.1089/bfm.2015.0070
2 Insights on
- Reduced Staphylococcus Load in Breast Milk
- Reduced Breast Pain
- High evidence
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.
- 2015-10
- RCT · n = 65
- Complementary therapies in medicine 23(5)
- - Soheila Rezapour-Firouzi
  - Seyed Rafie Arefhosseini
  - Mehrangiz Ebrahimi-Mamaghani
  - Behzad Baradaran
  - Elyar Sadeghihokmabad
  - Somaiyeh Mostafaei
  - Mohammadali Torbati
  - Mahtaj Chehreh
- PubMed: 26365444
- DOI: 10.1016/j.ctim.2015.07.003
4 Insights on
- High evidence
A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice.
- 2015-10
- Clinical Trial
- Research in Microbiology 166(8)
- - Soumi De Montijo-Prieto
  - E. Moreno
  - Triana Bergillos-Meca
  - A. Lasserrot
  - M. Ruíz-López
  - A. Ruiz-Bravo
  - M. Jiménez-Valera
- PubMed: 26272025
- DOI: 10.1016/j.resmic.2015.07.010
2 Insights on
- Enhanced IFN-γ Production
- Enhanced Immunity to Intestinal Infections
- Low evidence
- Animal Study
In vitro and in vivo examination of anticolonization of pathogens by Lactobacillus paracasei FJ861111.1.
- 2015-10
- Journal of Dairy Science 98(10)
- - Kan Deng
  - Tingtao Chen
  - Qinglong Wu
  - Hongbo Xin
  - Q. Wei
  - Ping Hu
  - Xiaolei Wang
  - Xin Wang
  - Hua Wei
  - N. Shah
- PubMed: 26254535
- DOI: 10.3168/jds.2015-9761
16 Insights on
- Low evidence
- Rigorous Journal
Impact of non-starter lactobacilli on release of peptides with angiotensin-converting enzyme inhibitory and antioxidant activities during bovine milk fermentation.
- 2015-10
- Food Microbiology 51
- - L. Solieri
  - Giuseppina Sefora Rutella
  - D. Tagliazucchi
- PubMed: 26187835
- DOI: 10.1016/j.fm.2015.05.012
4 Insights on
- Low evidence
- Highly Cited
The study on the candidate probiotic properties of encapsulated yeast, Saccharomyces cerevisiae JCM 7255, in Nile Tilapia (Oreochromis niloticus).
- 2015-10
- Research in Veterinary Science 102
- - K. Pinpimai
  - C. Rodkhum
  - N. Chansue
  - T. Katagiri
  - M. Maita
  - N. Pirarat
- PubMed: 26412528
- DOI: 10.1016/j.rvsc.2015.07.021
4 Insights on
- Low evidence
Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization
- 2015-09
- Clinical Trial
- Infection and Immunity 83(9)
- - K. Patras
  - P. Wescombe
  - B. Rösler
  - J. Hale
  - J. Tagg
  - K. Doran
- PubMed: 26077762
- DOI: 10.1128/IAI.00409-15
2 Insights on
- Reduced Group B Streptococcus Colonization
- Reduced Vaginal Group B Streptococcus Colonization
- Low evidence
- Animal Study
Patients Receiving Prebiotics and Probiotics Before Liver Transplantation Develop Fewer Infections Than Controls: A Systematic Review and Meta-Analysis.
- 2015-09
- Meta-Analysis
- Clinical Gastroenterology and Hepatology 13(9)
- - Tarek Sawas
  - Shadi Al Halabi
  - Ruben Hernaez
  - W. Carey
  - W. Cho
- PubMed: 26044318
- DOI: 10.1016/j.cgh.2015.05.027
5 Insights on
- High evidence
- Highly Cited
In vitro probiotic characteristics of Lactobacillus plantarum ZDY 2013 and its modulatory effect on gut microbiota of mice.
- 2015-09
- Journal of Dairy Science 98(9)
- - Renhui Huang
  - X. Tao
  - C. Wan
  - S. Li
  - Hengyi Xu
  - Feng Xu
  - N. Shah
  - Hua Wei
- PubMed: 26142853
- DOI: 10.3168/jds.2014-9153
4 Insights on
- Low evidence
- Rigorous Journal
Lactobacillus sakei K040706 evokes immunostimulatory effects on macrophages through TLR 2-mediated activation.
- 2015-09
- Clinical Trial
- International Immunopharmacology 28(1)
- - J. Jung
  - Ji-Sun Shin
  - Suel-Gie Lee
  - Y. Rhee
  - Chang-Won Cho
  - Hee‐Do Hong
  - Kyung-Tae Lee
- PubMed: 26049027
- DOI: 10.1016/j.intimp.2015.05.037
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea.
- 2015-08
- RCT · n = 363
- Beneficial Microbes 6(4)
- - E. Dinleyici
  - Ateş Kara
  - N. Dalgıç
  - Zafer Kurugöl
  - V. Arıca
  - Ozge Metin
  - E. Temur
  - O. Turel
  - S. Guven
  - O. Yasa
  - S. Bulut
  - G. Tanır
  - A. Yazar
  - A. Karbuz
  - M. Sancar
  - M. Erguven
  - G. Akça
  - Makbule Eren
  - M. Ozen
  - Yvan Vandenplas
- PubMed: 25653151
- DOI: 10.3920/BM2014.0086
5 Insights on
- High evidence
- Large Human Trial
Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats.
- 2015-08
- RCT · n = 18
- Clinical Nutrition 34(4)
- - I. L. Ahrén
  - Jie Xu
  - G. Önning
  - C. Olsson
  - S. Ahrné
  - G. Molin
- PubMed: 25194632
- DOI: 10.1016/j.clnu.2014.08.009
2 Insights on
- Reduced Aminotransferase Levels
- Reduced Blood Pressure
- Low evidence
- Highly Cited
- Animal Study
Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia.
- 2015-08
- RCT · n = 128
- Atherosclerosis 241(2)
- - H. Y. Ahn
  - Minjoo Kim
  - J. Chae
  - Y. Ahn
  - J. Sim
  - Il-dong Choi
  - Sang-Hyun Lee
  - J. H. Lee
- PubMed: 26117402
- DOI: 10.1016/j.atherosclerosis.2015.06.030
3 Insights on
- High evidence
Polypodium leucotomos supplementation in the treatment of scalp actinic keratosis: could it improve the efficacy of photodynamic therapy?
- 2015-08
- RCT
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 41(8)
- - Matteo Auriemma
  - Marta Di Nicola
  - Salvador Gonzalez
  - Stefano Piaserico
  - Alessandra Capo
  - Paolo Amerio
- PubMed: 26218723
- DOI: 10.1097/dss.0000000000000425
2 Insights on
- Reduced Actinic Keratosis Count
- Reduced Actinic Keratosis Recurrence
- High evidence
The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.
- 2015-08
- RCT · n = 92
- Nutrition, Metabolism and Cardiovascular Diseases 25(8)
- - H. Y. Ahn
  - M. Kim
  - Y. Ahn
  - J. Sim
  - Il-dong Choi
  - S. Lee
  - J. H. Lee
- PubMed: 26044516
- DOI: 10.1016/j.numecd.2015.05.002
3 Insights on
- High evidence
Effect of Lactobacillus rhamnosus GG Administration on Vancomycin-Resistant Enterococcus Colonization in Adults with Comorbidities.
- 2015-08
- RCT
- Antimicrobial agents and chemotherapy 59(8)
- - Shira Doron
  - Patricia L Hibberd
  - Barry Goldin
  - Cheleste Thorpe
  - Laura McDermott
  - David R Snydman
- PubMed: 26014940
- DOI: 10.1128/aac.00300-15
1 Insight on
- Reduced Vancomycin-Resistant Enterococcus Colonization
- High evidence
Influence of Lactobacillus brevis 15 and Lactobacillus plantarum 13 on blood glucose and body weight in rats after high-fructose diet.
- 2015-08
- RCT · n = 24
- Beneficial Microbes 6(4)
- - M. Yakovlieva
  - T. Tacheva
  - S. Mihaylova
  - R. Tropcheva
  - K. Trifonova
  - A. Toleкova
  - Svetla Danova
  - T. Vlaykova
- PubMed: 25691100
- DOI: 10.3920/BM2014.0012
5 Insights on
- Low evidence
- Animal Study
Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study.
- 2015-08
- RCT · n = 28
- Beneficial Microbes 6(4)
- - K. Miyazawa
  - M. Kawase
  - A. Kubota
  - K. Yoda
  - G. Harata
  - M. Hosoda
  - F. He
- PubMed: 25653155
- DOI: 10.3920/BM2014.0108
2 Insights on
- Increased T Cell Count
- Reduced CD28 Expression Loss in CD8+ T Cells
- High evidence
Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women.
- 2015-07
- RCT · n = 36
- The Journal of Nutrition 145(7)
- - Edna P Nyangale
  - S. Farmer
  - H. Cash
  - D. Keller
  - D. Chernoff
  - G. Gibson
- PubMed: 25948780
- DOI: 10.3945/jn.114.199802
6 Insights on
- High evidence
Interaction effects of dietary supplementation of heat-killed Lactobacillus plantarum and β-glucan on growth performance, digestibility and immune response of juvenile red sea bream, Pagrus major.
- 2015-07
- Clinical Trial
- Fish & Shellfish Immunology 45(1)
- - M. Dawood
  - S. Koshio
  - M. Ishikawa
  - S. Yokoyama
- PubMed: 25661844
- DOI: 10.1016/j.fsi.2015.01.033
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Encapsulated Lactococcus lactis with enhanced gastrointestinal survival for the development of folate enriched functional foods.
- 2015-07
- Bioresource Technology 188
- - J. Divya
  - K. Nampoothiri
- PubMed: 25686721
- DOI: 10.1016/j.biortech.2015.01.073
2 Insights on
- Improved Gastrointestinal Survival
- Increased Folate Levels
- Low evidence
Role of probiotic Lactobacillus fermentum KKL1 in the preparation of a rice based fermented beverage.
- 2015-07
- Bioresource Technology 188
- - Kuntal Ghosh
  - M. Ray
  - A. Adak
  - S. Halder
  - A. Das
  - A. Jana
  - Saswati Parua Mondal
  - C. Vágvölgyi
  - P. K. Das Mohapatra
  - B. Pati
  - K. C. Mondal
- PubMed: 25693452
- DOI: 10.1016/j.biortech.2015.01.130
3 Insights on
- Low evidence
- Highly Cited
Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting.
- 2015-07
- RCT · n = 64
- Jornal de Pediatria 91(4)
- - E. Dinleyici
  - N. Dalgıç
  - S. Guven
  - Ozge Metin
  - O. Yasa
  - Z. Kurugol
  - O. Turel
  - G. Tanır
  - A. Yazar
  - V. Arıca
  - M. Sancar
  - A. Karbuz
  - M. Eren
  - M. Ozen
  - A. Kara
  - Y. Vandenplas
- PubMed: 25986615
- DOI: 10.1016/j.jped.2014.10.009
4 Insights on
- High evidence
Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.
- 2015-07
- Clinical Trial
- Free radical biology & medicine 84
- - Gema Pereira-Caro
  - Christine M Oliver
  - Rangika Weerakkody
  - Tanoj Singh
  - Michael Conlon
  - Gina Borges
  - Luz Sanguansri
  - Trevor Lockett
  - Susan A Roberts
  - Alan Crozier
  - Mary Ann Augustin
- PubMed: 25801290
- DOI: 10.1016/j.freeradbiomed.2015.03.010
8 Insights on
- Moderate evidence