Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice.
- 2014-07
- Clinical Trial
- American Journal of Obstetrics and Gynecology 211(1)
- - Siwen Yang
  - Wei Li
  - J. Challis
  - G. Reid
  - S. O. Kim
  - A. Bocking
- PubMed: 24486224
- DOI: 10.1016/j.ajog.2014.01.029
2 Insights on
- Reduced Preterm Births
- Reduced Inflammation
- Low evidence
- Animal Study
Modulation of the inflammation–coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll‐like receptor 2
- 2014-07
- Clinical Trial
- Microbiology and Immunology 58(7)
- - H. Zelaya
  - J. Villena
  - Andres Gramajo Lopez
  - S. Alvarez
  - Graciela Agüero
- PubMed: 24888715
- DOI: 10.1111/1348-0421.12163
2 Insights on
- Reduced Lung Damage
- Improved Cytokine Production
- Low evidence
- Animal Study
Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages.
- 2014-07
- Clinical Trial
- International Immunopharmacology 21(1)
- - Se-Eun Jang
  - M. Han
  - Se-Young Kim
  - Dong-Hyun Kim
- PubMed: 24815859
- DOI: 10.1016/j.intimp.2014.04.021
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Yacon effects in immune response and nutritional status of iron and zinc in preschool children.
- 2014-06
- Clinical Trial · n = 59
- Nutrition (Burbank, Los Angeles County, Calif.) 30(6)
- - Maria das Graças Vaz-Tostes
  - Mirelle Lomar Viana
  - Mariana Grancieri
  - Tereza Cecília dos Santos Luz
  - Heberth de Paula
  - Rogério Graça Pedrosa
  - Neuza Maria Brunoro Costa
- PubMed: 24631386
- DOI: 10.1016/j.nut.2013.10.016
9 Insights on
- High evidence
Effect of Probiotics Containing Lactobacillus paracasei SD1 on Salivary Mutans Streptococci and Lactobacilli in Orthodontic Cleft Patients: A Double-Blinded, Randomized, Placebo-Controlled Study
- 2014-05
- RCT · n = 30
- The Cleft Palate-Craniofacial Journal 51(3)
- - W. Ritthagol
  - Chontira Saetang
  - R. Teanpaisan
- PubMed: 23656594
- DOI: 10.1597/12-243
6 Insights on
- High evidence
Altered Transcription of Murine Genes Induced in the Small Bowel by Administration of Probiotic Strain Lactobacillus rhamnosus HN001
- 2014-05
- Clinical Trial
- Applied and Environmental Microbiology 80(9)
- - G. Tannock
  - Corinda Taylor
  - B. Lawley
  - D. Loach
  - M. Gould
  - Amy C. Dunn
  - A. McLellan
  - M. Black
  - L. McNoe
  - J. Dekker
  - P. Gopal
  - M. Collett
- PubMed: 24584241
- DOI: 10.1128/AEM.00336-14
2 Insights on
- Improved Resistance to Intestinal Pathogens
- Enhanced Epithelial Cell Migration
- Low evidence
- Animal Study
Draft Genome Sequence of Bifidobacterium animalis subsp. lactis Strain CECT 8145, Able To Improve Metabolic Syndrome In Vivo
- 2014-05
- Genome Announcements 2(2)
- - E. Chenoll
  - F. Codoñer
  - A. Silva
  - J. F. Martínez-Blanch
  - P. Martorell
  - Daniel Ramón
  - S. Genovés
- PubMed: 24675853
- DOI: 10.1128/genomeA.00183-14
2 Insights on
- Reduced Body Fat
- Improved Metabolic Syndrome Biomarkers
- Low evidence
Dietary supplementation of Bacillus subtilis and fructooligosaccharide enhance the growth, non-specific immunity of juvenile ovate pompano, Trachinotus ovatus and its disease resistance against Vibrio vulnificus.
- 2014-05
- Fish & Shellfish Immunology 38(1)
- - Qin Zhang
  - Hairui Yu
  - T. Tong
  - Wanping Tong
  - Lanfang Dong
  - Mingzhu Xu
  - Zhicheng Wang
- PubMed: 24614017
- DOI: 10.1016/j.fsi.2014.02.008
13 Insights on
- Low evidence
- Highly Cited
Lactobacillus sakei modulates mule duck microbiota in ileum and ceca during overfeeding.
- 2014-04
- Clinical Trial
- Poultry Science 93(4)
- - F. Vasai
  - K. Ricaud
  - L. Cauquil
  - L. Cauquil
  - L. Cauquil
  - P. Daniel
  - C. Peillod
  - Karine Gontier
  - A. Tizaoui
  - Olivier Bouchez
  - Sylvie Combes
  - Sylvie Combes
  - Sylvie Combes
  - S. Davail
- PubMed: 24706969
- DOI: 10.3382/ps.2013-03497
1 Insight on
- Reduced Richness Indicators in Ileum
- Low evidence
- Rigorous Journal
- Animal Study
EFFECT OF Bifidobacterium animalis ON MICE INFECTED WITH Strongyloides venezuelensis
- 2014-04
- Clinical Trial
- Revista do Instituto de Medicina Tropical de São Paulo 56(2)
- - T. Oliveira-Sequeira
  - É. David
  - C. Ribeiro
  - S. Guimarães
  - A. P. Masseno
  - S. Katagiri
  - J. Sequeira
- PubMed: 24626410
- DOI: 10.1590/S0036-46652014000200003
2 Insights on
- Reduced Pathogenic Load
- Improved Intestinal Mucosal Histology
- Low evidence
- Animal Study
Exopolysaccharide-producing Bifidobacterium animalis subsp. lactis strains and their polymers elicit different responses on immune cells from blood and gut associated lymphoid tissue.
- 2014-04
- Anaerobe 26
- - C. Hidalgo-Cantabrana
  - M. Nikolić
  - P. López
  - A. Suárez
  - Marija S. Miljković
  - M. Kojić
  - A. Margolles
  - N. Golić
  - P. Ruas-Madiedo
- PubMed: 24445155
- DOI: 10.1016/j.anaerobe.2014.01.003
3 Insights on
- Low evidence
Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.
- 2014-04
- RCT
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(4)
- - N. Suzuki
  - M. Yoneda
  - Kazunari Tanabe
  - A. Fujimoto
  - Kosaku Iha
  - K. Seno
  - Kazuhiko Yamada
  - T. Iwamoto
  - Y. Masuo
  - T. Hirofuji
- PubMed: 24556493
- DOI: 10.1016/j.oooo.2013.12.400
6 Insights on
- High evidence
Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets.
- 2014-03
- RCT · n = 20
- Veterinary Immunology and Immunopathology 158(1-2)
- - Tanja Lähteinen
  - A. Lindholm
  - T. Rinttilä
  - S. Junnikkala
  - R. Kant
  - T. Pietilä
  - K. Levonen
  - I. von Ossowski
  - G. Solano-Aguilar
  - M. Jakava-Viljanen
  - A. Palva
- PubMed: 24074625
- DOI: 10.1016/j.vetimm.2013.09.002
12 Insights on
- Low evidence
- Animal Study
Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study.
- 2014-03
- Clinical Trial
- Advances in therapy 31(3)
- - Mikio Momoeda
  - Hidetaka Sasaki
  - Eiko Tagashira
  - Masayuki Ogishima
  - Yuichi Takano
  - Kazunori Ochiai
- PubMed: 24604699
- DOI: 10.1007/s12325-014-0106-z
15 Insights on
- Moderate evidence
A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects.
- 2014-03
- RCT
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 65
- - Gustavo F Gonzales
  - Carla Gonzales
- PubMed: 24389453
- DOI: 10.1016/j.fct.2013.12.039
3 Insights on
- High evidence
Accumulation of polyphosphate in Lactobacillus spp. and its involvement in stress resistance.
- 2014-03
- Applied and environmental microbiology 80(5)
- - Cristina Alcántara
  - Amalia Blasco
  - Manuel Zúñiga
  - Vicente Monedero
- PubMed: 24375133
- DOI: 10.1128/aem.03997-13
1 Insight on
- Reduced Polyphosphate Accumulation
- Low evidence
- Rigorous Journal
Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model.
- 2014-02
- The Journal of Nutritional Biochemistry 25(2)
- - A. Reichold
  - Sibylle A. Brenner
  - Astrid Spruss
  - K. Förster-Fromme
  - I. Bergheim
  - S. Bischoff
- PubMed: 24445036
- DOI: 10.1016/j.jnutbio.2013.09.011
6 Insights on
- Low evidence
Herbal preparations for the menopause: beyond isoflavones and black cohosh.
- 2014-02
- Review
- Maturitas 77(2)
- - Herman T Depypere
  - Frank H Comhaire
- PubMed: 24314619
- DOI: 10.1016/j.maturitas.2013.11.001
1 Insight on
- Reduced Vasomotor Symptom
- Low evidence
Anti-Inflammatory Properties of Streptococcus salivarius, a Commensal Bacterium of the Oral Cavity and Digestive Tract
- 2014-02
- Applied and Environmental Microbiology 80(3)
- - Ghalia Kaci
  - D. Goudercourt
  - V. Dennin
  - B. Pot
  - J. Doré
  - S. Ehrlich
  - P. Renault
  - H. Blottière
  - C. Daniel
  - C. Delorme
- PubMed: 24271166
- DOI: 10.1128/AEM.03133-13
1 Insight on
- Reduced Inflammation Levels
- Moderate evidence
- Highly Cited
- Rigorous Journal
Administration of Bacillus subtilis strains in the rearing water enhances the water quality, growth performance, immune response, and resistance against Vibrio harveyi infection in juvenile white shrimp, Litopenaeus vannamei.
- 2014-01
- Fish & Shellfish Immunology 36(1)
- - Hadi Zokaeifar
  - N. Babaei
  - C. Saad
  - M. Kamarudin
  - K. Sijam
  - J. Balcázar
- PubMed: 24161773
- DOI: 10.1016/j.fsi.2013.10.007
5 Insights on
- Low evidence
- Highly Cited
Optimization for production of exopolysaccharides with antitumor activity in vitro from Paecilomyces hepiali.
- 2014-01
- Carbohydrate Polymers 99
- - Zhongwei Wu
  - Junwen Lu
  - Xiaoqing Wang
  - Bing Hu
  - Hong Ye
  - Jia-Qin Fan
  - Muhammad Abid
  - Xiaoxiong Zeng
- PubMed: 24274500
- DOI: 10.1016/j.carbpol.2013.08.010
1 Insight on
- Increased Anticancer Activity
- Low evidence
Effects of Clostridium butyricum on growth performance, immune function, and cecal microflora in broiler chickens challenged with Escherichia coli K88.
- 2014-01
- RCT · n = 360
- Poultry Science 93(1)
- - Lijun Zhang
  - Lijun Zhang
  - G. Cao
  - X. Zeng
  - L. Zhou
  - P. Ferket
  - Y. Xiao
  - A. Chen
  - C. M. Yang
  - C. M. Yang
- PubMed: 24570422
- DOI: 10.3382/ps.2013-03412
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Treatment assignment guesses by study participants in a double-blind dose escalation clinical trial of saw palmetto.
- 2014-01
- RCT · n = 155
- Journal of alternative and complementary medicine (New York, N.Y.) 20(1)
- - Jeannette Y Lee
  - Page Moore
  - John Kusek
  - Michael Barry
- PubMed: 23383975
- DOI: 10.1089/acm.2012.0284
1 Insight on
- Improved AUA Symptom Index
- High evidence
- Large Human Trial
Lactobacillus salivarius: bacteriocin and probiotic activity.
- 2013-12
- Food Microbiology 36(2)
- - Soumaya Messaoudi
  - M. Manai
  - Gilles Kergourlay
  - H. Prévost
  - N. Connil
  - J. Chobert
  - X. Dousset
- PubMed: 24010610
- DOI: 10.1016/j.fm.2013.05.010
4 Insights on
- Low evidence
- Highly Cited
Efficacy of Saccharomyces boulardii on necrotizing enterocolitis or sepsis in very low birth weight infants: a randomised controlled trial.
- 2013-12
- RCT · n = 208
- Early Human Development 89(12)
- - O. Serce
  - D. Benzer
  - T. Gursoy
  - G. Karatekin
  - F. Ovalı
- PubMed: 24041815
- DOI: 10.1016/j.earlhumdev.2013.08.013
2 Insights on
- Time to Full Enteral Feeding in Postnatal Age
- Incidence of Necrotizing Enterocolitis
- High evidence
- Highly Cited
The effect of Pediococcus acidilactici bacteria used as probiotic supplement on the growth and non-specific immune responses of green terror, Aequidens rivulatus.
- 2013-12
- RCT · n = 60
- Fish & Shellfish Immunology 35(6)
- - Alireza Neissi
  - G. Rafiee
  - M. Nematollahi
  - O. Safari
- PubMed: 24161762
- DOI: 10.1016/j.fsi.2013.09.036
8 Insights on
- Low evidence
- Animal Study
Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials.
- 2013-12
- Review
- Journal of ethnopharmacology 150(3)
- - M Miroddi
  - G Calapai
  - M Navarra
  - P L Minciullo
  - S Gangemi
- PubMed: 24140586
- DOI: 10.1016/j.jep.2013.09.047
2 Insights on
- Reduced Anxiety
- Reduced Insomnia Symptoms
- Low evidence
A comparison of two probiotic strains of bifidobacteria in premature infants.
- 2013-12
- RCT · n = 21
- The Journal of Pediatrics 163(6)
- - M. Underwood
  - K. Kalanetra
  - Nicholas A. Bokulich
  - Zachery T Lewis
  - M. Mirmiran
  - D. Tancredi
  - D. Mills
- PubMed: 23993139
- DOI: 10.1016/j.jpeds.2013.07.017
3 Insights on
- High evidence
- Highly Cited
Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on enterohemorrhagic Escherichia coli infection using mouse and intestinal cell models.
- 2013-12
- Clinical Trial
- Journal of Dairy Science 96(12)
- - Yen-Po Chen
  - T. Y. Lee
  - W. Hong
  - H. Hsieh
  - Ming-Ju Chen
- PubMed: 24140320
- DOI: 10.3168/jds.2013-7015
3 Insights on
- Low evidence
- Animal Study
Effect of Lactobacillus salivarius Ls-33 on fecal microbiota in obese adolescents.
- 2013-12
- RCT · n = 50
- Clinical Nutrition 32(6)
- - N. Larsen
  - F. Vogensen
  - R. Gøbel
  - K. Michaelsen
  - S. Forssten
  - S. Lahtinen
  - M. Jakobsen
- PubMed: 23510724
- DOI: 10.1016/j.clnu.2013.02.007
3 Insights on
- High evidence
- Highly Cited