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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of daily consumption of psyllium, oat bran and polyGlycopleX on obesity-related disease risk factors: A critical review.
- 2019-01
- Review
- Nutrition (Burbank, Los Angeles County, Calif.) 57
- - Monica Jane
  - Jenny McKay
  - Sebely Pal
- PubMed: 30153584
- DOI: 10.1016/j.nut.2018.05.036
4 Insights on
- Low evidence
A dietary pattern rich in calcium, potassium, and protein is associated with tibia bone mineral content and strength in young adults entering initial military training.
- 2019-01
- RCT · n = 401
- The American journal of clinical nutrition 109(1)
- - Anna T Nakayama
  - Laura J Lutz
  - Adela Hruby
  - James P Karl
  - James P McClung
  - Erin Gaffney-Stomberg
- PubMed: 30615068
- DOI: 10.1093/ajcn/nqy199
2 Insights on
- Improved Bone Mineral Content
- Improved Bone Strength
- High evidence
- Large Human Trial
Effects of dietary Enterococcus faecium NCIMB 11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens
- 2019-01
- RCT · n = 360
- Poultry Science 98(1)
- - Yuanyuan Wu
  - W. Zhen
  - Y. Geng
  - Zhong Wang
  - Yuming Guo
- PubMed: 30137622
- DOI: 10.3382/ps/pey368
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
- 2019-01
- RCT
- Journal of clinical psychopharmacology 39(1)
- - Craig Surman
  - Atilla Ceranoglu
  - Carrie Vaudreuil
  - Brittany Albright
  - Mai Uchida
  - Amy Yule
  - Andrea Spencer
  - Heidi Boland
  - Rebecca Grossman
  - Lauren Rhodewalt
  - Maura Fitzgerald
  - Joseph Biederman
- PubMed: 30566416
- DOI: 10.1097/jcp.0000000000000990
8 Insights on
- High evidence
Pilot Analysis of Early Lactobacillus rhamnosus GG for Infant Colic Prevention.
- 2019-01
- RCT · n = 184
- Journal of pediatric gastroenterology and nutrition 68(1)
- - Michael D Cabana
  - Michelle McKean
  - Amy L Beck
  - Valerie Flaherman
- PubMed: 30052571
- DOI: 10.1097/mpg.0000000000002113
2 Insights on
- Reduced Colic Symptoms
- Reduced Colic
- High evidence
- Large Human Trial
Characterization of Bacillus subtilis from gastrointestinal tract of hybrid Hulong grouper (Epinephelus fuscoguttatus × E. lanceolatus) and its effects as probiotic additives.
- 2019-01
- Clinical Trial
- Fish & Shellfish Immunology 84
- - Sheng Zhou
  - D. Song
  - Xiaofeng Zhou
  - Xinliang Mao
  - Xuefeng Zhou
  - Sunli Wang
  - Jingguang Wei
  - Youhua Huang
  - Wenxiong Wang
  - S. Xiao
  - Q. Qin
- PubMed: 30463174
- DOI: 10.1016/j.fsi.2018.10.058
14 Insights on
- Low evidence
- Animal Study
Lactobacillus plantarum YS2 (yak yogurt Lactobacillus) exhibited an activity to attenuate activated carbon-induced constipation in male Kunming mice.
- 2019-01
- Clinical Trial
- Journal of Dairy Science 102(1)
- - Xin Zhao
  - Y. Qian
  - Guijie Li
  - Ruokun Yi
  - Kun-Young Park
  - Jia-Le Song
- PubMed: 30527985
- DOI: 10.3168/jds.2018-15206
10 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Bifidobacterium may benefit the prevention of necrotizing enterocolitis in preterm infants: A systematic review and meta-analysis.
- 2019-01
- Meta-Analysis
- International Journal of Surgery 61
- - Xiu-li Zhu
  - Xiao-Gang Tang
  - Fan Qu
  - Yu Zheng
  - Wenhao Zhang
  - Yu-qiao Diao
- PubMed: 30500473
- DOI: 10.1016/j.ijsu.2018.11.026
6 Insights on
- High evidence
Problem-Solving Exercise for Undergraduate Students Involving the Japanese Fermented Food Natto †
- 2019-01
- Journal of Microbiology & Biology Education 20(1)
- - Yoko Yoshiyama
  - J. Shima
  - T. Fushiki
- PubMed: 31160925
- DOI: 10.1128/jmbe.v20i1.1614
1 Insight on
- Increased Protein Intake
- Low evidence
The effect of kefir produced from natural kefir grains on the intestinal microbial populations and antioxidant capacities of Balb/c mice.
- 2019-01
- Food Research International 115
- - F. Erdoğan
  - S. Ozarslan
  - Z. Guzel‐Seydim
  - Tuğba Kök Taş
- PubMed: 30599959
- DOI: 10.1016/j.foodres.2018.10.080
7 Insights on
- Low evidence
Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis.
- 2019-01
- Journal of Dairy Science 102(1)
- - Ewa Wasilewska
  - D. Złotkowska
  - Barbara Wróblewska
- PubMed: 30343915
- DOI: 10.3168/jds.2018-14520
18 Insights on
- Low evidence
- Rigorous Journal
Probiotics Streptococcus salivarius 24SMB and Streptococcus oralis 89a interfere with biofilm formation of pathogens of the upper respiratory tract
- 2018-12
- BMC Infectious Diseases 18(1)
- - Alessandro Bidossi
  - R. De Grandi
  - Marco Toscano
  - M. Bottagisio
  - E. De Vecchi
  - M. Gelardi
  - L. Drago
- PubMed: 30545317
- DOI: 10.1186/s12879-018-3576-9
1 Insight on
- Reduced Acute Otitis Media
- Low evidence
- Rigorous Journal
Lack of Benefit of Lactobacillus reuteri DSM 17938 as an Addition to the Treatment of Functional Constipation.
- 2018-12
- RCT · n = 33
- Journal of pediatric gastroenterology and nutrition 67(6)
- - Oleg Jadrešin
  - Sara Sila
  - Ivana Trivić
  - Zrinjka Mišak
  - Iva Hojsak
  - Sanja Kolaček
- PubMed: 30134331
- DOI: 10.1097/mpg.0000000000002134
6 Insights on
- High evidence
Effects of Lactobacillus acidophilus LA-3 on physicochemical and sensory parameters of açaí and mango based smoothies and its survival following simulated gastrointestinal conditions.
- 2018-12
- Food Research International 114
- - W. A. Luciano
  - Thais Costa Matte
  - Isabella Araújo Portela
  - Lorena Lucena de Medeiros
  - Marcos dos Santos Lima
  - J. F. Maciel
  - E. L. de Souza
  - Estefânia F Garcia
  - M. Magnani
- PubMed: 30361012
- DOI: 10.1016/j.foodres.2018.08.005
3 Insights on
- Low evidence
Effect of Lactobacillus Rhamnosus on serum uremic toxins (phenol and P-Cresol) in hemodialysis patients: A double blind randomized clinical trial.
- 2018-12
- RCT · n = 42
- Clinical Nutrition ESPEN 28
- - F. Eidi
  - Fatemeh Poor-Reza Gholi
  - A. Ostadrahimi
  - N. Dalili
  - F. Samadian
  - A. Barzegari
- PubMed: 30390875
- DOI: 10.1016/j.clnesp.2018.08.010
1 Insight on
- Reduced Uremic Toxins Levels
- High evidence
Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA-mediated phosphorylation of hormone-sensitive lipase and ERK-mediated downregulation of perilipin in 3T3-L1 adipocytes
- 2018-12
- BMC Complementary and Alternative Medicine 18(1)
- - M. Ge
  - Rui Guo
  - Hai-xia Lou
  - Wen Zhang
- PubMed: 30526586
- DOI: 10.1186/s12906-018-2389-0
3 Insights on
- Low evidence
- Rigorous Journal
Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose-induced oxidation in male Kuming mice.
- 2018-12
- Journal of Dairy Science 101(12)
- - Huayi Suo
  - Shanchun Liu
  - Jian Li
  - Yangping Ding
  - Hongwei Wang
  - Yu Zhang
  - Xin Zhao
  - Jia-Le Song
- PubMed: 30292551
- DOI: 10.3168/jds.2018-14758
4 Insights on
- Low evidence
- Rigorous Journal
Inhibition of Aeromonas hydrophila‐induced intestinal inflammation and mucosal barrier function damage in crucian carp by oral administration of Lactococcus lactis
- 2018-12
- Fish & Shellfish Immunology 83
- - Yuhao Dong
  - Yuanyuan Yang
  - Jin Liu
  - Furqan Awan
  - Chengping Lu
  - Yongjie Liu
- PubMed: 30236608
- DOI: 10.1016/j.fsi.2018.09.041
5 Insights on
- Low evidence
Dietary yeast hydrolysate and brewer's yeast supplementation could enhance growth performance, innate immunity capacity and ammonia nitrogen stress resistance ability of Pacific white shrimp (Litopenaeus vannamei)
- 2018-11
- RCT
- Fish & Shellfish Immunology 82
- - Min Jin
  - J. Xiong
  - Qi-cun Zhou
  - Ye Yuan
  - Xuexi Wang
  - P. Sun
- PubMed: 30099143
- DOI: 10.1016/j.fsi.2018.08.020
2 Insights on
- Improved Innate Immunity
- Improved Resistance to Ammonia Nitrogen Stress
- High evidence
- Highly Cited
Use of Saccharomyces cerevisiae var. boulardii in co-fermentations with S. cerevisiae for the production of craft beers with potential healthy value-added.
- 2018-11
- International Journal of Food Microbiology 284
- - A. Capece
  - R. Romaniello
  - A. Pietrafesa
  - Gabriella Siesto
  - Rocchina Pietrafesa
  - Marianna Zambuto
  - P. Romano
- PubMed: 29990636
- DOI: 10.1016/j.ijfoodmicro.2018.06.028
1 Insight on
- Increased Antioxidant Activity
- Low evidence
- Highly Cited
Synergistic effects of dietary Bacillus sp. SJ‐10 plus &bgr;‐glucooligosaccharides as a synbiotic on growth performance, innate immunity and streptococcosis resistance in olive flounder (Paralichthys olivaceus)
- 2018-11
- RCT
- Fish & Shellfish Immunology 82
- - M. T. Hasan
  - W. Jang
  - Haham Kim
  - Bong-Joo Lee
  - K. Kim
  - Sang-woo Hur
  - S. Lim
  - S. Bai
  - I. Kong
- PubMed: 30194054
- DOI: 10.1016/j.fsi.2018.09.002
3 Insights on
- High evidence
Effect of sub-chronic exposure to lead (Pb) and Bacillus subtilis on Carassius auratus gibelio: Bioaccumulation, antioxidant responses and immune responses.
- 2018-10
- Clinical Trial
- Ecotoxicology and Environmental Safety 161
- - Yuwei Yin
  - Peijun Zhang
  - Xinyan Yue
  - Xiaoyan Du
  - Wei Li
  - Yulin Yin
  - Cheng Yi
  - Yuehong Li
- PubMed: 29957583
- DOI: 10.1016/j.ecoenv.2018.06.056
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease.
- 2018-10
- Clinical Trial
- Journal of Dairy Science 101(10)
- - M. Seo
  - E. Park
  - S. Ko
  - E. Choi
  - S. Kim
- PubMed: 30100498
- DOI: 10.3168/jds.2018-15014
6 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Vaginal Bifidobacterium breve for preventing urogenital infections: Development of delayed release mucoadhesive oral tablets
- 2018-10
- International Journal of Pharmaceutics 550(1-2)
- - B. Giordani
  - L. Melgoza
  - C. Parolin
  - C. Foschi
  - A. Marangoni
  - A. Abruzzo
  - F. Dalena
  - T. Cerchiara
  - F. Bigucci
  - B. Luppi
  - B. Vitali
- PubMed: 30195082
- DOI: 10.1016/j.ijpharm.2018.09.003
4 Insights on
- Low evidence
The effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional constipation in children. A randomized, double-blind, placebo-controlled, multicentre trial.
- 2018-10
- RCT · n = 129
- Clinics and research in hepatology and gastroenterology 42(5)
- - Agnieszka Wegner
  - Aleksandra Banaszkiewicz
  - Jaroslaw Kierkus
  - Piotr Landowski
  - Anna Korlatowicz-Bilar
  - Sabina Wiecek
  - Jaroslaw Kwiecien
  - Agnieszka Gawronska
  - Lukasz Dembinski
  - Grazyna Czaja-Bulsa
  - Piotr Socha
- PubMed: 29650440
- DOI: 10.1016/j.clinre.2018.03.008
7 Insights on
- High evidence
- Large Human Trial
Feeding European sea bass (Dicentrarchus labrax) juveniles with a functional synbiotic additive (mannan oligosaccharides and Pediococcus acidilactici): An effective tool to reduce low fishmeal and fish oil gut health effects?
- 2018-10
- Fish & Shellfish Immunology 81
- - S. Torrecillas
  - F. Rivero-Ramírez
  - Marisol Izquierdo
  - M. J. Caballero
  - A. Makol
  - P. Suarez‐Bregua
  - Á. Fernández-Montero
  - Josep Rotllant
  - D. Montero
- PubMed: 29981880
- DOI: 10.1016/j.fsi.2018.07.007
2 Insights on
- Increased Body Weight
- Reduced Gut Humoral Proinflammatory Response
- Low evidence
TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial.
- 2018-09
- RCT · n = 80
- Journal of integrative medicine 16(5)
- - Mehranghiz Ebrahimi-Mameghani
  - Mohammad Asghari-Jafarabadi
  - Khatereh Rezazadeh
- PubMed: 30177026
- DOI: 10.1016/j.joim.2018.05.006
5 Insights on
- High evidence
Enterococcus faecium WEFA23 from infants lessens high-fat-diet-induced hyperlipidemia via cholesterol 7-alpha-hydroxylase gene by altering the composition of gut microbiota in rats.
- 2018-09
- Clinical Trial
- Journal of Dairy Science 101(9)
- - Fuqing Huang
  - Fen Zhang
  - Di Xu
  - Zhihong Zhang
  - Feng Xu
  - X. Tao
  - Liang Qiu
  - Hua Wei
- PubMed: 29935822
- DOI: 10.3168/jds.2017-13713
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Clostridium butyricum MIYAIRI 588 as Adjunctive Therapy for Treatment-Resistant Major Depressive Disorder: A Prospective Open-Label Trial.
- 2018-09
- RCT · n = 20
- Clinical neuropharmacology 41(5)
- - Tsuyoshi Miyaoka
  - Misako Kanayama
  - Rei Wake
  - Sadayuki Hashioka
  - Maiko Hayashida
  - Michiharu Nagahama
  - Shihoh Okazaki
  - Satoko Yamashita
  - Shoko Miura
  - Hiroyuki Miki
  - Hiroyuki Matsuda
  - Masahiro Koike
  - Muneto Izuhara
  - Tomoko Araki
  - Keiko Tsuchie
  - Ilhamuddin Abdul Azis
  - Ryosuke Arauchi
  - Rostia Arianna Abdullah
  - Arata Oh-Nishi
  - Jun Horiguchi
- PubMed: 30234616
- DOI: 10.1097/wnf.0000000000000299
5 Insights on
- High evidence
- Highly Cited
Comparative study of three predominant gut Bacillus strains and a commercial B. amyloliquefaciens as probiotics on the performance of Clarias gariepinus
- 2018-09
- RCT
- Fish & Shellfish Immunology 80
- - R. Reda
  - M. El-Hady
  - K. Selim
  - H. El-Sayed
- PubMed: 29920384
- DOI: 10.1016/j.fsi.2018.06.031
5 Insights on
- High evidence