Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.
- 2026-01
- Review
- Molecular nutrition & food research 70(2)
- - Fanette Fontaine
  - Sondra Turjeman
  - Meriam Haib
  - Maria Carmen Collado
  - Karel Callens
  - Omry Koren
- PubMed: 41555705
- DOI: 10.1002/mnfr.70385
1 Insight on
- Improved Atopic Dermatitis Symptoms
- Moderate evidence
- Rigorous Journal
The effect of riboflavin on the mean attack frequency, severity, and duration of migraine headaches: A systematic review and dose-response meta-analysis of clinical trials.
- 2026-01
- Review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 31(1)
- - Sepide Amini
  - Zahra Heidari
  - Cain C T Clark
  - Mohammad Bagherniya
- PubMed: 41769676
- DOI: 10.4103/jrms.jrms_547_24
2 Insights on
- Reduced Migraine Frequency
- Reduced Migraine Duration
- Low evidence
Vitamin E and cognitive function: A systematic review of clinical evidence.
- 2026-01
- Systematic Review · n = 488
- Nutrition research (New York, N.Y.) 145
- - Arwa M Amin
  - Hamza Mostafa
- PubMed: 41418497
- DOI: 10.1016/j.nutres.2025.11.009
1 Insight on
- Reduced Cognitive Impairment
- High evidence
Structural, genomic and phenotypic analysis of exopolysaccharide produced by Streptococcus thermophilus ST65.
- 2026-01
- International journal of biological macromolecules 340
- - Yanyan Zhang
  - Wenyan Liao
  - Luyao Zhang
  - Xia Gong
  - Mei Han
- PubMed: 41539519
- DOI: 10.1016/j.ijbiomac.2026.150200
2 Insights on
- Improved Immune Response
- Improved Antioxidant Activity
- Low evidence
- Animal Study
Comparative effectiveness of Panax notoginseng saponins-related agents and antiplatelet agents in ischemic stroke: A systematic review and network meta-analysis.
- 2026-01
- Systematic Review · n = 424
- Journal of ethnopharmacology 355
- - Hongrui Zhang
  - Luda Feng
  - Xinxing Lai
  - Yonghong Gao
  - Ning Liang
  - Cuilin Que
  - Zixin Cheng
  - Na Li
  - Jiawang Li
  - Ziteng Hu
  - Yannan He
  - Zhenhong Liu
  - Ying Gao
- PubMed: 40769440
- DOI: 10.1016/j.jep.2025.120364
3 Insights on
- High evidence
A randomized controlled trial of probiotics to reduce the severity of oral mucositis in patients with oropharyngeal carcinoma undergoing concurrent chemoradiotherapy.
- 2026-01
- RCT · n = 70
- Journal of cancer research and therapeutics 22(1)
- - Saloni Sojitra
  - Tej Prakash Soni
  - Nidhi Patni
  - Dinesh Kumar Singh
  - Naresh Jakhotia
  - Sheh Rawat
  - Anil Kumar Gupta
  - Tara Chand Gupta
  - Naresh Ledwani
  - Harish Singhal
  - Shantanu Sharma
  - Ravindra Singh Gothwal
- PubMed: 41910295
- DOI: 10.4103/jcrt.jcrt_1070_25
4 Insights on
- High evidence
Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.
- 2026-01
- RCT · n = 176
- Journal of vascular surgery. Venous and lymphatic disorders 14(1)
- - SungA Bae
  - Hakju Kim
  - Nak-Hoon Son
  - Minkwan Kim
  - Sungjoon Park
  - In Hyun Jung
- PubMed: 41242464
- DOI: 10.1016/j.jvsv.2025.102355
4 Insights on
- High evidence
- Large Human Trial
Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
- 2026-01
- RCT
- The journal of prevention of Alzheimer's disease 13(1)
- - Yinyue Liu
  - Zili Yu
  - Zhengjun Cai
  - Li Zhao
  - Yu Wang
  - Yajie Guo
  - Xiaonan Su
  - Yuli Miao
  - Bin Yi
  - Yanhong Wang
  - Xumei Zhang
- PubMed: 40945966
- DOI: 10.1016/j.tjpad.2025.100369
1 Insight on
- Improved Cognitive Function
- High evidence
Efficacy of Probiotic Lactobacillus spp. Isolated From Healthy Korean Indigenous Calves.
- 2026-01
- Clinical Trial
- Veterinary medicine and science 12(1)
- - Ji-Yeong Ku
  - Mi-Jin Lee
  - Youngwoo Jung
  - Youngjun Kim
  - Kwang-Man Park
  - Jonghun Baek
  - Byoungsoo Kim
  - Ji-Seon Yoon
  - Jinho Park
- PubMed: 41482829
- DOI: 10.1002/vms3.70742
5 Insights on
- Low evidence
- Animal Study
Probiotic strain identification and safety assessment of unlabeled bacteria in infant products.
- 2026-01
- International journal of food microbiology 445
- - Nanlan Wang
  - Yarong Wu
  - Yang Liu
  - Qian Wen
  - Fan Bai
  - Yafang Tan
  - Yujun Cui
  - Xingyin Liu
  - Yujing Bi
  - Ruifu Yang
  - Peng Luo
- PubMed: 41175552
- DOI: 10.1016/j.ijfoodmicro.2025.111500
1 Insight on
- Reduced Toxicity
- Low evidence
Gut microbiota and immune regulation by Lactobacillus delbrueckii subsp. bulgaricus LB42: From preclinical safety assessment to clinical evidence.
- 2026-01
- RCT
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 207
- - Jingyan Wang
  - Yinhua Liu
  - Chengsheng Zhu
  - Zhiying Wang
  - Sijia Wang
  - Shuguang Fang
  - Fei Xu
- PubMed: 41241129
- DOI: 10.1016/j.fct.2025.115851
5 Insights on
- High evidence
Engineered bacteria and bacteria-derived nanomaterials for cancer therapy: Mechanisms, designs and advances.
- 2026-01
- Review
- Bioactive materials 55
- - Qinzhen Cheng
  - Yalan Zhu
  - Shiwen Lv
  - Jiacheng Shi
  - Mingjie Kuang
  - Li Wang
  - Xiaoyuan Ji
- PubMed: 41368325
- DOI: 10.1016/j.bioactmat.2025.09.012
1 Insight on
- Cancer Treatment Support
- Low evidence
Ginsenosides for Multi-target Intervention in Alzheimer's Disease: Current Evidence, Challenges, and Future Directions.
- 2026-01
- Review
- Molecular neurobiology 63(1)
- - Ghaleb Oriquat
  - Afaq Mahdi Ali
  - Malathi H
  - Israa Abdulhameed Ahmad
  - Laxmidhar Maharana
  - Laxmidhar Maharana
  - Ashish Singh Chauhan
  - Vimal Arora
  - Bilakshan Purohit
  - Manoj Kumar-Mishra
- PubMed: 42141250
- DOI: 10.1007/s12035-026-05910-z
3 Insights on
- Low evidence
Lactobacillus gasseri-derived postbiotics promote osteogenic differentiation in BMSCs via ameliorating mitochondrial oxidative stress.
- 2026-01
- Biochemical and biophysical research communications 795
- - Ziwei Guo
  - Yun Yuan
  - Keyu Lu
  - Shi Yin
  - Wei Bi
- PubMed: 41389616
- DOI: 10.1016/j.bbrc.2025.153113
3 Insights on
- Low evidence
- Animal Study
Streptococcus thermophilus alleviates fatty liver disease by regulating gut microbiota, lipid metabolism, and inflammation.
- 2026-01
- International immunopharmacology 168
- - Junlin Xia
  - Yanbin Cheng
  - Lixuan Sang
  - Qingyu Wei
  - Quansheng Li
  - Bing Chang
- PubMed: 41275833
- DOI: 10.1016/j.intimp.2025.115905
4 Insights on
- Low evidence
Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
- 2026-01
- RCT
- The Journal of nutrition 156(1)
- - Christina Diekmann
  - Tim B Schiemann
  - Hannah F Kienēs
  - Carolin Wiechmann
  - Christina Kopp
  - Birgit Stoffel-Wagner
  - Martin Coenen
  - Robert Németh
  - Michael Wagner
  - Sarah Egert
- PubMed: 41232773
- DOI: 10.1016/j.tjnut.2025.11.003
1 Insight on
- Reduced Hunger Ratings
- High evidence
Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.
- 2026-01
- RCT
- Food science & nutrition 14(1)
- - Chengsheng Zhu
  - Yinhua Liu
  - Yanyan Chen
  - Zhiying Wang
  - Ya Gao
  - Fei Xu
  - Junyi Huang
- PubMed: 41523285
- DOI: 10.1002/fsn3.71437
3 Insights on
- High evidence
Gut Microbiota and Dyslipidemia in Type 2 Diabetes: A Pilot Study of 16S rRNA Profiles and Predicted Functional Shifts.
- 2026-01
- Observational · n = 15
- Journal of diabetes research 2026(1)
- - Godfred Antony Menezes
  - Priyadharshini Sekar
  - Areebah Akhter
  - Ketaki Devendra Tayade
  - Sana Fathima
  - Zaina Falak Zahir Hussain
  - Abhay Nigam
- PubMed: 41923582
- DOI: 10.1155/jdr/9317962
2 Insights on
- Improved Blood Lipid Profile
- Atherogenic Lipid Profile
- Low evidence
The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.
- 2026-01
- RCT
- Contemporary clinical trials 160
- - Michelle R Klawans
  - Olivia Kohrman
  - W Braxton Jackson
  - Chandra L Jackson
  - Christine N Metz
  - Ganesa Wegienka
  - Alison Motsinger-Reif
  - Anne Z Steiner
  - Donna D Baird
  - Dale P Sandler
  - Anne Marie Z Jukic
- PubMed: 41352534
- DOI: 10.1016/j.cct.2025.108176
3 Insights on
- High evidence
Impact of Sodium Ascorbate High Dose on Quality of Life and Pain in Patients Diagnosed With and Treated for Terminal Cancer (Real-World Data Study).
- 2026-01
- Observational · n = 92
- Integrative cancer therapies 25
- - Hugo Mario Galindo Salom
  - Carlos Alberto Carrillo Bravo
  - Helber Armando Prieto Lozano
  - Paulo Andrés López Posada
- PubMed: 41606996
- DOI: 10.1177/15347354251414640
2 Insights on
- Improved Quality of Life
- Reduced Pain
- Moderate evidence
The effect of exercise and soy protein intake on physical frailty score improvement in community-dwelling elderly: a randomized controlled trial.
- 2026-01
- RCT · n = 84
- Experimental gerontology 213
- - Masakazu Imaoka
  - Mitsumasa Hida
  - Misa Nakamura
  - Keiko Sakai
  - Emi Anzai
  - Takashi Ichise
  - Nobuhiko Tachibana
  - Ien Tei
  - Yoshinori Hasegawa
- PubMed: 41386386
- DOI: 10.1016/j.exger.2025.112995
1 Insight on
- Improved Walking Speed
- High evidence
Optimizing Aeromonas hydrophila vaccine efficacy in common carp: The role of free vs. microencapsulated Lactiplantibacillus plantarum and Lactobacillus delbrueckii bulgaricus.
- 2026-01
- n = 540
- Fish & shellfish immunology 168
- - M Alishahi
  - M A K Aakool
  - R Peyghan
  - M Khosravi
  - D Gharibi
- PubMed: 41238066
- DOI: 10.1016/j.fsi.2025.110996
5 Insights on
- Low evidence
- Animal Study
Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches.
- 2026-01
- Review
- Anais brasileiros de dermatologia 101(1)
- - Valentina Burckhardt-Bravo
  - Rodrigo Funes-Ferrada
  - Fernando Valenzuela
- PubMed: 41544313
- DOI: 10.1016/j.abd.2025.501249
1 Insight on
- Reduced Acne Severity
- Low evidence
Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.
- 2026-01
- Review · n = 4,755
- Translational sports medicine 2026(1)
- - Marcos D M Drummond
  - Ronaldo A D Silva
  - Nelson Carvas Junior
  - Miércio S Melo
  - Matheus H L Ferreira
- PubMed: 41635649
- DOI: 10.1155/tsm2/5557511
2 Insights on
- Increased Muscle Strength
- Increased Fat-Free Mass
- High evidence
The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.
- 2026-01
- Systematic Review
- Integrative cancer therapies 25
- - Sarah Benna-Doyle
  - Suzanne Grant
  - Alison Maunder
  - Jing Liu
  - Melik Ibrahim
  - Adele Cave
  - Chhiti Pandey
  - Monica Tang
  - Eng-Siew Koh
  - Geoff Delaney
  - Deep Jyoti Bhuyan
  - Victoria Choi
  - Ki Kwon
  - Maria Gonzalez
  - Susannah Graham
  - Ashanya Malalasekera
  - Carolyn Ee
- PubMed: 41482855
- DOI: 10.1177/15347354251405267
13 Insights on
- High evidence
Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study.
- 2026-01
- RCT · n = 36
- Journal of the Formosan Medical Association = Taiwan yi zhi 125(1)
- - Chun-Hsin Chen
  - Chih-Chiang Chiu
  - Yi-Hang Chiu
  - Chin-Hao Chang
  - Yu-Han Chang
  - Ming-Chyi Huang
  - Mong-Liang Lu
  - Po-Yu Chen
- PubMed: 39645464
- DOI: 10.1016/j.jfma.2024.11.019
2 Insights on
- Improved Cognitive Function
- Reduced Psychotic Symptom Severity
- High evidence
Role of 70 °C heating on immunostimulatory effects of probiotic bifidobacteria in infant formula.
- 2026-01
- Food research international (Ottawa, Ont.) 223
- - Akira Sen
  - Sayaka Ishihara
  - Masahiro Ando
  - Hiroki Kaneko
  - Riko Mishima
  - Tatsuki Nishimura
  - Yukihiro Hishida
  - Miyuki Tanaka
  - Haruko Takeyama
  - Toshitaka Odamaki
- PubMed: 41360542
- DOI: 10.1016/j.foodres.2025.117846
1 Insight on
- Improved Immunostimulatory Activity
- Low evidence
From Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age-Related Macular Degeneration-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-01
- Review · n = 860
- Journal of ophthalmology 2026(1)
- - Wei-Xiang Wang
  - Chen-Chi Wang
  - Wei-Cherng Hsu
  - Yi-Jie Peng
- PubMed: 42028334
- DOI: 10.1155/joph/2155378
4 Insights on
- High evidence
Successful Treatment of Lactobacillus rhamnosus Endocarditis With Intravenous Daptomycin: A Case Report and Literature Review.
- 2026-01
- Case Report
- Case reports in infectious diseases 2026(1)
- - Mehboob A Rehan
  - J Todd Bagwell
  - S Blake Wachter
  - Sandeep Singh Jubbal
- PubMed: 41607419
- DOI: 10.1155/crdi/9295802
1 Insight on
- Resolved Endocarditis
- Low evidence
Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial.
- 2025-12
- RCT · n = 105
- Complementary therapies in medicine 95
- - Melika Jafari Dehnayebi
  - Pouya Zeidy
  - Soheila Shamsikhani
  - Mehdi Salehi
  - Mehdi Safarabadi
- PubMed: 41101745
- DOI: 10.1016/j.ctim.2025.103266
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
- Large Human Trial