Cariogenicity of the Probiotic Bacterium Lactobacillus salivarius in Rats2005Caries Research 39(6)M. MatsumotoM. TsujiH. SasakiK. FujitaR. NomuraK. NakanoS. ShintaniT. OoshimaPubMed: 16251792DOI: 10.1159/0000881834 Insights on Increased Dental CariesIncreased Incidence of Dental CariesIncreased Caries ScoresImproved Adherence to Tooth Surface
Inclusion of Lactobacillus salivarius strain revealed a positive effect on improving growth performance, fecal microbiota and immunological responses in chicken2020-10-17Archives of Microbiology 203(2)S. SureshkumarHwi-Cheul LeeSun Keun JungDongjun KimK. OhHyeon YangY. JoHaesun LeeSukchan LeeS. ByunPubMed: 33068123DOI: 10.1007/s00203-020-02088-313 Insights on Stabilized Fecal MicrobiotaReduced Inflammatory Cytokine LevelsAltered Gut Microbiota CompositionReduced Serum Cytokine LevelsAltered Gut MicrobiotaReduced Pro-inflammatory Cytokine LevelsImproved Gut HealthUnchanged Intestinal MorphologyImproved Fecal MicrobiotaImproved Growth PerformanceImproved Gut Microbiota CompositionMaintained Morphological IntegrityImproved Immunological Response
Lactobacillus salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens2022-12-19Cells 11(24)Lihui ZhuR. LiaoJiwen HuangChangfeng XiaoYunzhou YangHuiying WangD. HeHuaxiang YanChangsuo YangPubMed: 36552896DOI: 10.3390/cells1124413315 Insights on Reduced Aspartate Transaminase ActivitySuppressed PPAR/SREBP Pathway Gene ExpressionReduced Alanine Transaminase ActivityReduced Triglyceride LevelsModulated PPAR/SREBP PathwaySuppressed PPAR/SREBP Pathway Gene ActivityRegulated Liver Lipid MetabolismReduced Liver FatImproved Liver FunctionReduced Liver Enzyme ActivityDecreased MBOAT2 ExpressionRegulated Lipid MetabolismRegulated miR-130a-5p LevelsReduced Liver Fat DepositionRegulation of miR-130a-5p Expression
Predominance of a bacteriocin-producing Lactobacillus salivarius component of a five-strain probiotic in the porcine ileum and effects on host immune phenotype.2008-05FEMS Microbiology Ecology 64(2)M. WalshG. GardinerO. HartP. LawlorM. DalyB. LynchB. RichertS. RadcliffeL. GiblinC. HillG. FitzgeraldC. StantonP. RossPubMed: 18373687DOI: 10.1111/j.1574-6941.2008.00454.x7 Insights on Increased Ileal Enterobacteriaceae CountsIncreased Ileal IL-8 mRNA ExpressionReduced CTLA-4 Induction on CD4 T CellsIncreased CD4+ and CD8+ T Cell ProportionReduced CTLA-4 Expression on CD4 T CellsIncreased Interleukin-8 Expression in the IleumAltered T Cell Subsets
Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets2006-01Acta Odontologica Scandinavica 64(5)E. ÇaglarSule Kavaloglu CildirS. ErgeneliN. SandalliS. TwetmanPubMed: 16945898DOI: 10.1080/000163506008017093 Insights on Reduced Salivary Mutans Streptococci LevelsReduced Salivary Lactobacilli LevelsReduced Salivary Levels of Mutans Streptococci
Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-κB and autophagy signaling pathways.2020Food & Function 11(1)G. JiaXiaofeng LiuN. CheYongjun XiaGuangqiang WangZ. XiongHui ZhangLian-zhong AiPubMed: 31957758DOI: 10.1039/c9fo02476j13 Insights on Suppressed NF-κB ActivationIncreased M2 Macrophage Phenotype AdoptionReduced Proinflammatory MediatorsInhibited NF-κB ActivationImproved Immune ResponseReduced Pro-Inflammatory Mediator ProductionReduced Inflammatory Cytokines ExpressionImproved Autophagy RegulationImproved Pharyngeal HealthEnhanced AutophagyReduced Inflammatory ResponseReduced Severity of S. aureus-induced PharyngitisReduced Immunosuppression in Pharyngitis
Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.2017-08-29Molecular Nutrition & Food Research 61(11)A. Rodríguez‐NogalesF. AlgieriJ. Garrido-MesaT. VezzaM. P. UtrillaN. ChuecaFederico GarcíaM. OlivaresM. Rodríguez-CabezasJ. GálvezPubMed: 28752563DOI: 10.1002/mnfr.20170014415 Insights on Improved Colonic Immune ResponseRestored Th1/Th2 Cytokine BalanceImproved Colonic Immune Response Markers ExpressionImproved Immune ResponseImproved Gut Microbiota BalanceImproved Microbiota BalanceRestored Regulatory T Cell PopulationImproved Microbial DiversityImproved Gut Microbiota CompositionRestored Regulatory T Cell Population in Mesenteric Lymph NodesImproved Colonic HealthImproved Immune Marker ExpressionRestored Intestinal Barrier FunctionImproved Macroscopic Colonic DamageRestored Treg Cell Population in MLNs
Antimicrobial activity of Lactobacillus salivarius and Lactobacillus fermentum against Staphylococcus aureus2017-02-02Pathogens and Disease 75(2)Mi-Sun KangHae-Soon LimJong-Suk OhY. LimK. Wuertz-KozakJanette M. HarroM. ShirtliffY. AchermannPubMed: 28158586DOI: 10.1093/femspd/ftx0095 Insights on Increased Antipathogen Activity Against Staphylococcus AureusReduced Staphylococcus aureus ViabilityPotentially Effective Antibacterial ProteinsReduced Staphylococcus Aureus InfectionReduced Staphylococcal Infections
Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial2014-09-02BMC Oral Health 14(1)Tetsuyo NishiharaN. SuzukiM. YonedaT. HirofujiPubMed: 25178882DOI: 10.1186/1472-6831-14-1108 Insights on Reduced Mutans Streptococcus CountsIncreased Salivary Buffering CapacityReduced Mutans Streptococci LevelsImproved Salivary Buffering CapacityIncreased Lactobacilli LevelsIncreased Lactobacillus LevelsReduced Levels of Mutans StreptococciReduced Salivary Levels of Mutans Streptococci
Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.2014-04Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(4)N. SuzukiM. YonedaKazunari TanabeA. FujimotoKosaku IhaK. SenoKazuhiko YamadaT. IwamotoY. MasuoT. HirofujiPubMed: 24556493DOI: 10.1016/j.oooo.2013.12.4009 Insights on Reduced Ubiquitous Bacteria LevelsReduced Probing DepthsReduced Organoleptic Test ScoresReduced Fusobacterium Nucleatum LevelsReduced Probing DepthReduced Volatile Sulfur CompoundsReduced Bacterial LoadReduced Probing Pocket DepthReduced Oral Malodor
Genome Sequence of Lactobacillus salivarius SMXD51, a Potential Probiotic Strain Isolated from Chicken Cecum, Showing Anti-Campylobacter Activity2012-06Journal of Bacteriology 194(11)Gilles KergourlaySoumaya MessaoudiX. DoussetH. PrévostPubMed: 22582370DOI: 10.1128/JB.00344-121 Insight on Reduced Campylobacter Infection
Lactobacillus salivarius CTC2197 Prevents Salmonella enteritidis Colonization in Chickens1999-11Applied and Environmental Microbiology 65(11)Mònica PascualM. HugasJ. I. BadiolaJosep Maria MonfortM. GarrigaPubMed: 10543812DOI: 10.1128/AEM.65.11.4981-4986.19995 Insights on Increased Need for Repeated DosingSuccessful Gastrointestinal Tract ColonizationReduced Salmonella enteritidis ColonizationGastrointestinal Tract Colonization by Probiotic StrainRequirement for Sustained Dosage in Gastrointestinal Tract
In vitro immunomodulatory activity of Lactobacillus fermentum CECT5716 and Lactobacillus salivarius CECT5713: two probiotic strains isolated from human breast milk.2010-12Immunobiology 215(12)F. Pérez-CanoHonglin DongP. YaqoobPubMed: 20219262DOI: 10.1016/j.imbio.2010.01.0044 Insights on Increased Regulatory T Cell CountIncreased Activation of Regulatory T CellsIncreased CD8+ T CellsImproved Natural Killer Cell Activation
Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue2020-04-09Microorganisms 8(4)Mon-Chien LeeY. HsuH. HoShih‐Hung HsiehY. KuoHsin‐Ching SungChi-Chang HuangPubMed: 32283729DOI: 10.3390/microorganisms804054512 Insights on Reduced Creatine Kinase LevelsImproved EnduranceEnhanced Glycogen StorageReduced Post-Exercise Lactate LevelsImproved Muscle StrengthIncreased Hepatic Glycogen StorageImproved Exercise PerformanceReduced Serum Ammonia LevelsReduced Ammonia LevelsReduced Lactate LevelsReduced Blood Urea Nitrogen LevelsReduced Blood Lactate Levels
Complete Genome Sequence of Lactobacillus salivarius CECT 5713, a Probiotic Strain Isolated from Human Milk and Infant Feces2010-10Journal of Bacteriology 192(19)E. JiménezRocío MartínAntonio MaldonadoV. MartínAranzazu Gómez de SeguraL. FernándezJ. M. RodríguezPubMed: 20675488DOI: 10.1128/JB.00703-106 Insights on Improved Anti-infection ResponseEnhanced Anti-Infective PropertiesReduced InflammationImproved ImmunomodulationEnhanced Immunomodulatory FunctionReduced Inflammatory Response
Effect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota2012-02-17PLoS ONE 7(2)Eliette Riboulet-BissonM. SturmeI. JefferyM. M. O’DonnellM. M. O’DonnellB. NevilleB. FordeM. ClaessonH. HarrisG. GardinerP. G. CaseyP. LawlorP. O’TooleR. RossPubMed: 22363561DOI: 10.1371/journal.pone.00311132 Insights on Reduced Impact of Gram-negative MicroorganismsAltered Spirochaetes Abundance in Pig Microbiota
Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children.2010-11Nutrition 26(11-12)J. MaldonadoF. Lara‐VillosladaS. SierraLluis SempereMarta GómezJ. M. RodríguezJ. BozaJ. XausM. OlivaresPubMed: 20018483DOI: 10.1016/j.nut.2009.08.0236 Insights on Increased Fecal Butyrate LevelsIncreased Fecal Butyric Acid ConcentrationIncreased Fecal Lactobacilli ContentNo Adverse Health EffectsPresence of Lactobacillus salivarius CECT5713 in FecesIncreased Fecal Lactobacilli
Integrated transcriptomic and proteomic analysis of the bile stress response in probiotic Lactobacillus salivarius LI01.2017-01Journal of Proteomics 150L. LvRen YanHai-Yan ShiD. ShiD. FangHuiyong JiangWen-rui WuF. GuoXia-wei JiangSilan GuYun-bo ChenJian YaoLanjuan LiPubMed: 27585996DOI: 10.1016/j.jprot.2016.08.0213 Insights on Enhanced Liver ProtectionImproved Liver FunctionImproved Tolerance to Bile Salts
Prevention of Infectious Mastitis by Oral Administration of Lactobacillus salivarius PS2 During Late Pregnancy.2015-11-26Clinical Infectious Diseases 62(5)L. FernándezNívia CárdenasRebeca ArroyoS. ManzanoE. JiménezV. MartínJ. M. RodríguezPubMed: 26611780DOI: 10.1093/cid/civ9744 Insights on Reduced Milk Bacterial CountsReduced Occurrence of MastitisReduced Incidence of Infectious MastitisReduced Milk Bacterial Counts During Mastitis
Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study.2008-09-12Journal of Clinical Periodontology 35(10)H. ShimauchiG. MayanagiS. NakayaMaiko MinamibuchiYasuhiro ItoK. YamakiH. HirataPubMed: 18727656DOI: 10.1111/j.1600-051X.2008.01306.x9 Insights on Reduced Plaque Index in SmokersReduced Probing DepthsImproved Periodontal HealthDecreased Salivary Lactoferrin LevelsReduced Salivary Lf Level in SmokersImproved Plaque IndexReduced Probing DepthReduced Salivary Lactoferrin LevelsReduced Plaque Index
Impact of lyophilized Lactobacillus salivarius DSPV 001P administration on growth performance, microbial translocation, and gastrointestinal microbiota of broilers reared under low ambient temperature.2017-10Research in Veterinary Science 114J. BlajmanC. OliveroM. L. FusariJ. ZimmermannE. RosslerA. BerisvilA. R. ScharpenD. AstesanaL. SotoMarcelo SignoriniM. V. ZbrunL. FrizzoPubMed: 28743079DOI: 10.1016/j.rvsc.2017.07.0119 Insights on Improved Body WeightReduced Colitis-Related MortalityImproved Growth PerformanceReduced MortalityImproved Feed Conversion RatioUnchanged Intestinal Bacterial ConcentrationsIncreased Feed IntakeMaintained Intestinal Microbiota BalanceUnchanged Gut Microbiota Composition
Screening of Lactobacillus salivarius strains from the feces of Chinese populations and the evaluation of their effects against intestinal inflammation in mice.2020Food & Function 11(1)Q. ZhaiXudan ShenShi CenChengcheng ZhangF. TianJianxin ZhaoHao ZhangYuzheng XueWei ChenPubMed: 31915776DOI: 10.1039/c9fo02116g10 Insights on Improved Gastrointestinal ToleranceReduced Intestinal InflammationImproved Intestinal Barrier FunctionImproved Intestinal MicroenvironmentImproved Treg/Th-17 BalanceImproved ImmunomodulationReduced Nuclear Factor Kappa B ActivationInhibited NF-kB Pathway ActivationImproved Colonic HistopathologyReduced NF-kB Activation
Lactobacillus salivarius CML352 Isolated from Chinese Local Breed Chicken Modulates the Gut Microbiota and Improves Intestinal Health and Egg Quality in Late-Phase Laying Hens2022-03-28Microorganisms 10(4)Chang XuFuxiao WeiXinyue YangYuqing FengDan LiuYongfei HuPubMed: 35456777DOI: 10.3390/microorganisms1004072610 Insights on Reduced MyD88 ExpressionReduced Visceral FatImproved Intestinal FunctionIncreased MUC-2 ExpressionImproved Intestinal Mucosal ImmunityReduced Firmicutes/Bacteroidetes RatioImproved Gastrointestinal HealthImproved Egg QualityReduced TLR4 ExpressionReduced IFN-γ Expression
Safety assessment of the human milk-isolated probiotic Lactobacillus salivarius CECT5713.2007-08Journal of Dairy Science 90(8)F. Lara‐VillosladaS. SierraM. Díaz-RoperoM. OlivaresJ. XausPubMed: 17638967DOI: 10.3168/JDS.2006-68521 Insights on Reduced Bacterial TranslocationIncreased Plasma Serum Alpha-Amyloid ProteinAbsence of Treatment-Associated Bacterial TranslocationNonpathogenic in High Doses for MiceNonpathogenic ConditionIncreased Serum Amyloid ProteinNo Adverse Weight or Intake Effects in MiceSignificant Bacterial Translocation with Intraperitoneal AdministrationNo Illness or Death from Bacterial Translocation (Intraperitoneal Administration)No Adverse Effects on Body Weight or Food IntakeAbsence of Bacterial Translocation to Liver or SpleenAbsence of BacteremiaNo BacteremiaMaintained Body WeightNo Bacteremia or Translocation of Bacteria to Vital OrgansNo Hepatic or Splenic Translocation with Oral AdministrationNonpathogenic for MiceEnsured Safety for Human ConsumptionNo Adverse Effects from Intraperitoneal AdministrationNo Illness or Death Despite Bacterial TranslocationNonpathogenic Even at High Doses
Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother-child pair.2006-10International Journal of Food Microbiology 112(1)R. MartínE. JiménezM. OlivaresM. MarínL. FernándezJ. XausJ. M. RodríguezPubMed: 16843562DOI: 10.1016/J.IJFOODMICRO.2006.06.0115 Insights on Increased Survival in Gastrointestinal TractEnhanced Antimicrobial ResistanceReduced Intestinal Cell AdhesionMaintained Gastric Mucin IntegrityReduced Biogenic Amine Production
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 improves acute liver injury induced by d-galactosamine in rats2014-03-18Applied Microbiology and Biotechnology 98(12)L. LvXin-Jun HuGuiyun QianHua ZhangH. LuBei-wen ZhengLi JiangLan-Juan LiPubMed: 24639205DOI: 10.1007/s00253-014-5638-212 Insights on Reduced Bacterial TranslocationIncreased Interleukin-10 LevelsAltered Gut Microbiota CompositionImproved Cecal Microbiome ProfileReduced Liver Enzyme LevelsIncreased Anti-Inflammatory Cytokine LevelsReduced Elevated Liver EnzymesAltered Gut Microbiome CompositionStabilized Total Bilirubin LevelsPrevented Increase in Total BilirubinAltered Cecal MicrobiomeAggravated Liver Injury
Effect of Lactobacillus salivarius Ls-33 on fecal microbiota in obese adolescents.2013-12Clinical Nutrition 32(6)N. LarsenF. VogensenR. GøbelK. MichaelsenS. ForsstenS. LahtinenM. JakobsenPubMed: 23510724DOI: 10.1016/j.clnu.2013.02.0073 Insights on Increased Short Chain Fatty AcidsUnchanged Cell Numbers of Fecal BacteriaModified Fecal Microbiota
Intestinal and immunological effects of daily oral administration of Lactobacillus salivarius CECT5713 to healthy adults.2010-06Anaerobe 16(3)S. SierraF. Lara‐VillosladaLluis SempereM. OlivaresJ. BozaJ. XausPubMed: 20159049DOI: 10.1016/j.anaerobe.2010.02.0018 Insights on Increased Interleukin-10 LevelsImproved Immune ResponseIncreased Lactobacillus CountsImproved Bowel Movement FrequencyIncreased Plasma Immunoglobulin LevelsImproved Gut MicrobiotaNo Reported Adverse EffectsIncreased Fecal Lactobacilli
Lactobacillus salivarius: bacteriocin and probiotic activity.2013-12Food Microbiology 36(2)Soumaya MessaoudiM. ManaiGilles KergourlayH. PrévostN. ConnilJ. ChobertX. DoussetPubMed: 24010610DOI: 10.1016/j.fm.2013.05.0105 Insights on Increased Probiotic ConsumptionEnhanced Food SafetyIncreased Antibiotic UseIncreased Antibacterial ActivityModulated Microbiota Composition
The synergy of dietary supplements Lactobacillus salivarius LI01 and Bifidobacterium longum TC01 in alleviating liver failure in rats treated with D-galactosamine.2021Food & Function 12(20)Aoxiang ZhugeShengjie LiYin YuanBo LiLanjuan LiPubMed: 34546256DOI: 10.1039/d1fo01807h4 Insights on Improved Intestinal Barrier FunctionReduced Liver DamageReduced Pro-Inflammatory CytokinesImproved Gut Microbiota