March 2016 Supplement Research Papers

• March 1

  • Lactobacillus reuteri Inhibition of Enteropathogenic Escherichia coli Adherence to Human Intestinal Epithelium

    • 2016-03-01
    • Frontiers in Microbiology 7
    • • Alistair D. S. Walsham
      • D. Mackenzie
      • V. Cook
      • S. Wemyss-Holden
      • Claire L. Hews
      • N. Juge
      • S. Schüller

    • PubMed: 26973622
    • DOI: 10.3389/fmicb.2016.00244

    2 Insights on

    • Reduced Enteropathogenic Escherichia coli (EPEC) Adhesion
    • Increased EPEC Microcolony Size

    • Low evidence

  • Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis.

    • 2016-03-01
    • Clinical Trial
    • Food & Function 6(2)
    • • N. Ivanovic
      • R. Minić
      • L. Dimitrijević
      • Sanja Radojević Škodrić
      • I. Živković
      • B. Djordjevic

    • PubMed: 25518825
    • DOI: 10.1039/c4fo00843j

    16 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Serum Cholesterol Levels
    • Improved Immunomodulation
    • Reduced LDL Cholesterol
    • Reduced TNF-α Levels
    • Reduced Serum Cholesterol
    • Increased Leptin Levels
    • Reduced CD25+ Cells
    • Reduced IL-6 Production
    • Improved Liver Histology
    • Reduced Interleukin-6 Production
    • Reduced HDL Levels
    • Increased CD3+CD4+ Cell Counts
    • Increased CD3+CD8+ Cell Counts

    • Low evidence
    • Animal Study

  • The viability of Lactobacillus fermentum CECT5716 is not essential to exert intestinal anti-inflammatory properties.

    • 2016-03-01
    • Food & Function 6(4)
    • • A. Rodríguez‐Nogales
      • F. Algieri
      • T. Vezza
      • N. Garrido-Mesa
      • M. Olivares
      • M. Comalada
      • C. Riccardi
      • M. P. Utrilla
      • M. Rodríguez-Cabezas
      • J. Gálvez

    • PubMed: 25700085
    • DOI: 10.1039/c4fo00938j

    4 Insights on

    • Reduced Inflammatory Response
    • Reduced Intestinal Inflammation
    • Reduced Pro-Inflammatory Mediator Production
    • Reduced Proinflammatory Mediators

    • Low evidence
• March 8

  • Benefits of Bifidobacterium breve M-16V Supplementation in Preterm Neonates - A Retrospective Cohort Study

    • 2016-03-08
    • Meta-Analysis
    • PLOS ONE 11(3)
    • • S. Patole
      • Shripada C Rao
      • A. Keil
      • E. Nathan
      • D. Doherty
      • K. Simmer

    • PubMed: 26953798
    • DOI: 10.1371/journal.pone.0150775

    4 Insights on

    • Reduced All-Cause Mortality
    • Reduced Occurrence of NEC (Bell's Stage 2 or Higher)
    • Reduced Mortality Risk
    • Absence of Probiotic-Induced Sepsis

    • High evidence
    • Highly Cited
    • Rigorous Journal
• March 9

  • Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial

    • 2016-03-09
    • RCT · n = 62
    • European Journal of Clinical Nutrition 70(5)
    • • Fumiko Higashikawa
      • M. Noda
      • Tomokazu Awaya
      • Narandalai Danshiitsoodol
      • Y. Matoba
      • T. Kumagai
      • Masanori Sugiyama

    • PubMed: 26956126
    • DOI: 10.1038/ejcn.2016.17

    5 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Fat Percentage
    • Reduced Body Fat Mass
    • Stable Glucose Metabolism Markers

    • High evidence
    • Highly Cited
• March 11

  • Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress.

    • 2016-03-11
    • RCT · n = 47
    • Beneficial Microbes 7(2)
    • • Akito Kato-Kataoka
      • K. Nishida
      • M. Takada
      • K. Suda
      • M. Kawai
      • K. Shimizu
      • Akira Kushiro
      • R. Hoshi
      • O. Watanabe
      • Tomoki Igarashi
      • K. Miyazaki
      • Y. Kuwano
      • K. Rokutan

    • PubMed: 26689231
    • DOI: 10.3920/BM2015.0100

    15 Insights on

    • Reduced Anxiety Levels
    • Reduced Anxiety
    • Reduced Salivary Cortisol Levels Under Stress
    • Increased Faecal Serotonin Levels
    • Reduced Physical Symptoms of Stress
    • Reduced Anxiety-Related Physiological Changes
    • Reduced Pre-Examination Physical Symptoms
    • Increased Serotonin Levels
    • Reduced Physical Symptoms
    • Reduced Anxiety-Related Biomarkers
    • Reduced Anxiety Responses
    • Stabilized Physiological Stress Markers
    • Stabilized Cortisol Levels
    • Reduced Anxiety Biomarkers
    • Elevated Fecal Serotonin Levels

    • High evidence
    • Highly Cited

  • Prophage-mediated modulation of interaction of Streptococcus thermophilus J34 with human intestinal epithelial cells and its competition against human pathogens.

    • 2016-03-11
    • Beneficial Microbes 7(2)
    • • C. Guigas
      • K. Faulhaber
      • D. Duerbeck
      • H. Neve
      • K. Heller

    • PubMed: 26689226
    • DOI: 10.3920/BM2015.0108

    1 Insight on

    • Reduced Pathogen Adhesion

    • Low evidence
• March 14

  • Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function

    • 2016-03-14
    • RCT · n = 118
    • Microbial Ecology in Health & Disease 27(0)
    • • Tomonori Sugawara
      • D. Sawada
      • Y. Ishida
      • Kotaro Aihara
      • Yumeko Aoki
      • Isao Takehara
      • Kazuhiko Takano
      • S. Fujiwara

    • PubMed: 26979643
    • DOI: 10.3402/mehd.v27.30259

    14 Insights on

    • Improved Bowel Movement Frequency
    • Increased Bifidobacterium Levels in Feces
    • Increased Bowel Movements
    • Improved Fecal Odor
    • Reduced Fecal p-Cresol Levels
    • Reduced Clostridium Cluster IV Content
    • Improved Parasympathetic Activity
    • Enhanced Autonomic Activity Total Power
    • Reduced Fecal Odor
    • Improved Stool Frequency
    • Enhanced Parasympathetic Nervous System Activity
    • Increased Parasympathetic Nervous System Activity
    • Increased Parasympathetic Nerve Activity
    • Enhanced Autonomic Nervous System Activity

    • High evidence
    • Rigorous Journal
• March 15

  • Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice.

    • 2016-03-15
    • RCT · n = 120
    • World Journal of Gastroenterology 21(27)
    • • Fang-yan Wang
      • Jiammin Liu
      • Hai-Hua Luo
      • Ai-hua Liu
      • Yong Jiang

    • PubMed: 26217085
    • DOI: 10.3748/wjg.v21.i27.8340

    3 Insights on

    • Reduced Inflammatory Response
    • Enhanced Antioxidant Enzyme Activity
    • Reduced Gastric Mucosal Injury

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Simple, fast, and accurate methodology for quantitative analysis using Fourier transform infrared spectroscopy, with bio-hybrid fuel cell examples.

    • 2016-03-15
    • MethodsX 3
    • • David M Mackie
      • Justin P Jahnke
      • Marcus S Benyamin
      • James J Sumner

    • PubMed: 26977411
    • DOI: 10.1016/j.mex.2016.02.002

    2 Insights on

    • Improved Quantitative Analysis Methodology for FTIR Mixtures
    • Improved Analytical Accuracy

    • Low evidence
• March 22

  • Dietary supplements for dysmenorrhoea.

    • 2016-03-22
    • Meta-Analysis · n = 3,101
    • The Cochrane database of systematic reviews 2016(3)
    • • Porjai Pattanittum
      • Naowarat Kunyanone
      • Julie Brown
      • Ussanee S Sangkomkamhang
      • Joanne Barnes
      • Vahid Seyfoddin
      • Jane Marjoribanks

    • PubMed: 27000311
    • DOI: 10.1002/14651858.cd002124.pub2

    1 Insight on

    • Reduced Pain Intensity

    • High evidence
• March 24

  • Post-sensitization administration of non-digestible oligosaccharides and Bifidobacterium breve M-16V reduces allergic symptoms in mice.

    • 2016-03-24
    • Immunity, Inflammation and Disease 4(2)
    • • B. Van Esch
      • S. Abbring
      • M. Diks
      • G. Dingjan
      • L. Harthoorn
      • A. P. Vos
      • J. Garssen

    • PubMed: 27933160
    • DOI: 10.1002/iid3.101

    6 Insights on

    • Reduced Allergic Symptoms
    • Increased Regulatory T Cell Count
    • Increased Short Chain Fatty Acids
    • Reduced Allergic Responses
    • Modulated Cytokine Production
    • Reduced Anaphylactic Shock Symptoms

    • Low evidence
• March 28

  • Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.

    • 2016-03-28
    • RCT · n = 3
    • Journal of Microbiology and Biotechnology 26(3)
    • • Il-dong Choi
      • Sung-Hwan Kim
      • Ji-Woong Jeong
      • Dong Eun Lee
      • C. Huh
      • S. Hong
      • J. Sim
      • Y. Ahn

    • PubMed: 26699746
    • DOI: 10.4014/jmb.1512.12018

    4 Insights on

    • Increased Free Fatty Acid Levels
    • Reduced Triglycerides
    • Elevated Plasma Glycerol Levels
    • Increased Plasma ApoA-V Levels

    • Low evidence
    • Animal Study
• Undated – 3 supplement studies

  • Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5(1A).

    • 2016-03
    • Clinical Trial
    • Microbes and Infection 18(3)
    • • A. T. Vieira
      • V. Rocha
      • L. Tavares
      • Cristiana C Garcia
      • M. Teixeira
      • S. Oliveira
      • G. Cassali
      • C. Gamba
      • F. Martins
      • J. Nicoli

    • PubMed: 26548605
    • DOI: 10.1016/j.micinf.2015.10.008

    4 Insights on

    • Reduced Lung Damage
    • Reduced Mortality Risk
    • Increased IL-10 Production
    • Reduced Bacterial Load in Lungs

    • Low evidence
    • Highly Cited
    • Animal Study

  • Evaluation of probiotic properties of Lactobacillus plantarum WLPL04 isolated from human breast milk.

    • 2016-03
    • Journal of Dairy Science 99(3)
    • • Meiling Jiang
      • Fen Zhang
      • C. Wan
      • Yonghua Xiong
      • N. Shah
      • Hua Wei
      • X. Tao

    • PubMed: 26805974
    • DOI: 10.3168/jds.2015-10434

    10 Insights on

    • Reduced Inflammation Levels
    • Reduced Pathogen Growth
    • Reduced Pathogen Infection
    • Enhanced Antimicrobial Resistance
    • Reduced Pathogen Adhesion
    • Improved Gastrointestinal Survival
    • Reduced Pathogenic Bacteria
    • Reduced Exposure to Harmful Substances
    • Increased Exopolysaccharide Production
    • Reduced Toxicity from Sodium Dodecyl Sulfate

    • Moderate evidence
    • Highly Cited
    • Rigorous Journal

  • Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults.

    • 2016-03
    • RCT · n = 30
    • Molecular Nutrition & Food Research 60(5)
    • • Huicui Meng
      • Yujin Lee
      • Zhaoyong Ba
      • Jiayu Peng
      • Junli Lin
      • Alexander S Boyer
      • J. Fleming
      • E. Furumoto
      • R. Roberts
      • P. Kris-Etherton
      • C. Rogers

    • PubMed: 26821116
    • DOI: 10.1002/mnfr.201500665

    16 Insights on

    • Improved NK-Cell Cytotoxicity
    • Reduced Upper Respiratory Tract Infection Days
    • Improved Immune Function
    • Reduced Upper Respiratory Infections
    • Improved Immune Cell Function
    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced URTI Symptoms
    • Increased IL-2 Secretion
    • Unchanged Immune Function
    • Reduced Upper Respiratory Tract Infection Severity
    • Reduced Duration of Upper Respiratory Tract Infection
    • Improved Regulatory T Cell Function
    • No Change in Immune Outcomes
    • Reduced Upper Respiratory Symptoms
    • No Change in Immune Response
    • Reduced Cold/Flu Severity

    • High evidence
    • Rigorous Journal