April 2016 Supplement Research Papers

• April 5

  • Ganoderma lucidum (Reishi mushroom) for cancer treatment.

    • 2016-04-05
    • Meta-Analysis
    • The Cochrane database of systematic reviews 2019(1)
    • • Xingzhong Jin
      • Julieta Ruiz Beguerie
      • Daniel Man-Yeun Sze
      • Godfrey C F Chan

    • PubMed: 27045603
    • DOI: 10.1002/14651858.cd007731.pub3

    8 Insights on

    • Enhanced Natural Killer Cell Tumoricidal Activity
    • Improved Quality of Life
    • Increased Intestinal T-Cell Count
    • Increased CD4+ T Cell Count
    • Improved Tumor Response
    • Increased CD8 Percentage
    • Increased Leukocyte Count
    • Increased CD4-CD8 Ratio

    • High evidence

  • Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.

    • 2016-04-05
    • Molecular Medicine Reports 13(5)
    • • Baoji Song
      • H. Zhan
      • Quan Bian
      • Junping Gu

    • PubMed: 27053336
    • DOI: 10.3892/mmr.2016.5091

    1 Insight on

    • Reduced Expression of STAT3-Dependent Tumor-Associated Genes

    • Low evidence
    • Rigorous Journal
• April 7

  • Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

    • 2016-04-07
    • RCT · n = 18
    • Nutrients 8(4)
    • • Yi-Ming Chen
      • Li Wei
      • Yen-Shuo Chiu
      • Y. Hsu
      • Tsung-Yu Tsai
      • Ming-Fu Wang
      • Chi-Chang Huang

    • PubMed: 27070637
    • DOI: 10.3390/nu8040205

    35 Insights on

    • Reduced Body Weight
    • Improved Weight Management
    • Reduced Triglyceride Levels
    • Increased Muscle Mass
    • Improved Grip Strength
    • Improved Endurance
    • Reduced Serum Ammonia Levels
    • Reduced Creatine Kinase Levels
    • Reduced Serum Glucose Levels
    • Enhanced Slow Muscle Fiber Development
    • Reduced Serum Albumin Levels
    • Reduced Blood Urea Nitrogen Levels
    • Reduced Serum Creatinine Levels
    • Improved Energy Levels
    • Reduced Serum Triacylglycerols
    • Improved Exercise Performance
    • Reduced Blood Glucose Levels
    • Improved Muscle Strength
    • Reduced Lactate Levels
    • Reduced Ammonia Levels
    • Reduced Post-Exercise Lactate Levels
    • Improved Metabolic Health
    • Reduced Physical Fatigue
    • Improved Muscle Composition
    • Improved Serum Biomarkers
    • Reduced Serum D-Lactate Levels
    • Increased Type I Muscle Fiber Count
    • Reduced Glucose Levels
    • Improved Health Markers
    • Improved Metabolic Profile
    • Improved Muscle Endurance
    • Reduced Exercise-Induced Ammonia Levels
    • Reduced Exercise-Induced Glucose Levels
    • Increased Endurance Swimming Time
    • Reduced Fatigue

    • Low evidence
    • Highly Cited
    • Animal Study
• April 12

  • Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials.

    • 2016-04-12
    • Review
    • Nutrition & metabolism 13(1)
    • • Carine Dion
      • Eric Chappuis
      • Christophe Ripoll

    • PubMed: 27073407
    • DOI: 10.1186/s12986-016-0086-x

    5 Insights on

    • Increased Specific Antibody Levels
    • Improved Immune Response to Influenza Vaccination
    • Reduced Cold Incidence
    • Improved IgG Response to Vaccination
    • Improved IgE Response to Vaccination

    • Low evidence
• April 13

  • Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose – an emerging prebiotic

    • 2016-04-13
    • PROTEOMICS 16(9)
    • • Hasan Ufuk Celebioglu
      • M. Ejby
      • A. Majumder
      • Carsten Købler
      • Y. Goh
      • K. Thorsen
      • Bjarne Schmidt
      • Sarah O’Flaherty
      • M. Abou Hachem
      • S. Lahtinen
      • S. Jacobsen
      • T. Klaenhammer
      • S. Brix
      • K. Mølhave
      • B. Svensson

    • PubMed: 26959526
    • DOI: 10.1002/pmic.201500212

    1 Insight on

    • Increased Cellular Adhesion

    • Low evidence
    • Rigorous Journal

  • Effects of supplementing an active dry yeast product on rumen microbial community composition and on subsequent rumen fermentation of lactating cows in the mid-to-late lactation period.

    • 2016-04-13
    • Clinical Trial · n = 15
    • Animal Science Journal 88(1)
    • • Y. Uyeno
      • K. Akiyama
      • T. Hasunuma
      • H. Yamamoto
      • Hiroaki Yokokawa
      • T. Yamaguchi
      • K. Kawashima
      • M. Itoh
      • S. Kushibiki
      • M. Hirako

    • PubMed: 27072297
    • DOI: 10.1111/asj.12612

    1 Insight on

    • Reduced Acetate to Propionate Ratio

    • Low evidence
    • Animal Study
• April 19

  • Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans.

    • 2016-04-19
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 64(17)
    • • P. Martorell
      • S. Llopis
      • Núria González
      • E. Chenoll
      • Noemi López-Carreras
      • A. Aleixandre
      • Yang Chen
      • Edwuard D Karoly
      • D. Ramón
      • S. Genovés

    • PubMed: 27054371
    • DOI: 10.1021/acs.jafc.5b05934

    9 Insights on

    • Reduced Triglyceride Levels
    • Improved Lipid Metabolism
    • Regulated Tryptophan Metabolism
    • Reduced Total Lipid Levels
    • Enhanced Antioxidant Response
    • Enhanced Antioxidant Enzyme Activity
    • Reduced Lipid Levels
    • Enhanced Antioxidant Defense
    • Improved Satiety Response

    • Low evidence
    • Animal Study
• April 22

  • Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial

    • 2016-04-22
    • RCT · n = 47
    • Acta Odontologica Scandinavica 74(5)
    • • M. Jørgensen
      • M. Keller
      • C. Kragelund
      • K. Hamberg
      • D. Ericson
      • C. Nielsen
      • S. Twetman

    • PubMed: 27104984
    • DOI: 10.3109/00016357.2016.1169439

    2 Insights on

    • Unchanged Salivary IgA Levels
    • No Change in Salivary Cytokine Levels

    • High evidence
• April 25

  • Lactobacillus rhamnosus GG Intake Modifies Preschool Children’s Intestinal Microbiota, Alleviates Penicillin-Associated Changes, and Reduces Antibiotic Use

    • 2016-04-25
    • RCT · n = 319
    • PLOS ONE 11(4)
    • • K. Korpela
      • A. Salonen
      • L. Virta
      • M. Kumpu
      • R. Kekkonen
      • W. D. de Vos

    • PubMed: 27111772
    • DOI: 10.1371/journal.pone.0154012

    2 Insights on

    • Reduced Antibiotic-Associated Gastrointestinal Complaints
    • Reduced Antibiotic Use

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis

    • 2016-04-25
    • Clinical Trial
    • European Journal of Nutrition 56(4)
    • • M. Rigo-Adrover
      • M. Rigo-Adrover
      • S. Saldaña-Ruíz
      • S. Saldaña-Ruíz
      • K. Limpt
      • K. Knipping
      • J. Garssen
      • J. Knol
      • À. Franch
      • À. Franch
      • M. Castell
      • M. Castell
      • F. Pérez-Cano
      • F. Pérez-Cano

    • PubMed: 27112962
    • DOI: 10.1007/s00394-016-1213-1

    2 Insights on

    • Reduced Incidence of Severe Diarrhoea
    • Improved Specific Antibody Response

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 4 supplement studies

  • Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens.

    • 2016-04
    • RCT
    • Poultry Science 95(4)
    • • Q. Peng
      • X. Zeng
      • Jinlong Zhu
      • Siyuan Wang
      • X. Liu
      • C. Hou
      • P. Thacker
      • S. Qiao

    • PubMed: 26772658
    • DOI: 10.3382/ps/pev435

    18 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Increased Lactic Acid Bacteria Levels
    • Improved Intestinal Microbiota
    • Increased Secretory IgA Level
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Reduced E. coli Levels
    • Increased SCFA Levels
    • Improved Gut Microbiota Balance
    • Reduced Harmful Gut Bacteria
    • Increased Short Chain Fatty Acids
    • Reduced Fecal Escherichia coli Levels
    • Increased Short Chain Fatty Acid Profiles
    • Increased Secretory Immunoglobulin A
    • Improved Intestinal Microbial Composition
    • Increased Average Daily Gain During Finisher Period
    • Unchanged Intestinal Morphology
    • Enhanced SCFA Production

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Fermented milk with probiotic Lactobacillus rhamnosus S1K3 (MTCC5957) protects mice from salmonella by enhancing immune and nonimmune protection mechanisms at intestinal mucosal level.

    • 2016-04
    • Clinical Trial
    • The Journal of Nutritional Biochemistry 30
    • • T. S. Kemgang
      • S. Kapila
      • V. P. Shanmugam
      • S. Reddi
      • R. Kapila

    • PubMed: 27012622
    • DOI: 10.1016/j.jnutbio.2015.11.018

    14 Insights on

    • Improved Immune Response
    • Improved Intestinal Barrier Integrity
    • Improved Intestinal Mucosal Immunity
    • Reduced Salmonella Enterica Invasion
    • Reduced Salmonella Incidence
    • Increased Secretory IgA Level
    • Enhanced Tight Junction Integrity
    • Improved Overall Health Status
    • Reduced Pathogen Infection
    • Enhanced Immune Response
    • Regulated Cytokine Levels
    • Increased Fecal Secretory IgA Levels
    • Enhanced Intestinal Integrity
    • Improved Cytokine Levels

    • Low evidence
    • Animal Study

  • Antagonistics against pathogenic Bacillus cereus in milk fermentation by Lactobacillus plantarum ZDY2013 and its anti-adhesion effect on Caco-2 cells against pathogens.

    • 2016-04
    • Journal of Dairy Science 99(4)
    • • Zhihong Zhang
      • X. Tao
      • N. Shah
      • Hua Wei

    • PubMed: 26830743
    • DOI: 10.3168/jds.2015-10587

    2 Insights on

    • Reduced Pathogenic Bacillus Cereus Levels
    • Reduced Enterotoxin-Producing Bacillus Cereus Adhesion

    • Low evidence
    • Rigorous Journal

  • High-Dose Probiotic Supplementation Containing Lactobacillus casei for 7 Days Does Not Enhance Salivary Antimicrobial Protein Responses to Exertional Heat Stress Compared With Placebo.

    • 2016-04
    • RCT · n = 8
    • International Journal of Sport Nutrition and Exercise Metabolism 26(2)
    • • S. Gill
      • A. Teixeira
      • F. Rosado
      • Martin Cox
      • R. Costa

    • PubMed: 26479711
    • DOI: 10.1123/ijsnem.2015-0171

    3 Insights on

    • Enhanced Salivary Antimicrobial Protein Responses
    • Elevated Salivary Antimicrobial Protein Levels Due to Exertional Heat Stress
    • Improved Saliva Flow Rate

    • High evidence