October 2018 Supplement Research Papers

• October 2

  • Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption.

    • 2018-10-02
    • Clinical Trial
    • Nutrients 10(10)
    • • Xiaoqin Li
      • Jiawei Yin
      • Yalun Zhu
      • Xiaoqian Wang
      • Xiaoli Hu
      • Wei Bao
      • Yue Huang
      • Liangkai Chen
      • Sijing Chen
      • Wei Yang
      • Zhilei Shan
      • Liegang Liu

    • PubMed: 30279333
    • DOI: 10.3390/nu10101403

    3 Insights on

    • Reduced Body Fat Mass
    • Reduced Body Fat Percentage
    • Changed Short-Chain Fatty Acid Level

    • High evidence
    • Rigorous Journal
• October 3

  • Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials.

    • 2018-10-03
    • Meta-Analysis
    • Current hypertension reports 20(11)
    • • Mohammad Sadegh Mirenayat
      • Sajjad Moradi
      • Hamed Mohammadi
      • Mohammad Hossein Rouhani

    • PubMed: 30284051
    • DOI: 10.1007/s11906-018-0898-3

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Aortic Systolic Blood Pressure

    • High evidence
• October 4

  • Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad‐Spectrum Antibiotic‐Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups

    • 2018-10-04
    • Clinical Trial
    • Molecular Nutrition & Food Research 62(22)
    • • E. Fuglsang
      • L. Krych
      • M. Lundsager
      • D. Nielsen
      • H. Frøkiaer

    • PubMed: 30211987
    • DOI: 10.1002/mnfr.201800510

    3 Insights on

    • Increased T Cell Activation
    • Restored Granulopoiesis
    • Increased Granulocyte Count

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 8

  • Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health

    • 2018-10-08
    • Frontiers in Microbiology 9
    • • L. Anton
      • Luz-Jeannette Sierra
      • A. Devine
      • Guillermo O. Barila
      • Laura M. Heiser
      • Amy G. Brown
      • M. Elovitz

    • PubMed: 30349508
    • DOI: 10.3389/fmicb.2018.02181

    2 Insights on

    • Reduced Cervical Inflammation
    • Protection of Cervical Epithelial Barrier

    • Low evidence
    • Highly Cited
• October 9

  • Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences.

    • 2018-10-09
    • Clinical Trial
    • Food & Function 9(6)
    • • G. Zhu
      • Fangli Ma
      • Gang Wang
      • Yuanyuan Wang
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen

    • PubMed: 29892745
    • DOI: 10.1039/c8fo00100f

    5 Insights on

    • Improved Glucose Regulation
    • Regulated Blood Lipid Levels
    • Reduced Metabolic Syndrome
    • Reduced Dysbiosis
    • Enhanced Pancreatic Health

    • Low evidence
    • Animal Study

  • Protective Effect of Pediococcus pentosaceus LI05 Against Clostridium difficile Infection in a Mouse Model

    • 2018-10-09
    • Clinical Trial
    • Frontiers in Microbiology 9
    • • Qiaomai Xu
      • Silan Gu
      • Yunbo Chen
      • Jiazheng Quan
      • L. Lv
      • Da-Zhi Chen
      • B. Zheng
      • Lichen Xu
      • Lanjuan Li

    • PubMed: 30356740
    • DOI: 10.3389/fmicb.2018.02396

    6 Insights on

    • Restored Gut Microbiome Balance
    • Reduced Inflammatory Immune Mediators
    • Improved Survival Rate
    • Reduced Inflammation Levels
    • Improved Intestinal Histopathology
    • Improved Intestinal Barrier Function

    • Low evidence
    • Animal Study
• October 10

  • Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials.

    • 2018-10-10
    • RCT
    • Nutrients 10(10)
    • • Keiko Unno
      • Daisuke Furushima
      • Shingo Hamamoto
      • Kazuaki Iguchi
      • Hiroshi Yamada
      • Akio Morita
      • Hideki Horie
      • Yoriyuki Nakamura

    • PubMed: 30308973
    • DOI: 10.3390/nu10101468

    1 Insight on

    • Reduced Anxiety

    • High evidence
    • Rigorous Journal

  • Effects of Probiotic (Bifidobacterium longum 35624) Supplementation on Exercise Performance, Immune Modulation, and Cognitive Outlook in Division I Female Swimmers

    • 2018-10-10
    • RCT · n = 17
    • Sports 6(4)
    • • Aaron F Carbuhn
      • Shelby M Reynolds
      • C. W. Campbell
      • L. Bradford
      • J. Deckert
      • A. Kreutzer
      • A. Fry

    • PubMed: 30308984
    • DOI: 10.3390/sports6040116

    1 Insight on

    • Improved Cognitive Function

    • High evidence

  • l-selenomethionine supplementation in children and adolescents with autoimmune thyroiditis: A randomized double-blind placebo-controlled clinical trial.

    • 2018-10-10
    • RCT
    • Journal of clinical pharmacy and therapeutics 44(1)
    • • Ioannis Kyrgios
      • Styliani Giza
      • Eleni P Kotanidou
      • Angeliki Kleisarchaki
      • Vasiliki Rengina Tsinopoulou
      • Vasiliki Rengina Tsinopoulou
      • Anastasia Papadopoulou
      • Anthi-Marina Markantonatou
      • Eleni Kanellidou
      • Anastasia Giannakou
      • Assimina Galli-Tsinopoulou

    • PubMed: 30306604
    • DOI: 10.1111/jcpt.12765

    3 Insights on

    • Reduced Thyroid Gland Volume
    • Reduced Anti-thyroglobulin Antibody Level
    • Reduced Anti-Thyroid Peroxidase Antibody Level

    • High evidence
• October 11

  • The Effects of Probiotic Formulation Pretreatment (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) on a Lipopolysaccharide Rat Model

    • 2018-10-11
    • RCT · n = 4
    • Journal of the American College of Nutrition 38(3)
    • • Ghazaleh Mohammadi
      • L. Dargahi
      • A. Peymani
      • Y. Mirzanejad
      • S. Alizadeh
      • T. Naserpour
      • Marjan Nassiri-Asl

    • PubMed: 30307792
    • DOI: 10.1080/07315724.2018.1487346

    3 Insights on

    • No Significant Improvement in Memory Retention
    • Reduced Pro-Inflammatory Cytokines
    • Enhanced Brain-Derived Neurotrophic Factor Levels

    • Low evidence
    • Animal Study

  • Whole-Genome Sequence of Lactobacillus salivarius DJ-sa-01, Isolated from Chicken Small Intestine.

    • 2018-10-11
    • Microbiology resource announcements 7(14)
    • • Dongjun Kim
      • Mun-Ju Cho
      • Seungchan Cho
      • Yongjun Lee
      • Sung June Byun
      • Sukchan Lee

    • PubMed: 30533717
    • DOI: 10.1128/mra.00987-18

    3 Insights on

    • Increased Salivary Lactobacilli Levels
    • Reduced Gastrointestinal Infections
    • Improved Gastrointestinal Health

    • Low evidence
• October 12

  • Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease

    • 2018-10-12
    • Clinical Trial · n = 20
    • Circulation Research 123(9)
    • • Mobin Malik
      • T. Suboc
      • Sudhi Tyagi
      • N. Salzman
      • Jingli Wang
      • Rong Ying
      • Michael J. Tanner
      • Mamatha Kakarla
      • J. Baker
      • Michael E. Widlansky

    • PubMed: 30355158
    • DOI: 10.1161/CIRCRESAHA.118.313565

    4 Insights on

    • Improved Endothelium-Dependent Vasodilation in Resistance Arteries
    • Altered Plasma Metabolite Levels
    • Reduced Inflammation Levels
    • Improved Vascular Endothelial Function

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

    • 2018-10-12
    • Clinical Trial
    • Frontiers in Microbiology 9
    • • Xinpeng Jiang
      • S. Gu
      • Di Liu
      • Lili Zhao
      • S. Xia
      • Xinmiao He
      • Hongyan Chen
      • Junwei Ge

    • PubMed: 30369917
    • DOI: 10.3389/fmicb.2018.02425

    7 Insights on

    • Maintained Normal Mucosal Barrier Function
    • Reduced Oxidative Stress
    • Protected Small Intestinal Integrity
    • Reduced Intestinal Inflammation
    • Improved Gut Integrity
    • Preserved Small Intestinal Villus Integrity
    • Reduced Hepatic Oxidative Stress

    • Low evidence
    • Animal Study
• October 16

  • Lactobacillus fermentum strains from human breast milk with probiotic properties and cholesterol-lowering effects

    • 2018-10-16
    • Food Science and Biotechnology 28(2)
    • • M. Asan-Ozusaglam
      • A. Gunyakti

    • PubMed: 30956862
    • DOI: 10.1007/s10068-018-0494-y

    1 Insight on

    • Improved Auto-Aggregation Capability

    • Low evidence

  • What Roles Do Probiotics Play in the Eradication of Helicobacter pylori? Current Knowledge and Ongoing Research.

    • 2018-10-16
    • Review
    • Gastroenterology research and practice 2018
    • • Han-Yi Song
      • Long Zhou
      • Dong-Yan Liu
      • Xin-Jie Yao
      • Yan Li

    • PubMed: 30410538
    • DOI: 10.1155/2018/9379480

    4 Insights on

    • Absence of Treatment-Related Side Effects
    • Increased Helicobacter pylori Eradication Rate
    • Reduced Gastric Inflammation
    • Reduced Helicobacter pylori Colonization

    • Low evidence
• October 22

  • Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo-controlled trial.

    • 2018-10-22
    • RCT · n = 474
    • Acta paediatrica (Oslo, Norway : 1992) 107(12)
    • • R F Slykerman
      • J Kang
      • N Van Zyl
      • C Barthow
      • K Wickens
      • T Stanley
      • C Coomarasamy
      • G Purdie
      • R Murphy
      • J Crane
      • E A Mitchell

    • PubMed: 30246890
    • DOI: 10.1111/apa.14590

    5 Insights on

    • Reduced Anxiety
    • Improved Intelligence
    • Reduced Depression
    • Improved Attention Span
    • Improved Cognitive Function

    • High evidence
    • Large Human Trial

  • Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in d-galactosamine-treated rats

    • 2018-10-22
    • Clinical Trial
    • Applied Microbiology and Biotechnology 103(1)
    • • Yating Li
      • L. Lv
      • Jianzhong Ye
      • D. Fang
      • D. Shi
      • Wen-rui Wu
      • Qing Wang
      • Jingjing Wu
      • Liya Yang
      • Xiaoyuan Bian
      • Xianwan Jiang
      • Huiyong Jiang
      • Ren Yan
      • Conggao Peng
      • Lanjuan Li

    • PubMed: 30345482
    • DOI: 10.1007/s00253-018-9454-y

    7 Insights on

    • Increased Interleukin-10 Levels
    • Reduced Elevated Serum Alanine Aminotransferase (ALT)
    • Reduced Total Bile Acid Levels
    • Reduced Inflammation Levels
    • Reduced Lipopolysaccharide-Binding Protein
    • Alleviated Liver Injury
    • Improved Intestinal Barrier Function

    • Low evidence
    • Animal Study

  • Growth in Hyper-Concentrated Sweet Whey Triggers Multi Stress Tolerance and Spray Drying Survival in Lactobacillus casei BL23: From the Molecular Basis to New Perspectives for Sustainable Probiotic Production

    • 2018-10-22
    • Frontiers in Microbiology 9
    • • Song Huang
      • Floriane Gaucher
      • C. Cauty
      • J. Jardin
      • Y. Le Loir
      • R. Jeantet
      • X. Chen
      • G. Jan

    • PubMed: 30405593
    • DOI: 10.3389/fmicb.2018.02548

    7 Insights on

    • Reduced Incidence of Colon Cancer
    • Increased Pathogen Resistance
    • Protection Against Induced Colitis
    • Modulated Immune Response
    • Protection Against Induced Colon Cancer
    • Protection Against Colitis
    • Reduced Risk of Pathogen Dissemination

    • Low evidence
• October 24

  • Lactobacillus plantarum 299v Reduces the Incidence of Clostridium difficile Infection in Nephrology and Transplantation Ward—Results of One Year Extended Study

    • 2018-10-24
    • Observational · n = 54
    • Nutrients 10(11)
    • • S. Dudzicz
      • A. Kujawa-Szewieczek
      • Katarzyna Kwiecień
      • A. Więcek
      • M. Adamczak

    • PubMed: 30355985
    • DOI: 10.3390/nu10111574

    1 Insight on

    • Reduced Clostridium difficile Infection

    • High evidence
• October 29

  • The Cheese Matrix Modulates the Immunomodulatory Properties of Propionibacterium freudenreichii CIRM-BIA 129 in Healthy Piglets

    • 2018-10-29
    • Clinical Trial · n = 3
    • Frontiers in Microbiology 9
    • • Houem Rabah
      • Stéphanie Ferret-Bernard
      • Song Huang
      • L. Le Normand
      • Fabien J. Cousin
      • Floriane Gaucher
      • R. Jeantet
      • G. Boudry
      • G. Jan

    • PubMed: 30420848
    • DOI: 10.3389/fmicb.2018.02584

    2 Insights on

    • Increased Short Chain Fatty Acids
    • Increased Bifidobacterial Population

    • Low evidence
    • Animal Study

  • Strain-specific properties of Lactobacillus plantarum for prevention of Salmonella infection.

    • 2018-10-29
    • Clinical Trial
    • Food & Function 9(7)
    • • Junsheng Liu
      • Diangeng Hu
      • Yingqi Chen
      • Hongxuan Huang
      • Hao Zhang
      • Jianxin Zhao
      • Zhennan Gu
      • Wei Chen

    • PubMed: 29956713
    • DOI: 10.1039/c8fo00365c

    2 Insights on

    • Reduced Salmonella Infection
    • Improved Immune Response

    • Low evidence
    • Animal Study

  • Caraway as Important Medicinal Plants in Management of Diseases.

    • 2018-10-29
    • Review
    • Natural products and bioprospecting 9(1)
    • • Mohaddese Mahboubi

    • PubMed: 30374904
    • DOI: 10.1007/s13659-018-0190-x

    2 Insights on

    • Reduced Functional Dyspepsia Symptoms
    • Reduced Irritable Bowel Syndrome Symptoms

    • Low evidence
• Undated – 5 supplement studies

  • Effect of sub-chronic exposure to lead (Pb) and Bacillus subtilis on Carassius auratus gibelio: Bioaccumulation, antioxidant responses and immune responses.

    • 2018-10
    • Clinical Trial
    • Ecotoxicology and Environmental Safety 161
    • • Yuwei Yin
      • Peijun Zhang
      • Xinyan Yue
      • Xiaoyan Du
      • Wei Li
      • Yulin Yin
      • Cheng Yi
      • Yuehong Li

    • PubMed: 29957583
    • DOI: 10.1016/j.ecoenv.2018.06.056

    6 Insights on

    • Reduced Lead Toxicity
    • Reduced Lead Bioaccumulation
    • Enhanced Immune Response
    • Improved Antioxidant Activity
    • Improved Immune Response
    • Enhanced Antioxidant Activity

    • Low evidence
    • Highly Cited
    • Animal Study

  • Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease.

    • 2018-10
    • Clinical Trial
    • Journal of Dairy Science 101(10)
    • • M. Seo
      • E. Park
      • S. Ko
      • E. Choi
      • S. Kim

    • PubMed: 30100498
    • DOI: 10.3168/jds.2018-15014

    6 Insights on

    • Reduced Inflammation Levels
    • Reduced Myeloperoxidase Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Colonic Inflammation
    • Reduced Inflammatory Bowel Disease Symptoms
    • Reduced TNF-α Signaling

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Feeding European sea bass (Dicentrarchus labrax) juveniles with a functional synbiotic additive (mannan oligosaccharides and Pediococcus acidilactici): An effective tool to reduce low fishmeal and fish oil gut health effects?

    • 2018-10
    • Fish & Shellfish Immunology 81
    • • S. Torrecillas
      • F. Rivero-Ramírez
      • Marisol Izquierdo
      • M. J. Caballero
      • A. Makol
      • P. Suarez‐Bregua
      • Á. Fernández-Montero
      • Josep Rotllant
      • D. Montero

    • PubMed: 29981880
    • DOI: 10.1016/j.fsi.2018.07.007

    2 Insights on

    • Increased Body Weight
    • Reduced Gut Humoral Proinflammatory Response

    • Low evidence

  • The effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional constipation in children. A randomized, double-blind, placebo-controlled, multicentre trial.

    • 2018-10
    • RCT · n = 129
    • Clinics and research in hepatology and gastroenterology 42(5)
    • • Agnieszka Wegner
      • Aleksandra Banaszkiewicz
      • Jaroslaw Kierkus
      • Piotr Landowski
      • Anna Korlatowicz-Bilar
      • Sabina Wiecek
      • Jaroslaw Kwiecien
      • Agnieszka Gawronska
      • Lukasz Dembinski
      • Grazyna Czaja-Bulsa
      • Piotr Socha

    • PubMed: 29650440
    • DOI: 10.1016/j.clinre.2018.03.008

    7 Insights on

    • Reduced Hard Stool Passage
    • Reduced Fecal Incontinence
    • Reduced Stool Withholding
    • Reduced Stool Volume
    • Reduced Pain During Defecation
    • Reduced Abdominal Pain
    • Increased Bowel Movements

    • High evidence
    • Large Human Trial

  • Vaginal Bifidobacterium breve for preventing urogenital infections: Development of delayed release mucoadhesive oral tablets

    • 2018-10
    • International Journal of Pharmaceutics 550(1-2)
    • • B. Giordani
      • L. Melgoza
      • C. Parolin
      • C. Foschi
      • A. Marangoni
      • A. Abruzzo
      • F. Dalena
      • T. Cerchiara
      • F. Bigucci
      • B. Luppi
      • B. Vitali

    • PubMed: 30195082
    • DOI: 10.1016/j.ijpharm.2018.09.003

    4 Insights on

    • Enhanced Gastrointestinal Stress Resistance
    • Enhanced Survival under Gastrointestinal Stress
    • Enhanced Cell Adherence
    • Improved Adherence to Human Cells

    • Low evidence