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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of micronutrient supplementation on immune function in older adults: a meta-analysis.
- 2026-05-22
- Systematic Review
- Frontiers in immunology 17
- - Die Li
  - Ting Wang
  - Lei Xiao
  - Kun Li
- PubMed: 42254024
- DOI: 10.3389/fimmu.2026.1732861
4 Insights on
- High evidence
Clinical efficacy of different supplemental doses of vitamins A and D in preventing bronchopulmonary dysplasia in preterm infants: A network meta-analysis based on randomized controlled trials.
- 2026-05-22
- Meta-Analysis · n = 4,357
- Medicine 105(21)
- - Qingfeng Yu
  - Xiao Chen
  - Jing Chen
  - Lan Peng
  - Kui Luo
- PubMed: 42175407
- DOI: 10.1097/md.0000000000048956
3 Insights on
- High evidence
Management of osteoporosis in older men: a systematic review of randomized trials of pharmacological and non-pharmacological strategies.
- 2026-05-22
- Systematic Review
- Archives of osteoporosis 21(1)
- - Marco Antonio Araújo da Rocha-Loures
  - Cristiano Augusto de Freitas Zerbini
  - Elaine de Azevedo
  - Laura Christina Martinez
  - Maria Fernanda Brandao de Resende Guimaraes
  - André Silva Franco
  - Juliane Aline Paupitz
  - Mailze Campos Bezerra
  - Vera Lucia Szejnfeld
  - Maria Roberta Melo Pereira Soares
  - Felipe Merchan Ferraz Grizzo
  - Alex Rocha Bernardes da Silva
  - Denise Manjurma da Silva Reis
  - Diego Silveira da Silva
  - Gustavo Waclawovsky
- PubMed: 42174334
- DOI: 10.1007/s11657-026-01709-6
1 Insight on
- Increased Bone Mineral Density
- High evidence
Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews.
- 2026-05-21
- Systematic Review
- Frontiers in medicine 13
- - Chuankai Shi
  - Taimin Zhang
  - Yaru Xie
  - Jiajia Li
  - Changxu Chen
  - Jiangwei Liu
- PubMed: 42254374
- DOI: 10.3389/fmed.2026.1801273
3 Insights on
- High evidence
Effect of Polyphenol Supplementation on Post-Exercise Recovery in Adult Male Soccer Players: A Systematic Review.
- 2026-05-21
- Systematic Review
- Nutrients 18(10)
- - Verónica Silva Díaz
  - Antonio Castillo-Paredes
  - Alexander Javier Iman Torres
  - Anthony Enrique Alves Vargas
  - Eduardo Guzmán-Muñoz
  - Jose Jairo Narrea Vargas
- PubMed: 42197097
- DOI: 10.3390/nu18101638
2 Insights on
- Reduced Muscle Soreness
- Improved Subjective Well-being
- High evidence
- Rigorous Journal
The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.
- 2026-05-20
- RCT · n = 56
- PloS one 21(5)
- - Eleanor Jackson
  - Timothy Riley
  - Paul G Overton
- PubMed: 42160304
- DOI: 10.1371/journal.pone.0349512
2 Insights on
- Improved Delayed Memory
- Reduced Distractibility
- High evidence
Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis.
- 2026-05-20
- Meta-Analysis · n = 9,067
- BMJ (Clinical research ed.) 393
- - Olivier Massé
  - Claudia Mei Mercurio
  - Sébastien Dupuis
  - Maya Al Sahwi
  - Alexandra Arruda
  - Gabriel Dallaire
  - Katherine Desforges
  - Nicolas Dugré
  - David Williamson
- PubMed: 42161415
- DOI: 10.1136/bmj-2025-088050
6 Insights on
- High evidence
The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.
- 2026-05-19
- RCT · n = 17
- Nutrients 18(10)
- - Anselm Johannes Schlemmer
  - Sascha Hammer
  - Simon Fandler-Höfler
  - Kordula Lang-Illievich
  - Helmar Bornemann-Cimenti
- PubMed: 42197069
- DOI: 10.3390/nu18101609
9 Insights on
- High evidence
- Rigorous Journal
Effects of different menthol administration routes on endurance performance and physiological responses in the heat: a network meta-analysis.
- 2026-05-18
- Systematic Review
- Frontiers in nutrition 13
- - Yongliang Zhu
  - Junyu Zhao
  - Jiayi Yao
  - Haozhe Wang
  - Xiaotong Yuan
- PubMed: 42232581
- DOI: 10.3389/fnut.2026.1833420
4 Insights on
- High evidence
Exploring the Role of Cissus quadrangularis in Osteoporosis Management.
- 2026-05-18
- Review
- Orthopedic research and reviews 18
- - Nicola Manocchio
  - Andrea Sorbino
  - Antonio Devito
  - Luca Gallelli
  - Daniele Romanello
  - Sara Rotunno
  - Calogero Foti
  - Alberto Migliore
- PubMed: 42180261
- DOI: 10.2147/orr.s609378
7 Insights on
- Low evidence
Astragalus membranaceus Modulates Inflammatory Markers Without Enhancing Muscle Function Following Intensified Resistance Training.
- 2026-05-18
- RCT
- Nutrients 18(10)
- - Simone Villanova
  - Marco Gatti
  - Marta Colosio
  - Letizia Giusti
  - Giulia Papetti
  - Pietro Blumetti
  - Simone Porcelli
- PubMed: 42197058
- DOI: 10.3390/nu18101598
11 Insights on
- High evidence
- Rigorous Journal
Vitamin B12 Supplementation: Is More Always Better?
- 2026-05-18
- Review
- Nutrients 18(10)
- - Manuela Yepes-Calderón
  - Caecilia S E Doorenbos
  - Mariken E Stegmann
  - Daan J Touw
  - Hermie J M Harmsen
  - M Rebecca Heiner-Fokkema
  - Francjan J van Spronsen
  - Eva Corpeleijn
  - Stephan J L Bakker
- PubMed: 42197057
- DOI: 10.3390/nu18101597
4 Insights on
- Moderate evidence
- Rigorous Journal
High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.
- 2026-05-18
- RCT · n = 498
- JAMA network open 9(5)
- - Olivia Frigast Frederiksen
  - Jens Richardt Møllegaard Jepsen
  - Nicklas Brustad
  - Rebecca Vinding
  - Julie Bøjstrup Rosenberg
  - Parisa Mohammadzadeh
  - María Hernández-Lorca
  - Ann-Marie Malby Schoos
  - Nilo Vahman
  - Birte Y Glenthøj
  - Birgitte Fagerlund
  - Niels Bilenberg
  - Klaus Bønnelykke
  - Bjørn H Ebdrup
  - Kristina Aagaard
  - Bo Chawes
- PubMed: 42149595
- DOI: 10.1001/jamanetworkopen.2026.11464
3 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
Multicenter retrospective observational study on the clinical effectiveness of butyrate-producing Clostridium butyricum containing probiotics in patients with COVID-19.
- 2026-05-17
- Observational
- Virulence 17(1)
- - Yoshihiko Morikawa
  - Hideo Kato
  - Takumi Umemura
  - Jun Hirai
  - Yuichi Shibata
  - Mao Hagihara
  - Nobuhiro Asai
  - Hiroshige Mikamo
  - Takuya Iwamoto
- PubMed: 42127027
- DOI: 10.1080/21505594.2026.2673650
3 Insights on
- Low evidence
Saroglitazar and vitamin E vs. lifestyle interventions in metabolic dysfunction associated steatotic liver disease: A 3-arm randomised study.
- 2026-05-16
- RCT · n = 136
- The Indian journal of medical research 163
- - Anurag Kumar Tiwari
  - Gurvachan Singh
  - Vinod Kumar
  - Dawesh Prakash Yadav
  - Sunit Kumar Shukla
  - Virendra Singh
  - Gaurav Mishra
  - Narendra Kumar Tiwary
  - Anand Anunay
  - Divyanshi Singh
  - Deepika Chaturvedi
- PubMed: 42237829
- DOI: 10.25259/ijmr_2511_2025
3 Insights on
- High evidence
- Large Human Trial
Chromium as a Modulator of Insulin Receptor Activity: A Systematic Review of Its Role in Metabolic Syndrome and Type 2 Diabetes.
- 2026-05-15
- Review
- Diabetes, metabolic syndrome and obesity : targets and therapy 19
- - Abdullatif Taha Babakr
  - Mohammed Hasan Mukhtar
  - Abeer Shaker Elmoursy Ali
  - Mohammad A Althubiti
  - Gad Allah Modawe
  - Sameer Hasan Fatani
  - Wesam A Nasif
- PubMed: 42163851
- DOI: 10.2147/dmso.s581925
2 Insights on
- Improved Insulin Sensitivity
- Improved Homeostasis
- Low evidence
The Effects of Colostrum Bovinum Supplementation on Human Body Fat Content and/or Blood Lipid Profile: A Systematic Review of Clinical Trials.
- 2026-05-15
- Systematic Review
- Nutrients 18(10)
- - Zuzanna Goluch
  - Ewelina Książek
  - Aldona Wierzbicka-Rucińska
  - Ireneusz Skawina
  - Robert Dudkowiak
- PubMed: 42197039
- DOI: 10.3390/nu18101579
5 Insights on
- High evidence
- Rigorous Journal
The Effects of Astaxanthin Supplementation on Exercise Recovery Biomarkers and Exercise Performance: A Systematic Review and Meta-Analysis.
- 2026-05-15
- Meta-Analysis
- Nutrients 18(10)
- - Shuning Liu
  - Wenqian Yao
  - Yan Wei
  - Samuhaer Azhati
  - Yutong Wu
  - Wen Zhong
  - Pengda Wang
  - Heping Dai
  - Kai Zhao
  - Chang Liu
- PubMed: 42197030
- DOI: 10.3390/nu18101570
7 Insights on
- High evidence
- Rigorous Journal
Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial.
- 2026-05-15
- RCT · n = 35
- JAMA network open 9(5)
- - Hampus Yngwe
  - Pontus Plavén-Sigray
  - Carl Johan Ekman
  - Eva Henje
  - Anders Berglund
  - Mikael Tiger
  - Maria Beckman
  - Johan Lundberg
- PubMed: 42138922
- DOI: 10.1001/jamanetworkopen.2026.12589
2 Insights on
- Reduced Depression Symptoms
- Reduced Montgomery-Åsberg Depression Rating Scale Score
- High evidence
- Rigorous Journal
Clinical Applications and Therapeutic Potential of Nano-Bio Fusion Gel in Oral Soft Tissue Therapy: A Critical Narrative Review.
- 2026-05-14
- Review
- Gels (Basel, Switzerland) 12(5)
- - Gábor Kammerhofer
  - Ákos Tamás Nagy
  - Árpád Joób-Fancsaly
  - György Szmirnov
  - Ilona Szmirnova
  - Dániel Végh
  - Márton Kivovics
  - György Szabó
  - Zsolt Németh
- PubMed: 42196113
- DOI: 10.3390/gels12050429
11 Insights on
- Low evidence
Amino acids: Missing link in preeclampsia pathogenesis?
- 2026-05-14
- Observational · n = 84
- European journal of nutrition 65(4)
- - Iclal Sena Gezer
  - Hasan Altinsoy
  - Ayse Gulcin Bastemur
  - Ozlem Dogan
  - Atakan Tanacan
  - Fatma Doga Ocal
  - Dilek Sahin
  - Nuray Yazihan
- PubMed: 42133093
- DOI: 10.1007/s00394-026-03977-x
2 Insights on
- Reduced Preeclampsia Risk
- Increased Preeclampsia Risk
- High evidence
- Rigorous Journal
Investigation of oral bromelain supplementation on the healing of skin flap reconstruction after Mohs micrographic surgery (MMS) for non-melanoma skin cancers (NMSCs).
- 2026-05-14
- RCT · n = 60
- BMC surgery 26(1)
- - Ehsanollah Rahimi-Movaghar
  - Amir Ehtemami
  - Melina Ghaneiyan
  - Tahmineh Tahouri
  - Sahand Hedayati Omami
  - Hila Fahimi
- PubMed: 42135693
- DOI: 10.1186/s12893-026-03820-4
5 Insights on
- High evidence
Effects of β-alanine supplementation on kickboxing-specific anaerobic performance, neuromuscular power, and strength endurance: A randomized, double-blind, placebo-controlled trial.
- 2026-05-13
- RCT · n = 14
- PloS one 21(5)
- - Furkan Hasan Küçük
  - Cebrail Gençoğlu
  - Osman Ateş
  - Jonatas Deivyson Reis Da Silva Duarte
  - Dino Belošević
  - Salih Çabuk
  - Muhammet Raşit İnaç
  - Süleyman Ulupınar
  - Serhat Özbay
- PubMed: 42127019
- DOI: 10.1371/journal.pone.0346898
8 Insights on
- High evidence
A Review of the Properties of Clinically Evaluated Plant-Derived Agents in the Treatment of Respiratory Infections.
- 2026-05-12
- Review · n = 94
- Nutrients 18(10)
- - Alexandra S Alexandrova
  - Vasil S Boyanov
  - Liliya Y Boyanova
  - Raina T Gergova
- PubMed: 42196994
- DOI: 10.3390/nu18101534
2 Insights on
- Reduced Severity of Respiratory Tract Infection
- Reduced Duration of Respiratory Tract Infection
- High evidence
- Rigorous Journal
Pharmacological treatments for Friedreich ataxia.
- 2026-05-12
- Meta-Analysis · n = 574
- The Cochrane database of systematic reviews 2026(5)
- - Shane Lyons
  - Mary Kearney
  - Michael C Fahey
  - Prashant Janjal
  - Massimo Pandolfo
  - Patricia Patton
- PubMed: 42117563
- DOI: 10.1002/14651858.cd007791.pub5
4 Insights on
- High evidence
N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
- 2026-05-11
- Systematic Review · n = 566
- BMC psychiatry 26(1)
- - Mohamed Awad E Ahmed
  - Mufreh Amin
  - Yomna Emad Abdalla
  - Amr Abdelghani
  - Nourhan Eid
  - Aya Samy
  - Omar Kassar
  - Khalid Radwan Alsaadany
  - Mohamed Ezzat M Mansour
- PubMed: 42115982
- DOI: 10.1186/s12888-026-08124-8
2 Insights on
- Reduced Alcohol Craving
- Reduced PTSD Severity
- High evidence
Folate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases.
- 2026-05-11
- Systematic Review
- Journal of global health 16
- - Samantha Yoo
  - Azita Montazeri
  - Derrick Bennett
  - Yacong Bo
  - Peizhan Chen
  - Susan Duthie
  - Natalie Jensen
  - Atipatsa Kaminga
  - Jun-Shi Lai
  - Xue Li
  - Amanda J MacFarlane
  - Homero Martinez
  - Helene McNulty
  - Franco Momoli
  - Ron Munger
  - Rajendra Prasad Parajuli
  - Monique Potvin Kent
  - Michele Rubini
  - Marjanne Senekal
  - Lindsey Sikora
  - Alain Stintzi
  - Evropi Theodoratou
  - Hui Wang
  - Ann Yaktine
  - Julian Little
- PubMed: 42100908
- DOI: 10.7189/jogh.16.04160
2 Insights on
- Reduced Risk of Coronary Heart Disease
- Reduced Risk of Stroke
- High evidence
Post-activation performance enhancement (PAPE) and taurine combination improves anaerobic performance in highly trained wrestlers: a double-blind, randomized, crossover study.
- 2026-05-11
- RCT
- Journal of the International Society of Sports Nutrition 23(1)
- - Süleyman Bi̇lgi̇n
  - Yusuf Buzdağli
  - Murat Ozan
  - Umut Yilmaz
  - Çağrı Çi̇ydem
  - Cemre Didem Eyi̇pinar
  - Muhammet Raşit İnaç
  - Ufuk Han Bağaçli
  - Halil Uçar
  - Erdinç Şiktar
  - Mücahit Dursun
- PubMed: 42112616
- DOI: 10.1080/15502783.2026.2673071
4 Insights on
- High evidence
Influence of vitamin D supplementation on ovarian reserve as reflected by anti-Müllerian hormone levels: a meta-analysis of randomized controlled trials.
- 2026-05-11
- Meta-Analysis · n = 992
- Frontiers in endocrinology 17
- - Sitian Fang
  - Yijia Li
  - Xinyu Fan
  - Liping Zheng
- PubMed: 42199796
- DOI: 10.3389/fendo.2026.1832704
1 Insight on
- Changed Anti-Müllerian Hormone Level
- High evidence
Vitamin D and Vitamin B12 in Psychiatric Disorders: An Exploratory Systematic Review and Meta-Analysis of Nutrient-Specific Status and Supplementation Evidence.
- 2026-05-10
- Review
- Diseases (Basel, Switzerland) 14(5)
- - Lavinia-Alexandra Moroianu
  - Cecilia Curis
  - Valeriu Ardeleanu
  - Roxana Elena Bogdan-Goroftei
  - Simona-Dana Mitincu-Caramfil
  - Marius Moroianu
  - Alina Pleșea-Condratovici
- PubMed: 42187879
- DOI: 10.3390/diseases14050167
1 Insight on
- Reduced Psychiatric Symptom Severity
- Low evidence