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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Influence of Bacillus subtilis GCB-13-001 on growth performance, nutrient digestibility, blood characteristics, faecal microbiota and faecal score in weanling pigs.
- 2019-09-20
- RCT
- Journal of Animal Physiology and Animal Nutrition 103(6)
- - Huan Wang
  - Kun Phil Kim
  - I. Kim
- PubMed: 31538695
- DOI: 10.1111/jpn.13199
5 Insights on
- High evidence
An exploratory pilot study evaluating the supplementation of standard antibiotic therapy with probiotic lactobacilli in south African women with bacterial vaginosis
- 2019-09-18
- RCT · n = 39
- BMC Infectious Diseases 19(1)
- - H. Marcotte
  - P. Larsson
  - Kasper Krogh Andersen
  - F. Zuo
  - L. S. Mikkelsen
  - E. Brandsborg
  - G. Gray
  - F. Laher
  - K. Otwombe
- PubMed: 31533663
- DOI: 10.1186/s12879-019-4425-1
1 Insight on
- Increased Vaginal Lactobacilli Colonization
- High evidence
- Rigorous Journal
Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model
- 2019-09-18
- RCT
- Frontiers in Physiology 10
- - Sujuan Ding
  - Yong Ma
  - Gang Liu
  - Wenxin Yan
  - Hongmei Jiang
  - Jun Fang
- PubMed: 31620010
- DOI: 10.3389/fphys.2019.01152
16 Insights on
- Low evidence
- Animal Study
Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice.
- 2019-09-17
- Current drug safety 14(3)
- - Ahmed Mohamed Nabil Helaly
  - Yomna Ahmed El-Attar
  - Mahmoud Khalil
  - Doaa Shams El-Din Ahmed Ghorab
  - Adel Mahmoud El-Mansoury
- PubMed: 31195950
- DOI: 10.2174/1574886314666190612130921
3 Insights on
- Low evidence
- Animal Study
Yacon syrup reduces postprandial glycemic response to breakfast: A randomized, crossover, double-blind clinical trial.
- 2019-09-15
- RCT · n = 40
- Food research international (Ottawa, Ont.) 126
- - Lia Silveira Adriano
  - Ana Paula Dionísio
  - Fernando Antônio Pinto de Abreu
  - Antônio Augusto Ferreira Carioca
  - Guilherme Julião Zocolo
  - Nedio Jair Wurlitzer
  - Claudia de Oliveira Pinto
  - Ariclécio Cunha de Oliveira
  - Helena Alves de Carvalho Sampaio
- PubMed: 31732062
- DOI: 10.1016/j.foodres.2019.108682
3 Insights on
- High evidence
Ameliorative Effects of Probiotic Lactobacillus paracasei NL41 on Insulin Sensitivity, Oxidative Stress and Beta-Cell Function in a Type 2 Diabetes Mellitus Rat Model.
- 2019-09-12
- RCT · n = 18
- Molecular Nutrition & Food Research 63(22)
- - Z. Zeng
  - Qipeng Yuan
  - Rui Yu
  - Jinlan Zhang
  - Huiqin Ma
  - Shangwu Chen
- PubMed: 31433912
- DOI: 10.1002/mnfr.201900457
23 Insights on
- Low evidence
- Animal Study
Protective effects of Lactobacillus plantarum against chronic alcohol-induced liver injury in the murine model
- 2019-09-12
- Applied Microbiology and Biotechnology 103(20)
- - T. J. Fang
  - Jiun-Ting Guo
  - Ming-Kuem Lin
  - Meng-Shiou Lee
  - Yen-Lien Chen
  - Wen-Hsin Lin
- PubMed: 31515596
- DOI: 10.1007/s00253-019-10122-8
5 Insights on
- Low evidence
Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets.
- 2019-09-09
- RCT · n = 60
- Journal of Animal Physiology and Animal Nutrition 103(6)
- - Qi Wang
  - Qian Sun
  - R. Qi
  - Jing Wang
  - Xiaoyu Qiu
  - Zuohua Liu
  - Jinxiu Huang
- PubMed: 31498508
- DOI: 10.1111/jpn.13198
8 Insights on
- Low evidence
- Animal Study
Saccharomyces cerevisiae as a probiotic feed additive to non and pseudo‐ruminant feeding: a review
- 2019-09-08
- Review
- Journal of Applied Microbiology 128(3)
- - M. Elghandour
  - Z. Tan
  - S. A. Abu Hafsa
  - M. Adegbeye
  - R. Greiner
  - E. Ugbogu
  - J. Cedillo Monroy
  - A. Salem
- PubMed: 31429174
- DOI: 10.1111/jam.14416
9 Insights on
- Moderate evidence
- Highly Cited
Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis.
- 2019-09-07
- Meta-Analysis
- World journal of gastroenterology 25(33)
- - Ya-Ting Li
  - Hong Xu
  - Jian-Zhong Ye
  - Wen-Rui Wu
  - Ding Shi
  - Dai-Qiong Fang
  - Yang Liu
  - Lan-Juan Li
- PubMed: 31543689
- DOI: 10.3748/wjg.v25.i33.4999
2 Insights on
- Reduced Duration of Diarrhea
- Reduced Stool Frequency
- High evidence
Chinese Medicines for Preventing and Treating Radiation-Induced Pulmonary Injury: Still a Long Way to Go.
- 2019-09-05
- Review
- Frontiers in pharmacology 10
- - Yan Ding
  - Yuechao Liu
  - Hongliang Li
  - Yong Li
  - Minglun Li
  - Ming Liu
  - Xianhe Wang
  - Fengjun Cao
  - Xuanbin Wang
- PubMed: 31616288
- DOI: 10.3389/fphar.2019.00927
2 Insights on
- Reduced Radiation-Induced Pulmonary Injury
- Improved Treatment Efficacy for Radiation-Induced Pulmonary Injury
- Low evidence
Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study.
- 2019-09-04
- RCT
- Nutrients 11(9)
- - Ezgi Bellikci-Koyu
  - Banu Pınar Sarer-Yurekli
  - Yakut Akyon
  - Fadime Aydin-Kose
  - Cem Karagozlu
  - Ahmet Gokhan Ozgen
  - Annika Brinkmann
  - Andreas Nitsche
  - Koray Ergunay
  - Engin Yilmaz
  - Zehra Buyuktuncer
- PubMed: 31487797
- DOI: 10.3390/nu11092089
6 Insights on
- High evidence
- Rigorous Journal
The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
- 2019-09-04
- RCT · n = 40
- Complementary medicine research 27(1)
- - Hamidreza Ardalani
  - Parisa Jandaghi
  - Aramsadat Meraji
  - Maryam Hassanpour Moghadam
- PubMed: 31484191
- DOI: 10.1159/000502280
3 Insights on
- High evidence
Assessment of Freeze-Dried Immobilized Lactobacillus casei as Probiotic Adjunct Culture in Yogurts
- 2019-09-01
- Foods 8(9)
- - D. Dimitrellou
  - P. Kandylis
  - Y. Kourkoutas
- PubMed: 31480583
- DOI: 10.3390/foods8090374
1 Insight on
- Improved Sensory Function
- Low evidence
Bacteriocin activity of Lactobacillus brevis and Lactobacillus paracasei ssp. paracasei.
- 2019-09-01
- Journal of Medical Microbiology 68(9)
- - R. Iseppi
  - P. Messi
  - Stefania Camellini
  - C. Sabia
- PubMed: 31364964
- DOI: 10.1099/jmm.0.001045
3 Insights on
- Low evidence
Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum
- 2019-08-27
- RCT
- PeerJ 7
- - Md Javed Foysal
  - T. Nguyen
  - Md. Reaz Chaklader
  - M. Siddik
  - C. Tay
  - R. Fotedar
  - S. Gupta
- PubMed: 31523510
- DOI: 10.7717/peerj.7553
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome.
- 2019-08-21
- Review
- Frontiers in microbiology 10
- - Yu Gu
  - Guoqiong Zhou
  - Xiali Qin
  - Shumin Huang
  - Bangmao Wang
  - Hailong Cao
- PubMed: 31497000
- DOI: 10.3389/fmicb.2019.01894
1 Insight on
- Improved Irritable Bowel Syndrome Symptoms
- Low evidence
The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study.
- 2019-08-21
- RCT
- Nutrients 11(9)
- - Krzysztof Durkalec-Michalski
  - Krzysztof Kusy
  - Monika Ciekot-Sołtysiak
  - Jacek Zieliński
- PubMed: 31438535
- DOI: 10.3390/nu11091961
3 Insights on
- High evidence
- Rigorous Journal
Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88
- 2019-08-21
- RCT · n = 96
- Journal of Animal Science and Biotechnology 10(1)
- - X. Peng
  - Ru Wang
  - Liang Hu
  - Qiang Zhou
  - Yang Liu
  - Min Yang
  - Z. Fang
  - Yan Lin
  - Shengyu Xu
  - B. Feng
  - Jian Li
  - Xuemei Jiang
  - Y. Zhuo
  - Hua Li
  - De Wu
  - L. Che
- PubMed: 31452881
- DOI: 10.1186/s40104-019-0376-z
4 Insights on
- Low evidence
- Animal Study
Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults
- 2019-08-21
- RCT · n = 289
- Scientific Reports 9(1)
- - R. Madempudi
  - J. Ahire
  - J. Neelamraju
  - A. Tripathi
  - S. Nanal
- PubMed: 31434935
- DOI: 10.1038/s41598-019-48554-x
4 Insights on
- High evidence
- Rigorous Journal
Colonization of Germ-Free Piglets with Commensal Lactobacillus amylovorus, Lactobacillus mucosae, and Probiotic E. coli Nissle 1917 and Their Interference with Salmonella Typhimurium
- 2019-08-20
- Clinical Trial
- Microorganisms 7(8)
- - I. Splichal
  - S. Donovan
  - Zdislava Splichalova
  - Vera Neuzil Bunesova
  - E. Vlková
  - Vera Jenistova
  - J. Killer
  - R. Svejstil
  - E. Skřivanová
  - A. Splichalova
- PubMed: 31434337
- DOI: 10.3390/microorganisms7080273
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial.
- 2019-08-19
- RCT · n = 120
- PloS one 14(8)
- - Barbara Troesch
  - Johann Demmelmair
  - Martina Gimpfl
  - Christina Hecht
  - Goran Lakovic
  - Robert Roehle
  - Ljilja Sipka
  - Branka Trisic
  - Milica Vusurovic
  - Rotraut Schoop
  - Sznezana Zdjelar
  - Berthold Koletzko
- PubMed: 31425504
- DOI: 10.1371/journal.pone.0216790
11 Insights on
- High evidence
- Large Human Trial
Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- 2019-08-16
- RCT · n = 78
- Nutrients 11(8)
- - Å. Håkansson
  - Carin Andrén Aronsson
  - C. Brundin
  - E. Oscarsson
  - G. Molin
  - D. Agardh
- PubMed: 31426299
- DOI: 10.3390/nu11081925
12 Insights on
- High evidence
An In Vitro Enrichment Strategy for Formulating Synergistic Synbiotics.
- 2019-08-15
- Applied and environmental microbiology 85(16)
- - Car Reen Kok
  - David Fabian Gomez Quintero
  - Clement Niyirora
  - Devin Rose
  - Amanda Li
  - Robert Hutkins
- PubMed: 31201276
- DOI: 10.1128/aem.01073-19
1 Insight on
- Improved Gut Microbiome Establishment
- Low evidence
- Rigorous Journal
Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.
- 2019-08-14
- RCT
- Journal of orthopaedic surgery and research 14(1)
- - Chunhua Zhang
  - Sujuan Xue
  - Yong Wang
  - Dan Yu
  - Limei Hua
  - Chunhua Guo
  - Dawei Wang
  - Min Lei
- PubMed: 31412879
- DOI: 10.1186/s13018-019-1310-y
5 Insights on
- High evidence
Effects of oligosaccharides on the growth and stress tolerance of Lactobacillus plantarum ZLP001 in vitro, and the potential synbiotic effects of L. plantarum ZLP001 and fructo-oligosaccharide in post-weaning piglets.
- 2019-08-14
- RCT
- Journal of Animal Science 97(11)
- - Jing Wang
  - Sixin Wang
  - Hui Liu
  - Dongyan Zhang
  - Yamin Wang
  - H. Ji
- PubMed: 31410455
- DOI: 10.1093/jas/skz254
3 Insights on
- High evidence
- Rigorous Journal
Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis
- 2019-08-14
- Meta-Analysis
- Helicobacter 24(5)
- - Ben‐Gang Zhou
  - Lingxiao Chen
  - Bohua Li
  - Lin-Yan Wan
  - Yao-Wei Ai
- PubMed: 31414551
- DOI: 10.1111/hel.12651
7 Insights on
- High evidence
Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial.
- 2019-08-13
- RCT
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 34(11)
- - Mary Sharpe
  - Vibhuti Shah
  - Tatiana Freire-Lizama
  - Elizabeth C Cates
  - Kory McGrath
  - Iuliana David
  - Sara Cowan
  - Janaya Letkeman
  - Emily Stewart-Wilson
- PubMed: 31362572
- DOI: 10.1080/14767058.2019.1650907
2 Insights on
- Reduced Vaginal Group B Streptococcus Colonization
- No Documented Adverse Effects
- High evidence
The Application of Lactobacillus reuteri CCM 8617 and Flaxseed Positively Improved the Health of Mice Challenged with Enterotoxigenic E. coli O149:F4
- 2019-08-13
- RCT · n = 60
- Probiotics and Antimicrobial Proteins 12(3)
- - Z. Andrejčáková
  - D. Sopková
  - R. Vlčková
  - Z. Hertelyová
  - S. Gancarčíková
  - R. Nemcová
- PubMed: 31410766
- DOI: 10.1007/s12602-019-09578-x
4 Insights on
- Low evidence
- Animal Study
Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study
- 2019-08-10
- RCT · n = 60
- Nutrients 11(8)
- - K. Nishida
  - D. Sawada
  - Y. Kuwano
  - Hiroki Tanaka
  - K. Rokutan
- PubMed: 31405122
- DOI: 10.3390/nu11081859
10 Insights on
- High evidence
- Highly Cited