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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade
- 2018-08-07
- RCT · n = 4
- Molecular Nutrition & Food Research 62(19)
- - Iñaki Robles‐Vera
  - M. Toral
  - Néstor de la Visitación
  - M. Sánchez
  - M. Romero
  - M. Olivares
  - R. Jiménez
  - J. Duarte
- PubMed: 30028078
- DOI: 10.1002/mnfr.201800298
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.
- 2018-08-06
- Meta-Analysis
- BMC gastroenterology 18(1)
- - Valeria Agamennone
  - Cyrille A M Krul
  - Ger Rijkers
  - Remco Kort
- PubMed: 30078376
- DOI: 10.1186/s12876-018-0831-x
1 Insight on
- Reduced Antibiotic-Associated Diarrhea
- High evidence
Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2.
- 2018-08-01
- RCT
- American Journal of Physiology-Gastrointestinal and Liver Physiology 315(2)
- - T. Hoang
  - Baokun He
  - Ting Wang
  - D. Tran
  - J. M. Rhoads
  - Yuying Liu
- PubMed: 29648878
- DOI: 10.1152/ajpgi.00084.2017
10 Insights on
- Low evidence
- Animal Study
Effect of Lactobacillus salivarius on growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs challenged with F4+ enterotoxigenic Escherichia coli
- 2018-08-01
- RCT · n = 201
- Asian-Australasian Journal of Animal Sciences 31(8)
- - Harutai Sayan
  - P. Assavacheep
  - Kris Angkanaporn
  - Anongnart Assavacheep
- PubMed: 29642683
- DOI: 10.5713/ajas.17.0746
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals.
- 2018-08-01
- Clinical Trial · n = 45
- Journal of acquired immune deficiency syndromes (1999) 78(4)
- - Caroline J Arnbjerg
  - Beate Vestad
  - Johannes R Hov
  - Karin K Pedersen
  - Sofie Jespersen
  - Helle H Johannesen
  - Kristian Holm
  - Bente Halvorsen
  - Eva Fallentin
  - Adam E Hansen
  - Theis Lange
  - Andreas Kjær
  - Marius Trøseid
  - Barbara M Fischer
  - Susanne D Nielsen
- PubMed: 29874201
- DOI: 10.1097/qai.0000000000001693
11 Insights on
- High evidence
Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome
- 2018-07-30
- Clinical Trial · n = 33
- British Journal of Nutrition 120(6)
- - L. J. Bernini
  - A. Simão
  - C. H. B. de Souza
  - D. Alfieri
  - L. Segura
  - G. N. Costa
  - I. Dichi
- PubMed: 30058513
- DOI: 10.1017/S0007114518001861
6 Insights on
- High evidence
Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players
- 2018-07-26
- RCT · n = 25
- Sports 6(3)
- - Jeremy R. Townsend
  - David Bender
  - William C. Vantrease
  - Philip A. Sapp
  - Ann M. Toy
  - Clint A Woods
  - Kent D. Johnson
- PubMed: 30049931
- DOI: 10.3390/sports6030070
1 Insight on
- Reduced TNF-α Concentration
- High evidence
The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans.
- 2018-07-24
- RCT
- Nutrients 10(8)
- - Emma L Wightman
  - Philippa A Jackson
  - Julie Khan
  - Joanne Forster
  - Felix Heiner
  - Bjoern Feistel
  - Cynthia G Suarez
  - Ivo Pischel
  - David O Kennedy
- PubMed: 30042362
- DOI: 10.3390/nu10080955
8 Insights on
- High evidence
- Rigorous Journal
Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction
- 2018-07-24
- Frontiers in Physiology 9
- - N. Fernandez
  - Laura Wrzosek
  - J. M. Radziwill-Bienkowska
  - B. Ringot-Destrez
  - M. Duviau
  - Marie‐Louise Noordine
  - V. Laroute
  - V. Robert
  - C. Cherbuy
  - M. Daveran-Mingot
  - M. Cocaign-Bousquet
  - R. Léonard
  - C. Robbe-Masselot
  - F. Rul
  - E. Ogier-Denis
  - Muriel Thomas
  - M. Mercier-Bonin
- PubMed: 30087622
- DOI: 10.3389/fphys.2018.00980
6 Insights on
- Low evidence
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial
- 2018-07-22
- RCT
- Journal of Internal Medicine 284(3)
- - Anna G. Nilsson
  - Anna G. Nilsson
  - D. Sundh
  - Fredrik Bäckhed
  - Fredrik Bäckhed
  - M. Lorentzon
  - M. Lorentzon
- PubMed: 29926979
- DOI: 10.1111/joim.12805
1 Insight on
- Reduced Bone Loss
- High evidence
- Highly Cited
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
- 2018-07-19
- RCT · n = 230
- The New England journal of medicine 379(3)
- - Yutaka Niihara
  - Scott T Miller
  - Julie Kanter
  - Sophie Lanzkron
  - Wally R Smith
  - Lewis L Hsu
  - Victor R Gordeuk
  - Kusum Viswanathan
  - Sharada Sarnaik
  - Ifeyinwa Osunkwo
  - Edouard Guillaume
  - Swayam Sadanandan
  - Lance Sieger
  - Joseph L Lasky
  - Eduard H Panosyan
  - Osbourne A Blake
  - Tamara N New
  - Rita Bellevue
  - Lan T Tran
  - Rafael L Razon
  - Charles W Stark
  - Lynne D Neumayr
  - Elliott P Vichinsky
- PubMed: 30021096
- DOI: 10.1056/nejmoa1715971
2 Insights on
- Reduced Hospitalization
- Reduced Pain Crises
- High evidence
- Large Human Trial
- Highly Cited
The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.
- 2018-07-10
- Review
- Frontiers in microbiology 9
- - Iman Salem
  - Amy Ramser
  - Nancy Isham
  - Mahmoud A Ghannoum
- PubMed: 30042740
- DOI: 10.3389/fmicb.2018.01459
2 Insights on
- Improved Skin Hydration
- Improved Skin Barrier Function
- Moderate evidence
- Highly Cited
Lactobacillus rhamnosus Probiotic Food as a Tool for Empowerment Across the Value Chain in Africa
- 2018-07-10
- Frontiers in Microbiology 9
- - Nieke Westerik
  - R. Kort
  - W. Sybesma
  - G. Reid
- PubMed: 30042747
- DOI: 10.3389/fmicb.2018.01501
1 Insight on
- Improved Nutritional Status
- Low evidence
Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.
- 2018-07-06
- Food science and biotechnology 27(6)
- - Eric Banan-Mwine Daliri
  - Byong H Lee
  - Byun-Jae Park
  - Se-Hun Kim
  - Deog-Hwan Oh
- PubMed: 30483443
- DOI: 10.1007/s10068-018-0423-0
3 Insights on
- Low evidence
Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study
- 2018-07-04
- RCT · n = 40
- Food & Nutrition Research 62(0)
- - M. Majeed
  - K. Nagabhushanam
  - S. Arumugam
  - Shaheen Majeed
  - Furqan Ali
- PubMed: 29997457
- DOI: 10.29219/fnr.v62.1218
9 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.
- 2018-07-03
- RCT
- Chronobiology international 35(10)
- - Takafumi Fukuda
  - Atsushi Haraguchi
  - Masaki Takahashi
  - Takashi Nakaoka
  - Mayuko Fukazawa
  - Jin Okubo
  - Mamiho Ozaki
  - Ayana Kanatome
  - Rena Ohya
  - Yutaka Miura
  - Kuniaki Obara
  - Shigenobu Shibata
- PubMed: 29969301
- DOI: 10.1080/07420528.2018.1490315
1 Insight on
- Delayed Dim Light Melatonin Onset
- High evidence
Fermented camel milk by Lactococcus lactis subsp. cremoris attenuates erythrocytes oxidative stress-induced hematological and immunological damage in CCl4-intoxicated mice
- 2018-07-02
- RCT · n = 28
- Environmental Science and Pollution Research 25(26)
- - H. Hamed
  - Fatma Châari
  - Zied Ghannoudi
  - Kaouther Dhouib
  - S. Châabouni
  - A. Feki
  - A. Gargouri
- PubMed: 29968212
- DOI: 10.1007/s11356-018-2623-9
4 Insights on
- Low evidence
- Animal Study
Lactobacillus fermentum Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling
- 2018-06-28
- Clinical Trial
- Molecular Nutrition & Food Research 62(14)
- - M. Toral
  - M. Romero
  - A. Rodríguez‐Nogales
  - R. Jiménez
  - Iñaki Robles‐Vera
  - F. Algieri
  - N. Chueca-Porcuna
  - M. Sánchez
  - Néstor de la Visitación
  - M. Olivares
  - Federico García
  - F. Pérez-Vizcaino
  - J. Gálvez
  - J. Duarte
- PubMed: 29851248
- DOI: 10.1002/mnfr.201800033
6 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics
- 2018-06-28
- RCT
- Microbiome 6(1)
- - Janina A. Krumbeck
  - H. Rasmussen
  - R. Hutkins
  - Jennifer L Clarke
  - Krista M Shawron
  - A. Keshavarzian
  - J. Walter
- PubMed: 29954454
- DOI: 10.1186/s40168-018-0494-4
3 Insights on
- High evidence
- Highly Cited
Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet.
- 2018-06-22
- Clinical Trial · n = 10
- Journal of Proteome Research 17(8)
- - A. Martinic
  - J. Barouei
  - Zachary A. Bendiks
  - Darya O Mishchuk
  - Dustin D Heeney
  - Roy J Martin
  - M. Marco
  - C. Slupsky
- PubMed: 29931981
- DOI: 10.1021/acs.jproteome.8b00282
5 Insights on
- Low evidence
- Animal Study
Anti-obesity properties of the strain Bifidobacterium animalis subsp. lactis CECT 8145 in Zücker fatty rats.
- 2018-06-15
- RCT · n = 20
- Beneficial Microbes 9(4)
- - N. L. Carreras
  - P. Martorell
  - E. Chenoll
  - S. Genovés
  - Daniel Ramón
  - A. Aleixandre
- PubMed: 29695181
- DOI: 10.3920/BM2017.0141
19 Insights on
- Low evidence
- Animal Study
Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men.
- 2018-06-15
- RCT · n = 11
- Amino acids 51(1)
- - Diogo Bassinello
  - Vitor de Salles Painelli
  - Eimear Dolan
  - Manoel Lixandrão
  - Monique Cajueiro
  - Mariana de Capitani
  - Bryan Saunders
  - Craig Sale
  - Guilherme G Artioli
  - Bruno Gualano
  - Hamilton Roschel
- PubMed: 29905904
- DOI: 10.1007/s00726-018-2593-8
3 Insights on
- High evidence
A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children.
- 2018-06-15
- RCT · n = 129
- Beneficial Microbes 9(4)
- - P. Kosuwon
  - M. Lao-Araya
  - S. Uthaisangsook
  - C. Lay
  - J. Bindels
  - J. Knol
  - P. Chatchatee
- PubMed: 29633642
- DOI: 10.3920/BM2017.0110
3 Insights on
- High evidence
Comparative Genomic and Phenotypic Analysis of the Vaginal Probiotic Lactobacillus rhamnosus GR-1
- 2018-06-15
- Frontiers in Microbiology 9
- - M. Petrova
  - Jean M. Macklaim
  - S. Wuyts
  - T. Verhoeven
  - J. Vanderleyden
  - G. Gloor
  - S. Lebeer
  - G. Reid
- PubMed: 29963028
- DOI: 10.3389/fmicb.2018.01278
1 Insight on
- Improved Oxidative Stress Resistance
- Low evidence
Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study.
- 2018-06-15
- RCT · n = 141
- Beneficial Microbes 9(4)
- - M. Sudha
  - N. Jayanthi
  - M. Aasin
  - R.D. Dhanashri
  - T. Anirudh
- PubMed: 29695183
- DOI: 10.3920/BM2017.0129
11 Insights on
- High evidence
Effects of heat-treated Lactobacillus crispatus KT-11 strain consumption on improvement of oral cavity environment: a randomised double-blind clinical trial.
- 2018-06-15
- RCT · n = 16
- Beneficial Microbes 9(4)
- - K. Tobita
  - I. Watanabe
  - M. Tomokiyo
  - M. Saito
- PubMed: 29633644
- DOI: 10.3920/BM2017.0137
3 Insights on
- High evidence
Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice
- 2018-06-13
- Clinical Trial
- PLOS ONE 13(6)
- - S. Arai
  - N. Iwabuchi
  - Sachiko Takahashi
  - J. Xiao
  - F. Abe
  - S. Hachimura
- PubMed: 29897995
- DOI: 10.1371/journal.pone.0199018
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Potential Use of Bacillus coagulans in the Food Industry
- 2018-06-13
- Review
- Foods 7(6)
- - Gözde Konuray
  - Z. Erginkaya
- PubMed: 29899254
- DOI: 10.3390/foods7060092
2 Insights on
- Increased Thermal Resilience
- Increased Probiotic Activity
- Moderate evidence
- Highly Cited
Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8
- 2018-06-13
- Clinical Trial
- Nutrients 10(6)
- - H. M. Corpuz
  - Saki Ichikawa
  - Misa Arimura
  - Toshihiro Mihara
  - T. Kumagai
  - Takakazu Mitani
  - Soichiro Nakamura
  - S. Katayama
- PubMed: 29899283
- DOI: 10.3390/nu10060762
3 Insights on
- Low evidence
- Animal Study
Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
- 2018-06-12
- RCT · n = 388
- Probiotics and Antimicrobial Proteins 11(3)
- - Liqing Huang
  - L. Luo
  - Yaru Zhang
  - Zhong Wang
  - Z. Xia
- PubMed: 29948799
- DOI: 10.1007/s12602-018-9434-7
5 Insights on
- Low evidence
- Animal Study