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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Irritable bowel syndrome symptom severity improves equally with probiotic and placebo
- 2017-06-06
- RCT · n = 340
- World Journal of Gastroenterology 22(48)
- - Anna Lyra
  - M. Hillilä
  - T. Huttunen
  - Sofia Männikkö
  - M. Taalikka
  - Julia Tennilä
  - A. Tarpila
  - S. Lahtinen
  - A. Ouwehand
  - L. Veijola
- PubMed: 28082816
- DOI: 10.3748/wjg.v22.i48.10631
3 Insights on
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
Modulatory effects of l-carnitine plus l-acetyl-carnitine on neuroendocrine control of hypothalamic functions in functional hypothalamic amenorrhea (FHA).
- 2017-06-02
- Clinical Trial · n = 27
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 33(12)
- - Alessandro D Genazzani
  - Giulia Despini
  - Adam Czyzyk
  - Agnieszka Podfigurna
  - Tommaso Simoncini
  - Blazej Meczekalski
- PubMed: 28573875
- DOI: 10.1080/09513590.2017.1332587
4 Insights on
- Moderate evidence
The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy.
- 2017-06-02
- Review
- Oncotarget 8(35)
- - Ya-Hui Ding
  - Lin-Yan Qian
  - Jie Pang
  - Jing-Yang Lin
  - Qiang Xu
  - Li-Hong Wang
  - Dong-Sheng Huang
  - Hai Zou
- PubMed: 28938693
- DOI: 10.18632/oncotarget.18346
2 Insights on
- Reduced Inflammation
- Modulated Immune Response
- Low evidence
Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial.
- 2017-06-01
- RCT · n = 5,860
- JAMA ophthalmology 135(6)
- - María L Camacho-Barcia
  - Mònica Bulló
  - Jesús F Garcia-Gavilán
  - Miguel Ruiz-Canela
  - Dolores Corella
  - Ramón Estruch
  - Montserrat Fitó
  - Alfredo García-Layana
  - Fernando Arós
  - Miquel Fiol
  - José Lapetra
  - Lluis Serra-Majem
  - Xavier Pintó
  - Ana García-Arellano
  - Ernest Vinyoles
  - José Vicente Sorli
  - Jordi Salas-Salvadó
- PubMed: 28494067
- DOI: 10.1001/jamaophthalmol.2017.1076
1 Insight on
- Reduced Cataract Incidence
- High evidence
- Large Human Trial
Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity
- 2017-05-31
- RCT · n = 200
- Nutrients 9(6)
- - Ayoung Lee
  - Young Ju Lee
  - H. J. Yoo
  - Minkyung Kim
  - Yeeun Chang
  - Dong Seog Lee
  - J. H. Lee
- PubMed: 28561762
- DOI: 10.3390/nu9060558
14 Insights on
- High evidence
- Highly Cited
Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori.
- 2017-05-30
- Beneficial Microbes 8(3)
- - G. Marcial
  - J. Villena
  - G. Faller
  - A. Hensel
  - G. F. de Valdez
- PubMed: 28504579
- DOI: 10.3920/BM2016.0186
4 Insights on
- Low evidence
Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial
- 2017-05-30
- BMC Pediatrics 17(1)
- - J. Smilowitz
  - Jackelyn Moya
  - Melissa A. Breck
  - Chelsea Cook
  - A. Fineberg
  - K. Angkustsiri
  - M. Underwood
- PubMed: 28558732
- DOI: 10.1186/s12887-017-0886-9
13 Insights on
- Low evidence
- Rigorous Journal
Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice.
- 2017-05-30
- Clinical Trial
- Beneficial Microbes 8(3)
- - N. Barbieri
  - M. Herrera
  - S. Salva
  - J. Villena
  - S. Alvarez
- PubMed: 28504568
- DOI: 10.3920/BM2016.0152
4 Insights on
- Low evidence
- Animal Study
Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (TIM-1).
- 2017-05-30
- Beneficial Microbes 8(3)
- - D. Keller
  - R. V. Dinter
  - H. Cash
  - S. Farmer
  - Koen Venema
- PubMed: 28504581
- DOI: 10.3920/BM2016.0196
3 Insights on
- Low evidence
Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice
- 2017-05-25
- Clinical Trial
- Nutrients 9(6)
- - Xiaoyong Chen
  - Xin Zhao
  - Hongwei Wang
  - Zelin Yang
  - Jian Li
  - Huayi Suo
- PubMed: 28587089
- DOI: 10.3390/nu9060545
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice
- 2017-05-23
- Clinical Trial
- Nutrients 9(6)
- - Se-Eun Jang
  - Jin-Ju Jeong
  - Su-Young Choi
  - Hyun-Jee Kim
  - M. Han
  - Dong-Hyun Kim
- PubMed: 28545241
- DOI: 10.3390/nu9060531
5 Insights on
- Low evidence
- Animal Study
Study protocol: evaluation of the probiotic Lactobacillus Fermentum CECT5716 for the prevention of mastitis in breastfeeding women: a randomised controlled trial.
- 2017-05-19
- RCT · n = 600
- BMC pregnancy and childbirth 17(1)
- - Diana M Bond
  - Jonathan M Morris
  - Natasha Nassar
- PubMed: 28525984
- DOI: 10.1186/s12884-017-1330-8
3 Insights on
- High evidence
- Large Human Trial
The Genomic Basis of Lactobacilli as Health-Promoting Organisms.
- 2017-05-19
- Microbiology Spectrum 5(3)
- - E. Salvetti
  - P. O’Toole
- PubMed: 28643623
- DOI: 10.1128/microbiolspec.BAD-0011-2016
2 Insights on
- Increased Longevity
- Improved Overall Health
- Low evidence
Bifidobacteria and Their Health-Promoting Effects.
- 2017-05-19
- Microbiology Spectrum 5(3)
- - C. Hidalgo-Cantabrana
  - S. Delgado
  - L. Ruiz
  - P. Ruas-Madiedo
  - B. Sánchez
  - A. Margolles
- PubMed: 28643627
- DOI: 10.1128/microbiolspec.BAD-0010-2016
2 Insights on
- Increased Bifidobacterial Development
- Improved Immune System Maturation
- Low evidence
- Highly Cited
Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
- 2017-05-17
- Clinical Trial
- Nutrients 9(5)
- - M. G. Zubiría
  - S. Gambaro
  - María Amanda Rey
  - P. Carasi
  - M. Serradell
  - A. Giovambattista
- PubMed: 28513533
- DOI: 10.3390/nu9050470
7 Insights on
- Low evidence
- Animal Study
Cheese supplemented with probiotics reduced the Candida levels in denture wearers-RCT.
- 2017-05-16
- RCT
- Oral diseases 23(7)
- - T Y Miyazima
  - K H Ishikawa
  - Mpa Mayer
  - Smi Saad
  - Aem Nakamae
- PubMed: 28346730
- DOI: 10.1111/odi.12669
1 Insight on
- Reduced Oral Candida Level
- High evidence
Modulation of gut microbiota and increase in fecal water content in mice induced by administration of Lactobacillus kefiranofaciens DN1.
- 2017-05-08
- RCT · n = 16
- Food & Function 8(2)
- - Dana Jeong
  - Dong‐Hyeon Kim
  - Il‐Byeong Kang
  - Hyunsook Kim
  - K. Song
  - Hong-Seok Kim
  - K. Seo
- PubMed: 28121325
- DOI: 10.1039/c6fo01559j
4 Insights on
- Low evidence
- Animal Study
L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study.
- 2017-05-08
- RCT
- Human psychopharmacology 32(4)
- - Somaye Arabzadeh
  - Maryam Shahhossenie
  - Bita Mesgarpour
  - Farzin Rezaei
  - Mohammad Reza Shalbafan
  - Zahra Ghiasi
  - Shahin Akhondzadeh
- PubMed: 28485008
- DOI: 10.1002/hup.2584
1 Insight on
- Reduced Obsessive-Compulsive Symptoms
- High evidence
Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) on caecum microbioma and productive performance in broiler chickens
- 2017-05-04
- PLOS ONE 12(5)
- - A. De Cesare
  - F. Sirri
  - G. Manfreda
  - Paola Moniaci
  - A. Giardini
  - M. Zampiga
  - A. Meluzzi
- PubMed: 28472118
- DOI: 10.1371/journal.pone.0176309
8 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults.
- 2017-05-02
- RCT
- International journal of food sciences and nutrition 69(1)
- - Ewa Sicińska
  - Anna Brzozowska
  - Anna Brzozowska
  - Wojciech Roszkowski
  - Paul M Finglas
- PubMed: 28460586
- DOI: 10.1080/09637486.2017.1320536
1 Insight on
- Reduced Homocysteine Level
- High evidence
Effects of a Lactobacillus salivarius mixture on performance, intestinal health and serum lipids of broiler chickens
- 2017-05-01
- Clinical Trial
- PLOS ONE 12(5)
- - P. Shokryazdan
  - Mohammad Faseleh Jahromi
  - J. Liang
  - K. Ramasamy
  - C. C. Sieo
  - Y. Ho
- PubMed: 28459856
- DOI: 10.1371/journal.pone.0175959
7 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial.
- 2017-04-26
- RCT · n = 94
- Beneficial Microbes 8(2)
- - M. Takada
  - K. Nishida
  - Y. Gondo
  - H. Kikuchi-Hayakawa
  - H. Ishikawa
  - K. Suda
  - M. Kawai
  - R. Hoshi
  - Y. Kuwano
  - K. Miyazaki
  - K. Rokutan
- PubMed: 28443383
- DOI: 10.3920/BM2016.0150
6 Insights on
- High evidence
- Highly Cited
Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.
- 2017-04-26
- Clinical Trial
- Beneficial Microbes 8(2)
- - Christiane Danilo
  - E. Constantopoulos
  - Laurel A. K. McKee
  - Hao Chen
  - Jessica A. Regan
  - Yulia Lipovka
  - S. Lahtinen
  - Lotta Stenman
  - Thuy-Vi V. Nguyen
  - Kristian P. Doyle
  - Marvin J. Slepian
  - Zain I Khalpey
  - J. Konhilas
- PubMed: 28409534
- DOI: 10.3920/BM2016.0119
5 Insights on
- Low evidence
- Animal Study
Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats.
- 2017-04-26
- Clinical Trial
- Beneficial Microbes 8(2)
- - Satvinder Singh
  - R. Sharma
  - S. Malhotra
  - R. Pothuraju
  - U. Shandilya
- PubMed: 28008783
- DOI: 10.3920/BM2016.0090
5 Insights on
- Low evidence
- Animal Study
Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp. infantis in vitro and in humanised mice.
- 2017-04-26
- Beneficial Microbes 8(2)
- - Š. Musilová
  - Nikol Modrackova
  - P. Hermanová
  - Tomas Hudcovic
  - R. Svejstil
  - Vojtech Rada
  - V. Tejnecký
  - V. Bunesova
- PubMed: 28116928
- DOI: 10.3920/BM2016.0138
5 Insights on
- Low evidence
Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis
- 2017-04-24
- RCT · n = 5
- PLOS ONE 12(4)
- - L. Celiberto
  - R. Bedani
  - N. Dejani
  - Alexandra Ivo de Medeiros
  - José Antonio Sampaio Zuanon
  - L. C. Spolidorio
  - Maria Angela Tallarico Adorno
  - Maria Bernadete Amâncio Varesche
  - Fábio Carrilho Galvão
  - S. Valentini
  - G. Font de Valdez
  - E. Rossi
  - D. Cavallini
- PubMed: 28437455
- DOI: 10.1371/journal.pone.0175935
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Identification of proteins involved in the anti-inflammatory properties of Propionibacterium freudenreichii by means of a multi-strain study
- 2017-04-13
- Scientific Reports 7(1)
- - S. Deutsch
  - M. Mariadassou
  - P. Nicolas
  - S. Parayre
  - Rozenn Le Guellec
  - Victoria Chuat
  - V. Péton
  - C. Le Maréchal
  - J. Burati
  - V. Loux
  - V. Briard-Bion
  - J. Jardin
  - C. Ple
  - B. Foligné
  - G. Jan
  - H. Falentin
- PubMed: 28406170
- DOI: 10.1038/srep46409
1 Insight on
- Reduced Inflammation
- Low evidence
Evaluation of the Probiotic Strain Bifidobacterium longum subsp. Infantis CECT 7210 Capacities to Improve Health Status and Fight Digestive Pathogens in a Piglet Model
- 2017-04-11
- Clinical Trial · n = 72
- Frontiers in Microbiology 8
- - Emili Barba-Vidal
  - L. Castillejos
  - Paola López-Colom
  - M. Rivero Urgell
  - J. A. Moreno Muñoz
  - S. Martín-Orúe
- PubMed: 28443068
- DOI: 10.3389/fmicb.2017.00533
6 Insights on
- Low evidence
- Animal Study
Effect of combined consumption of Lactobacillus brevis KB290 and β-carotene on minor diarrhoea-predominant irritable bowel syndrome-like symptoms in healthy subjects: a randomised, double-blind, placebo-controlled, parallel-group trial.
- 2017-04-09
- RCT
- International journal of food sciences and nutrition 68(8)
- - Nobuo Fuke
  - Koichi Aizawa
  - Hiroyuki Suganuma
  - Tomohisa Takagi
  - Yuji Naito
- PubMed: 28391736
- DOI: 10.1080/09637486.2017.1311843
3 Insights on
- High evidence
Total Phenolic Content and Antioxidant Activity of Mycelial Extracts from the Medicinal Fungus Paecilomyces hepiali (Ascomycetes).
- 2017-04-07
- International Journal of Medicinal Mushrooms 19(1)
- - Lan Jiang
  - Yi Li
  - WEN-JING Wang
  - Abdessamad Imoulan
  - Yi‐Jian Yao
- PubMed: 28322145
- DOI: 10.1615/IntJMedMushrooms.v19.i1.40
1 Insight on
- Increased Antioxidant Activity
- Low evidence