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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Effect of Probiotic Supplementation on Cytokine Modulation in Athletes After a Bout of Exercise: A Systematic Review and Meta-Analysis.
- 2025-05-22
- Systematic Review · n = 19
- Sports medicine - open 11(1)
- - Diego Aparicio-Pascual
  - Vicente Javier Clemente-Suárez
  - José Francisco Tornero-Aguilera
  - Alejandro Rubio-Zarapuz
- PubMed: 40402402
- DOI: 10.1186/s40798-025-00860-7
2 Insights on
- Increased Interleukin-10 Levels
- Increased Anti-Inflammatory Cytokine IL-10
- High evidence
Microbial dynamics and Pseudomonas natural product production in milk and dairy products.
- 2025-05-22
- Review
- Natural product reports 42(5)
- - Ina Wasmuth
  - Christina Warinner
  - Pierre Stallforth
- PubMed: 40028703
- DOI: 10.1039/d4np00074a
2 Insights on
- Improved Gut Microbiota Diversity
- Improved Gastrointestinal Health
- Low evidence
Unravelling the gut-brain connection: a systematic review of migraine and the gut microbiome.
- 2025-05-21
- Systematic Review
- The journal of headache and pain 26(1)
- - Caroline W Mugo
  - Ella Church
  - Richard D Horniblow
  - Susan P Mollan
  - Hannah Botfield
  - Lisa J Hill
  - Alexandra J Sinclair
  - Olivia Grech
- PubMed: 40399789
- DOI: 10.1186/s10194-025-02039-7
4 Insights on
- High evidence
ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions.
- 2025-05-21
- Review
- Gut microbes 17(1)
- - Eduard Flores Ventura
  - Jonathan A Lane
  - Sondra Turjeman
  - Nikoletta Vidra
  - Gisela Adrienne Weiss
  - Gabriele Gross
  - Ching-Yu Chang
  - Omry Koren
- PubMed: 40397816
- DOI: 10.1080/19490976.2025.2501186
7 Insights on
- Low evidence
Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements.
- 2025-05-21
- Review
- Frontiers in psychology 16
- - Quancheng Yang
  - Yi Lv
  - Shenrong Gao
  - Yu Zhang
  - Xuejia Zhai
- PubMed: 40491948
- DOI: 10.3389/fpsyg.2025.1529339
2 Insights on
- Reduced Depression Symptoms
- Improved Depression Severity
- Low evidence
Intralesional injection of vitamin D3, platelet rich plasma versus their combination in treatment of keloid: a clinical, radiological and immunohistochemical study.
- 2025-05-20
- RCT
- Archives of dermatological research 317(1)
- - Nagwa Mohammad Elwan
  - Yomna Mazid El-Hamd Neinaa
  - Radwa Mostafa Elkhouly
  - Raghdah Magdy Dagher
  - Shady Fikry Abdel Salaam
- PubMed: 40392350
- DOI: 10.1007/s00403-025-04244-5
4 Insights on
- High evidence
Time-of-day-dependent effects of a green tea extract on postprandial glycemia and insulinemia in healthy adults: a randomized, controlled, double-blind, cross-over intervention.
- 2025-05-19
- RCT
- Food & function 16(10)
- - Noha Sulaimani
  - Erika J Rosbotham
  - Rebekah Warnock
  - Louise Polzella
  - Rebecca Judowski
  - Luca Nicolotti
  - Michael J Houghton
  - Gary Williamson
  - Maxine P Bonham
- PubMed: 40308148
- DOI: 10.1039/d4fo04843a
2 Insights on
- Improved Insulin Levels
- Reduced Postprandial Glucose
- High evidence
- Rigorous Journal
Impact of Lactiplantibacillus plantarum on the fermentation quality, nutritional enhancement, and microbial dynamics of whole plant soybean silage.
- 2025-05-19
- Frontiers in microbiology 16
- - He Meng
  - Yuwen Xu
  - Lin Wang
  - Jianping Wang
  - Bing Wang
  - Huimin Wu
  - Donghui Hou
  - Sui Wang
  - Xiaohong Tong
  - Yan Jiang
  - Shaodong Wang
- PubMed: 40458705
- DOI: 10.3389/fmicb.2025.1565951
2 Insights on
- Improved Microbial Community Composition
- Enhanced Lysine Biosynthesis
- Low evidence
Randomized trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain: 540 mg vs. 900 mg dose comparison.
- 2025-05-19
- RCT
- British journal of clinical pharmacology 91(9)
- - Robert J Shulman
  - Bruno P Chumpitazi
  - Daniel Gonzalez
  - Uttam Garg
  - Salma Musaad
  - Jiali Wen
  - Gregory L Kearns
- PubMed: 40390282
- DOI: 10.1002/bcp.70097
2 Insights on
- Reduced Colonic Contraction Frequency
- Reduced Whole Gut Contraction Frequency
- High evidence
Hypoglycemic, Antioxidant Activities, and Probiotic Characteristics of Lacticaseibacillus rhamnosus LBUX2302 Isolated from Stool Samples of Neonates.
- 2025-05-18
- Life (Basel, Switzerland) 15(5)
- - Pedro A Reyes-Castillo
  - Ana Laura Esquivel-Campos
  - Edgar Torres-Maravilla
  - Eduardo Zúñiga-León
  - Felipe Mendoza-Pérez
  - Rosa González-Vázquez
  - María Guadalupe Córdova-Espinoza
  - María Angélica Gutiérrez-Nava
  - Raquel González-Vázquez
  - Lino Mayorga-Reyes
- PubMed: 40430230
- DOI: 10.3390/life15050804
3 Insights on
- Low evidence
The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis.
- 2025-05-18
- Meta-Analysis
- Nutrients 17(10)
- - Mette Peters Michaelsen
  - Michelle Poulsen
  - Anne Ahrendt Bjerregaard
  - Maria Borgstrøm
  - Lotte Kraglund Poulsen
  - Maria Bach Chortsen
  - Sahra Gatten Henriksen
  - Ulrik Schiøler Kesmodel
- PubMed: 40431450
- DOI: 10.3390/nu17101710
3 Insights on
- High evidence
- Rigorous Journal
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.
- 2025-05-18
- RCT · n = 35
- Nutrients 17(10)
- - Lucrezia Laterza
  - Cesare Cremon
  - Gaetano Coppola
  - Carlo Romano Settanni
  - Rossella Maresca
  - Martina Strazzeri
  - Eleonora Durini
  - Valentina Petito
  - Franco Scaldaferri
  - Giorgio Gargari
  - Diego Mora
  - Elnaz Vojoudi Yazdi
  - Chiara Marangelo
  - Gianluca Ianiro
  - Lorenza Putignani
  - Maria Raffaella Barbaro
  - Giovanni Marasco
  - Giovanni Barbara
  - Antonio Gasbarrini
- PubMed: 40431448
- DOI: 10.3390/nu17101708
4 Insights on
- High evidence
- Rigorous Journal
Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East.
- 2025-05-17
- Review
- Sultan Qaboos University medical journal 25(1)
- - Shihab Al-Makhmari
  - Abir Al-Aufi
  - Saleh Al-Kindi
  - Maha Alriyami
  - Hussein Sakr
  - Mohamed-Rachid Boulassel
  - Khalid M Abu Khadra
  - Rahma Al-Haddabi
  - Ammar Boudaka
  - Jumana Saleh
- PubMed: 40641727
- DOI: 10.18295/2075-0528.2852
5 Insights on
- Low evidence
Riboflavin treatment in L-2-hydroxyglutaric aciduria: report on a pediatric patient and literature review.
- 2025-05-17
- Review
- Journal of applied genetics 67(2)
- - Patryk Lipiński
  - Elżbieta Ciara
  - Anna Bogdańska
  - Elżbieta Jurkiewicz
  - Anna Tylki-Szymańska
- PubMed: 40380983
- DOI: 10.1007/s13353-025-00974-4
5 Insights on
- Low evidence
Comparative Efficacy of Nutritional Supplements in Modulating Lung Function and Exercise Capacity in COPD Patients: A Network Meta-Analysis.
- 2025-05-17
- Systematic Review
- International journal of chronic obstructive pulmonary disease 20
- - Yi Zeng
  - Tian He
  - Xinyi Ma
  - Qiong Guo
  - Jing Zhang
- PubMed: 40401105
- DOI: 10.2147/copd.s517252
3 Insights on
- High evidence
Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis.
- 2025-05-16
- Meta-Analysis · n = 345
- Sultan Qaboos University medical journal 25(1)
- - Nasiba Al Maqrashi
  - Salim Al Busaidi
  - Sara Al-Rasbi
  - Abdullah M Al Alawi
  - Juhaina S Al-Maqbali
- PubMed: 40641714
- DOI: 10.18295/2075-0528.2848
3 Insights on
- High evidence
Wild Hops in Breadmaking Among Bulgarians: From History to Modern Perspectives and Future Potentials.
- 2025-05-16
- Review
- Foods (Basel, Switzerland) 14(10)
- - Anely Nedelcheva
  - Dauro Mattia Zocchi
  - Naji Sulaiman
  - Renata Sõukand
  - Andrea Pieroni
  - Antonella Pasqualone
- PubMed: 40428547
- DOI: 10.3390/foods14101767
1 Insight on
- Improved Antimicrobial Production
- Low evidence
Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review.
- 2025-05-15
- Systematic Review
- Journal of medicinal food 28(6)
- - Irislene Costa Pereira
  - Raquel Barros Passos
  - Camila de Meneses Caetano Viana
  - Isabele Frazão Mascarenhas
  - Glauto Tuquarre de Melo Nascimento
  - Felipe Cavalcanti Carneiro da Silva
  - João Marcelo de Castro E Sousa
  - Francisco Leonardo Torres-Leal
- PubMed: 40372963
- DOI: 10.1089/jmf.2023.0027
3 Insights on
- High evidence
Probiotic Lactobacillus Species Modulate Immune Responses During Vaginal Epithelial Cell Colonization.
- 2025-05-15
- The Journal of infectious diseases 232(3)
- - Marisa Valentine
  - Diletta Rosati
  - Axel Dietschmann
  - Tim B Schille
  - Mihai G Netea
  - Bernhard Hube
  - Mark S Gresnigt
- PubMed: 40372982
- DOI: 10.1093/infdis/jiaf221
3 Insights on
- Low evidence
Nutraceutical Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Path to Liver Health.
- 2025-05-13
- Review
- Nutrients 17(10)
- - Emmanouil Vrentzos
  - George Pavlidis
  - Emmanouil Korakas
  - Aikaterini Kountouri
  - Loukia Pliouta
  - George D Dimitriadis
  - Vaia Lambadiari
- PubMed: 40431398
- DOI: 10.3390/nu17101657
1 Insight on
- Improved Biochemical Change
- Moderate evidence
- Rigorous Journal
Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.
- 2025-05-13
- Meta-Analysis
- International journal of impotence research 38(1)
- - Sally Suharyani
  - Bella Amanda
  - Jesselyn Angellee
  - William William
  - Timotius Ivan Hariyanto
  - Reny I'tishom
- PubMed: 40360723
- DOI: 10.1038/s41443-025-01086-7
3 Insights on
- High evidence
Can soy isoflavones in combination with soy protein change serum levels of C-reactive protein among patients with chronic inflammatory diseases? A systematic review and meta-analysis on randomized controlled trials.
- 2025-05-12
- Meta-Analysis
- Journal of health, population, and nutrition 44(1)
- - Ali Gholami
  - Bahareh Amirkalali
  - Mitra Hariri
- PubMed: 40355968
- DOI: 10.1186/s41043-025-00902-6
1 Insight on
- Reduced C-Reactive Protein Levels
- High evidence
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.
- 2025-05-12
- RCT
- Frontiers in immunology 16
- - Samira Rastgoo
  - Katayoun Pourvali
  - Seyed Ahmad Raeissadat
  - Ghazaleh Eslamian
  - Hamid Zand
- PubMed: 40421021
- DOI: 10.3389/fimmu.2025.1570441
6 Insights on
- High evidence
Propolis supplementation on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis of randomized controlled trials.
- 2025-05-12
- Systematic Review
- Frontiers in nutrition 12
- - Hossein Bahari
  - Mostafa Shahraki Jazinaki
  - Mohsen Aliakbarian
  - Mohammad Rashidmayvan
  - Haniyeh Golafrouz
  - Iman Rahnama
  - Rozita Khodashahi
  - Mahsa Malekahmadi
- PubMed: 40421039
- DOI: 10.3389/fnut.2025.1542184
12 Insights on
- High evidence
Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players.
- 2025-05-12
- RCT
- Journal of the International Society of Sports Nutrition 22(1)
- - Reza Sadeghi
  - Mohammad Hemmatinafar
  - Fereshteh Eftekhari
  - Babak Imanian
  - Negar Koureshfard
- PubMed: 40353739
- DOI: 10.1080/15502783.2025.2505184
5 Insights on
- High evidence
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
- 2025-05-10
- Meta-Analysis
- Advances in nutrition (Bethesda, Md.) 16(6)
- - Sasan Amanat
  - Aimee L Dordevic
  - Amy Brodtmann
  - Barbara R Cardoso
- PubMed: 40355028
- DOI: 10.1016/j.advnut.2025.100440
2 Insights on
- Improved Cognitive Function
- Worsened Cognitive Function
- High evidence
Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review.
- 2025-05-09
- Review
- Current research in microbial sciences 8
- - George Michael Nicolas
- PubMed: 40337641
- DOI: 10.1016/j.crmicr.2025.100392
2 Insights on
- Reduced Pathogen Growth
- Reduced Pathogen Activity
- Low evidence
The dynamic linkage between covid-19 and nutrition: a review from a probiotics perspective using machine learning and bibliometric analysis.
- 2025-05-09
- Review
- Frontiers in nutrition 12
- - Christos Stefanis
  - Christina Tsigalou
  - Ioanna Bezirtzoglou
  - Gregoria Mitropoulou
  - Chrysoula Voidarou
  - Elisavet Stavropoulou
- PubMed: 40416372
- DOI: 10.3389/fnut.2025.1575130
1 Insight on
- Reduced COVID-19 Immune Support Needs
- Low evidence
Next-Generation Wound Care: A Scoping Review on Probiotic, Prebiotic, Synbiotic, and Postbiotic Cutaneous Formulations.
- 2025-05-09
- Review
- Pharmaceuticals (Basel, Switzerland) 18(5)
- - Patrícia Machado
  - Felipe Neme Ribeiro
  - Fernanda Cristina Wroblevski Giublin
  - Naomi Gerzvolf Mieres
  - Fernanda Stumpf Tonin
  - Roberto Pontarolo
  - Marcel Henrique Marcondes Sari
  - Raul Edison Luna Lazo
  - Luana Mota Ferreira
- PubMed: 40430523
- DOI: 10.3390/ph18050704
1 Insight on
- Improved Wound Healing
- Low evidence
Probiotics and mediterranean diet for breast cancer management and prevention?
- 2025-05-08
- Review
- Cell stress 9
- - Ehssan A Sharif-Askari
  - Khadija M Atoui
  - Ali K Mteyrek
  - Lama M Fawaz
- PubMed: 40417456
- DOI: 10.15698/cst2025.05.303
2 Insights on
- Improved Gut Microbiota Composition
- Supportive Effect in Breast Cancer Management
- Low evidence