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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Characteristics of exopolysaccharides from Paecilomyces hepiali and their simulated digestion and fermentation in vitro by human intestinal microbiota.
- 2024-05
- International journal of biological macromolecules 266
- - Zhongwei Wu
  - Rongxian Zhang
  - Jie Wang
  - Tenglong Li
  - Guang Zhang
  - Chaohui Zhang
  - Hong Ye
  - Xiaoxiong Zeng
- PubMed: 38552700
- DOI: 10.1016/j.ijbiomac.2024.131198
3 Insights on
- Low evidence
High Degree of Desensitization After 1 Year of Early-Life Peanut Oral Immunotherapy: Small Children Oral Immunotherapy (SmaChO) Randomized Controlled Trial.
- 2024-05
- RCT · n = 75
- The journal of allergy and clinical immunology. In practice 12(5)
- - Carina Uhl
  - Susanna Klevebro
  - Eva Sverremark-Ekström
  - Sandra G Tedner
  - Josef Brandström
  - Chrystalleni Papageorgiou
  - Erik Melén
  - Jon R Konradsen
  - Caroline Nilsson
  - Anna Asarnoj
- PubMed: 38428524
- DOI: 10.1016/j.jaip.2024.02.030
1 Insight on
- Increased Tolerated Peanut Protein Dose
- High evidence
Oral Administration of Bifidobacterium lactis Ameliorates Cognitive Deficits in Mice Intracerebroventricularly Administered Amyloid Beta via Regulation the Activation of Mitogen-activated Protein Kinases.
- 2024-05
- Food science of animal resources 44(3)
- - Jong Kyu Choi
  - Oh Yun Kwon
  - Seung Ho Lee
- PubMed: 38765290
- DOI: 10.5851/kosfa.2024.e5
3 Insights on
- Low evidence
Use of ancient grains for the management of diabetes mellitus: A systematic review and meta-analysis.
- 2024-05
- Meta-Analysis · n = 717
- Nutrition, metabolism, and cardiovascular diseases : NMCD 34(5)
- - Camilla Elena Magi
  - Laura Rasero
  - Edoardo Mannucci
  - Guglielmo Bonaccorsi
  - Francesco Ranaldi
  - Luigia Pazzagli
  - Paola Faraoni
  - Nadia Mulinacci
  - Stefano Bambi
  - Yari Longobucco
  - Ilaria Dicembrini
  - Paolo Iovino
- PubMed: 38553358
- DOI: 10.1016/j.numecd.2024.03.005
2 Insights on
- Reduced LDL Cholesterol
- Reduced Blood Cholesterol
- High evidence
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-response Meta-Analysis of Randomized Controlled Trials.
- 2024-05
- Meta-Analysis · n = 2,041
- Clinical therapeutics 46(5)
- - Amin Mirrafiei
  - Ahmad Jayedi
  - Sakineh Shab-Bidar
- PubMed: 38594107
- DOI: 10.1016/j.clinthera.2024.03.002
6 Insights on
- High evidence
Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- 2024-05
- Meta-Analysis · n = 1,033
- Current pharmaceutical biotechnology 25(7)
- - Hossein Hosseini
  - Farideh Ghavidel
  - Mahdieh Aliyari
  - Seyed Isaac Hashemy
  - Tannaz Jamialahmadi
  - Amirhossein Sahebkar
- PubMed: 37859312
- DOI: 10.2174/0113892010266109230928000134
6 Insights on
- High evidence
Improving sarcopenia in older adults: a systematic review and meta-analysis of randomized controlled trials of whey protein supplementation with or without resistance training.
- 2024-04
- Meta-Analysis · n = 1,154
- The journal of nutrition, health & aging 28(4)
- - Ming-Lin Li
  - Fei Zhang
  - Han-Yong Luo
  - Zi-Wei Quan
  - Yi-Fei Wang
  - Le-Tian Huang
  - Jia-He Wang
- PubMed: 38350303
- DOI: 10.1016/j.jnha.2024.100184
13 Insights on
- High evidence
The effect of probiotic Bifidobacterium lactis Bl-04 on innate antiviral responses invitro.
- 2024-04
- Heliyon 10(8)
- - Sinikka Latvala
  - Markus J Lehtinen
  - Sanna M Mäkelä
  - Derek Nedveck
  - Bryan Zabel
  - Ilmari Ahonen
  - Liisa Lehtoranta
  - Ronald B Turner
  - Jenni Liljavirta
- PubMed: 38665561
- DOI: 10.1016/j.heliyon.2024.e29588
5 Insights on
- Low evidence
Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT.
- 2024-04
- RCT · n = 630
- Psychiatry research 334
- - Sarah El-Heis
  - Sheila J Barton
  - Hsin Fang Chang
  - Heidi Nield
  - Vanessa Cox
  - Sevasti Galani
  - Wayne Cutfield
  - Shiao-Yng Chan
  - Keith M Godfrey
- PubMed: 38402742
- DOI: 10.1016/j.psychres.2024.115813
3 Insights on
- High evidence
- Large Human Trial
Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial.
- 2024-03
- RCT · n = 48
- Injury 55(3)
- - Faezeh Gouhari
  - Reza Zandi
  - Amir Mehrvar
  - Shahin Talebi
  - Zahra Vahdat Shariatpanahi
- PubMed: 38042695
- DOI: 10.1016/j.injury.2023.111253
6 Insights on
- High evidence
Metabolomics analysis of okara probiotic beverages fermented with Lactobacillus gasseri and Limosilactobacillus fermentum by LC-QTOF-MS/MS.
- 2024-03
- Food chemistry: X 21
- - Zihan Gao
  - Melody Chang Zhou
  - Jing Lin
  - Yuyun Lu
  - Shao Quan Liu
- PubMed: 38357377
- DOI: 10.1016/j.fochx.2024.101178
3 Insights on
- Low evidence
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
- 2024-03
- Meta-Analysis · n = 2,358
- Thyroid : official journal of the American Thyroid Association 34(3)
- - Valentina V Huwiler
  - Stephanie Maissen-Abgottspon
  - Zeno Stanga
  - Stefan Mühlebach
  - Roman Trepp
  - Lia Bally
  - Arjola Bano
- PubMed: 38243784
- DOI: 10.1089/thy.2023.0556
11 Insights on
- High evidence
Effects of L-Carnitine Supplementation on the Rate of Weight Gain and Biomarkers of Environmental Enteric Dysfunction in Children with Severe Acute Malnutrition: A Double-Blind Randomized Controlled Clinical Trial.
- 2024-03
- RCT · n = 98
- The Journal of nutrition 154(3)
- - Jinat Alam
  - Shah Mohammad Fahim
  - Md Ridwan Islam
  - Md Ashraful Alam
  - Md Amran Gazi
  - Tahmeed Ahmed
- PubMed: 38331348
- DOI: 10.1016/j.tjnut.2024.01.031
5 Insights on
- High evidence
Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism.
- 2024-03
- Clinical Trial · n = 25
- Physiological reports 12(6)
- - Lauren M Greaves
  - Kendall S Zaleski
  - Alexs A Matias
  - Abena O Gyampo
  - Gaia Giuriato
  - Meaghan Lynch
  - Brian Lora
  - Tawn Tomasi
  - Emma Basso
  - Emma Finegan
  - Jack Schickler
  - Massimo Venturelli
  - Justin A DeBlauw
  - Elena Shostak
  - Oliver E Blum
  - Stephen J Ives
- PubMed: 38537943
- DOI: 10.14814/phy2.15988
1 Insight on
- Reduced Muscle Deoxygenation Rate
- High evidence
Eight weeks of daily cottonseed oil intake attenuates postprandial angiopoietin-like proteins 3 and 4 responses compared to olive oil in adults with hypercholesterolemia: A secondary analysis of a randomized clinical trial.
- 2024-03
- RCT · n = 21
- Nutrition research (New York, N.Y.) 123
- - M Catherine Prater
  - Alex R Scheurell
  - Chad M Paton
  - Jamie A Cooper
- PubMed: 38295507
- DOI: 10.1016/j.nutres.2024.01.006
3 Insights on
- High evidence
Exploring the efficacy of a novel prebiotic-like growth promoter on broiler chicken production performance.
- 2024-03
- Clinical Trial
- Veterinary and animal science 23
- - Zulfqarul Haq
  - Ankur Rastogi
  - Ramesh Kumar Sharma
  - Pratiksha Raghuwanshi
  - Maninder Singh
  - Azmat Alam Khan
  - Syed Mudasir Ahmad
- PubMed: 38283334
- DOI: 10.1016/j.vas.2023.100331
6 Insights on
- Moderate evidence
Effect of Medicago sativa seed powder (Plus vitamin E vs. vitamin E alone) on semen analysis in men with idiopathic infertility: A double blind randomized clinical trial.
- 2024-03
- RCT · n = 60
- Journal of ethnopharmacology 322
- - Azita Sadough Shahmirzadi
  - Hamid Shafi
  - Hoda Shirafkan
  - Zahra Memariani
  - Narjes Gorji
  - Reihaneh Moeini
- PubMed: 38103848
- DOI: 10.1016/j.jep.2023.117606
3 Insights on
- High evidence
Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study.
- 2024-03
- RCT
- Behavioural brain research 460
- - Natsumi Mutoh
  - Masamichi Moriya
  - Chendong Xu
  - Kumiko Kato
  - Satoshi Arai
  - Noriyuki Iwabuchi
  - Miyuki Tanaka
  - Yin Jinghua
  - Ronko Itamura
  - Kaoru Sakatani
  - Shinichi Warisawa
- PubMed: 38128887
- DOI: 10.1016/j.bbr.2023.114820
2 Insights on
- Improved Sleep Quality
- Improved Mood
- High evidence
Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials.
- 2024-03
- Meta-Analysis · n = 61
- Journal of integrative medicine 22(2)
- - Zhen-Yu Ma
  - Shu-Ping Yang
  - Ying Li
  - Tian-Tian Xu
  - Ya-Lin Yang
  - Hui-Yong Yang
  - Heng-Bing Li
  - Le-Jin Zhou
  - Yong Diao
  - Su-Yun Li
- PubMed: 38413255
- DOI: 10.1016/j.joim.2024.01.008
3 Insights on
- High evidence
The Effects of L-Carnitine Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-response Meta-analysis.
- 2024-02
- Meta-Analysis · n = 1,412
- Clinical therapeutics 46(2)
- - Shiva Rahimipour Anaraki
  - Yasaman Aali
  - Mahlagha Nikbaf-Shandiz
  - Niloufar Rasaei
  - Alireza Khadem
  - Hossein Bahari
  - Zeinab Khalse
  - Samira Rastgoo
  - Farideh Shiraseb
  - Omid Asbaghi
- PubMed: 38101999
- DOI: 10.1016/j.clinthera.2023.11.002
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial.
- 2024-02
- RCT · n = 591
- The American journal of clinical nutrition 119(2)
- - Kristina Aagaard
  - Jens Richardt Møllegaard Jepsen
  - Astrid Sevelsted
  - David Horner
  - Rebecca Vinding
  - Julie Bøjstrup Rosenberg
  - Nicklas Brustad
  - Anders Eliasen
  - Parisa Mohammadzadeh
  - Nilofar Følsgaard
  - María Hernández-Lorca
  - Birgitte Fagerlund
  - Birte Y Glenthøj
  - Morten Arendt Rasmussen
  - Niels Bilenberg
  - Jakob Stokholm
  - Klaus Bønnelykke
  - Bjørn H Ebdrup
  - Bo Chawes
- PubMed: 38072183
- DOI: 10.1016/j.ajcnut.2023.12.002
2 Insights on
- Reduced Autism Risk
- Reduced Risk of ADHD
- High evidence
- Large Human Trial
Efficacy of parsley seed-supplemented bread in improving serum osteopontin level and renal health in obese women: A nutritional intervention study.
- 2024-02
- Clinical Trial · n = 85
- Clinical nutrition ESPEN 59
- - Hend A Essa
  - Salwa M El Shebini
  - Maha I A Moaty
  - Nihad H Ahmed
  - Ahmed M S Hussein
  - Magda S Mohamed
- PubMed: 38220388
- DOI: 10.1016/j.clnesp.2023.12.022
7 Insights on
- High evidence
The role of probiotics and synbiotics on treatment of gestational diabetes: systematic review and meta-analysis.
- 2024-02
- Review · n = 896
- AJOG global reports 4(1)
- - Arresta Vitasatria Suastika
  - I Gde Raka Widiana
  - Ni Nengah Dwi Fatmawati
  - Ketut Suastika
  - Ivana Beatrice Paulus
  - I Nengah Sujaya
- PubMed: 38322777
- DOI: 10.1016/j.xagr.2023.100285
9 Insights on
- High evidence
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- 2024-02
- Meta-Analysis · n = 1,284
- Current drug targets 25(2)
- - Mohammad Ali Goudarzi
  - Zahra Sohrabi
  - Mohammad Hashem Hashempur
  - Saeed Nosratabadi
  - Zahra Namkhah
  - Cain C T Clark
  - Neda Haghighat
- PubMed: 38141198
- DOI: 10.2174/0113894501272740231219072525
1 Insight on
- Reduced Body Weight
- High evidence
Antimutagenic activity of different forms of Bifidobacterium lactis probiotic against aflatoxin B1 by Ames method.
- 2024-02
- Toxicon : official journal of the International Society on Toxinology 239
- - Mehdi Pakizeh
  - Leila Nouri
  - Mohammad Hossein Azizi
- PubMed: 38211806
- DOI: 10.1016/j.toxicon.2024.107608
3 Insights on
- Low evidence
Lactobacillus amylovorus Promotes Lactose Utilization in Small Intestine and Enhances Intestinal Barrier Function in Intrauterine Growth Restricted Piglets.
- 2024-02
- Clinical Trial
- The Journal of nutrition 154(2)
- - Yujun Wu
  - Xiaoyi Liu
  - Youwei Zou
  - Xiangyu Zhang
  - Zhenyu Wang
  - Jie Hu
  - Dandan Han
  - Jinbiao Zhao
  - Zhaolai Dai
  - Junjun Wang
- PubMed: 38072153
- DOI: 10.1016/j.tjnut.2023.12.004
3 Insights on
- Moderate evidence
Sunflower seed extract supplementation reduces body fat in adults with obesity: A double-blind, randomized, placebo-controlled trial.
- 2024-02
- RCT · n = 100
- Nutrition research (New York, N.Y.) 122
- - Ha-Na Kim
  - Yun-Ah Lee
  - Sang-Wook Song
- PubMed: 38217909
- DOI: 10.1016/j.nutres.2023.12.004
4 Insights on
- High evidence
- Large Human Trial
Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta-analysis of randomized controlled trials.
- 2024-02
- Meta-Analysis
- International wound journal 21(2)
- - Mina Zamanifard
  - Morteza Nasiri
  - Fatemeh Yarahmadi
  - Sahar Zonoori
  - Omolbanin Razani
  - Zahra Salajegheh
  - Mohammad Imanipour
  - Seyed Mohammad Mohammadi
  - Nabi Jomehzadeh
  - Masoomeh Asadi
- PubMed: 38356150
- DOI: 10.1111/iwj.14760
3 Insights on
- High evidence
What is the effect of lactoferrin on oral and jawbone tissue repair? A systematic review.
- 2024-01
- Systematic Review · n = 742
- The British journal of oral & maxillofacial surgery 62(1)
- - Camila Barcellos Calderipe
  - Alini Cardoso Soares
  - Rafael Dos Santos Giorgis
  - Antonio Cesar Manentti Fogaça
  - Marcos Antonio Torriani
  - Luisa Quevedo Grave
  - Lauren Frenzel Schuch
  - Ana Carolina Uchoa Vasconcelos
- PubMed: 38042716
- DOI: 10.1016/j.bjoms.2023.10.019
1 Insight on
- Improved Wound Repair
- High evidence
The effect of vitamin B12 on idiopathic tinnitus.
- 2024-01
- RCT · n = 140
- American journal of otolaryngology 45(1)
- - Mohammadhossein Dadgarnia
  - Mohammad Mandegari
  - Vahid Zand
  - Sedighe Vaziribozorg
  - Hadi Zare-Zardini
  - Kimia Mousaviyazdi
  - Mohammadali Kheradmandi
- PubMed: 37647778
- DOI: 10.1016/j.amjoto.2023.104028
1 Insight on
- Reduced Tinnitus Severity
- High evidence
- Large Human Trial