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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Influence of synbiotic supplementation on performance, fecal consistency, cecal microbiome, and egg quality of hens during late laying phase.
- 2026-06
- RCT · n = 240
- Poultry science 105(6)
- - Koonphol Pongmanee
  - Konkawat Rassmidatta
  - Ting-Yu Lee
  - Jin-Seng Lin
  - Chanporn Chaosap
  - Kazeem D Adeyemi
  - Yuwares Ruangpanit
- PubMed: 41916054
- DOI: 10.1016/j.psj.2026.106851
3 Insights on
- High evidence
Lactobacillus salivarius D5 improves growth performance and immune function in broilers by reducing Escherichia coli abundance and regulating the gut microbiota.
- 2026-06
- Clinical Trial
- Poultry science 105(6)
- - Yingting You
  - Yonglong Zhu
  - Deshi Shi
  - Xiang Li
  - Muhammad Akhtar
  - Lizhen Ren
  - Guilin Fu
  - Yingying Chen
  - Qiujing Chen
  - Naiji Zhou
  - Zutao Zhou
  - Yuncai Xiao
- PubMed: 41905065
- DOI: 10.1016/j.psj.2026.106768
5 Insights on
- Moderate evidence
A 90-day oral toxicity study of heat-treated Bifidobacterium longum CECT 7347 (ES1 HT) Postbiotic in rats.
- 2026-06
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 212
- - Jay S Petrick
  - Roger Mariné-Casadó
  - Richard Day
  - Patricia Martorell
  - Carolina C Venditti
  - Empar Chenoll
- PubMed: 41724422
- DOI: 10.1016/j.fct.2026.116025
2 Insights on
- No Adverse Effects
- Maintained Safety with Repeated Oral Exposure
- Low evidence
- Animal Study
Multifaceted biocontrol mechanisms of Bacillus amyloliquefaciens F028 against Botrytis cinerea in postharvest tomato fruit.
- 2026-06
- International journal of food microbiology 455
- - Fu-Lai Han
  - Jin-Xiu Zhao
  - Ming-Yi Wang
  - Meng-Fei Li
  - Zhe Zhang
  - Xiao-Hang Cui
  - Yu-Fei Li
  - Hao-Jie Jiang
  - Qing-Xue Jiao
  - Jie Yang
  - Xin Liu
  - Guang-Chao Liu
- PubMed: 41946202
- DOI: 10.1016/j.ijfoodmicro.2026.111766
3 Insights on
- Low evidence
Engineering SCFAs with dietary fibre combinations: insights from a kinetic-microbiome single-subject longitudinal study.
- 2026-06
- Case Report
- Food research international (Ottawa, Ont.) 233
- - Christo Opperman
  - Charmaine Lloyd
  - Vishal Ratanpaul
  - Thi Thu Hao Van
  - Charles Brennan
  - Rajaraman Eri
- PubMed: 41942178
- DOI: 10.1016/j.foodres.2026.118846
1 Insight on
- Increased Butyrate Production
- Low evidence
Lactobacillus casei serves as a primary functional strain in fecal microbiota-mediated neuroprotection against cerebral ischemia/reperfusion injury.
- 2026-06
- Pathology, research and practice 282
- - Li Niu
  - Yumin Tan
  - Wenlu Cao
  - Ermin Wang
  - Feng Qi
- PubMed: 41946028
- DOI: 10.1016/j.prp.2026.156441
4 Insights on
- Low evidence
Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming.
- 2026-06
- RCT · n = 115
- Microbial pathogenesis 215
- - Rui Ma
  - Bo Jia
  - Xiangyang Zhang
  - Zhixin Zhao
  - Feiyan Zhao
  - Min-Tze Liong
  - Adli Ali
  - Intan Juliana Abd Hamid
  - Taufiq Hidayat Hasan
  - Fahisham Taib
  - Zhihong Sun
- PubMed: 41802657
- DOI: 10.1016/j.micpath.2026.108431
3 Insights on
- High evidence
In vitro and in vivo toxicological safety assessment of indigenous probiotic Lacticaseibacillus rhamnosus NCDC 610.
- 2026-06
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 212
- - Angela Joseph
  - S V Salini
  - Battula Narsimlu
  - Sachin Kumar
  - Manorama Kumari
  - Pradip V Behare
- PubMed: 41819674
- DOI: 10.1016/j.fct.2026.116060
2 Insights on
- Safety And Tolerability
- Reduced Virulence-Associated Activity
- Low evidence
Efficacy of Clematis chinensis Osbeck extract mouthwash as a complementary therapy for halitosis: A randomized, double-blind controlled trial.
- 2026-06
- RCT · n = 67
- Complementary therapies in medicine 98
- - Yu-Rin Kim
  - Seoul-Hee Nam
- PubMed: 41771359
- DOI: 10.1016/j.ctim.2026.103340
1 Insight on
- Reduced Halitosis
- High evidence
A comprehensive review on structural, chemical, and functional perspectives of dietary polysaccharide-driven gut microbiota modulation: Mechanisms and challenges.
- 2026-06
- Review
- Biochemistry and biophysics reports 46
- - Athira Jayasree Subhash
  - Mohamed Abdin
  - Gafar Babatunde Bamigbade
  - Maduni Paththuwe Arachchi
  - Naeem Ullah
  - Mutamed Ayyash
- PubMed: 42004542
- DOI: 10.1016/j.bbrep.2026.102575
1 Insight on
- Modulated Gut Microbiota
- Low evidence
The effect of red pepper/capsaicin on cardiovascular risk factors: a systematic review, meta-analysis, and GRADE assessment.
- 2026-06
- Meta-Analysis · n = 821
- Nutrition, metabolism, and cardiovascular diseases : NMCD 36(6)
- - Seyed Mojtaba Ghoreishy
  - Maryam Zeydi
  - Vahid Hadi
  - Nastaran Jafarbeglou
  - Yasamin Atabaki
  - Mohammad Keshavarz Mohammadian
  - Hossein Imani
  - Amirhossein Hemmati
  - Saeid Hadi
- PubMed: 41856833
- DOI: 10.1016/j.numecd.2026.104616
1 Insight on
- Reduced Total Cholesterol
- High evidence
Effect of packaging-induced oxygen microenvironments on the viability and metabolism of Lactobacillus paracasei in yogurt.
- 2026-06
- Food chemistry 513
- - Tao Sun
  - Siying Ren
  - Jiaqi Ouyang
  - Linze Liu
  - Jin Li
  - Xueyan Yun
  - Tungalag Dong
- PubMed: 41916224
- DOI: 10.1016/j.foodchem.2026.149078
3 Insights on
- Low evidence
Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk.
- 2026-06
- Biochimica et biophysica acta. Molecular basis of disease 1872(5)
- - Katarzyna Trzos
  - Tomasz Hutsch
  - Anastasiia Koval
  - Danuta Śmierciak
  - Gabriela Machaj
  - Leidy-Alejandra G Molano
  - Jacqueline Rehner
  - Md Mobashir Rahman
  - Maximilian Olaf Förster
  - Marcin Bednarek
  - Bahtiyar Yilmaz
  - Magdalena Pilarczyk-Zurek
  - Szymon Surma
  - Joanna Koziel
  - Marcin Krawczyk
  - Andreas Keller
  - Sören L Becker
  - Guillem Ylla
  - Jolanta Jura
  - Jerzy Kotlinowski
- PubMed: 41846103
- DOI: 10.1016/j.bbadis.2026.168216
1 Insight on
- Modulated Gut Microbiome Composition
- Low evidence
- Animal Study
New combination therapy of praziquantel and Lactobacillus plantarum for enhancing the treatment of clonorchiasis in mice.
- 2026-06
- Food and waterborne parasitology 43
- - Yeting Ma
  - Xiaocen Wang
  - Xu Zhang
  - Yanhui Yu
  - Zhenzhen Liu
  - Penglin Bao
  - Meng Liu
  - Yuru Wang
  - Xiaodan Yuan
  - Hongyu Wang
  - Pengtao Gong
  - Nan Zhang
  - Xin Li
  - Jianhua Li
- PubMed: 41969850
- DOI: 10.1016/j.fawpar.2026.e00333
6 Insights on
- Low evidence
Lack of genotoxicity and subchronic toxicity in safety assessment studies of a Clostridium beijerinckii formulation.
- 2026-06
- Toxicology reports 16
- - Esther J Yu
  - John Eid
  - Jaime Hernandez-Maldonado
  - Andrew Cheng
  - Tara Kurihara
  - Jason L Blum
  - Denise DiCarlo Emery
  - Barry Lynch
- PubMed: 41727408
- DOI: 10.1016/j.toxrep.2026.102212
1 Insight on
- No Adverse Effects
- Low evidence
Chemo-immunotherapeutic potential of Lactobacillus rhamnosus GG and its bioengineering for cancer therapy.
- 2026-05
- Biomaterials 328
- - Zhaonan Liu
  - Qing Guan
  - Jianfeng Xin
  - Wei Tang
  - Yu Chen
  - Jiaying Zhang
  - Junjie Chen
  - Shijie Bi
  - Peng Wang
  - Jun Liu
- PubMed: 41237436
- DOI: 10.1016/j.biomaterials.2025.123848
2 Insights on
- Increased Cell Death
- Enhanced Antitumor Immune Response
- Low evidence
Gegen Qinlian decoction alleviates bacterial diarrhea via Lactobacillus amylovorus-modulated restoration of colonic water transport through the cAMP/CFTR/AQP3 pathway.
- 2026-05
- Microbial pathogenesis 214
- - Zhen-Ye Luo
  - Zhe Chen
  - Feng-Lin Zhang
  - Chang-Shun Liu
  - Fei-Long Chen
  - Ze-Zhong Zheng
  - Xiao-Mei Tan
- PubMed: 41802655
- DOI: 10.1016/j.micpath.2026.108434
3 Insights on
- Low evidence
- Animal Study
Advocating gut-retina connection and microbiota mediated pathways in management of age-related macular degeneration: Preclinical to clinical perspective.
- 2026-05
- Review
- Ageing research reviews 117
- - Pramod V Waghmare
  - Kaustubh Ajit Kolekar
  - Bushra Bashir
  - Popat S Kumbhar
  - Kalpana S Patil
  - Gaurav Gupta
  - Parteek Prasher
  - Saurabh Kumar Jha
  - John Disouza
  - Shailendra S Gurav
  - Kamal Dua
  - Sachin Kumar Singh
- PubMed: 41759744
- DOI: 10.1016/j.arr.2026.103071
4 Insights on
- Low evidence
Functional bread containing synbiotic microcapsules loaded with Lactobacillus delbrueckii subsp. bulgaricus and enzymatic levan.
- 2026-05
- Food chemistry 511
- - Pınar Aytar Çelik
  - Dilan Barut Yavaş
  - Benay Çolak
  - Belma Nural Yaman
  - Özlem Erdal Altıntaş
  - Seda Doğan
  - Arzu Akın
  - Ebru Toksoy Öner
  - Ahmet Çabuk
- PubMed: 41812452
- DOI: 10.1016/j.foodchem.2026.148823
1 Insight on
- Increased Butyric Acid Production
- Low evidence
Effects of marine-derived Enterococcus durans YQ-6 on growth performance, intestinal health and microbial community of Leizhou black ducks.
- 2026-05
- RCT · n = 180
- Poultry science 105(5)
- - Yufeng Gou
  - Jiang Wu
  - Qiucheng Yao
  - Namula Zhao
  - Haiyan Wu
  - Zhibao Chen
- PubMed: 41691807
- DOI: 10.1016/j.psj.2026.106568
2 Insights on
- Improved Growth Performance
- Improved Intestinal Health
- High evidence
Structure-activity relationship of Laminaria japonica polysaccharide in promoting acetic acid synthesis by Lactobacillus rhamnosus GG.
- 2026-05
- Food research international (Ottawa, Ont.) 231
- - Jiabin Wu
  - Yaqing Lin
  - Hangyu Huang
  - Lin Wang
  - Yi Zhang
  - Jin Wang
  - Lei Pan
- PubMed: 41819923
- DOI: 10.1016/j.foodres.2026.118756
4 Insights on
- Low evidence
Probiotic combinations affect characteristics of chickpea yogurt: an investigation on physicochemical, rheological, and organoleptic properties and SCFAs fermentation.
- 2026-05
- Food chemistry 510
- - Haiyang Shi
  - Jing Luo
  - Zhexin Fan
  - Baokun Li
  - Xiaoqian Chen
  - Bingyuan Lei
  - Yingying Qiu
  - Jiancheng Wang
  - Tong Pan
  - Wenwei Lu
  - Zhifeng Fang
- PubMed: 41795525
- DOI: 10.1016/j.foodchem.2026.148756
2 Insights on
- Increased Short-Chain Fatty Acid Production
- Improved Short-Chain Fatty Acid Production
- Low evidence
Enhanced flavor and biogenic amine safety of salt-reduced Doubanjiang through co-inoculated fermentation with Pediococcus acidilactici and Zygosaccharomyces rouxii.
- 2026-05
- n = 226
- Food research international (Ottawa, Ont.) 232
- - Shenglan Liao
  - Youming Li
  - Jiayao Lin
  - Xiaoyi Wang
  - Yunhao Lu
  - Weiqin Deng
  - Qiang He
  - Yuanlong Chi
  - Zhenghong Xu
- PubMed: 41895950
- DOI: 10.1016/j.foodres.2026.118871
1 Insight on
- Improved Food Safety
- Moderate evidence
Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice.
- 2026-05
- Nutrition (Burbank, Los Angeles County, Calif.) 145
- - Piotr Wlaź
  - Karolina Skonieczna-Żydecka
  - Adrian Wiater
  - Daniel Styburski
  - Małgorzata Majewska
  - Anna Boguszewska-Czubara
  - Elżbieta Wyska
  - Alan González-Ibarra
  - Nikola Gapińska
  - Dorota Luchowska-Kocot
  - Renata Żelazowska
  - Marcin Grąz
  - Katarzyna Socała
- PubMed: 41576857
- DOI: 10.1016/j.nut.2025.113083
1 Insight on
- Increased threshold for myoclonic seizures
- Low evidence
- Animal Study
Probiotic and antibacterial properties of recombinant Lactococcus lactis expressing the fusion antimicrobial peptides BMAP18-BSN37 in mice and chickens.
- 2026-04
- Poultry science 105(4)
- - Ruibiao Wang
  - Yukai Lin
  - Yu Xia
  - Suxian Liu
  - Doudou Feng
  - Siyang Li
  - Tengyue Zhou
  - Huarun Sun
  - Jiyuan Shen
  - Bo Wen
  - Minghui Li
  - Chengshui Liao
  - Baoliang Qin
  - Jianhe Hu
  - Yuanfang Ma
  - Ke Ding
  - Lei Wang
- PubMed: 41616534
- DOI: 10.1016/j.psj.2026.106507
4 Insights on
- Low evidence
- Animal Study
Bacteriocin gene-mediated ecological adaptation of Bifidobacterium breve in the adult human gut.
- 2026-04
- Clinical Trial
- Cell genomics 6(4)
- - Jingyu Wang
  - Xin Qian
  - Qing Li
  - Zhiying Jin
  - Na Liu
  - Jianxin Zhao
  - Wei Chen
  - Shaopu Wang
  - Peijun Tian
- PubMed: 41421358
- DOI: 10.1016/j.xgen.2025.101106
2 Insights on
- Improved Stability of Gut Microbiota
- Improved Strain-Level Competitive Fitness
- Moderate evidence
Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions.
- 2026-04
- Review
- Journal of advanced research 82
- - Qiong Wu
  - Guangqi Gao
  - Lai-Yu Kwok
  - Huimin Lv
  - Zhihong Sun
- PubMed: 40651630
- DOI: 10.1016/j.jare.2025.07.005
2 Insights on
- Improved Sleep Quality
- Improved Insomnia
- Low evidence
Chitosan and sulfated glucan nanoparticles: A novel strategy for cryopreservation of Lactobacillus plantarum.
- 2026-04
- Food research international (Ottawa, Ont.) 230
- - Tingyue Deng
  - Xiaowei Shen
  - Zeyu Han
  - Jing Liu
  - Bolin Zhang
  - Hongfei Zhao
- PubMed: 41794538
- DOI: 10.1016/j.foodres.2026.118549
1 Insight on
- Improved Survival During Cryopreservation
- Low evidence
Oral delivery of engineered Lactococcus lactis microcapsules expressing antioxidant enzymes for inflammatory bowel disease: Mechanisms of intestinal barrier repair and microbiota modulation.
- 2026-04
- Materials today. Bio 37
- - Yue Meng
  - Chao Miao
  - Jiaxin Guo
  - Wei Zhang
  - Ling Guo
  - Yu Zhang
  - Yujun Jiang
- PubMed: 41716339
- DOI: 10.1016/j.mtbio.2026.102902
3 Insights on
- Low evidence
Exploring the Hypoglycemic Activity and Mechanism of Polyphenols From Highland Barley Through Lactobacillus acidophilus Fermentation.
- 2026-04
- Journal of food science 91(4)
- - Mengyao Zhu
  - Xu Guo
  - Yingying Chen
  - Shutao Sun
  - Qidong Ren
  - Muxuan Wang
  - Mengqi Zhang
  - Chao Liu
  - Ningyang Li
- PubMed: 41972482
- DOI: 10.1111/1750-3841.71061
4 Insights on
- Low evidence
- Rigorous Journal