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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.
- 2017-08-29
- RCT · n = 10
- Molecular Nutrition & Food Research 61(11)
- - A. Rodríguez‐Nogales
  - F. Algieri
  - J. Garrido-Mesa
  - T. Vezza
  - M. P. Utrilla
  - N. Chueca
  - Federico García
  - M. Olivares
  - M. Rodríguez-Cabezas
  - J. Gálvez
- PubMed: 28752563
- DOI: 10.1002/mnfr.201700144
12 Insights on
- Low evidence
- Highly Cited
- Animal Study
Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-α in adipose tissue.
- 2017-08-29
- Clinical Trial
- Molecular Nutrition & Food Research 61(11)
- - Dong‐Hyeon Kim
  - Dana Jeong
  - Il‐Byeong Kang
  - Hyunsook Kim
  - K. Song
  - K. Seo
- PubMed: 28691342
- DOI: 10.1002/mnfr.201700252
7 Insights on
- Low evidence
- Highly Cited
- Animal Study
Comparison of the effect of lavender and bitter orange on sleep quality in postmenopausal women: A triple-blind, randomized, controlled clinical trial.
- 2017-08-25
- RCT · n = 52
- Women & health 58(8)
- - Mahin Kamalifard
  - Azizeh Farshbaf-Khalili
  - Mahsa Namadian
  - Yunes Ranjbar
  - Sepideh Herizchi
- PubMed: 28749734
- DOI: 10.1080/03630242.2017.1353575
1 Insight on
- Improved Sleep Quality
- High evidence
Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial.
- 2017-08-24
- RCT
- Beneficial microbes 8(4)
- - S Manzano
  - J De Andrés
  - I Castro
  - J M Rodríguez
  - E Jiménez
  - I Espinosa-Martos
- PubMed: 28555502
- DOI: 10.3920/bm2017.0009
3 Insights on
- High evidence
- Rigorous Journal
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis.
- 2017-08-24
- Meta-Analysis · n = 702
- Critical reviews in food science and nutrition 58(15)
- - Amirhossein Sahebkar
  - Matteo Pirro
  - Maciej Banach
  - Dimitri P Mikhailidis
  - Stephen L Atkin
  - Arrigo F G Cicero
- PubMed: 28609140
- DOI: 10.1080/10408398.2017.1332572
4 Insights on
- High evidence
Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease.
- 2017-08-24
- Clinical Trial
- Beneficial Microbes 8(4)
- - J. Bailey
  - Valérie Vince
  - Neil Williams
  - T. Cogan
- PubMed: 28618865
- DOI: 10.3920/BM2016.0110
5 Insights on
- Low evidence
- Animal Study
Probiotic Bifidobacterium bifidum G9‐1 attenuates 5‐fluorouracil‐induced intestinal mucositis in mice via suppression of dysbiosis‐related secondary inflammatory responses
- 2017-08-24
- Clinical Trial
- Clinical and Experimental Pharmacology and Physiology 44(10)
- - S. Kato
  - N. Hamouda
  - Yoshitaro Kano
  - Yousuke Oikawa
  - Yoshiki Tanaka
  - Kenjiro Matsumoto
  - K. Amagase
  - M. Shimakawa
- PubMed: 28590519
- DOI: 10.1111/1440-1681.12792
3 Insights on
- Low evidence
- Animal Study
A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO).
- 2017-08-23
- RCT · n = 33
- The Journal of antimicrobial chemotherapy 72(11)
- - Anna K Barker
  - Megan Duster
  - Susan Valentine
  - Timothy Hess
  - Laurie Archbald-Pannone
  - Richard Guerrant
  - Nasia Safdar
- PubMed: 28961980
- DOI: 10.1093/jac/dkx254
4 Insights on
- High evidence
Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells
- 2017-08-23
- RCT
- Frontiers in Immunology 8
- - P. de Vos
  - Z. Mujagic
  - B. de Haan
  - R. Siezen
  - P. Bron
  - M. Meijerink
  - J. Wells
  - A. Masclee
  - M. Boekschoten
  - M. Faas
  - F. Troost
- PubMed: 28878772
- DOI: 10.3389/fimmu.2017.01000
6 Insights on
- High evidence
Lactobacillus reuteri DSM 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain.
- 2017-08-22
- RCT · n = 54
- Acta paediatrica (Oslo, Norway : 1992) 106(11)
- - M Maragkoudaki
  - G Chouliaras
  - R Orel
  - A Horvath
  - H Szajewska
  - A Papadopoulou
- PubMed: 28712129
- DOI: 10.1111/apa.13992
5 Insights on
- High evidence
Lactobacillus helveticus-fermented milk containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) improves cognitive function in healthy middle-aged adults: a randomised, double-blind, placebo-controlled trial
- 2017-08-18
- RCT
- International Journal of Food Sciences and Nutrition 69(3)
- - K. Ohsawa
  - F. Nakamura
  - Naoto Uchida
  - S. Mizuno
  - H. Yokogoshi
- PubMed: 28819993
- DOI: 10.1080/09637486.2017.1365824
4 Insights on
- High evidence
Peptidoglycan from Immunobiotic Lactobacillus rhamnosus Improves Resistance of Infant Mice to Respiratory Syncytial Viral Infection and Secondary Pneumococcal Pneumonia
- 2017-08-10
- Clinical Trial
- Frontiers in Immunology 8
- - Patricia Clua
  - P. Kanmani
  - H. Zelaya
  - A. Tada
  - A. Kober
  - S. Salva
  - S. Alvarez
  - S. Alvarez
  - H. Kitazawa
  - J. Villena
  - J. Villena
- PubMed: 28848552
- DOI: 10.3389/fimmu.2017.00948
3 Insights on
- Low evidence
- Animal Study
In Vitro and In Vivo Evaluation of Lactobacillus delbrueckii subsp. bulgaricus KLDS1.0207 for the Alleviative Effect on Lead Toxicity
- 2017-08-08
- Nutrients 9(8)
- - Bailiang Li
  - Da Jin
  - Shang-fu Yu
  - Smith Etareri Evivie
  - Zafarullah Muhammad
  - G. Huo
  - Fei Liu
- PubMed: 28786945
- DOI: 10.3390/nu9080845
4 Insights on
- Moderate evidence
Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides
- 2017-08-03
- Microbial Biotechnology 10(6)
- - C. Allonsius
  - M. V. D. van den Broek
  - I. De Boeck
  - Shari Kiekens
  - E. Oerlemans
  - F. Kiekens
  - K. Foubert
  - Dieter Vandenheuvel
  - P. Cos
  - P. Delputte
  - S. Lebeer
- PubMed: 28772020
- DOI: 10.1111/1751-7915.12799
3 Insights on
- Low evidence
- Highly Cited
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats
- 2017-07-31
- Clinical Trial
- Scientific Reports 7(1)
- - D. Shi
  - L. Lv
  - D. Fang
  - Wen-rui Wu
  - Chenxia Hu
  - Lichen Xu
  - Yanfei Chen
  - Jing Guo
  - Xinjun Hu
  - Ang Li
  - F. Guo
  - Jianzhong Ye
  - Yating Li
  - D. Andayani
  - Lanjuan Li
- PubMed: 28761060
- DOI: 10.1038/s41598-017-07091-1
3 Insights on
- Low evidence
- Animal Study
Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine.
- 2017-07-28
- Review
- Phytotherapy research : PTR 31(10)
- - Sidney J Stohs
- PubMed: 28752649
- DOI: 10.1002/ptr.5879
2 Insights on
- Increased Blood Pressure
- Increased Heart Rate
- Low evidence
Genome Characteristics of Lactobacillus fermentum Strain JDFM216 for Application as Probiotic Bacteria.
- 2017-07-28
- Journal of Microbiology and Biotechnology 27(7)
- - S. Jang
  - J. Heo
  - M. Park
  - Minho Song
  - J. N. Kim
  - S. Jo
  - Do-Youn Jeong
  - H. Lee
  - Younghoon Kim
  - Sangnam Oh
- PubMed: 28438015
- DOI: 10.4014/jmb.1703.03013
2 Insights on
- Improved Immune Response
- Extended Lifespan
- Low evidence
Evaluation of In Vivo Probiotic Efficiency of Bacillus amyloliquefaciens in Labeo rohita Challenged by Pathogenic Strain of Aeromonas hydrophila MTCC 1739
- 2017-07-25
- RCT
- Probiotics and Antimicrobial Proteins 10(2)
- - Ankita Nandi
  - G. Banerjee
  - Su Dan
  - K. Ghosh
  - A. Ray
- PubMed: 28744833
- DOI: 10.1007/s12602-017-9310-x
2 Insights on
- Improved Immune Function
- Reduced Hepatic Oxidative Stress
- High evidence
The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
- 2017-07-25
- RCT · n = 30
- Endocrine research 43(1)
- - Khadijeh Nasri
  - Sedighe Akrami
  - Maryam Rahimi
  - Mohsen Taghizadeh
  - Masoud Behfar
  - Mohammad Reza Mazandaranian
  - Abbas Kheiry
  - Mohammad Reza Memarzadeh
  - Zatollah Asemi
- PubMed: 28742409
- DOI: 10.1080/07435800.2017.1346661
6 Insights on
- High evidence
Influence of commercial inactivated yeast derivatives on the survival of probiotic bacterium Lactobacillus rhamnosus HN001 in an acidic environment.
- 2017-07-24
- AMB Express 7(1)
- - Mingzhan Toh
  - Shao Quan Liu
- PubMed: 28747041
- DOI: 10.1186/s13568-017-0456-4
1 Insight on
- Improved Survival of Probiotic Bacteria
- Low evidence
Probiotic Characteristics of Lactobacillus curvatus DN317, a Strain Isolated from Chicken Ceca
- 2017-07-24
- Probiotics and Antimicrobial Proteins 9(4)
- - M. Zommiti
  - N. Connil
  - J. B. Hamida
  - M. Ferchichi
- PubMed: 28741151
- DOI: 10.1007/s12602-017-9301-y
2 Insights on
- Reduced Serum Cholesterol Levels
- Improved Anti-Microbial Activity Against Campylobacter Jejuni
- Low evidence
Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis
- 2017-07-17
- Meta-Analysis
- World Journal of Gastroenterology 23(2)
- - Amélie Cayzeele-Decherf
  - Fanny Pélerin
  - S. Leuillet
  - Benoit Douillard
  - B. Housez
  - M. Cazaubiel
  - G. K. Jacobson
  - Peter Jüsten
  - P. Desreumaux
- PubMed: 28127207
- DOI: 10.3748/wjg.v23.i2.336
3 Insights on
- High evidence
- Rigorous Journal
Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials
- 2017-07-10
- Systematic Review
- International Journal of Obesity 41(11)
- - Louise Crovesy
  - M. Ostrowski
  - D. M. Ferreira
  - E. L. Rosado
  - Marcia Soares-Mota
- PubMed: 28792488
- DOI: 10.1038/ijo.2017.161
2 Insights on
- Reduced Body Weight
- Reduced Body Fat
- High evidence
- Highly Cited
Antifungal Microbial Agents for Food Biopreservation-A Review.
- 2017-07-08
- Review
- Microorganisms 5(3)
- - Marcia Leyva Salas
  - Jérôme Mounier
  - Florence Valence
  - Monika Coton
  - Anne Thierry
  - Emmanuel Coton
- PubMed: 28698479
- DOI: 10.3390/microorganisms5030037
1 Insight on
- Reduced Fungal Load
- Moderate evidence
- Highly Cited
Influence of the Fruit Juice Carriers on the Ability of Lactobacillus plantarum DSM20205 to Improve in Vitro Intestinal Barrier Integrity and Its Probiotic Properties.
- 2017-07-05
- Journal of Agricultural and Food Chemistry 65(28)
- - E. Valero-Cases
  - N. Roy
  - M. Frutos
  - R. Anderson
- PubMed: 28627169
- DOI: 10.1021/acs.jafc.7b01551
1 Insight on
- Improved Intestinal Barrier Function
- Low evidence
Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training.
- 2017-07-01
- RCT · n = 26
- Journal of Applied Physiology 123(1)
- - Y. Gepner
  - J. Hoffman
  - E. Shemesh
  - Jeffrey R Stout
  - D. Church
  - Alyssa N. Varanoske
  - H. Zelicha
  - I. Shelef
  - Yacov Chen
  - H. Frankel
  - I. Ostfeld
- PubMed: 28408697
- DOI: 10.1152/japplphysiol.01116.2016
3 Insights on
- High evidence
Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial.
- 2017-06-30
- RCT · n = 60
- Neurogastroenterology and motility 29(12)
- - M Martinelli
  - D Ummarino
  - F P Giugliano
  - E Sciorio
  - C Tortora
  - D Bruzzese
  - D De Giovanni
  - I Rutigliano
  - S Valenti
  - C Romano
  - A Campanozzi
  - E Miele
  - A Staiano
- PubMed: 28665038
- DOI: 10.1111/nmo.13145
1 Insight on
- Reduced Crying Time
- High evidence
Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats
- 2017-06-29
- RCT · n = 32
- PLOS ONE 12(6)
- - M. S. Ricoldi
  - F. Furlaneto
  - L. Oliveira
  - G. C. Teixeira
  - Jéssica P Pischiotini
  - A. L. Moreira
  - E. Ervolino
  - M. N. de Oliveira
  - C. Bogsan
  - S. Salvador
  - M. Messora
- PubMed: 28662142
- DOI: 10.1371/journal.pone.0179946
7 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effects of Bifidobacterium animalis subsp. lactis BB-12® on the lipid/lipoprotein profile and short chain fatty acids in healthy young adults: a randomized controlled trial
- 2017-06-29
- RCT · n = 30
- Nutrition Journal 16(1)
- - Yujin Lee
  - Zhaoyong Ba
  - R. Roberts
  - C. Rogers
  - J. Fleming
  - Huicui Meng
  - E. Furumoto
  - P. Kris-Etherton
- PubMed: 28662676
- DOI: 10.1186/s12937-017-0261-6
8 Insights on
- High evidence
Combination of Metabolomic and Proteomic Analysis Revealed Different Features among Lactobacillus delbrueckii Subspecies bulgaricus and lactis Strains While In Vivo Testing in the Model Organism Caenorhabditis elegans Highlighted Probiotic Properties
- 2017-06-28
- Frontiers in Microbiology 8
- - E. Zanni
  - Emily Schifano
  - S. Motta
  - F. Sciubba
  - C. Palleschi
  - P. Mauri
  - G. Perozzi
  - D. Uccelletti
  - C. Devirgiliis
  - A. Miccheli
- PubMed: 28702021
- DOI: 10.3389/fmicb.2017.01206
9 Insights on
- Low evidence