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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Dose-Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies.
- 2024-11-26
- Meta-Analysis · n = 747
- Nutrients 16(23)
- - Yuanyuan Dong
  - Darren C Greenwood
  - James Webster
  - Chinwe Uzokwe
  - Jinhui Tao
  - Laura J Hardie
  - Janet E Cade
- PubMed: 39683447
- DOI: 10.3390/nu16234050
1 Insight on
- Increased Rheumatoid Arthritis Risk
- High evidence
- Rigorous Journal
Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.
- 2024-11-26
- RCT · n = 126
- BMC gastroenterology 24(1)
- - Jing Yu
  - Chen Cui
  - Kai Ma
  - Peng Yang
  - Yizhou Jiang
  - Xiaoyong Wang
- PubMed: 39592940
- DOI: 10.1186/s12876-024-03524-0
1 Insight on
- Increased Helicobacter pylori Eradication Rate
- High evidence
- Large Human Trial
Effects of Mentha on blood pressure: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
- 2024-11-25
- Meta-Analysis
- BMC complementary medicine and therapies 24(1)
- - Faezeh Nematolahi
  - Abbas Mohtashamian
  - Ghazal Kaveh
  - Nasrin Sharifi
  - Alireza Milajerdi
- PubMed: 39587518
- DOI: 10.1186/s12906-024-04701-0
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
Uncovering the Probiotic Supplement Landscape: Market Offerings, Sales Patterns, and Future Forecasts Using Machine Learning Approach - A Case Study of Montenegro.
- 2024-11-25
- Observational
- Probiotics and antimicrobial proteins 17(6)
- - Martinović Anđela
  - Martinović Ivan
  - Diego Mora
  - Stefania Arioli
- PubMed: 39581930
- DOI: 10.1007/s12602-024-10400-6
4 Insights on
- Moderate evidence
- Rigorous Journal
Therapeutic effect of total glucosides of paeony on IgA vasculitis nephritis: progress and prospects.
- 2024-11-25
- Review
- Molecular biology reports 52(1)
- - Zhifeng Wang
  - Jiao Yang
  - Pengfen He
  - Junfeng Lan
  - Ting Shi
  - Shuangfeng Xu
  - Zhihui Hao
  - Yujiang Xi
  - Jian Wang
  - Ping He
- PubMed: 39585482
- DOI: 10.1007/s11033-024-10041-6
4 Insights on
- Low evidence
Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity.
- 2024-11-24
- Review
- Current issues in molecular biology 46(12)
- - Bogdana Virgolici
  - Maria-Zinaida Dobre
  - Daciana Costina Andrada Stefan
- PubMed: 39727928
- DOI: 10.3390/cimb46120800
5 Insights on
- Low evidence
Effect of Micronutrients on HIV-Related Clinical Outcomes Among Adults Living With HIV on Antiretroviral Therapy: Systematic Review and Meta-analysis.
- 2024-11-22
- Meta-Analysis · n = 4,000
- Nutrition reviews 83(7)
- - Elile Monisola Okoka
  - Moshood Abiodun Kuyebi
  - Oluwafemi Temitayo Oyadiran
  - Temitayo Rebecca Okusanya
  - Emmanuella Onaku
  - Moshood Olanrewaju Omotayo
  - Ajibola Ibraheem Abioye
- PubMed: 39576658
- DOI: 10.1093/nutrit/nuae171
7 Insights on
- High evidence
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
- 2024-11-21
- Systematic Review · n = 1,226
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 169(1)
- - Ling He
  - Yulin Fan
  - Yuanmei Hu
  - Chunhua Tian
  - Ying Tian
  - Jidong Zhang
  - Yanping Ren
  - Jun Tan
- PubMed: 39569767
- DOI: 10.1002/ijgo.16032
3 Insights on
- High evidence
Different infant formulas can activate toll-like receptor 9 in vitro and inhibit interleukin 6 in human primary intestinal epithelial cells.
- 2024-11-21
- European journal of nutrition 64(1)
- - Kathrin Hedegger
  - Theresa Hommel
  - Monika Schaubeck
  - Martina Gimpfl
  - Maik Dahlhoff
- PubMed: 39567370
- DOI: 10.1007/s00394-024-03507-7
2 Insights on
- Reduced Intestinal Inflammation
- Reduced IL6 Production in Intestinal Epithelial Cells
- Low evidence
- Rigorous Journal
The Effects of Okra Consumption on Glycemic Parameters and Lipid Profile in Adults: A Systematic Review and Meta-Analysis.
- 2024-11-20
- Review · n = 521
- Food science & nutrition 12(12)
- - Xiaolei Zhang
  - Jinxin Miao
  - Yagang Song
  - Mingsan Miao
- PubMed: 39723095
- DOI: 10.1002/fsn3.4599
4 Insights on
- High evidence
Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes.
- 2024-11-19
- Meta-Analysis · n = 5,569
- The Cochrane database of systematic reviews 2024(11)
- - Kiattisak Kongwattanakul
  - Chatuporn Duangkum
  - Chetta Ngamjarus
  - Pisake Lumbiganon
  - Anna Cuthbert
  - Jo Weeks
  - Jen Sothornwit
- PubMed: 39560075
- DOI: 10.1002/14651858.cd007079.pub4
12 Insights on
- High evidence
Health Benefits of Prebiotics, Probiotics, Synbiotics, and Postbiotics.
- 2024-11-19
- Review
- Nutrients 16(22)
- - Nasser Al-Habsi
  - Maha Al-Khalili
  - Syed Ariful Haque
  - Moussa Elias
  - Nada Al Olqi
  - Tasnim Al Uraimi
- PubMed: 39599742
- DOI: 10.3390/nu16223955
2 Insights on
- Improved Immune Function
- Improved Cholesterol Levels
- Moderate evidence
- Rigorous Journal
Daily intake of a dairy-based nutritional supplement improved self-reported gastrointestinal symptoms and modulated microbiota in adult Chinese volunteers.
- 2024-11-19
- Observational · n = 46
- Scientific reports 14(1)
- - Klaudyna Borewicz
  - Yifan Zhao
  - Yaqiong Zhu
- PubMed: 39562633
- DOI: 10.1038/s41598-024-79360-9
4 Insights on
- High evidence
- Rigorous Journal
Meta-analysis of the effect of sophora flavescens on tumor metastasis-induced bone neuropathic pain.
- 2024-11-19
- Systematic Review · n = 463
- Frontiers in pharmacology 15
- - Cheng Chang
  - Di Sun
  - Zhilei Zhang
  - Lei He
  - Qiang Wang
  - Yingchao Shen
  - Hengzhou Zhu
  - Donghua Fan
- PubMed: 39629083
- DOI: 10.3389/fphar.2024.1474982
2 Insights on
- Reduced Pain Intensity
- Improved Performance Status
- High evidence
Healthy lifestyle choices: new insights into vitiligo management.
- 2024-11-18
- Meta-Analysis · n = 542
- Frontiers in immunology 15
- - Xin Liang
  - Fei Guo
  - Qian Fan
  - Xiaoce Cai
  - Jiao Wang
  - Jiale Chen
  - Fang Liu
  - Yuhua Du
  - Yan Chen
  - Xin Li
- PubMed: 39624091
- DOI: 10.3389/fimmu.2024.1440705
8 Insights on
- High evidence
Orange Peel Lactiplantibacillus plantarum: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity.
- 2024-11-18
- Pharmaceutics 16(11)
- - Elisa Corazza
  - Asia Pizzi
  - Carola Parolin
  - Barbara Giordani
  - Angela Abruzzo
  - Federica Bigucci
  - Teresa Cerchiara
  - Barbara Luppi
  - Beatrice Vitali
- PubMed: 39598593
- DOI: 10.3390/pharmaceutics16111470
2 Insights on
- Reduced Pathogen Growth
- Reduced Inflammation
- Low evidence
Modulation of Serum Metabolic Profiles by Bifidobacterium breve BBr60 in Obesity: A Randomized Controlled Trial.
- 2024-11-17
- RCT · n = 75
- Foods (Basel, Switzerland) 13(22)
- - Ying Wu
  - Dejiao Gao
  - Yujia Pan
  - Yao Dong
  - Zhouya Bai
  - Shaobin Gu
- PubMed: 39594072
- DOI: 10.3390/foods13223655
3 Insights on
- High evidence
The Impact of Probiotics on Clinical Symptoms and Peripheral Cytokines Levels in Parkinson's Disease: Preliminary In Vivo Data.
- 2024-11-15
- RCT
- Brain sciences 14(11)
- - Luca Magistrelli
  - Elena Contaldi
  - Annalisa Visciglia
  - Giovanni Deusebio
  - Marco Pane
  - Angela Amoruso
- PubMed: 39595910
- DOI: 10.3390/brainsci14111147
4 Insights on
- High evidence
Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial.
- 2024-11-15
- RCT
- Frontiers in nutrition 11
- - Ke Chen
  - Kaihong Zeng
  - Shanshan Jin
  - Yu Ma
  - Limei Cai
  - Ping Xu
  - Yang Nie
  - Li Luo
  - Qinghua Yu
  - Changqi Liu
- PubMed: 39619284
- DOI: 10.3389/fnut.2024.1479186
5 Insights on
- High evidence
Impact of L-carnitine supplementation on gastric emptying and bowel function in pediatric ketogenic diet therapy: a clinical trial.
- 2024-11-15
- RCT · n = 30
- Scientific reports 14(1)
- - May Fouad Nassar
  - Mennatallah Osama Shata
  - Shrouk Mohamed Awadallah
  - Mennatallah Ayman Youssef
  - Haya Essam Ibrahim
- PubMed: 39543202
- DOI: 10.1038/s41598-024-78779-4
4 Insights on
- High evidence
- Rigorous Journal
Carnosine Supplementation Has No Effect on Inflammatory Markers in Adults with Prediabetes and Type 2 Diabetes: A Randomised Controlled Trial.
- 2024-11-15
- RCT · n = 88
- Nutrients 16(22)
- - Saeede Saadati
  - Maximilian de Courten
  - Cyril Deceneux
  - Magdalena Plebanski
  - David Scott
  - Jakub Mesinovic
  - Paul Jansons
  - Giancarlo Aldini
  - James Cameron
  - Jack Feehan
  - Aya Mousa
  - Barbora de Courten
- PubMed: 39599686
- DOI: 10.3390/nu16223900
10 Insights on
- High evidence
- Rigorous Journal
Investigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study.
- 2024-11-15
- RCT
- Journal of Alzheimer's disease : JAD 102(3)
- - Yu Fung Yau
  - Irwin K Cheah
  - Rathi Mahendran
  - Richard My Tang
  - Ru Yuan Chua
  - Rachel Es Goh
  - Lei Feng
  - Jialiang Li
  - Ee Heok Kua
  - Christopher Chen
  - Barry Halliwell
- PubMed: 39544014
- DOI: 10.1177/13872877241291253
2 Insights on
- Improved Attention Span
- Stabilized Neurofilament Light Chain Level
- High evidence
Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review.
- 2024-11-14
- Systematic Review
- Environmental geochemistry and health 46(12)
- - Maria-Nefeli Georgaki
  - Sophia Tsokkou
  - Antonios Keramas
  - Theodora Papamitsou
  - Sofia Karachrysafi
  - Nerantzis Kazakis
- PubMed: 39541030
- DOI: 10.1007/s10653-024-02297-5
1 Insight on
- Improved Fasting Plasma Glucose
- High evidence
Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women.
- 2024-11-14
- RCT
- Nutrients 16(22)
- - Maria Imperatrice
  - Anissa Lasfar
  - Colin A J van Kalkeren
  - Freddy Troost
- PubMed: 39599665
- DOI: 10.3390/nu16223879
6 Insights on
- High evidence
- Rigorous Journal
L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials.
- 2024-11-13
- Meta-Analysis · n = 393
- BMC cardiovascular disorders 24(1)
- - Zahra Mohammadi
  - Mahdi Ravankhah
  - Mohammad Ahmadi
  - Omid Keshavarzian
  - Isaac Azari
  - Mozhan Abdollahi
  - Mehdi Rezaei
  - Hamed Akbari
- PubMed: 39538180
- DOI: 10.1186/s12872-024-04318-8
5 Insights on
- High evidence
The Effect of Spirulina Supplementation on Blood Pressure in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Clinical Trials.
- 2024-11-11
- Meta-Analysis
- Phytotherapy research : PTR 39(1)
- - Hamidreza Shiri
  - Javad Yasbolaghi Sharahi
  - Maryam Alizadeh Sani
  - Seyyed Mohammad Javad Mousavi
  - Mohammad Hadi Nematollahi
  - Ali Akbar Soleimani
  - Jamal Amri
  - Ghodratollah Panahi
- PubMed: 39529406
- DOI: 10.1002/ptr.8377
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
Microbiological profile of patients with generalized gingivitis undergoing periodontal therapy and administration of Bifidobacterium animalis subsp. lactis HN019: A randomized clinical trial.
- 2024-11-11
- RCT · n = 30
- PloS one 19(11)
- - Flavia Furlaneto
  - Yara Loyanne de Almeida Silva Levi
  - Débora de Souza Ferreira Sávio
  - Izadora Cianfa Firmino da Silveira
  - Adriana Miranda de Oliveira
  - Talita Gomes Baêta Lourenço
  - Marcella Costa Ribeiro
  - Pedro Henrique Felix Silva
  - Sergio Luiz de Souza Salvador
  - Ana Paula Vieira Colombo
  - Michel Reis Messora
- PubMed: 39527605
- DOI: 10.1371/journal.pone.0310529
3 Insights on
- High evidence
Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation.
- 2024-11-11
- Journal of nanobiotechnology 22(1)
- - Jinyan Li
  - Mengdie Shi
  - Yubo Wang
  - Jinyan Liu
  - Shuiping Liu
  - Weili Kang
  - Xianjiao Liu
  - Xingxiang Chen
  - Kehe Huang
  - Yunhuan Liu
- PubMed: 39529091
- DOI: 10.1186/s12951-024-02979-3
4 Insights on
- Low evidence
- Animal Study
Effects of Nigella sativa on disease activity, T lymphocytes and inflammatory cytokine profiles in pediatric systemic lupus erythematosus: A randomized controlled trial.
- 2024-11-11
- RCT · n = 32
- Narra J 4(3)
- - Wisnu Barlianto
  - Desy Wulandari
  - Tita L Sari
  - Rafika R Rachmaningrum
  - Rayi I Asasain
- PubMed: 39816053
- DOI: 10.52225/narra.v4i3.1063
6 Insights on
- High evidence
Effects of Vitamin C Supplements on Clinical Outcomes and Hospitalization Duration for Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis.
- 2024-11-11
- Meta-Analysis · n = 3,429
- Nutrition reviews 83(7)
- - Maorong Qin
  - Kun Xu
  - Zhuo Chen
  - Xiaojie Wen
  - Yifu Tang
  - Yangyu Gao
  - Hao Zhang
  - Xingming Ma
- PubMed: 39527016
- DOI: 10.1093/nutrit/nuae154
4 Insights on
- High evidence