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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Therapeutic Potential of Gynostemma pentaphyllum Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
- 2025-02-21
- RCT
- Nutrients 17(5)
- - Jihyun Lee
  - Yongxun Jin
  - Xinrui Zhang
  - Myoungrae Kim
  - Ayoung Koh
  - Shuyi Zhou
  - Changhyun Lee
  - Minji Seo
  - Shinjae Kim
  - Suye Jo
  - Youngjoo Kim
  - Seri Kwon
  - Kyuhan Kim
  - Chanyeong Heo
- PubMed: 40077637
- DOI: 10.3390/nu17050767
5 Insights on
- High evidence
- Rigorous Journal
Microencapsulation and Probiotic Characterization of Lactiplantibacillus plantarum LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis.
- 2025-02-20
- Nutrients 17(5)
- - Cynthia Garfias Noguez
  - Morayma Ramírez Damián
  - Alicia Ortiz Moreno
  - Yazmín Karina Márquez Flores
  - Liliana Alamilla Beltrán
  - Mario Márquez Lemus
  - Luis G Bermúdez Humarán
  - María Elena Sánchez Pardo
- PubMed: 40077619
- DOI: 10.3390/nu17050749
1 Insight on
- Reduced Ulcerative Colitis Symptoms
- Low evidence
- Rigorous Journal
- Animal Study
Add-on effects of total glucosides of paeony on conventional therapies for psoriasis: a systematic review and meta-analysis of randomized controlled trials.
- 2025-02-19
- Systematic Review · n = 140
- Frontiers in pharmacology 16
- - Ziqing Li
  - Jie Lu
  - Kewen Guan
  - Haiwen Liang
  - Chuanjian Lu
  - Jingjie Yu
- PubMed: 40046738
- DOI: 10.3389/fphar.2025.1527288
1 Insight on
- Reduced Psoriasis Area and Severity Index Score
- High evidence
Genomic insights into the beneficial potential of Bifidobacterium and Enterococcus strains isolated from Cameroonian infants.
- 2025-02-19
- Observational · n = 26
- Microbial genomics 11(2)
- - Pierre Marie Kaktcham
  - Magdalena Kujawska
  - Edith Marius Foko Kouam
  - Laverdure Tchamani Piame
  - Michele Letitia Tchabou Tientcheu
  - Julia Mueller
  - Angela Felsl
  - Bastian-Alexander Truppel
  - François Zambou Ngoufack
  - Lindsay J Hall
- PubMed: 39969280
- DOI: 10.1099/mgen.0.001354
1 Insight on
- Detected Antimicrobial Resistance Genes
- Low evidence
Characterization and Anti-Inflammatory Effects of Akkermansia muciniphila-Derived Extracellular Vesicles.
- 2025-02-19
- Microorganisms 13(2)
- - Sasa Zhao
  - Jie Xiang
  - Minhazul Abedin
  - Jingyi Wang
  - Zhiwen Zhang
  - Zhongwei Zhang
  - Hua Wu
  - Junsong Xiao
- PubMed: 40005829
- DOI: 10.3390/microorganisms13020464
2 Insights on
- Reduced Intestinal Inflammation
- Reduced Oxidative Stress
- Low evidence
Targeting gut microbiota dysbiosis in inflammatory bowel disease: a systematic review of current evidence.
- 2025-02-18
- Systematic Review
- Frontiers in medicine 12
- - Asmaa Farah
  - Pradipta Paul
  - Anfal Sher Khan
  - Aparajita Sarkar
  - Sa'ad Laws
  - Ali Chaari
- PubMed: 40041456
- DOI: 10.3389/fmed.2025.1435030
1 Insight on
- Improved Effectiveness in Inflammatory Bowel Disease
- High evidence
Effects of cocoa extract supplementation and multivitamin/multimineral supplements on self-reported fractures in the Cocoa Supplement and Multivitamins Outcomes Study randomized clinical trial.
- 2025-02-18
- RCT
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 40(5)
- - Carolyn J Crandall
  - Sharon Chou
  - Eunjung Kim
  - Dana Ratnarajah
  - Nancy R Cook
  - Allison Clar
  - Howard D Sesso
  - JoAnn E Manson
  - Meryl S LeBoff
- PubMed: 39964350
- DOI: 10.1093/jbmr/zjaf030
2 Insights on
- Reduced Total Clinical Fracture
- Reduced Nonvertebral Fracture
- High evidence
Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment.
- 2025-02-18
- Review
- Theranostics 15(8)
- - Guangze Sang
  - Bingkai Wang
  - Yujie Xie
  - Yu Chen
  - Feng Yang
- PubMed: 40093907
- DOI: 10.7150/thno.103983
5 Insights on
- Low evidence
Biotinidase Deficiency Induced Optic Neuropathy: A Case Report and Literature Review.
- 2025-02-18
- Review
- Neuro-ophthalmology (Aeolus Press) 49(3)
- - Angela A Cao
  - Meghan M Brown
  - Michael S Lee
  - Anita M Rashidi
  - Vania Rashidi
- PubMed: 40190376
- DOI: 10.1080/01658107.2024.2424209
1 Insight on
- Improved Visual Function
- Low evidence
Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review.
- 2025-02-18
- Systematic Review
- Nutrition reviews 83(9)
- - Meenakshi Sachdeva
  - Abhishek Purohit
  - Meenakshi Malik
  - Lovely Jain
  - Pranita Pradhan
  - Joseph L Mathew
- PubMed: 39964959
- DOI: 10.1093/nutrit/nuae227
2 Insights on
- Increased Hemoglobin Levels
- Increased Vitamin B12 Levels
- High evidence
Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial.
- 2025-02-17
- RCT
- Nutrients 17(4)
- - Sabina López-Toledo
  - María Cruz Pineda De la Cruz
  - Itzae Adonai Gutiérrez-Hurtado
  - Ana L Gijón-Soriano
  - Enrique Martínez-Martínez
  - Carlos Valencia-Santiago
  - José E Orellana-Centeno
  - Sergio A Ramírez-García
  - Royer Pacheco-Cruz
- PubMed: 40005038
- DOI: 10.3390/nu17040709
4 Insights on
- High evidence
- Rigorous Journal
Effect of Nigella sativa seed extract on estradiol, FSH levels, and vaginal maturity index in menopausal women: A randomized controlled trial.
- 2025-02-17
- RCT
- Narra J 5(1)
- - Khairani Sukatendel
  - Reni H Hasibuan
  - Muhammad Fg Siregar
  - Dwi Faradina
  - Deri Edianto
  - Letta S Lintang
  - Muhammad Rusda
  - Vega Inriani
- PubMed: 40352190
- DOI: 10.52225/narra.v5i1.1399
4 Insights on
- High evidence
Promising Antidepressant Potential: The Role of Lactobacillus rhamnosus GG in Mental Health and Stress Response.
- 2025-02-17
- n = 56
- Probiotics and antimicrobial proteins 17(6)
- - Musab Işık
  - Fadime Köse
  - Cansu Özbayer
  - Özcan Budak
  - Rumeysa Keleş Kaya
  - Derya Güzel Erdoğan
  - Mehmet Arif Demirci
  - Songül Doğanay
  - Cahit Bağcı
- PubMed: 39962033
- DOI: 10.1007/s12602-025-10470-0
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Development of Subtle Iron Deficiency During Vitamin E Treatment For Metabolic Dysfunction-Associated Steatotic Liver Disease.
- 2025-02-17
- Clinical Trial · n = 20
- Journal of dietary supplements 22(2)
- - Maren C Podszun
  - Ahmad Samer Alawad
  - Shilpa Lingala
  - Nevitt Morris
  - Wen Chun A Huang
  - Yaron Rotman
- PubMed: 39960325
- DOI: 10.1080/19390211.2025.2465414
2 Insights on
- Improved Iron Levels
- Developed Anemia
- Moderate evidence
Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players.
- 2025-02-14
- RCT
- Nutrients 17(4)
- - Zhaolong Wang
  - Haoyu Du
  - Huixin Li
  - Kai Zhao
  - Bingran Zhao
  - Yifei Ma
  - Jiashuo Zhang
  - Kangshuo Wu
  - Wei Jiang
  - Chang Liu
- PubMed: 40005009
- DOI: 10.3390/nu17040681
4 Insights on
- High evidence
- Rigorous Journal
Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review.
- 2025-02-14
- Systematic Review · n = 4,708
- Human reproduction update 31(3)
- - Naomi Graafland
  - Melek Rousian
  - Merle L de Zwart
  - Regine P M Steegers-Theunissen
  - Eric A P Steegers
  - Anke G Posthumus
- PubMed: 39953705
- DOI: 10.1093/humupd/dmaf001
1 Insight on
- Improved Embryonic Growth
- High evidence
Neurodevelopment and Growth 2 Years After Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial.
- 2025-02-13
- RCT · n = 134
- Acta paediatrica (Oslo, Norway : 1992) 114(8)
- - Erik Wejryd
  - Giovanna Marchini
  - Peter Bang
  - Baldvin Jonsson
  - Ulrika Ådén
  - Thomas Abrahamsson
- PubMed: 39945202
- DOI: 10.1111/apa.70030
4 Insights on
- High evidence
- Large Human Trial
The Association between Green Tea Consumption and Cognitive Function: A Meta-Analysis of Current Evidence.
- 2025-02-13
- Meta-Analysis · n = 929
- Neuroepidemiology 60(1)
- - Shiyao Zhou
  - Yating Zhu
  - Na Ren
  - Mishan Wu
  - Yu Liu
- PubMed: 39947165
- DOI: 10.1159/000543784
2 Insights on
- Reduced Dementia Risk
- Reduced Risk of Cognitive Impairment
- High evidence
Sheep-Derived Lactobacillus johnsonii M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs.
- 2025-02-13
- Clinical Trial · n = 72
- Microorganisms 13(2)
- - Zhuo Wang
  - Yuwei Zhao
  - Dingkun Fan
  - Jixian Zhang
  - Qiyu Diao
  - Kai Cui
- PubMed: 40005770
- DOI: 10.3390/microorganisms13020404
4 Insights on
- High evidence
Therapeutic Strategies to Modulate Gut Microbial Health: Approaches for Chronic Metabolic Disorder Management.
- 2025-02-13
- Review
- Metabolites 15(2)
- - Mariangela Rondanelli
  - Sara Borromeo
  - Alessandro Cavioni
  - Clara Gasparri
  - Ilaria Gattone
  - Elisa Genovese
  - Alessandro Lazzarotti
  - Leonardo Minonne
  - Alessia Moroni
  - Zaira Patelli
  - Claudia Razza
  - Claudia Sivieri
  - Eugenio Marzio Valentini
  - Gaetan Claude Barrile
- PubMed: 39997751
- DOI: 10.3390/metabo15020127
1 Insight on
- Improved Metabolic Health
- Low evidence
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.
- 2025-02-12
- Meta-Analysis
- Frontiers in cellular and infection microbiology 15
- - Manning Li
  - Ying Xie
- PubMed: 40012609
- DOI: 10.3389/fcimb.2025.1441185
9 Insights on
- High evidence
Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study.
- 2025-02-12
- RCT
- NPJ science of food 9(1)
- - Yohanes Tandoro
  - Hui-Fang Chiu
  - Chei-Ling Tan
  - Ming-Hong Hsieh
  - Yi-Wen Huang
  - Jianhua Yu
  - Li-Shu Wang
  - Chi-Ho Chan
  - Chin-Kun Wang
- PubMed: 39939643
- DOI: 10.1038/s41538-024-00356-w
3 Insights on
- High evidence
Role of microbiota in pain: From bench to bedside.
- 2025-02-11
- Review
- iMetaOmics 2(1)
- - Huiguang Ren
  - Bo Cao
  - Qixuan Xu
  - Ruiyang Zhao
  - Hanghang Li
  - Bo Wei
- PubMed: 41675715
- DOI: 10.1002/imo2.58
1 Insight on
- Improved Gastrointestinal Symptoms
- Low evidence
Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated Bifidobacterium animalis subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice.
- 2025-02-08
- Antioxidants (Basel, Switzerland) 14(2)
- - Mario de la Fuente-Muñoz
  - Marta Román-Carmena
  - Sara Amor
  - Daniel González-Hedström
  - Verónica Martinez-Rios
  - Patricia Martorell
  - Antonio M Inarejos-García
  - Reme García Bou
  - Sonia Guilera-Bermell
  - Ángel L García-Villalón
  - Miriam Granado
- PubMed: 40002381
- DOI: 10.3390/antiox14020193
5 Insights on
- Low evidence
Modulatory Effects of Multi-species/Multi-strain Synbiotic and L-carnitine Concomitant Supplementation on Atherogenic-Indices, Body Composition, Visceral Obesity, and Appetite in Metabolically Healthy Women with Obesity: A Double-Blind Randomized Controlled Clinical Trial.
- 2025-02-08
- RCT
- Probiotics and antimicrobial proteins 17(6)
- - Farnoush Fallah
  - Reza Mahdavi
- PubMed: 39921845
- DOI: 10.1007/s12602-025-10460-2
12 Insights on
- High evidence
- Rigorous Journal
Effect of N-Acetyl Cysteine as an Adjuvant Treatment in Alzheimer's Disease.
- 2025-02-07
- Review
- Brain sciences 15(2)
- - Sarah Monserrat Lomelí Martínez
  - Fermín Paul Pacheco Moisés
  - Oscar Kurt Bitzer-Quintero
  - Javier Ramírez-Jirano
  - Daniela L C Delgado-Lara
  - Irán Cortés Trujillo
  - Juan Heriberto Torres Jasso
  - Joel Salazar-Flores
  - Erandis Dheni Torres-Sánchez
- PubMed: 40002497
- DOI: 10.3390/brainsci15020164
1 Insight on
- Improved Cognitive Function
- Low evidence
Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies.
- 2025-02-07
- Systematic Review
- Frontiers in nutrition 12
- - Lucas Fornari Laurindo
  - Lívia Fornari Laurindo
  - Victória Dogani Rodrigues
  - Jéssica da Silva Camarinha Oliveira
  - Beatriz Leme Boaro
  - Adriano Cressoni Araújo
  - Elen Landgraf Guiguer
  - Claudia Rucco Penteado Detregiachi
  - Virgínia Maria Cavallari Strozze Catharin
  - Eduardo Federighi Baisi Chagas
  - Vitor Cavallari Strozze Catharin
  - Rosa Direito
  - Sandra Maria Barbalho
- PubMed: 39996006
- DOI: 10.3389/fnut.2025.1502815
3 Insights on
- High evidence
Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients.
- 2025-02-07
- RCT · n = 90
- BMC gastroenterology 25(1)
- - Qiyao Wei
  - Jing Zhao
- PubMed: 39920583
- DOI: 10.1186/s12876-025-03600-z
7 Insights on
- High evidence
Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children.
- 2025-02-06
- Review
- Frontiers in pediatrics 13
- - Yali Zhang
  - Yingying Xu
  - Ling Hu
  - Xiaomei Wang
- PubMed: 39981209
- DOI: 10.3389/fped.2025.1508613
2 Insights on
- Reduced Upper Respiratory Infections
- Reduced Antibiotic Use
- Low evidence
Effect of Microencapsulated Medium-Chain Fatty Acids, Lignocellulose, and Heat-Killed Lactobacillus plantarum L-137 Supplementation on Lactating Sow Performance, and Nutritional and Immunological Parameters in Colostrum.
- 2025-02-06
- RCT
- Veterinary sciences 12(2)
- - Nithat Wichasit
  - Wandee Tartrakoon
  - Rangsun Charoensook
  - Riantong Singanusong
  - Juan J Loor
  - Gaku Shoji
  - Satoru Onoda
  - Tossaporn Incharoen
- PubMed: 40005894
- DOI: 10.3390/vetsci12020134
2 Insights on
- Improved Immune Parameters
- Improved Lactation Performance
- High evidence