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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures
- 2018-12-08
- Nutrients 10(12)
- - A. Sandberg
  - G. Önning
  - N. Engström
  - Nathalie Scheers
- PubMed: 30544799
- DOI: 10.3390/nu10121949
2 Insights on
- Elevated Ferric Iron Levels
- Increased Ferric Reductase DCYTB Activity
- Moderate evidence
Lactobacillus paracasei K5 displays adhesion, anti-proliferative activity and apoptotic effects in human colon cancer cells.
- 2018-12-07
- Beneficial Microbes 9(6)
- - P. Chondrou
  - A. Karapetsas
  - D. Kiousi
  - D. Tsela
  - A. Tiptiri-Kourpeti
  - I. Anestopoulos
  - I. Kotsianidis
  - E. Bezirtzoglou
  - Aglaia Pappa
  - A. Galanis
- PubMed: 30353740
- DOI: 10.3920/BM2017.0183
3 Insights on
- Low evidence
Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults.
- 2018-12-07
- RCT · n = 241
- Beneficial Microbes 9(6)
- - M. Murata
  - J. Kondo
  - N. Iwabuchi
  - S. Takahashi
  - K. Yamauchi
  - F. Abe
  - K. Miura
- PubMed: 30099891
- DOI: 10.3920/BM2017.0197
7 Insights on
- High evidence
Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects.
- 2018-12-07
- RCT · n = 38
- Beneficial Microbes 9(6)
- - T. Inoue
  - Y. Kobayashi
  - N. Mori
  - M. Sakagawa
  - J.‐Z. Xiao
  - Toshio Moritani
  - Naoki Sakane
  - N. Nagai
- PubMed: 30198326
- DOI: 10.3920/BM2017.0193
5 Insights on
- High evidence
Potential Properties of Lactobacillus plantarum F-10 as a Bio-control Strategy for Wound Infections
- 2018-12-06
- Probiotics and Antimicrobial Proteins 11(4)
- - Tugce Onbas
  - O. Osmanagaoglu
  - F. Kiran
- PubMed: 30523603
- DOI: 10.1007/s12602-018-9486-8
3 Insights on
- Low evidence
Protective Effect of Lactobacillus diolivorans 1Z, Isolated From Brazilian Kefir, Against Salmonella enterica Serovar Typhimurium in Experimental Murine Models
- 2018-12-04
- Clinical Trial
- Frontiers in Microbiology 9
- - Mário Abatemarco Júnior
  - S. Sandes
  - M. F. Ricci
  - R. Arantes
  - Á. Nunes
  - J. Nicoli
  - E. Neumann
- PubMed: 30564201
- DOI: 10.3389/fmicb.2018.02856
6 Insights on
- Low evidence
- Animal Study
Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review.
- 2018-12-03
- Review
- Nutrients 10(12)
- - Darryn Willoughby
  - Susan Hewlings
  - Douglas Kalman
- PubMed: 30513859
- DOI: 10.3390/nu10121876
1 Insight on
- Maintained Lean Body Mass
- High evidence
- Highly Cited
- Rigorous Journal
Effects of Bacillus subtilis C‐3102 on production, hatching performance, egg quality, serum antioxidant capacity and immune response of laying breeders
- 2018-11-28
- RCT
- Journal of Animal Physiology and Animal Nutrition 103(1)
- - Xu Liu
  - Canyang Peng
  - X. Qu
  - Songchang Guo
  - Ji Fa Chen
  - Changqing He
  - Xuebin Zhou
  - S. Zhu
- PubMed: 30484908
- DOI: 10.1111/jpn.13022
8 Insights on
- High evidence
Effects of a sea buckthorn oil spray emulsion on dry eye.
- 2018-11-26
- RCT · n = 40
- Contact lens & anterior eye : the journal of the British Contact Lens Association 42(4)
- - Petra Larmo
  - Riikka Järvinen
  - Jarmo Laihia
  - Eliisa Löyttyniemi
  - Laura Maavirta
  - Baoru Yang
  - Heikki Kallio
  - Minna Sandberg-Lall
- PubMed: 30497904
- DOI: 10.1016/j.clae.2018.11.011
5 Insights on
- High evidence
Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children
- 2018-11-22
- RCT · n = 943
- New England Journal of Medicine 379(21)
- - D. Schnadower
  - P. Tarr
  - C. Casper
  - M. Gorelick
  - M. J. Dean
  - Karen J. O’Connell
  - P. Mahajan
  - A. Levine
  - S. Bhatt
  - C. Roskind
  - E. Powell
  - A. Rogers
  - C. Vance
  - R. Sapién
  - Cody S. Olsen
  - M. Metheney
  - Viani Dickey
  - C. Hall-Moore
  - S. Freedman
- PubMed: 30462938
- DOI: 10.1056/NEJMoa1802598
5 Insights on
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
Outcomes in preterm small versus appropriate for gestation infants after Bifidobacterium breve M-16 V supplementation
- 2018-11-22
- Observational · n = 1,380
- The Journal of Maternal-Fetal & Neonatal Medicine 33(13)
- - G. Athalye-Jape
  - N. Minaee
  - E. Nathan
  - K. Simmer
  - S. Patole
- PubMed: 30394171
- DOI: 10.1080/14767058.2018.1543657
11 Insights on
- High evidence
A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with Lactococcus lactis 11/19-B1 and Bifidobacterium lactis on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-γ Releasing Ability
- 2018-11-16
- RCT · n = 76
- Nutrients 10(11)
- - K. Nishiyama
  - Takahiro Kobayashi
  - Yuko Sato
  - Yoshihisa Watanabe
  - Riki Kikuchi
  - Ryoko Kanno
  - T. Koshizuka
  - Nozomu Miyazaki
  - Ken Ishioka
  - T. Suzutani
- PubMed: 30453487
- DOI: 10.3390/nu10111778
4 Insights on
- High evidence
Effects of Bacillus amyloliquefaciens and Bacillus subtilis on ileal digestibility of AA and total tract digestibility of CP and gross energy in diets fed to growing pigs.
- 2018-11-16
- RCT
- Journal of Animal Science 97(2)
- - L. Blavi
  - J. Jørgensen
  - H. Stein
- PubMed: 30445592
- DOI: 10.1093/jas/sky432
2 Insights on
- Improved Digestibility
- Improved Digestibility of Amino Acids
- High evidence
The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial
- 2018-11-14
- RCT · n = 68
- Scientific Reports 8(1)
- - M. Hsieh
  - W. Tsai
  - Yu-Pang Jheng
  - S. Su
  - Shu-Yi Wang
  - Chi-Chen Lin
  - Yi-Hsing Chen
  - Wen-Wei Chang
- PubMed: 30429496
- DOI: 10.1038/s41598-018-35014-1
13 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Suppression of Intestinal Epithelial Cell Chemokine Production by Lactobacillus rhamnosus R0011 and Lactobacillus helveticus R0389 Is Mediated by Secreted Bioactive Molecules.
- 2018-11-14
- Frontiers in immunology 9
- - Michael P Jeffrey
  - Janice L Strap
  - Holly Jones Taggart
  - Julia M Green-Johnson
- PubMed: 30524427
- DOI: 10.3389/fimmu.2018.02639
1 Insight on
- Reduced Chemokine Production
- Low evidence
Immobilization of cadmium and lead by Lactobacillus rhamnosus GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium
- 2018-11-14
- Gut Microbes 10(3)
- - Brendan A. Daisley
  - M. Monachese
  - M. Trinder
  - J. Bisanz
  - John Antonio Chmiel
  - J. Burton
  - G. Reid
- PubMed: 30426826
- DOI: 10.1080/19490976.2018.1526581
2 Insights on
- Reduced Heavy Metal Accumulation
- Improved Heavy Metal Sequestration
- Low evidence
- Rigorous Journal
Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years
- 2018-11-14
- RCT
- Pediatric Allergy and Immunology 29(8)
- - K. Wickens
  - C. Barthow
  - E. Mitchell
  - Janice Kang
  - N. van Zyl
  - G. Purdie
  - T. Stanley
  - P. Fitzharris
  - R. Murphy
  - J. Crane
- PubMed: 30430649
- DOI: 10.1111/pai.12982
10 Insights on
- High evidence
- Rigorous Journal
Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis
- 2018-11-14
- Meta-Analysis
- European Journal of Public Health 29(3)
- - Sarah King
  - D. Tancredi
  - I. Lenoir-Wijnkoop
  - Kelsie Gould
  - Hailey Vann
  - G. Connors
  - M. Sanders
  - J. Linder
  - A. Shane
  - D. Merenstein
- PubMed: 30219897
- DOI: 10.1093/eurpub/cky185
1 Insight on
- Reduced Antibiotic Usage
- High evidence
- Rigorous Journal
Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Paediatric Diseases
- 2018-11-10
- Nutrients 10(11)
- - Nicole Bozzi Cionci
  - L. Baffoni
  - F. Gaggía
  - D. Di Gioia
- PubMed: 30423810
- DOI: 10.3390/nu10111723
13 Insights on
- Moderate evidence
Lactobacillus plantarum bacteriocin is associated with intestinal and systemic improvements in diet-induced obese mice and maintains epithelial barrier integrity in vitro
- 2018-11-08
- Clinical Trial
- Gut Microbes 10(3)
- - Dustin D Heeney
  - Zhengyuan Zhai
  - Zachary A. Bendiks
  - J. Barouei
  - A. Martinic
  - C. Slupsky
  - M. Marco
- PubMed: 30409105
- DOI: 10.1080/19490976.2018.1534513
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Lactobacillus crispatus BC5 Interferes With Chlamydia trachomatis Infectivity Through Integrin Modulation in Cervical Cells
- 2018-11-06
- Frontiers in Microbiology 9
- - C. Parolin
  - G. Frisco
  - C. Foschi
  - B. Giordani
  - M. Salvo
  - B. Vitali
  - A. Marangoni
  - N. Calonghi
- PubMed: 30459737
- DOI: 10.3389/fmicb.2018.02630
2 Insights on
- Reduced Chlamydia trachomatis Infectivity
- Altered Epithelial Plasma Membrane Properties
- Low evidence
Short-Term Hemodynamic Effects of Modern Wheat Products Substitution in Diet with Ancient Wheat Products: A Cross-Over, Randomized Clinical Trial.
- 2018-11-04
- RCT
- Nutrients 10(11)
- - Arrigo F G Cicero
  - Federica Fogacci
  - Maddalena Veronesi
  - Elisa Grandi
  - Giovanni Dinelli
  - Silvana Hrelia
  - Claudio Borghi
- PubMed: 30400372
- DOI: 10.3390/nu10111666
4 Insights on
- High evidence
- Rigorous Journal
Bacteremia by Leuconostoc mesenteroides in an immunocompetent patient with chronic Chagas disease: a case report
- 2018-11-03
- Case Report · n = 1
- BMC Infectious Diseases 18(1)
- - M. G. Menegueti
  - G. G. Gaspar
  - Ana Maria Laus
  - A. Basile-Filho
  - F. Bellissimo-Rodrigues
  - M. Auxiliadora-Martins
- PubMed: 30390634
- DOI: 10.1186/s12879-018-3452-7
1 Insight on
- Reduced Bacteremia Incidence
- Low evidence
- Rigorous Journal
Caraway as Important Medicinal Plants in Management of Diseases.
- 2018-10-29
- Review
- Natural products and bioprospecting 9(1)
- - Mohaddese Mahboubi
- PubMed: 30374904
- DOI: 10.1007/s13659-018-0190-x
2 Insights on
- Reduced Irritable Bowel Syndrome Symptoms
- Reduced Functional Dyspepsia Symptoms
- Low evidence
The Cheese Matrix Modulates the Immunomodulatory Properties of Propionibacterium freudenreichii CIRM-BIA 129 in Healthy Piglets
- 2018-10-29
- Clinical Trial · n = 3
- Frontiers in Microbiology 9
- - Houem Rabah
  - Stéphanie Ferret-Bernard
  - Song Huang
  - L. Le Normand
  - Fabien J. Cousin
  - Floriane Gaucher
  - R. Jeantet
  - G. Boudry
  - G. Jan
- PubMed: 30420848
- DOI: 10.3389/fmicb.2018.02584
2 Insights on
- Increased Short Chain Fatty Acids
- Increased Bifidobacterial Population
- Low evidence
- Animal Study
Strain-specific properties of Lactobacillus plantarum for prevention of Salmonella infection.
- 2018-10-29
- Clinical Trial
- Food & Function 9(7)
- - Junsheng Liu
  - Diangeng Hu
  - Yingqi Chen
  - Hongxuan Huang
  - Hao Zhang
  - Jianxin Zhao
  - Zhennan Gu
  - Wei Chen
- PubMed: 29956713
- DOI: 10.1039/c8fo00365c
2 Insights on
- Improved Immune Response
- Reduced Salmonella Infection
- Low evidence
- Animal Study
Lactobacillus plantarum 299v Reduces the Incidence of Clostridium difficile Infection in Nephrology and Transplantation Ward—Results of One Year Extended Study
- 2018-10-24
- Observational · n = 54
- Nutrients 10(11)
- - S. Dudzicz
  - A. Kujawa-Szewieczek
  - Katarzyna Kwiecień
  - A. Więcek
  - M. Adamczak
- PubMed: 30355985
- DOI: 10.3390/nu10111574
1 Insight on
- Reduced Clostridium difficile Infection
- High evidence
Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo-controlled trial.
- 2018-10-22
- RCT · n = 474
- Acta paediatrica (Oslo, Norway : 1992) 107(12)
- - R F Slykerman
  - J Kang
  - N Van Zyl
  - C Barthow
  - K Wickens
  - T Stanley
  - C Coomarasamy
  - G Purdie
  - R Murphy
  - J Crane
  - E A Mitchell
- PubMed: 30246890
- DOI: 10.1111/apa.14590
5 Insights on
- High evidence
- Large Human Trial
Growth in Hyper-Concentrated Sweet Whey Triggers Multi Stress Tolerance and Spray Drying Survival in Lactobacillus casei BL23: From the Molecular Basis to New Perspectives for Sustainable Probiotic Production
- 2018-10-22
- Frontiers in Microbiology 9
- - Song Huang
  - Floriane Gaucher
  - C. Cauty
  - J. Jardin
  - Y. Le Loir
  - R. Jeantet
  - X. Chen
  - G. Jan
- PubMed: 30405593
- DOI: 10.3389/fmicb.2018.02548
7 Insights on
- Low evidence
Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in d-galactosamine-treated rats
- 2018-10-22
- Clinical Trial
- Applied Microbiology and Biotechnology 103(1)
- - Yating Li
  - L. Lv
  - Jianzhong Ye
  - D. Fang
  - D. Shi
  - Wen-rui Wu
  - Qing Wang
  - Jingjing Wu
  - Liya Yang
  - Xiaoyuan Bian
  - Xianwan Jiang
  - Huiyong Jiang
  - Ren Yan
  - Conggao Peng
  - Lanjuan Li
- PubMed: 30345482
- DOI: 10.1007/s00253-018-9454-y
7 Insights on
- Low evidence
- Animal Study