August 2019 Supplement Research Papers

• August 1

  • Improvement of cognitive functions by oral intake of Hericium erinaceus.

    • 2019-08-01
    • RCT
    • Biomedical research (Tokyo, Japan) 40(4)
    • • Yuusuke Saitsu
      • Akemi Nishide
      • Kenji Kikushima
      • Kuniyoshi Shimizu
      • Koichiro Ohnuki

    • PubMed: 31413233
    • DOI: 10.2220/biomedres.40.125

    3 Insights on

    • Improved Cognitive Function
    • Improved Visual Retention
    • Improved Verbal Paired-Associate Learning

    • High evidence

  • Recent advances in dairy goat products.

    • 2019-08-01
    • Review
    • Asian-Australasian Journal of Animal Sciences. 32(8)
    • • Lucia Sepe
      • Anastasio Argüello

    • PubMed: 31357271
    • DOI: 10.5713/ajas.19.0487

    2 Insights on

    • Increased Antioxidant Activity
    • Improved Overall Health

    • Low evidence
• August 5

  • Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease.

    • 2019-08-05
    • Review
    • Nutrients 11(8)
    • • Eirini Dimidi
      • Selina Rose Cox
      • Megan Rossi
      • Kevin Whelan

    • PubMed: 31387262
    • DOI: 10.3390/nu11081806

    4 Insights on

    • Improved Gastrointestinal Health
    • Increased Helicobacter pylori Eradication Rate
    • Reduced Symptoms of Lactose Malabsorption
    • Improved Lactose Malabsorption

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation.

    • 2019-08-05
    • RCT · n = 8
    • Food & Function 10(3)
    • • Shuang Yan
      • Bo Yang
      • Jichun Zhao
      • Jianxin Zhao
      • C. Stanton
      • R. P. Ross
      • Hao Zhang
      • Wei Chen

    • PubMed: 30806428
    • DOI: 10.1039/c9fo00014c

    4 Insights on

    • Reduced Inflammation Levels
    • Modulated Gut Microbiota
    • Maintained Mucosal Barrier Integrity
    • Increased Beneficial Gut Microbiota Abundance

    • Low evidence
    • Highly Cited
    • Animal Study
• August 6

  • Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.

    • 2019-08-06
    • Clinical Trial
    • Food & Function 10(3)
    • • Q. Zhai
      • Yang Liu
      • Chen Wang
      • DingWu Qu
      • Jianxin Zhao
      • Hao Zhang
      • F. Tian
      • Wei Chen

    • PubMed: 30768114
    • DOI: 10.1039/c8fo02554a

    2 Insights on

    • Increased Fecal Bile Acid Levels
    • Increased Lead Excretion

    • Low evidence
    • Animal Study
• August 8

  • Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial

    • 2019-08-08
    • RCT · n = 23
    • Journal of Applied Oral Science 27
    • • Oda Yuki
      • Chiaki Furutani
      • Yuika Mizota
      • Atsuko Wakita
      • Sumiyo Mimura
      • T. Kihara
      • M. Ohara
      • Yoshiyuki Okada
      • M. Okada
      • H. Nikawa

    • PubMed: 31365710
    • DOI: 10.1590/1678-7757-2018-0564

    2 Insights on

    • Reduced Probing Depth
    • Reduced PMA Index

    • High evidence
• August 10

  • Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study

    • 2019-08-10
    • RCT · n = 60
    • Nutrients 11(8)
    • • K. Nishida
      • D. Sawada
      • Y. Kuwano
      • Hiroki Tanaka
      • K. Rokutan

    • PubMed: 31405122
    • DOI: 10.3390/nu11081859

    10 Insights on

    • Improved Gut Microbiota
    • Reduced Anxiety Levels
    • Improved Mental Health
    • Improved Gut Microbiome Composition
    • Improved Sleep Quality
    • Reduced Salivary Chromogranin A Levels
    • Reduced Stress Indicators
    • Stabilized Gut Microbiota
    • Reduced Stress Biomarkers
    • Attenuated Stress-Induced Changes in Gut Microbiota

    • High evidence
    • Highly Cited

  • Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.

    • 2019-08-10
    • International journal of molecular sciences 20(16)
    • • Ghalia Khoder
      • Farah Al-Yassir
      • Asma Al Menhali
      • Prashanth Saseedharan
      • Subi Sugathan
      • Catherine Tomasetto
      • Sherif M Karam

    • PubMed: 31405107
    • DOI: 10.3390/ijms20163901

    4 Insights on

    • Increased Mucin Production
    • Reduced Pepsinogen Production
    • No Change in Body Weight or Food Consumption
    • Improved Gastric Mucosal Protection

    • Low evidence
    • Rigorous Journal
    • Animal Study
• August 13

  • Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial.

    • 2019-08-13
    • RCT
    • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 34(11)
    • • Mary Sharpe
      • Vibhuti Shah
      • Tatiana Freire-Lizama
      • Elizabeth C Cates
      • Kory McGrath
      • Iuliana David
      • Sara Cowan
      • Janaya Letkeman
      • Emily Stewart-Wilson

    • PubMed: 31362572
    • DOI: 10.1080/14767058.2019.1650907

    2 Insights on

    • Reduced Vaginal Group B Streptococcus Colonization
    • No Documented Adverse Effects

    • High evidence

  • The Application of Lactobacillus reuteri CCM 8617 and Flaxseed Positively Improved the Health of Mice Challenged with Enterotoxigenic E. coli O149:F4

    • 2019-08-13
    • RCT · n = 60
    • Probiotics and Antimicrobial Proteins 12(3)
    • • Z. Andrejčáková
      • D. Sopková
      • R. Vlčková
      • Z. Hertelyová
      • S. Gancarčíková
      • R. Nemcová

    • PubMed: 31410766
    • DOI: 10.1007/s12602-019-09578-x

    4 Insights on

    • Reduced Enterobacterial Counts
    • Increased Organic Acid Production
    • Improved n-6 to n-3 PUFA Ratio
    • Reduced Infection Severity

    • Low evidence
    • Animal Study
• August 14

  • Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

    • 2019-08-14
    • Meta-Analysis
    • Helicobacter 24(5)
    • • Ben‐Gang Zhou
      • Lingxiao Chen
      • Bohua Li
      • Lin-Yan Wan
      • Yao-Wei Ai

    • PubMed: 31414551
    • DOI: 10.1111/hel.12651

    7 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Constipation
    • Reduced Incidence of Constipation
    • Improved H Pylori Eradication Rates
    • Reduced Total Side Effects Incidence
    • Reduced Discontinuation Rates
    • Reduced Diarrhea

    • High evidence

  • Effects of oligosaccharides on the growth and stress tolerance of Lactobacillus plantarum ZLP001 in vitro, and the potential synbiotic effects of L. plantarum ZLP001 and fructo-oligosaccharide in post-weaning piglets.

    • 2019-08-14
    • RCT
    • Journal of Animal Science 97(11)
    • • Jing Wang
      • Sixin Wang
      • Hui Liu
      • Dongyan Zhang
      • Yamin Wang
      • H. Ji

    • PubMed: 31410455
    • DOI: 10.1093/jas/skz254

    3 Insights on

    • Improved Nutrient Digestibility
    • Improved Gain:Feed Ratio
    • Regulated Intestinal Microbiota

    • High evidence
    • Rigorous Journal

  • Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.

    • 2019-08-14
    • RCT
    • Journal of orthopaedic surgery and research 14(1)
    • • Chunhua Zhang
      • Sujuan Xue
      • Yong Wang
      • Dan Yu
      • Limei Hua
      • Chunhua Guo
      • Dawei Wang
      • Min Lei

    • PubMed: 31412879
    • DOI: 10.1186/s13018-019-1310-y

    5 Insights on

    • Improved Hand Function
    • Improved Radial Deviation
    • Improved Radial Inclination
    • Improved Ulnar Deviation
    • Improved Ulnar Variance

    • High evidence
• August 15

  • An In Vitro Enrichment Strategy for Formulating Synergistic Synbiotics.

    • 2019-08-15
    • Applied and environmental microbiology 85(16)
    • • Car Reen Kok
      • David Fabian Gomez Quintero
      • Clement Niyirora
      • Devin Rose
      • Amanda Li
      • Robert Hutkins

    • PubMed: 31201276
    • DOI: 10.1128/aem.01073-19

    1 Insight on

    • Improved Gut Microbiome Establishment

    • Low evidence
    • Rigorous Journal
• August 16

  • Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    • 2019-08-16
    • RCT · n = 78
    • Nutrients 11(8)
    • • Å. Håkansson
      • Carin Andrén Aronsson
      • C. Brundin
      • E. Oscarsson
      • G. Molin
      • D. Agardh

    • PubMed: 31426299
    • DOI: 10.3390/nu11081925

    12 Insights on

    • Increased Regulatory T Cell Populations
    • Modulated Peripheral Immune Response
    • Reduced Median Levels of IgA-tTG
    • Modulated Immune Response
    • Increased Natural Killer Cell Proportion
    • Decreased Naïve CD45RA+ T Helper Cells
    • Increased Natural Killer T Cells
    • Elevated IgG-tTG Levels
    • No Change in IgG-tTG Levels
    • Reduced Naïve CD45RA+ Th Cell Count
    • Increased NK Cell Count
    • Change in Immunoglobulin G Tissue Transglutaminase Levels

    • High evidence
• August 19

  • Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial.

    • 2019-08-19
    • RCT · n = 120
    • PloS one 14(8)
    • • Barbara Troesch
      • Johann Demmelmair
      • Martina Gimpfl
      • Christina Hecht
      • Goran Lakovic
      • Robert Roehle
      • Ljilja Sipka
      • Branka Trisic
      • Milica Vusurovic
      • Rotraut Schoop
      • Sznezana Zdjelar
      • Berthold Koletzko

    • PubMed: 31425504
    • DOI: 10.1371/journal.pone.0216790

    11 Insights on

    • Reduced Body Weight
    • Increased Body Weight Gain
    • Increased Head Circumference
    • Increased Caloric Intake in Females
    • Improved Body Weight Gain
    • Increased Weight Gain
    • Improved Head Circumference Gain
    • Improved Recumbent Length Gain
    • Increased Recumbent Length
    • Reduced Unmetabolized Folic Acid Level
    • Increased Red Cell Folate Level

    • High evidence
    • Large Human Trial
• August 20

  • Colonization of Germ-Free Piglets with Commensal Lactobacillus amylovorus, Lactobacillus mucosae, and Probiotic E. coli Nissle 1917 and Their Interference with Salmonella Typhimurium

    • 2019-08-20
    • Clinical Trial
    • Microorganisms 7(8)
    • • I. Splichal
      • S. Donovan
      • Zdislava Splichalova
      • Vera Neuzil Bunesova
      • E. Vlková
      • Vera Jenistova
      • J. Killer
      • R. Svejstil
      • E. Skřivanová
      • A. Splichalova

    • PubMed: 31434337
    • DOI: 10.3390/microorganisms7080273

    3 Insights on

    • Reduced Inflammation from Salmonella Typhimurium
    • Increased Susceptibility to Salmonella Infection
    • No Protection Against Salmonella-Induced Inflammation

    • Low evidence
    • Rigorous Journal
    • Animal Study
• August 21

  • The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome.

    • 2019-08-21
    • Review
    • Frontiers in microbiology 10
    • • Yu Gu
      • Guoqiong Zhou
      • Xiali Qin
      • Shumin Huang
      • Bangmao Wang
      • Hailong Cao

    • PubMed: 31497000
    • DOI: 10.3389/fmicb.2019.01894

    1 Insight on

    • Improved Irritable Bowel Syndrome Symptoms

    • Low evidence

  • Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults

    • 2019-08-21
    • RCT · n = 289
    • Scientific Reports 9(1)
    • • R. Madempudi
      • J. Ahire
      • J. Neelamraju
      • A. Tripathi
      • S. Nanal

    • PubMed: 31434935
    • DOI: 10.1038/s41598-019-48554-x

    4 Insights on

    • Reduced Abdominal Pain Severity
    • No Change in Cytokine Levels
    • Good Tolerability
    • Improved Spontaneous Bowel Movements

    • High evidence
    • Rigorous Journal

  • Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

    • 2019-08-21
    • RCT · n = 96
    • Journal of Animal Science and Biotechnology 10(1)
    • • X. Peng
      • Ru Wang
      • Liang Hu
      • Qiang Zhou
      • Yang Liu
      • Min Yang
      • Z. Fang
      • Yan Lin
      • Shengyu Xu
      • B. Feng
      • Jian Li
      • Xuemei Jiang
      • Y. Zhuo
      • Hua Li
      • De Wu
      • L. Che

    • PubMed: 31452881
    • DOI: 10.1186/s40104-019-0376-z

    4 Insights on

    • Improved Immune Response
    • Reduced Diarrhea Rate
    • Improved Gut Microbiome Composition
    • Reduced Intestinal Damage

    • Low evidence
    • Animal Study

  • The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study.

    • 2019-08-21
    • RCT
    • Nutrients 11(9)
    • • Krzysztof Durkalec-Michalski
      • Krzysztof Kusy
      • Monika Ciekot-Sołtysiak
      • Jacek Zieliński

    • PubMed: 31438535
    • DOI: 10.3390/nu11091961

    3 Insights on

    • Improved Anaerobic Capacity
    • Reduced Blood Lactate
    • Increased Fat-Free Mass

    • High evidence
    • Rigorous Journal
• August 27

  • Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum

    • 2019-08-27
    • RCT
    • PeerJ 7
    • • Md Javed Foysal
      • T. Nguyen
      • Md. Reaz Chaklader
      • M. Siddik
      • C. Tay
      • R. Fotedar
      • S. Gupta

    • PubMed: 31523510
    • DOI: 10.7717/peerj.7553

    3 Insights on

    • Improved Immune Response
    • Reduced Pathogenic Bacterial Abundance
    • Increased Growth Rate

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 11 supplement studies

  • Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice.

    • 2019-08
    • Clinical Trial
    • Biochemical and Biophysical Research Communications 516(2)
    • • Tian Tian
      • Bing Xu
      • Yinhua Qin
      • Liping Fan
      • Jian-jun Chen
      • P. Zheng
      • Xue Gong
      • Haiyang Wang
      • M. Bai
      • Juncai Pu
      • Jian Lu
      • W. Zhou
      • L. Zhao
      • Deyu Yang
      • P. Xie

    • PubMed: 31227215
    • DOI: 10.1016/j.bbrc.2019.06.053

    3 Insights on

    • Reduced Th2 Cytokine Levels
    • Improved Gut Microbiome Composition
    • Improved Depressive-Like Behaviours

    • Low evidence
    • Animal Study

  • Saccharomyces cerevisiae boulardii CNCM I-1079 affects health, growth, and fecal microbiota in milk-fed veal calves.

    • 2019-08
    • RCT · n = 84
    • Journal of Dairy Science 102(8)
    • • C. Villot
      • Tao Ma
      • David L. Renaud
      • M. Ghaffari
      • D. Gibson
      • A. Skidmore
      • E. Chevaux
      • L. Guan
      • M. A. Steele

    • PubMed: 31155261
    • DOI: 10.3168/jds.2018-16149

    4 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Antibiotic Usage
    • Maintained Growth During Diarrheal Episodes
    • Maintained Average Daily Gain in Diarrheic Calves

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effects of dietary b-glucan, mannan oligosaccharide, Lactobacillus plantarum and their combinations on growth performance, immunity and immune related gene expression of Caspian trout, Salmo trutta caspius (Kessler, 1877).

    • 2019-08
    • RCT
    • Fish & Shellfish Immunology 91
    • • M. J. Jami
      • A. Abedian Kenari
      • H. Paknejad
      • M. Mohseni

    • PubMed: 31085328
    • DOI: 10.1016/j.fsi.2019.05.024

    6 Insights on

    • Increased Serum Lysozyme Activity
    • Reduced Pro-inflammatory Gene Transcription
    • Increased Gut Lactobacillus plantarum Population
    • Increased Immunoglobulin M Levels
    • Improved Innate Humoral Immunity
    • Increased Serum Alternative Complement Activity

    • High evidence

  • Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: A randomized, double-blind, placebo-controlled study.

    • 2019-08
    • RCT · n = 142
    • Medicine 98(35)
    • • Jin Young Yoon
      • Jae Myung Cha
      • Seong Soo Hong
      • Hyung Kyung Kim
      • Min Seob Kwak
      • Jung Won Jeon
      • Hyun Phil Shin

    • PubMed: 31464895
    • DOI: 10.1097/md.0000000000016601

    5 Insights on

    • Improved Quality of Life
    • Improved Gastrointestinal Symptoms
    • Reduced Helicobacter Pylori Density
    • Improved Chronic Inflammation
    • Reduced Neutrophil Activity

    • High evidence
    • Large Human Trial

  • Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.

    • 2019-08
    • RCT · n = 10
    • Heart rhythm 16(8)
    • • Ehud Chorin
      • Aviram Hochstadt
      • Yoav Granot
      • Shafik Khoury
      • Arie Lorin Schwartz
      • Gilad Margolis
      • Rami Barashi
      • Dana Viskin
      • Eihab Ghantous
      • Michael Schnapper
      • Tal Mekori
      • Dana Fourey
      • Milton Ernesto Guevara-Valdivia
      • Manlio F Marquez
      • David Zeltzer
      • Raphael Rosso
      • Sami Viskin

    • PubMed: 31075442
    • DOI: 10.1016/j.hrthm.2019.04.039

    1 Insight on

    • Prolonged QT Interval

    • High evidence

  • Effect of fermented milk from Lactococcus lactis ssp. cremoris strain JFR1 on Salmonella invasion of intestinal epithelial cells.

    • 2019-08
    • Journal of Dairy Science 102(8)
    • • J. S. Zhang
      • M. Corredig
      • R. Morales-Rayas
      • A. Hassan
      • M. Griffiths
      • G. LaPointe

    • PubMed: 31202650
    • DOI: 10.3168/jds.2018-15669

    4 Insights on

    • Reduced IL-8 Production
    • Improved Barrier Integrity
    • Downregulated Salmonella Virulence Genes
    • Enhanced Barrier Integrity

    • Low evidence
    • Rigorous Journal

  • Improvement of taste and shelf life of yeasted low-salt bread containing functional sourdoughs using Lactobacillus amylovorus DSM 19280 and Weisella cibaria MG1.

    • 2019-08
    • International journal of food microbiology 302
    • • Markus C E Belz
      • Claudia Axel
      • Elke K Arendt
      • Kieran M Lynch
      • Brid Brosnan
      • Elizabeth M Sheehan
      • Aidan Coffey
      • Emanuele Zannini

    • PubMed: 30017109
    • DOI: 10.1016/j.ijfoodmicro.2018.07.015

    1 Insight on

    • Improved Taste Sensation

    • Low evidence

  • Nutritional quality of fresh and stored legumes sprouts - Effect of Lactobacillus plantarum 299v enrichment.

    • 2019-08
    • Food chemistry 288
    • • Michal Swieca
      • Urszula Gawlik-Dziki
      • Anna Jakubczyk
      • Justyna Bochnak
      • Małgorzata Sikora
      • Joanna Suliburska

    • PubMed: 30902300
    • DOI: 10.1016/j.foodchem.2019.02.135

    2 Insights on

    • Improved Digestibility
    • Maintained Nutritional Quality

    • Low evidence

  • Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2-5 Years of Age.

    • 2019-08
    • RCT · n = 60
    • The Pediatric infectious disease journal 38(8)
    • • Margaret N Kosek
      • Pablo Peñataro-Yori
      • Maribel Paredes-Olortegui
      • John Lefante
      • Cesar Ramal-Asayag
      • Marcelo Zamora-Babilonia
      • Graciela Meza-Sanchez
      • Richard A Oberhelman

    • PubMed: 30531312
    • DOI: 10.1097/inf.0000000000002267

    2 Insights on

    • Reduced Fever
    • Reduced Diarrhea

    • High evidence

  • Safety of Lactobacillus reuteri DSM 17938 in Healthy Children 2 to 5 Years of Age.

    • 2019-08
    • RCT · n = 60
    • Pediatric Infectious Disease Journal 38(8)
    • • M. Kosek
      • Pablo Peñataro-Yori
      • Maribel Paredes-Olórtegui
      • J. Lefante
      • César Ramal-Asayag
      • Marcelo Zamora-Babilonia
      • Graciela Meza-Sánchez
      • R. Oberhelman

    • PubMed: 30531312
    • DOI: 10.1097/INF.0000000000002267

    4 Insights on

    • Reduced Incidence of Adverse Events
    • Reduced Fever
    • Reduced Diarrhea
    • Reduced Adverse Event

    • High evidence

  • Clinical trial for the management dysmenorrhea using selected spices.

    • 2019-08
    • Clinical Trial
    • Complementary therapies in clinical practice 36
    • • Shabnam Omidvar
      • Fatemeh Nasiri-Amiri
      • Afsaneh Bakhtiari
      • Khyrunnisa Begum

    • PubMed: 31383440
    • DOI: 10.1016/j.ctcp.2019.04.002

    2 Insights on

    • Reduced Pain
    • Reduced Dysmenorrhea Symptoms

    • Moderate evidence