September 2019 Supplement Research Papers

• September 1

  • Assessment of Freeze-Dried Immobilized Lactobacillus casei as Probiotic Adjunct Culture in Yogurts

    • 2019-09-01
    • Foods 8(9)
    • • D. Dimitrellou
      • P. Kandylis
      • Y. Kourkoutas

    • PubMed: 31480583
    • DOI: 10.3390/foods8090374

    1 Insight on

    • Improved Sensory Function

    • Low evidence

  • Bacteriocin activity of Lactobacillus brevis and Lactobacillus paracasei ssp. paracasei.

    • 2019-09-01
    • Journal of Medical Microbiology 68(9)
    • • R. Iseppi
      • P. Messi
      • Stefania Camellini
      • C. Sabia

    • PubMed: 31364964
    • DOI: 10.1099/jmm.0.001045

    3 Insights on

    • Increased Antibacterial Activity
    • Enhanced Antimicrobial Resistance
    • Increased Cell Adhesion

    • Low evidence
• September 8

  • Saccharomyces cerevisiae as a probiotic feed additive to non and pseudo‐ruminant feeding: a review

    • 2019-09-08
    • Review
    • Journal of Applied Microbiology 128(3)
    • • M. Elghandour
      • Z. Tan
      • S. A. Abu Hafsa
      • M. Adegbeye
      • R. Greiner
      • E. Ugbogu
      • J. Cedillo Monroy
      • A. Salem

    • PubMed: 31429174
    • DOI: 10.1111/jam.14416

    9 Insights on

    • Maintained Physical Performance
    • Enhanced Immunity
    • Reduced Pathogenic Bacteria Levels
    • Improved Digestibility
    • Improved Animal Health
    • Improved Apparent Digestibility of Fiber
    • Improved Mucosal Immunity
    • Reduced Mycotoxin Levels
    • Reduced Postweaning Diarrhea

    • Moderate evidence
    • Highly Cited
• September 9

  • Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets.

    • 2019-09-09
    • RCT · n = 60
    • Journal of Animal Physiology and Animal Nutrition 103(6)
    • • Qi Wang
      • Qian Sun
      • R. Qi
      • Jing Wang
      • Xiaoyu Qiu
      • Zuohua Liu
      • Jinxiu Huang

    • PubMed: 31498508
    • DOI: 10.1111/jpn.13198

    8 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Diarrhea Incidence
    • Improved Intestinal Morphology
    • Improved Immune Response
    • Enhanced Antimicrobial Peptide Levels
    • Modulated Immune Response
    • Enhanced Antimicrobial Peptide Production

    • Low evidence
    • Animal Study
• September 12

  • Ameliorative Effects of Probiotic Lactobacillus paracasei NL41 on Insulin Sensitivity, Oxidative Stress and Beta-Cell Function in a Type 2 Diabetes Mellitus Rat Model.

    • 2019-09-12
    • RCT · n = 18
    • Molecular Nutrition & Food Research 63(22)
    • • Z. Zeng
      • Qipeng Yuan
      • Rui Yu
      • Jinlan Zhang
      • Huiqin Ma
      • Shangwu Chen

    • PubMed: 31433912
    • DOI: 10.1002/mnfr.201900457

    23 Insights on

    • Improved Insulin Sensitivity
    • Reduced Leptin Levels
    • Reduced Hepatic Oxidative Stress
    • Improved Blood Glucose Levels
    • Improved Lipid Profile
    • Reduced Blood Glucose Levels
    • Reduced Blood HbA1c Levels
    • Preserved Islets of Langerhans
    • Reduced Beta-Cell Loss
    • Reduced Alpha-cell Expansion
    • Reduced Oxidative Stress
    • Improved Blood Glucose Control
    • Reduced Glucagon Levels
    • Preserved Islet Function
    • Reduced Blood Leptin Levels
    • Improved Glucose Regulation
    • Improved Insulin Resistance
    • Reduction of Diabetes-Induced Organ Damage
    • Improved Dyslipidemia
    • Improved Beta-Cell Function
    • Regulated Blood Glucose Levels
    • Prevention of Beta-Cell Loss
    • Preserved Beta-Cell Function

    • Low evidence
    • Animal Study

  • Protective effects of Lactobacillus plantarum against chronic alcohol-induced liver injury in the murine model

    • 2019-09-12
    • Applied Microbiology and Biotechnology 103(20)
    • • T. J. Fang
      • Jiun-Ting Guo
      • Ming-Kuem Lin
      • Meng-Shiou Lee
      • Yen-Lien Chen
      • Wen-Hsin Lin

    • PubMed: 31515596
    • DOI: 10.1007/s00253-019-10122-8

    5 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Endotoxin Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Liver Enzyme Levels
    • Improved Antioxidant Enzyme Levels

    • Low evidence
• September 17

  • Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice.

    • 2019-09-17
    • Current drug safety 14(3)
    • • Ahmed Mohamed Nabil Helaly
      • Yomna Ahmed El-Attar
      • Mahmoud Khalil
      • Doaa Shams El-Din Ahmed Ghorab
      • Adel Mahmoud El-Mansoury

    • PubMed: 31195950
    • DOI: 10.2174/1574886314666190612130921

    3 Insights on

    • Reduced Neuroinflammation
    • Improved Gut-Brain Axis Related Neurobehavioral Measures
    • No Clear Reversal of Antibiotic-Induced Brain Injury

    • Low evidence
    • Animal Study
• September 18

  • Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model

    • 2019-09-18
    • RCT
    • Frontiers in Physiology 10
    • • Sujuan Ding
      • Yong Ma
      • Gang Liu
      • Wenxin Yan
      • Hongmei Jiang
      • Jun Fang

    • PubMed: 31620010
    • DOI: 10.3389/fphys.2019.01152

    16 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Body Weight
    • Reduced Colitis Severity
    • Reduced Colitis Symptoms
    • Reduced Colonic Inflammation
    • Reduced Relative Abundance of Bacteroidales
    • Reduced Tissue Damage from Colitis
    • Increased Serum Anti-inflammatory Metabolites
    • Increased Anti-Inflammatory Levels
    • Improved Microbiota Diversity
    • Elevated Serum Metabolites in Response to Inflammation
    • Improved Metabolic Profile
    • Reduced Body Weight Loss
    • Enhanced Serum Metabolite Levels Against Inflammation
    • Increased Serum Metabolites to Combat Inflammation
    • Improved Colonic Microbial Diversity

    • Low evidence
    • Animal Study

  • An exploratory pilot study evaluating the supplementation of standard antibiotic therapy with probiotic lactobacilli in south African women with bacterial vaginosis

    • 2019-09-18
    • RCT · n = 39
    • BMC Infectious Diseases 19(1)
    • • H. Marcotte
      • P. Larsson
      • Kasper Krogh Andersen
      • F. Zuo
      • L. S. Mikkelsen
      • E. Brandsborg
      • G. Gray
      • F. Laher
      • K. Otwombe

    • PubMed: 31533663
    • DOI: 10.1186/s12879-019-4425-1

    1 Insight on

    • Increased Vaginal Lactobacilli Colonization

    • High evidence
    • Rigorous Journal
• September 20

  • Influence of Bacillus subtilis GCB-13-001 on growth performance, nutrient digestibility, blood characteristics, faecal microbiota and faecal score in weanling pigs.

    • 2019-09-20
    • RCT
    • Journal of Animal Physiology and Animal Nutrition 103(6)
    • • Huan Wang
      • Kun Phil Kim
      • I. Kim

    • PubMed: 31538695
    • DOI: 10.1111/jpn.13199

    5 Insights on

    • Increased Body Weight
    • Improved Average Daily Gain
    • Improved Nutrient Digestibility
    • Increased Fecal Lactobacillus Count
    • Reduced Fecal Escherichia coli Count

    • High evidence
• September 24

  • Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants

    • 2019-09-24
    • RCT · n = 35
    • Biomedicine Hub 4(3)
    • • T. Oshiro
      • S. Nagata
      • Chongxin Wang
      • Takuya Takahashi
      • H. Tsuji
      • T. Asahara
      • K. Nomoto
      • H. Takei
      • H. Nittono
      • Y. Yamashiro

    • PubMed: 31993433
    • DOI: 10.1159/000502935

    11 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Increased Body Weight
    • Increased Total Bacterial Count
    • Improved Weight Gain
    • Increased Short Chain Fatty Acids
    • Increased Fecal Bifidobacterium Count
    • Increased Plasma Omega-3 Fatty Acids
    • Reduced Fecal Bile Acid Levels
    • Increased Body Weight Gain
    • Increased Total Fecal Bacterial Counts
    • Increased Total Fecal SCFAs

    • High evidence
    • Rigorous Journal
• September 27

  • Influence of Dietary Supplementation of Probiotic Pediococcus acidilactici MA18/5M During the Transition From Freshwater to Seawater on Intestinal Health and Microbiota of Atlantic Salmon (Salmo salar L.)

    • 2019-09-27
    • Frontiers in Microbiology 10
    • • Alexander Jaramillo-Torres
      • M. Rawling
      • A. Rodiles
      • Heidi E. Mikalsen
      • L. Johansen
      • J. Tinsley
      • T. Forberg
      • Elisabeth Aasum
      • M. Castex
      • D. Merrifield

    • PubMed: 31611864
    • DOI: 10.3389/fmicb.2019.02243

    7 Insights on

    • Improved Gut Microbiota
    • Improved Antiviral Response
    • Improved Survival After Viral Challenge
    • Modulated Gut Microbiota
    • Improved Survival Rate After IPNV Challenge
    • Enhanced Antiviral Response
    • Increased Survival Rate After IPNV Challenge

    • Low evidence
• September 30

  • Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review.

    • 2019-09-30
    • Review
    • Journal of pharmacopuncture 22(3)
    • • Azin Niazi
      • Vafa Baradaran Rahimi
      • Hooman Hatami
      • Reza Shirazinia
      • Reza Esmailzadeh-Dizaji
      • Nafiseh Askari
      • Vahid Reza Askari

    • PubMed: 31673442
    • DOI: 10.3831/kpi.2019.22.017

    1 Insight on

    • Reduced Cyclic Mastalgia

    • Low evidence
• Undated – 8 supplement studies

  • Partial characterization of a levan type exopolysaccharide (EPS) produced by Leuconostoc mesenteroides showing immunostimulatory and antioxidant activities.

    • 2019-09
    • International Journal of Biological Macromolecules 136
    • • O. Taylan
      • M. Yılmaz
      • E. Dertli

    • PubMed: 31201910
    • DOI: 10.1016/j.ijbiomac.2019.06.078

    2 Insights on

    • Reduced Inflammatory Response
    • Increased Antioxidant Capacity

    • Low evidence
    • Highly Cited

  • Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk.

    • 2019-09
    • Food Research International 123
    • • M. R. Riaz Rajoka
      • Haobin Zhao
      • H. Mehwish
      • Nan Li
      • Yao Lu
      • Ziyang Lian
      • D. Shao
      • M. Jin
      • Qi Li
      • Liqing Zhao
      • Junling Shi

    • PubMed: 31284979
    • DOI: 10.1016/J.FOODRES.2019.05.002

    4 Insights on

    • Increased Antioxidant Activity
    • Induced Apoptosis
    • Increased Anticancer Activity
    • Increased Anti-Tumor Activity

    • Low evidence

  • Bifidobacterium breve Bif195 Protects Against Small-intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers.

    • 2019-09
    • RCT · n = 75
    • Gastroenterology 157(3)
    • • Brynjulf Mortensen
      • C. Murphy
      • J. O’Grady
      • M. Lucey
      • G. Elsafi
      • L. Barry
      • V. Westphal
      • A. Wellejus
      • O. Lukjancenko
      • A. Eklund
      • H. Nielsen
      • Adam Baker
      • A. Damholt
      • J. V. H. van Hylckama Vlieg
      • F. Shanahan
      • M. Buckley

    • PubMed: 31095949
    • DOI: 10.1053/j.gastro.2019.05.008

    10 Insights on

    • Reduced Incidence of Adverse Events
    • Reduced Small-Intestinal Damage
    • Reduced Small-intestinal Ulcers
    • Reduced Intestinal Damage
    • Increased Safety
    • Reduced Small-Intestinal Enteropathy
    • Reduced Incidence of Ulcers
    • Reduced Ulcer Count
    • Reduced Ulcers Caused by ASA
    • Reduced Ulcer Formation

    • High evidence

  • "Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir".

    • 2019-09
    • Food Research International 123
    • • A. Bengoa
      • Carolina Iraporda
      • L. Acurcio
      • S. H. de Cicco Sandes
      • Karen Costa
      • Gabriele Moreira Guimarães
      • R. M. Esteves Arantes
      • E. Neumann
      • Á. Cantini Nunes
      • J. R. Nicoli
      • G. L. Garrote
      • A. Abraham

    • PubMed: 31284997
    • DOI: 10.1016/J.FOODRES.2019.04.041

    5 Insights on

    • Reduced Induced Innate Immune Response
    • Improved Probiotic Functionality for Functional Foods Development
    • Reduced IFN-γ Levels
    • Safe for Consumption with No Adverse Immune Effects
    • Increased Antibiotic Susceptibility

    • Low evidence

  • BACILLUS CLAUSII SEPTICEMIA IN A PEDIATRIC PATIENT AFTER TREATMENT WITH PROBIOTICS.

    • 2019-09
    • Case Report · n = 1
    • Pediatric Infectious Disease Journal 38(9)
    • • S. Joshi
      • S. Udani
      • Supratim Sen
      • S. Kirolikar
      • A. Shetty

    • PubMed: 31033906
    • DOI: 10.1097/INF.0000000000002350

    4 Insights on

    • Septicemia Incidence
    • Presence of Multidrug-Resistant Sepsis
    • Multiorgan Failure
    • Developed Septicemia

    • Low evidence

  • Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation.

    • 2019-09
    • International Journal of Biological Macromolecules 136
    • • Huifang Wang
      • Qiuxiang Zhang
      • Yuhan Niu
      • Xin Zhang
      • Rongrong Lu

    • PubMed: 31185242
    • DOI: 10.1016/j.ijbiomac.2019.06.041

    3 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation
    • Reduced Apoptosis

    • Low evidence

  • The Effect of 2 Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory, and Performance Responses During Self-Defense Training in Soldiers.

    • 2019-09
    • RCT · n = 16
    • Journal of Strength and Conditioning Research 33(9)
    • • J. Hoffman
      • Mattan W. Hoffman
      • H. Zelicha
      • Y. Gepner
      • D. Willoughby
      • Uri Feinstein
      • I. Ostfeld

    • PubMed: 31306390
    • DOI: 10.1519/JSC.0000000000003265

    10 Insights on

    • Increased Interferon-Gamma Levels
    • Reduced Interferon-Gamma Levels
    • Reduced IL-6 Levels
    • Maintained Physical Performance
    • Increased IL-10 Concentration
    • Decreased TNFα Levels
    • Increased Tumor Necrosis Factor-Alpha Levels
    • Enhanced Power Performance
    • Enhanced Speed Performance
    • Elevated Interleukin-6 Levels

    • High evidence

  • A single-centre investigator-blinded randomised parallel group clinical trial to investigate the effect of probiotic strains Streptococcus salivarius M18 and Lactobacillus acidophilus on gingival health of paediatric patients undergoing treatment with fixed orthodontic appliances: study protocol

    • 2019-09
    • RCT · n = 50
    • BMJ Open 9(9)
    • • E. Kaklamanos
      • Rania Nassar
      • S. Kalfas
      • M. Al Halabi
      • M. Kowash
      • Haifa Hannawi
      • I. Hussein
      • A. Salami
      • A. Hassan
      • A. Senok

    • PubMed: 31501124
    • DOI: 10.1136/bmjopen-2019-030638

    4 Insights on

    • Reduced Gingival Index
    • Reduced Bleeding on Probing (BOP)
    • Reduced Plaque Index
    • Altered Oral Microbiome Composition

    • High evidence
    • Rigorous Journal