September 2019 Supplement Research Papers

• September 1

  • Assessment of Freeze-Dried Immobilized Lactobacillus casei as Probiotic Adjunct Culture in Yogurts

    • 2019-09-01
    • Foods 8(9)
    • • D. Dimitrellou
      • P. Kandylis
      • Y. Kourkoutas

    • PubMed: 31480583
    • DOI: 10.3390/foods8090374

    1 Insight on

    • Improved Sensory Function

    • Low evidence

  • Bacteriocin activity of Lactobacillus brevis and Lactobacillus paracasei ssp. paracasei.

    • 2019-09-01
    • Journal of Medical Microbiology 68(9)
    • • R. Iseppi
      • P. Messi
      • Stefania Camellini
      • C. Sabia

    • PubMed: 31364964
    • DOI: 10.1099/jmm.0.001045

    3 Insights on

    • Enhanced Antimicrobial Resistance
    • Increased Antibacterial Activity
    • Increased Cell Adhesion

    • Low evidence
• September 4

  • Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study.

    • 2019-09-04
    • RCT
    • Nutrients 11(9)
    • • Ezgi Bellikci-Koyu
      • Banu Pınar Sarer-Yurekli
      • Yakut Akyon
      • Fadime Aydin-Kose
      • Cem Karagozlu
      • Ahmet Gokhan Ozgen
      • Annika Brinkmann
      • Andreas Nitsche
      • Koray Ergunay
      • Engin Yilmaz
      • Zehra Buyuktuncer

    • PubMed: 31487797
    • DOI: 10.3390/nu11092089

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Insulin Levels
    • Reduced Interferon-gamma Level
    • Reduced Systolic Blood Pressure
    • Reduced HOMA-IR
    • Reduced Tumor Necrosis Factor Alpha

    • High evidence
    • Rigorous Journal

  • The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.

    • 2019-09-04
    • RCT · n = 40
    • Complementary medicine research 27(1)
    • • Hamidreza Ardalani
      • Parisa Jandaghi
      • Aramsadat Meraji
      • Maryam Hassanpour Moghadam

    • PubMed: 31484191
    • DOI: 10.1159/000502280

    3 Insights on

    • Reduced Systolic Blood Pressure
    • Improved Body Mass Index
    • Reduced Diastolic Blood Pressure

    • High evidence
• September 5

  • Chinese Medicines for Preventing and Treating Radiation-Induced Pulmonary Injury: Still a Long Way to Go.

    • 2019-09-05
    • Review
    • Frontiers in pharmacology 10
    • • Yan Ding
      • Yuechao Liu
      • Hongliang Li
      • Yong Li
      • Minglun Li
      • Ming Liu
      • Xianhe Wang
      • Fengjun Cao
      • Xuanbin Wang

    • PubMed: 31616288
    • DOI: 10.3389/fphar.2019.00927

    2 Insights on

    • Reduced Radiation-Induced Pulmonary Injury
    • Improved Treatment Efficacy for Radiation-Induced Pulmonary Injury

    • Low evidence
• September 7

  • Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis.

    • 2019-09-07
    • Meta-Analysis
    • World journal of gastroenterology 25(33)
    • • Ya-Ting Li
      • Hong Xu
      • Jian-Zhong Ye
      • Wen-Rui Wu
      • Ding Shi
      • Dai-Qiong Fang
      • Yang Liu
      • Lan-Juan Li

    • PubMed: 31543689
    • DOI: 10.3748/wjg.v25.i33.4999

    2 Insights on

    • Reduced Stool Frequency
    • Reduced Duration of Diarrhea

    • High evidence
• September 8

  • Saccharomyces cerevisiae as a probiotic feed additive to non and pseudo‐ruminant feeding: a review

    • 2019-09-08
    • Review
    • Journal of Applied Microbiology 128(3)
    • • M. Elghandour
      • Z. Tan
      • S. A. Abu Hafsa
      • M. Adegbeye
      • R. Greiner
      • E. Ugbogu
      • J. Cedillo Monroy
      • A. Salem

    • PubMed: 31429174
    • DOI: 10.1111/jam.14416

    9 Insights on

    • Reduced Mycotoxin Levels
    • Reduced Postweaning Diarrhea
    • Maintained Physical Performance
    • Improved Mucosal Immunity
    • Reduced Pathogenic Bacteria Levels
    • Improved Digestibility
    • Improved Apparent Digestibility of Fiber
    • Improved Animal Health
    • Enhanced Immunity

    • Moderate evidence
    • Highly Cited
• September 9

  • Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets.

    • 2019-09-09
    • RCT · n = 60
    • Journal of Animal Physiology and Animal Nutrition 103(6)
    • • Qi Wang
      • Qian Sun
      • R. Qi
      • Jing Wang
      • Xiaoyu Qiu
      • Zuohua Liu
      • Jinxiu Huang

    • PubMed: 31498508
    • DOI: 10.1111/jpn.13198

    8 Insights on

    • Enhanced Antimicrobial Peptide Levels
    • Improved Intestinal Morphology
    • Improved Immune Response
    • Improved Intestinal Barrier Function
    • Improved Gut Microbiota Composition
    • Modulated Immune Response
    • Reduced Diarrhea Incidence
    • Enhanced Antimicrobial Peptide Production

    • Low evidence
    • Animal Study
• September 12

  • Ameliorative Effects of Probiotic Lactobacillus paracasei NL41 on Insulin Sensitivity, Oxidative Stress and Beta-Cell Function in a Type 2 Diabetes Mellitus Rat Model.

    • 2019-09-12
    • RCT · n = 18
    • Molecular Nutrition & Food Research 63(22)
    • • Z. Zeng
      • Qipeng Yuan
      • Rui Yu
      • Jinlan Zhang
      • Huiqin Ma
      • Shangwu Chen

    • PubMed: 31433912
    • DOI: 10.1002/mnfr.201900457

    23 Insights on

    • Prevention of Beta-Cell Loss
    • Reduced Blood Glucose Levels
    • Reduced Leptin Levels
    • Reduced Hepatic Oxidative Stress
    • Preserved Beta-Cell Function
    • Improved Beta-Cell Function
    • Reduced Alpha-cell Expansion
    • Improved Insulin Sensitivity
    • Regulated Blood Glucose Levels
    • Reduced Blood HbA1c Levels
    • Reduced Oxidative Stress
    • Reduced Beta-Cell Loss
    • Improved Blood Glucose Levels
    • Improved Dyslipidemia
    • Improved Glucose Regulation
    • Reduced Blood Leptin Levels
    • Reduction of Diabetes-Induced Organ Damage
    • Preserved Islets of Langerhans
    • Preserved Islet Function
    • Improved Blood Glucose Control
    • Reduced Glucagon Levels
    • Improved Lipid Profile
    • Improved Insulin Resistance

    • Low evidence
    • Animal Study

  • Protective effects of Lactobacillus plantarum against chronic alcohol-induced liver injury in the murine model

    • 2019-09-12
    • Applied Microbiology and Biotechnology 103(20)
    • • T. J. Fang
      • Jiun-Ting Guo
      • Ming-Kuem Lin
      • Meng-Shiou Lee
      • Yen-Lien Chen
      • Wen-Hsin Lin

    • PubMed: 31515596
    • DOI: 10.1007/s00253-019-10122-8

    5 Insights on

    • Reduced Liver Enzyme Levels
    • Improved Intestinal Barrier Function
    • Improved Antioxidant Enzyme Levels
    • Reduced Endotoxin Levels
    • Reduced Pro-inflammatory Cytokine Levels

    • Low evidence
• September 15

  • Yacon syrup reduces postprandial glycemic response to breakfast: A randomized, crossover, double-blind clinical trial.

    • 2019-09-15
    • RCT · n = 40
    • Food research international (Ottawa, Ont.) 126
    • • Lia Silveira Adriano
      • Ana Paula Dionísio
      • Fernando Antônio Pinto de Abreu
      • Antônio Augusto Ferreira Carioca
      • Guilherme Julião Zocolo
      • Nedio Jair Wurlitzer
      • Claudia de Oliveira Pinto
      • Ariclécio Cunha de Oliveira
      • Helena Alves de Carvalho Sampaio

    • PubMed: 31732062
    • DOI: 10.1016/j.foodres.2019.108682

    3 Insights on

    • Reduced Postprandial Triglyceride Level
    • Reduced Postprandial Insulin
    • Reduced Postprandial Glucose

    • High evidence
• September 17

  • Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice.

    • 2019-09-17
    • Current drug safety 14(3)
    • • Ahmed Mohamed Nabil Helaly
      • Yomna Ahmed El-Attar
      • Mahmoud Khalil
      • Doaa Shams El-Din Ahmed Ghorab
      • Adel Mahmoud El-Mansoury

    • PubMed: 31195950
    • DOI: 10.2174/1574886314666190612130921

    3 Insights on

    • Reduced Neuroinflammation
    • Improved Gut-Brain Axis Related Neurobehavioral Measures
    • No Clear Reversal of Antibiotic-Induced Brain Injury

    • Low evidence
    • Animal Study
• September 18

  • Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model

    • 2019-09-18
    • RCT
    • Frontiers in Physiology 10
    • • Sujuan Ding
      • Yong Ma
      • Gang Liu
      • Wenxin Yan
      • Hongmei Jiang
      • Jun Fang

    • PubMed: 31620010
    • DOI: 10.3389/fphys.2019.01152

    16 Insights on

    • Reduced Colonic Inflammation
    • Increased Anti-Inflammatory Levels
    • Reduced Body Weight
    • Reduced Body Weight Loss
    • Improved Metabolic Profile
    • Enhanced Serum Metabolite Levels Against Inflammation
    • Reduced Tissue Damage from Colitis
    • Reduced Relative Abundance of Bacteroidales
    • Reduced Colitis Symptoms
    • Increased Serum Metabolites to Combat Inflammation
    • Elevated Serum Metabolites in Response to Inflammation
    • Reduced Colitis Severity
    • Improved Colonic Microbial Diversity
    • Improved Diversity of Gut Microbiota
    • Improved Gut Microbiota Diversity
    • Increased Serum Anti-inflammatory Metabolites

    • Low evidence
    • Animal Study

  • An exploratory pilot study evaluating the supplementation of standard antibiotic therapy with probiotic lactobacilli in south African women with bacterial vaginosis

    • 2019-09-18
    • RCT · n = 39
    • BMC Infectious Diseases 19(1)
    • • H. Marcotte
      • P. Larsson
      • Kasper Krogh Andersen
      • F. Zuo
      • L. S. Mikkelsen
      • E. Brandsborg
      • G. Gray
      • F. Laher
      • K. Otwombe

    • PubMed: 31533663
    • DOI: 10.1186/s12879-019-4425-1

    1 Insight on

    • Increased Vaginal Lactobacilli Colonization

    • High evidence
    • Rigorous Journal
• September 20

  • Influence of Bacillus subtilis GCB-13-001 on growth performance, nutrient digestibility, blood characteristics, faecal microbiota and faecal score in weanling pigs.

    • 2019-09-20
    • RCT
    • Journal of Animal Physiology and Animal Nutrition 103(6)
    • • Huan Wang
      • Kun Phil Kim
      • I. Kim

    • PubMed: 31538695
    • DOI: 10.1111/jpn.13199

    5 Insights on

    • Increased Body Weight
    • Increased Fecal Lactobacillus Count
    • Improved Average Daily Gain
    • Improved Nutrient Digestibility
    • Reduced Fecal Escherichia coli Count

    • High evidence
• September 23

  • Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis.

    • 2019-09-23
    • Clinical Trial
    • Digestive diseases and sciences 65(4)
    • • Grettel García-Collinot
      • Eduardo Osiris Madrigal-Santillán
      • Michel A Martínez-Bencomo
      • Rosa A Carranza-Muleiro
      • Luis J Jara
      • Olga Vera-Lastra
      • Daniel H Montes-Cortes
      • Gabriela Medina
      • María Pilar Cruz-Domínguez

    • PubMed: 31549334
    • DOI: 10.1007/s10620-019-05830-0

    5 Insights on

    • Reduced Flatulence
    • Reduced Hydrogen Breath Level
    • Reduced Small Intestinal Bacterial Overgrowth
    • Reduced Abdominal Pain
    • Reduced Diarrhea Rate

    • High evidence
    • Rigorous Journal
• September 24

  • Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants

    • 2019-09-24
    • RCT · n = 35
    • Biomedicine Hub 4(3)
    • • T. Oshiro
      • S. Nagata
      • Chongxin Wang
      • Takuya Takahashi
      • H. Tsuji
      • T. Asahara
      • K. Nomoto
      • H. Takei
      • H. Nittono
      • Y. Yamashiro

    • PubMed: 31993433
    • DOI: 10.1159/000502935

    11 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Increased Plasma Omega-3 Fatty Acids
    • Increased Body Weight
    • Increased Fecal Bifidobacterium Count
    • Reduced Fecal Bile Acid Levels
    • Increased Body Weight Gain
    • Increased Short Chain Fatty Acids
    • Improved Weight Gain
    • Increased Total Bacterial Count
    • Increased Total Fecal SCFAs
    • Increased Total Fecal Bacterial Counts

    • High evidence
    • Rigorous Journal
• September 27

  • Influence of Dietary Supplementation of Probiotic Pediococcus acidilactici MA18/5M During the Transition From Freshwater to Seawater on Intestinal Health and Microbiota of Atlantic Salmon (Salmo salar L.)

    • 2019-09-27
    • Frontiers in Microbiology 10
    • • Alexander Jaramillo-Torres
      • M. Rawling
      • A. Rodiles
      • Heidi E. Mikalsen
      • L. Johansen
      • J. Tinsley
      • T. Forberg
      • Elisabeth Aasum
      • M. Castex
      • D. Merrifield

    • PubMed: 31611864
    • DOI: 10.3389/fmicb.2019.02243

    7 Insights on

    • Improved Survival After Viral Challenge
    • Increased Survival Rate After IPNV Challenge
    • Enhanced Antiviral Response
    • Improved Antiviral Response
    • Improved Survival Rate After IPNV Challenge
    • Improved Gut Microbiota
    • Modulated Gut Microbiota

    • Low evidence
• September 30

  • Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review.

    • 2019-09-30
    • Review
    • Journal of pharmacopuncture 22(3)
    • • Azin Niazi
      • Vafa Baradaran Rahimi
      • Hooman Hatami
      • Reza Shirazinia
      • Reza Esmailzadeh-Dizaji
      • Nafiseh Askari
      • Vahid Reza Askari

    • PubMed: 31673442
    • DOI: 10.3831/kpi.2019.22.017

    1 Insight on

    • Reduced Cyclic Mastalgia

    • Low evidence
• Undated – 10 supplement studies

  • Partial characterization of a levan type exopolysaccharide (EPS) produced by Leuconostoc mesenteroides showing immunostimulatory and antioxidant activities.

    • 2019-09
    • International Journal of Biological Macromolecules 136
    • • O. Taylan
      • M. Yılmaz
      • E. Dertli

    • PubMed: 31201910
    • DOI: 10.1016/j.ijbiomac.2019.06.078

    2 Insights on

    • Increased Antioxidant Capacity
    • Reduced Inflammatory Response

    • Low evidence
    • Highly Cited

  • Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk.

    • 2019-09
    • Food Research International 123
    • • M. R. Riaz Rajoka
      • Haobin Zhao
      • H. Mehwish
      • Nan Li
      • Yao Lu
      • Ziyang Lian
      • D. Shao
      • M. Jin
      • Qi Li
      • Liqing Zhao
      • Junling Shi

    • PubMed: 31284979
    • DOI: 10.1016/J.FOODRES.2019.05.002

    4 Insights on

    • Increased Anti-Tumor Activity
    • Increased Antioxidant Activity
    • Increased Anticancer Activity
    • Induced Apoptosis

    • Low evidence

  • Bifidobacterium breve Bif195 Protects Against Small-intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers.

    • 2019-09
    • RCT · n = 75
    • Gastroenterology 157(3)
    • • Brynjulf Mortensen
      • C. Murphy
      • J. O’Grady
      • M. Lucey
      • G. Elsafi
      • L. Barry
      • V. Westphal
      • A. Wellejus
      • O. Lukjancenko
      • A. Eklund
      • H. Nielsen
      • Adam Baker
      • A. Damholt
      • J. V. H. van Hylckama Vlieg
      • F. Shanahan
      • M. Buckley

    • PubMed: 31095949
    • DOI: 10.1053/j.gastro.2019.05.008

    10 Insights on

    • Reduced Small-Intestinal Enteropathy
    • Reduced Small-Intestinal Damage
    • Reduced Ulcer Count
    • Reduced Incidence of Adverse Events
    • Reduced Intestinal Damage
    • Reduced Incidence of Ulcers
    • Increased Safety
    • Reduced Ulcers Caused by ASA
    • Reduced Small-intestinal Ulcers
    • Reduced Ulcer Formation

    • High evidence

  • "Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir".

    • 2019-09
    • Food Research International 123
    • • A. Bengoa
      • Carolina Iraporda
      • L. Acurcio
      • S. H. de Cicco Sandes
      • Karen Costa
      • Gabriele Moreira Guimarães
      • R. M. Esteves Arantes
      • E. Neumann
      • Á. Cantini Nunes
      • J. R. Nicoli
      • G. L. Garrote
      • A. Abraham

    • PubMed: 31284997
    • DOI: 10.1016/J.FOODRES.2019.04.041

    5 Insights on

    • Increased Antibiotic Susceptibility
    • Safe for Consumption with No Adverse Immune Effects
    • Improved Probiotic Functionality for Functional Foods Development
    • Reduced IFN-γ Levels
    • Reduced Induced Innate Immune Response

    • Low evidence

  • Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation.

    • 2019-09
    • International Journal of Biological Macromolecules 136
    • • Huifang Wang
      • Qiuxiang Zhang
      • Yuhan Niu
      • Xin Zhang
      • Rongrong Lu

    • PubMed: 31185242
    • DOI: 10.1016/j.ijbiomac.2019.06.041

    3 Insights on

    • Reduced Intestinal Inflammation
    • Improved Intestinal Barrier Function
    • Reduced Apoptosis

    • Low evidence

  • BACILLUS CLAUSII SEPTICEMIA IN A PEDIATRIC PATIENT AFTER TREATMENT WITH PROBIOTICS.

    • 2019-09
    • Case Report · n = 1
    • Pediatric Infectious Disease Journal 38(9)
    • • S. Joshi
      • S. Udani
      • Supratim Sen
      • S. Kirolikar
      • A. Shetty

    • PubMed: 31033906
    • DOI: 10.1097/INF.0000000000002350

    4 Insights on

    • Developed Septicemia
    • Presence of Multidrug-Resistant Sepsis
    • Septicemia Incidence
    • Multiorgan Failure

    • Low evidence

  • The Effect of 2 Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory, and Performance Responses During Self-Defense Training in Soldiers.

    • 2019-09
    • RCT · n = 16
    • Journal of Strength and Conditioning Research 33(9)
    • • J. Hoffman
      • Mattan W. Hoffman
      • H. Zelicha
      • Y. Gepner
      • D. Willoughby
      • Uri Feinstein
      • I. Ostfeld

    • PubMed: 31306390
    • DOI: 10.1519/JSC.0000000000003265

    10 Insights on

    • Reduced Interferon-Gamma Levels
    • Increased Tumor Necrosis Factor-Alpha Levels
    • Elevated Interleukin-6 Levels
    • Enhanced Speed Performance
    • Enhanced Power Performance
    • Maintained Physical Performance
    • Increased IL-10 Concentration
    • Reduced IL-6 Levels
    • Decreased TNFα Levels
    • Increased Interferon-Gamma Levels

    • High evidence

  • A single-centre investigator-blinded randomised parallel group clinical trial to investigate the effect of probiotic strains Streptococcus salivarius M18 and Lactobacillus acidophilus on gingival health of paediatric patients undergoing treatment with fixed orthodontic appliances: study protocol

    • 2019-09
    • RCT · n = 50
    • BMJ Open 9(9)
    • • E. Kaklamanos
      • Rania Nassar
      • S. Kalfas
      • M. Al Halabi
      • M. Kowash
      • Haifa Hannawi
      • I. Hussein
      • A. Salami
      • A. Hassan
      • A. Senok

    • PubMed: 31501124
    • DOI: 10.1136/bmjopen-2019-030638

    4 Insights on

    • Altered Oral Microbiome Composition
    • Reduced Bleeding on Probing (BOP)
    • Reduced Gingival Index
    • Reduced Plaque Index

    • High evidence
    • Rigorous Journal

  • Addition of oat bran reduces HDL-C and does not potentialize effect of a low-calorie diet on remission of metabolic syndrome: A pragmatic, randomized, controlled, open-label nutritional trial.

    • 2019-09
    • RCT · n = 83
    • Nutrition (Burbank, Los Angeles County, Calif.) 65
    • • Leila Sicupira Carneiro de Souza Leão
      • Luana Azevedo de Aquino
      • Juliana Furtado Dias
      • Rosalina Jorge Koifman

    • PubMed: 31082790
    • DOI: 10.1016/j.nut.2019.03.007

    9 Insights on

    • Reduced Blood Glucose Levels
    • Reduced Body Weight
    • Reduced Body Mass Index
    • Reduced Systolic Blood Pressure
    • Reduced Metabolic Syndrome Prevalence
    • Increased HDL Cholesterol Levels
    • Reduced Diastolic Blood Pressure
    • Reduced Triacylglyceride Level
    • Reduced Waist Circumference

    • High evidence

  • The effects of supplementation with L-carnitine on apolipoproteins: A systematic review and meta-analysis of randomized trials.

    • 2019-09
    • Meta-Analysis
    • European journal of pharmacology 858
    • • Ali Sheikhi
      • Kurosh Djafarian
      • Moein Askarpour
      • Sakineh Shab-Bidar

    • PubMed: 31255604
    • DOI: 10.1016/j.ejphar.2019.172493

    2 Insights on

    • Reduced Apolipoprotein B100 Level
    • Reduced Apolipoprotein AI Level

    • High evidence