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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Health-Promoting Nature of Lactococcus lactis IBB109 and Lactococcus lactis IBB417 Strains Exhibiting Proliferation Inhibition and Stimulation of Interleukin-18 Expression in Colorectal Cancer Cells
- 2022-05-25
- Frontiers in Microbiology 13
- - Przemysław Sałański
  - M. Kowalczyk
  - J. Bardowski
  - A. Szczepankowska
- PubMed: 35694291
- DOI: 10.3389/fmicb.2022.822912
2 Insights on
- Improved Antibiotic Sensitivity
- Improved Intestinal Cell Adhesion
- Low evidence
The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG.
- 2022-05-25
- Applied microbiology and biotechnology 106(11)
- - Linda J Urbański
  - Silvia Bua
  - Andrea Angeli
  - Reza Zolfaghari Emameh
  - Harlan R Barker
  - Marianne Kuuslahti
  - Vesa P Hytönen
  - Seppo Parkkila
  - Claudiu T Supuran
- PubMed: 35612631
- DOI: 10.1007/s00253-022-11990-3
2 Insights on
- No Significant Effect on Probiotic Growth
- No Significant Effect on Cell Growth
- Low evidence
Effects of Dietary Supplementation With Clostridium butyricum on Growth Performance, Apparent Digestibility, Blood Metabolites, Ruminal Fermentation and Bacterial Communities of Fattening Goats
- 2022-05-24
- RCT
- Frontiers in Nutrition 9
- - Chengrui Zhang
  - Qingyuan Yu
  - Jihong Wang
  - Yidong Yu
  - Yonggen Zhang
  - Yukun Sun
- PubMed: 35685891
- DOI: 10.3389/fnut.2022.888191
3 Insights on
- High evidence
The effect of Rosa canina L. and a polyherbal formulation syrup in patients with attention-deficit/hyperactivity disorder: a study protocol for a multicenter randomized controlled trial.
- 2022-05-23
- RCT · n = 30
- Trials 23(1)
- - Haide Golsorkhi
  - Mostafa Qorbani
  - Mohammad Kamalinejad
  - Saeideh Sabbaghzadegan
  - Mohsen Bahrami
  - Mohammad Vafaee-Shahi
  - Hadi Montazerlotfelahi
  - Elham Abniki
  - Majid Dadmehr
- PubMed: 35606864
- DOI: 10.1186/s13063-022-06297-7
1 Insight on
- Improved ADHD Symptoms
- High evidence
Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis.
- 2022-05-23
- Review
- Evidence-based complementary and alternative medicine : eCAM 2022
- - Hye In Jeong
  - Soobin Jang
  - Kyeong Han Kim
- PubMed: 35656460
- DOI: 10.1155/2022/9282154
2 Insights on
- Reduced Postprandial Glucose
- Reduced Postprandial Insulin
- Low evidence
Short-term intestinal effects of water intake in fibre supplementation in healthy, low-habitual fibre consumers: a phase 2 clinical trial.
- 2022-05-23
- RCT
- International journal of food sciences and nutrition 73(6)
- - Gissele V R Gonçalves
  - Raíssa Canova
  - Sidia M Callegari-Jacques
  - Rafael Frandoloso
  - Luiz C Kreutz
  - Fernando Fornari
- PubMed: 35603590
- DOI: 10.1080/09637486.2022.2079117
7 Insights on
- High evidence
Anthocyanins in Chronic Diseases: The Power of Purple.
- 2022-05-23
- Review
- Nutrients 14(10)
- - Sunil K Panchal
  - Oliver D John
  - Michael L Mathai
  - Lindsay Brown
- PubMed: 35631301
- DOI: 10.3390/nu14102161
9 Insights on
- Moderate evidence
- Rigorous Journal
Lactiplantibacillus plantarum Y42 in Biofilm and Planktonic States Improves Intestinal Barrier Integrity and Modulates Gut Microbiota of Balb/c Mice
- 2022-05-17
- Clinical Trial
- Foods 11(10)
- - Lijuan Zhang
  - Yuan Meng
  - Jiayi Li
  - Jiang Yu
  - Guangqing Mu
  - Y. Tuo
- PubMed: 35627021
- DOI: 10.3390/foods11101451
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota.
- 2022-05-16
- Review
- Frontiers in cellular and infection microbiology 12
- - Anjana
  - Santosh Kumar Tiwari
- PubMed: 35651753
- DOI: 10.3389/fcimb.2022.851140
4 Insights on
- Moderate evidence
- Highly Cited
Effect of ancient Khorasan wheat on gut microbiota, inflammation, and short-chain fatty acid production in patients with fibromyalgia.
- 2022-05-14
- RCT
- World journal of gastroenterology 28(18)
- - Simone Baldi
  - Giuditta Pagliai
  - Monica Dinu
  - Leandro Di Gloria
  - Giulia Nannini
  - Lavinia Curini
  - Marco Pallecchi
  - Edda Russo
  - Elena Niccolai
  - Giovanna Danza
  - Stefano Benedettelli
  - Giovanna Ballerini
  - Barbara Colombini
  - Gianluca Bartolucci
  - Matteo Ramazzotti
  - Francesco Sofi
  - Amedeo Amedei
- PubMed: 35664958
- DOI: 10.3748/wjg.v28.i18.1965
6 Insights on
- High evidence
The Complex Role of Lactic Acid Bacteria in Food Detoxification.
- 2022-05-12
- Review
- Nutrients 14(10)
- - Penka Petrova
  - Alexander Arsov
  - Flora Tsvetanova
  - Tsvetomila Parvanova-Mancheva
  - Evgenia Vasileva
  - Lidia Tsigoriyna
  - Kaloyan Petrov
- PubMed: 35631179
- DOI: 10.3390/nu14102038
1 Insight on
- Improved Detoxification
- Moderate evidence
- Rigorous Journal
Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice.
- 2022-05-11
- Clinical Trial
- Food & Function 13(9)
- - Linlin Wang
  - Mao-zhou Chai
  - Jialiang Wang
  - Q. Yu
  - G. Wang
  - H. Zhang
  - Jianxin Zhao
  - Wei Chen
- PubMed: 35394000
- DOI: 10.1039/d1fo04151g
12 Insights on
- Low evidence
- Animal Study
Clustering Analysis of the Multi-Microbial Consortium by Lactobacillus Species Against Vaginal Dysbiosis Among Ecuadorian Women
- 2022-05-11
- Observational · n = 436
- Frontiers in Cellular and Infection Microbiology 12
- - David Pacha-Herrera
  - Maria P. Erazo-Garcia
  - Dario F. Cueva
  - M. Orellana
  - Pamela Borja-Serrano
  - Camila Arboleda
  - E. Tejera
  - A. Machado
- PubMed: 35646732
- DOI: 10.3389/fcimb.2022.863208
3 Insights on
- High evidence
A novel Lactobacillus bulgaricus isolate can maintain the intestinal health, improve the growth performance and reduce the colonization of E. coli O157:H7 in broilers
- 2022-05-11
- RCT · n = 80
- British Poultry Science 63(5)
- - L. Xiang
  - Z. Ying
  - M. Xue
  - P. Xiaoxian
  - L. Xiaorong
  - L. Chunyang
  - W. Yu
  - L. Mingcheng
  - L. Binxian
- PubMed: 35383527
- DOI: 10.1080/00071668.2022.2062220
8 Insights on
- Low evidence
- Animal Study
Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice.
- 2022-05-11
- Clinical Trial
- Food & Function 13(9)
- - Jiahuan Dong
  - Lijun Ping
  - Kangyong Zhang
  - H. Tang
  - Jie Liu
  - Deyu Liu
  - Li Zhao
  - S. Evivie
  - Bailiang Li
  - G. Huo
- PubMed: 35395665
- DOI: 10.1039/d1fo04204a
7 Insights on
- Low evidence
- Animal Study
Effect of Oral Intake of Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) on Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study
- 2022-05-11
- RCT · n = 27
- Nutrients 14(10)
- - Kyoungmi Jung
  - A. Kim
  - Ji-Hae Lee
  - Donghyun Cho
  - Juyeon Seo
  - Eun Sung Jung
  - Hye-Ji Kang
  - J. Roh
  - Wang Z Kim
- PubMed: 35631156
- DOI: 10.3390/nu14102015
14 Insights on
- High evidence
20 Years of Legislation - How Australia Has Responded to the Challenge of Regulating Genetically Modified Organisms in the Clinic.
- 2022-05-10
- Review
- Frontiers in medicine 9
- - Gabrielle M O'Sullivan
  - Joshua G Philips
  - Heidi J Mitchell
  - Michael Dornbusch
  - John E J Rasko
- PubMed: 35620726
- DOI: 10.3389/fmed.2022.883434
2 Insights on
- Improved Gastrointestinal Symptoms
- Improved Defecation Condition
- Low evidence
Assessments of Probiotic Potentials of Lactiplantibacillus plantarum Strains Isolated From Chinese Traditional Fermented Food: Phenotypic and Genomic Analysis
- 2022-05-09
- Frontiers in Microbiology 13
- - Yuwei Sun
  - Shiyao Zhang
  - Hong Li
  - Jiang Zhu
  - Zhijia Liu
  - Xiaosong Hu
  - Junjie Yi
- PubMed: 35615501
- DOI: 10.3389/fmicb.2022.895132
2 Insights on
- Increased Antibacterial Activity
- Increased Antioxidant Capacity
- Low evidence
Lactiplantibacillus plantarum J‐15 reduced calcium oxalate kidney stones by regulating intestinal microbiota, metabolism, and inflammation in rats
- 2022-05-07
- Clinical Trial
- The FASEB Journal 36(6)
- - Lei Tian
  - Yu Liu
  - Xiaofang Xu
  - Pengrui Jiao
  - Gaofei Hu
  - Yaqian Cui
  - Jixiang Chen
  - Yuchen Ma
  - X. Jin
  - Kun-jie Wang
  - Qun Sun
- PubMed: 35524736
- DOI: 10.1096/fj.202101972RR
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Continuous Ingestion of Lacticaseibacillus rhamnosus JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats
- 2022-05-05
- RCT · n = 20
- International Journal of Molecular Sciences 23(9)
- - A. Chudzik
  - Tymoteusz Slowik
  - Katarzyna Kochalska
  - A. Pankowská
  - Artur Łazorczyk
  - M. Andres-Mach
  - R. Rola
  - G. Stanisz
  - Anna Orzyłowska
- PubMed: 35563564
- DOI: 10.3390/ijms23095173
3 Insights on
- Low evidence
- Animal Study
Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis.
- 2022-05-03
- Systematic Review
- Frontiers in pharmacology 13
- - Tusheema Dutta
  - Uttpal Anand
  - Shreya Sikdar Mitra
  - Mimosa Ghorai
  - Niraj Kumar Jha
  - Nusratbanu K Shaikh
  - Mahipal S Shekhawat
  - Devendra Kumar Pandey
  - Devendra Kumar Pandey
  - Jarosław Proćków
  - Abhijit Dey
- PubMed: 35592415
- DOI: 10.3389/fphar.2022.827411
1 Insight on
- Reduced ADHD Symptoms
- High evidence
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
- 2022-05-03
- RCT · n = 365
- Circulation 145(18)
- - Axel C P Diederichsen
  - Jes S Lindholt
  - Sören Möller
  - Kristian A Øvrehus
  - Søren Auscher
  - Jess Lambrechtsen
  - Susanne E Hosbond
  - Dilek H Alan
  - Grazina Urbonaviciene
  - Søren W Becker
  - Maise H Fredgart
  - Selma Hasific
  - Lars Folkestad
  - Oke Gerke
  - Lars Melholt Rasmussen
  - Jacob E Møller
  - Hans Mickley
  - Jordi S Dahl
- PubMed: 35465686
- DOI: 10.1161/circulationaha.121.057008
1 Insight on
- Reduced Dephosphorylated-Uncarboxylated Matrix Gla Protein Level
- High evidence
- Large Human Trial
- Rigorous Journal
Lactiplantibacillus plantarum-12 Alleviates Inflammation and Colon Cancer Symptoms in AOM/DSS-Treated Mice through Modulating the Intestinal Microbiome and Metabolome
- 2022-05-03
- Clinical Trial
- Nutrients 14(9)
- - Fenglian Ma
  - Mengying Sun
  - Yinglong Song
  - Arong Wang
  - Shujuan Jiang
  - Fang Qian
  - Guangqing Mu
  - Y. Tuo
- PubMed: 35565884
- DOI: 10.3390/nu14091916
4 Insights on
- Low evidence
- Animal Study
The right bug in the right place: opportunities for bacterial vaginosis treatment.
- 2022-05-02
- Review
- NPJ biofilms and microbiomes 8(1)
- - Shengru Wu
  - Luisa Warchavchik Hugerth
  - Ina Schuppe-Koistinen
  - Juan Du
- PubMed: 35501321
- DOI: 10.1038/s41522-022-00295-y
1 Insight on
- Reduced Recurrence of Bacterial Vaginosis
- Low evidence
Primary care experience on Stimunex® gocce in children with recurrent respiratory infections: a real-world study during the COVID-19 pandemic era.
- 2022-05-01
- RCT · n = 160
- Allergologia et immunopathologia 50(3)
- - Alessandro Giannattasio
  - Elena Poggi
  - Gianfranco Trapani
  - Cosimo Muia
  - Luisella Zanino
  - Massimo Landi
  - Giorgio Ciprandi
- PubMed: 35527651
- DOI: 10.15586/aei.v50i3.562
5 Insights on
- High evidence
- Large Human Trial
[A multi-center, randomized controlled study on the effect of Saccharomyces boulardii combined with triple therapy for the initial eradication of Helicobacter pylori infection].
- 2022-05-01
- RCT · n = 497
- Zhonghua yi xue za zhi 102(18)
- - G B Yang
  - F L Hu
  - W Cheng
  - J Q Gao
  - Z Y Sheng
  - Y J Zhang
  - X L Du
  - Y Zuo
  - Y Li
  - B M Chen
  - Z H Wang
  - Zihan Zhao
- PubMed: 35545584
- DOI: 10.3760/cma.j.cn112137-20210811-01790
3 Insights on
- High evidence
- Large Human Trial
Identification, Biochemical Characterization, and Safety Attributes of Locally Isolated Lactobacillus fermentum from Bubalus bubalis (buffalo) Milk as a Probiotic
- 2022-04-30
- Clinical Trial
- Microorganisms 10(5)
- - S. Abid
  - A. Farid
  - Rameesha Abid
  - M. Rehman
  - Walaa F. Alsanie
  - M. Alhomrani
  - A. Alamri
  - S. M. Asdaq
  - D. Hefft
  - S. Saqib
  - M. Muzammal
  - S. Morshedy
  - Mashael W Alruways
  - S. Ghazanfar
- PubMed: 35630398
- DOI: 10.3390/microorganisms10050954
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Probiotics in Citrus Fruits Products: Health Benefits and Future Trends for the Production of Functional Foods-A Bibliometric Review.
- 2022-04-29
- Review
- Foods (Basel, Switzerland) 11(9)
- - Shênia Santos Monteiro
  - Verônica Macário de Oliveira
  - Matheus Augusto de Bittencourt Pasquali
- PubMed: 35564022
- DOI: 10.3390/foods11091299
3 Insights on
- Low evidence
Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial
- 2022-04-29
- RCT · n = 22
- Frontiers in Nutrition 9
- - Julia Rode
  - Hanna M. T. Edebol Carlman
  - J. König
  - Dirk Repsilber
  - A. N. Hutchinson
  - P. Thunberg
  - P. Andersson
  - J. Persson
  - A. Kiselev
  - Lori Lathrop Stern
  - B. Salomon
  - Ahmed Abdulilah Mohammed
  - J. Labus
  - R. Brummer
- PubMed: 35571902
- DOI: 10.3389/fnut.2022.827182
1 Insight on
- Enhanced Orbitofrontal Cortex Activation
- High evidence
The Probiotic Strain Bifidobacterium animalis ssp. lactis HY8002 Potentially Improves the Mucosal Integrity of an Altered Intestinal Microbial Environment
- 2022-04-29
- Frontiers in Microbiology 13
- - Joo-Yun Kim
  - S. Bang
  - Ju-Yeon Kim
  - Eunhye Choi
  - K. Heo
  - Jae-Jung Shim
  - Jung-Lyoul Lee
- PubMed: 35572671
- DOI: 10.3389/fmicb.2022.817591
4 Insights on
- Low evidence