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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota.
- 2022-04-28
- Frontiers in nutrition 9
- - Qi Zhang
  - Wen Zhao
  - Yuyang Zhao
  - Sufang Duan
  - Wei-Hsien Liu
  - Chao Zhang
  - Siyuan Sun
  - Tingting Wang
  - Xin Wang
  - Wei-Lian Hung
  - Ran Wang
- PubMed: 35571919
- DOI: 10.3389/fnut.2022.890316
3 Insights on
- Low evidence
Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals.
- 2022-04-28
- Review
- Foods (Basel, Switzerland) 11(9)
- - María Laura Werning
  - Annel M Hernández-Alcántara
  - María Julia Ruiz
  - Lorena Paola Soto
  - María Teresa Dueñas
  - Paloma López
  - Laureano Sebastián Frizzo
- PubMed: 35564008
- DOI: 10.3390/foods11091284
3 Insights on
- Low evidence
Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model
- 2022-04-27
- Clinical Trial
- Microbiology Spectrum 10(2)
- - Jingpeng Yang
  - Lingtong Meng
  - Hong Yang
- PubMed: 35311540
- DOI: 10.1128/spectrum.00672-22
7 Insights on
- Low evidence
- Animal Study
Evaluation of Modulatory Activities of Lactobacillus crispatus Strains in the Context of the Vaginal Microbiota
- 2022-04-27
- Microbiology Spectrum 10(2)
- - Chiara Argentini
  - Federico Fontana
  - Giulia Alessandri
  - G. Lugli
  - Leonardo Mancabelli
  - M. C. Ossiprandi
  - D. van Sinderen
  - M. Ventura
  - C. Milani
  - F. Turroni
- PubMed: 35266820
- DOI: 10.1128/spectrum.02733-21
3 Insights on
- Low evidence
Correction: Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
- 2022-04-27
- PloS one 17(4)
- - Yutaka Makizaki
  - Taiki Uemoto
  - Haruka Yokota
  - Miyuki Yamamoto
  - Yoshiki Tanaka
  - Hiroshi Ohno
- PubMed: 35476793
- DOI: 10.1371/journal.pone.0267927
5 Insights on
- Low evidence
Lactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathway
- 2022-04-26
- Clinical Trial
- Frontiers in Microbiology 13
- - F. A. L. Barroso
  - L. D. de Jesus
  - T. F. da Silva
  - V. L. Batista
  - J. Laguna
  - N. D. Coelho-Rocha
  - K. D. Vital
  - S. O. Fernandes
  - V. Cardoso
  - Ê. Ferreira
  - F. S. Martins
  - M. M. Drumond
  - Pamela Mancha-Agresti
  - Alexander Birbrair
  - D. Barh
  - V. Azevedo
- PubMed: 35558121
- DOI: 10.3389/fmicb.2022.858036
7 Insights on
- Low evidence
- Animal Study
Role of Lipoteichoic Acid from the Genus Apilactobacillus in Inducing a Strong IgA Response.
- 2022-04-26
- Applied and environmental microbiology 88(8)
- - Chiaki Matsuzaki
  - Tsukasa Shiraishi
  - Tai-Ying Chiou
  - Yukari Nakashima
  - Yasuki Higashimura
  - Shin-Ichi Yokota
  - Kenji Yamamoto
  - Tomoya Takahashi
- PubMed: 35380450
- DOI: 10.1128/aem.00190-22
2 Insights on
- Increased Immune Response
- Increased IgA-Inducing Activity
- Low evidence
- Rigorous Journal
- Animal Study
Influence of 2'-Fucosyllactose and Bifidobacterium longum Subspecies infantis Supplementation on Cognitive and Structural Brain Development in Young Pigs.
- 2022-04-25
- RCT
- Frontiers in neuroscience 16
- - Loretta T Sutkus
  - Sangyun Joung
  - Johanna Hirvonen
  - Henrik Max Jensen
  - Arthur C Ouwehand
  - Ratna Mukherjea
  - Sharon M Donovan
  - Ryan N Dilger
- PubMed: 35546890
- DOI: 10.3389/fnins.2022.860368
1 Insight on
- Improved Delayed Memory
- High evidence
Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction.
- 2022-04-21
- BMC immunology 23(1)
- - Xi Yue
  - Sun Wen
  - Ding Long-Kun
  - Yan Man
  - Sun Chang
  - Zhang Min
  - Li Shuang-Yu
  - Qian Xin
  - Ma Jie
  - Wu Liang
- PubMed: 35448938
- DOI: 10.1186/s12865-022-00495-3
2 Insights on
- Improved Intestinal Barrier Function
- Reduced Intestinal Inflammation
- Low evidence
The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies.
- 2022-04-19
- Systematic Review · n = 2,817
- International journal of molecular sciences 23(9)
- - Sauliha R Alli
  - Ilona Gorbovskaya
  - Jonathan C W Liu
  - Nathan J Kolla
  - Lisa Brown
  - Daniel J Müller
- PubMed: 35562885
- DOI: 10.3390/ijms23094494
1 Insight on
- Reduced Depression Symptoms
- High evidence
- Highly Cited
- Rigorous Journal
The Effect of Enterococcus faecium AL41 on the Acute Phase Proteins and Selected Mucosal Immune Molecules in Broiler Chickens
- 2022-04-18
- RCT · n = 80
- Life 12(4)
- - V. Karaffová
  - C. Tóthová
  - R. Szabóová
  - V. Révajová
  - A. Lauková
  - Z. Ševčíková
  - R. Herich
  - R. Žitňan
  - M. Levkut
  - M. Levkut
  - Z. Faixová
  - O. Nagy
- PubMed: 35455089
- DOI: 10.3390/life12040598
2 Insights on
- Enhanced Mucosal Immune Function
- Improved Immunity Status
- Low evidence
- Animal Study
Lactobacillus casei Improve Anti-Tuberculosis Drugs-Induced Intestinal Adverse Reactions in Rat by Modulating Gut Microbiota and Short-Chain Fatty Acids
- 2022-04-17
- Clinical Trial
- Nutrients 14(8)
- - Yue Li
  - Liangjie Zhao
  - Meiling Hou
  - Tianlin Gao
  - J. Sun
  - Hao Luo
  - Fengdan Wang
  - Feng Zhong
  - Aiguo Ma
  - Jing Cai
- PubMed: 35458230
- DOI: 10.3390/nu14081668
3 Insights on
- Low evidence
- Animal Study
The Impacts of Lactiplantibacillus plantarum on the Functional Properties of Fermented Foods: A Review of Current Knowledge
- 2022-04-15
- Review
- Microorganisms 10(4)
- - Birsen Yılmaz
  - S. Bangar
  - N. Echegaray
  - S. Suri
  - I. Tomasevic
  - José Manuel Lorenzo
  - E. Melekoglu
  - J. Rocha
  - F. Ozogul
- PubMed: 35456875
- DOI: 10.3390/microorganisms10040826
3 Insights on
- Moderate evidence
- Rigorous Journal
Lacticaseibacillus rhamnosus FM9 and Limosilactobacillus fermentum Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats
- 2022-04-15
- Clinical Trial
- Nutrients 14(8)
- - Hamza Zafar
  - Namrah Zafar
  - Abdulrahman Alshammari
  - Saeed S Alghamdi
  - Hafsa Raja
  - Amjad Ali
  - Abubakar Siddique
  - Syeda Duaa Tahir
  - S. Akbar
  - Maryum Arif
  - M. Alharbi
  - Abdur Rahman
- PubMed: 35458216
- DOI: 10.3390/nu14081654
4 Insights on
- Low evidence
- Animal Study
Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.
- 2022-04-13
- Systematic Review · n = 990
- Journal of immunology research 2022
- - Poliana Guiomar de Almeida Brasiel
  - Fernanda Verdini Guimarães
  - Patrícia Machado Rodrigues
  - Dumith Chequer Bou-Habib
  - Vinicius de Frias Carvalho
- PubMed: 35465348
- DOI: 10.1155/2022/8191253
2 Insights on
- Improved Lung Function
- Reduced Allergic Symptom Score
- High evidence
Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition
- 2022-04-13
- RCT
- Science Translational Medicine 14(640)
- - Michael J. Barratt
  - Sharika Nuzhat
  - Kazi Ahsan
  - S. Frese
  - Aleksandr A. Arzamasov
  - S. Sarker
  - M. M. Islam
  - P. Palit
  - Md. Ridwan Islam
  - M. Hibberd
  - Swetha Nakshatri
  - Carrie A. Cowardin
  - J. Guruge
  - A. Byrne
  - Siddarth Venkatesh
  - Vinaik Sundaresan
  - B. Henrick
  - R. Duar
  - Ryan D. Mitchell
  - G. Casaburi
  - Johann Prambs
  - Robin L. Flannery
  - M. Mahfuz
  - D. Rodionov
  - A. Osterman
  - David Kyle
  - T. Ahmed
  - J. Gordon
- PubMed: 35417188
- DOI: 10.1126/scitranslmed.abk1107
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial.
- 2022-04-12
- RCT
- Phytotherapy research : PTR 36(5)
- - Hadi Emamat
  - Seyyed Hossein Mousavi
  - Jalal Kargar Shouraki
  - Ebrahim Hazrati
  - Sayid Mahdi Mirghazanfari
  - Esmaeil Samizadeh
  - Maryam Hosseini
  - Vahid Hadi
  - Saeid Hadi
- PubMed: 35412685
- DOI: 10.1002/ptr.7441
7 Insights on
- High evidence
L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.
- 2022-04-12
- Clinical Trial
- Frontiers in cardiovascular medicine 9
- - Pasquale Mone
  - Antonella Pansini
  - Stanislovas S Jankauskas
  - Fahimeh Varzideh
  - Urna Kansakar
  - Angela Lombardi
  - Valentina Trimarco
  - Salvatore Frullone
  - Gaetano Santulli
- PubMed: 35498050
- DOI: 10.3389/fcvm.2022.868521
1 Insight on
- Improved Global Cognitive Function
- High evidence
Anti-Melanogenic and Antioxidant Effects of Cell-Free Supernatant from Lactobacillus gasseri BNR17
- 2022-04-08
- Microorganisms 10(4)
- - Sol Lee
  - Han-Oh Park
  - W. Yoo
- PubMed: 35456838
- DOI: 10.3390/microorganisms10040788
4 Insights on
- Low evidence
- Rigorous Journal
Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span.
- 2022-04-08
- Review
- Frontiers in microbiology 13
- - Liisa Lehtoranta
  - Reeta Ala-Jaakkola
  - Arja Laitila
  - Johanna Maukonen
- PubMed: 35464937
- DOI: 10.3389/fmicb.2022.819958
1 Insight on
- Improved Vaginal Microbiota Balance
- Low evidence
Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials.
- 2022-04-07
- RCT · n = 5
- International journal of environmental research and public health 19(8)
- - Ozcan Esen
  - Mustafa Can Eser
  - Mekki Abdioglu
  - Daniela Benesova
  - Tomasz Gabrys
  - Raci Karayigit
- PubMed: 35457330
- DOI: 10.3390/ijerph19084462
4 Insights on
- High evidence
The Anti-Cancer Potential of Heat-Killed Lactobacillus brevis KU15176 upon AGS Cell Lines through Intrinsic Apoptosis Pathway
- 2022-04-07
- International Journal of Molecular Sciences 23(8)
- - Chang-Hoon Hwang
  - N. Lee
  - H. Paik
- PubMed: 35456891
- DOI: 10.3390/ijms23084073
1 Insight on
- Reduced Inflammation Levels
- Low evidence
Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review.
- 2022-04-07
- Systematic Review · n = 10
- Frontiers in nutrition 9
- - Yao Lu
  - Bin Deng
  - Luhua Xu
  - Hanjiao Liu
  - Yinzhi Song
  - Fengxia Lin
- PubMed: 35464040
- DOI: 10.3389/fnut.2022.856287
7 Insights on
- High evidence
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives.
- 2022-04-06
- Review
- Frontiers in immunology 13
- - Elaine Dempsey
  - Sinéad C Corr
- PubMed: 35464397
- DOI: 10.3389/fimmu.2022.840245
1 Insight on
- Improved Gastrointestinal Health
- Moderate evidence
- Highly Cited
Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota.
- 2022-04-04
- Clinical Trial
- Journal of Agricultural and Food Chemistry 70(15)
- - Zhijing Liu
  - Xuan Zhou
  - Wan Wang
  - Liya Gu
  - Chuanbing Hu
  - Hong Sun
  - Cong Xu
  - J. Hou
  - Zhan-mei Jiang
- PubMed: 35377154
- DOI: 10.1021/acs.jafc.1c07884
7 Insights on
- Low evidence
- Animal Study
The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial.
- 2022-04-01
- RCT · n = 45
- Nutrition & diabetes 12(1)
- - Nahid Karamzad
  - Esmaeil Faraji
  - Shaghayegh Adeli
  - Mark J M Sullman
  - Bahram Pourghassem Gargari
- PubMed: 35365594
- DOI: 10.1038/s41387-022-00192-5
11 Insights on
- High evidence
Prebiotic Galacto-Oligosaccharides and Fructo-Oligosaccharides, but Not Acacia Gum, Increase Iron Absorption from a Single High-Dose Ferrous Fumarate Supplement in Iron-Depleted Women.
- 2022-04-01
- RCT · n = 30
- The Journal of nutrition 152(4)
- - Ambra Giorgetti
  - Frederike M D Husmann
  - Christophe Zeder
  - Isabelle Herter-Aeberli
  - Michael B Zimmermann
- PubMed: 35015879
- DOI: 10.1093/jn/nxac003
1 Insight on
- Improved Iron Absorption
- High evidence
Efficacy of Probiotics for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
- 2022-04-01
- Systematic Review
- Frontiers in cellular and infection microbiology 12
- - Tao Zhang
  - Cunzheng Zhang
  - Jindong Zhang
  - Feng Sun
  - Liping Duan
- PubMed: 35433498
- DOI: 10.3389/fcimb.2022.859967
6 Insights on
- High evidence
Tibetan Pig-Derived Probiotic Lactobacillus amylovorus SLZX20-1 Improved Intestinal Function via Producing Enzymes and Regulating Intestinal Microflora
- 2022-03-29
- Frontiers in Nutrition 9
- - Jiakun Shen
  - Jie Zhang
  - Ying Zhao
  - Zi-Qi Lin
  - Linbao Ji
  - Xi Ma
- PubMed: 35425795
- DOI: 10.3389/fnut.2022.846991
5 Insights on
- Low evidence
Lacticaseibacillus rhamnosus GG Counteracts Rotavirus-Induced Ion Secretion and Enterocyte Damage by Inhibiting Oxidative Stress and Apoptosis Through Specific Effects of Living and Postbiotic Preparations
- 2022-03-29
- Frontiers in Cellular and Infection Microbiology 12
- - V. Buccigrossi
  - M. Poeta
  - Valentina Cioffi
  - Sara Terranova
  - F. Nunziata
  - A. Lo Vecchio
  - A. Guarino
- PubMed: 35425719
- DOI: 10.3389/fcimb.2022.854989
2 Insights on
- Reduced Diarrhea Symptoms
- Protected Enterocyte Structure
- Low evidence