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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Safety and the probiotic potential of Bifidobacterium animalis CP-9.
- 2022-03-28
- Clinical Trial
- Journal of Food Science 87(5)
- - Hui-Yun Tsai
  - Ya-Chin Wang
  - Chorng-An Liao
  - Chia-Yan Su
  - Cheng-Hsieh Huang
  - Min-Hsi Chiu
  - Yao-Tsung Yeh
- PubMed: 35347713
- DOI: 10.1111/1750-3841.16129
2 Insights on
- Enhanced Intestinal Epithelial Cell Adhesion
- Reduced Oleic Acid-Induced Triglyceride Accumulation
- Low evidence
- Animal Study
Lactobacillus salivarius CML352 Isolated from Chinese Local Breed Chicken Modulates the Gut Microbiota and Improves Intestinal Health and Egg Quality in Late-Phase Laying Hens
- 2022-03-28
- Microorganisms 10(4)
- - Chang Xu
  - Fuxiao Wei
  - Xinyue Yang
  - Yuqing Feng
  - Dan Liu
  - Yongfei Hu
- PubMed: 35456777
- DOI: 10.3390/microorganisms10040726
4 Insights on
- Low evidence
- Rigorous Journal
Bacteriocin-Producing Strain Lactiplantibacillus plantarum LP17L/1 Isolated from Traditional Stored Ewe’s Milk Cheese and Its Beneficial Potential
- 2022-03-25
- Foods 11(7)
- - A. Lauková
  - M. Tomáška
  - M. Fraqueza
  - R. Szabóová
  - E. Bino
  - J. Ščerbová
  - M. Pogány Simonová
  - E. Dvorožňáková
- PubMed: 35407045
- DOI: 10.3390/foods11070959
4 Insights on
- Low evidence
- Rigorous Journal
Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study.
- 2022-03-23
- RCT
- The Journal of laryngology and otology 137(3)
- - M V Nasserallah
  - N M de Silva
  - V Tobin
  - W M Rozen
  - D J Hunter-Smith
- PubMed: 35317870
- DOI: 10.1017/s0022215122000743
3 Insights on
- High evidence
Bifidobacterium spp. as functional foods: A review of current status, challenges, and strategies
- 2022-03-23
- Review
- Critical Reviews in Food Science and Nutrition 63(26)
- - Baolin He
  - Yong Xiong
  - Teng-gen Hu
  - Min-hua Zong
  - Hong Wu
- PubMed: 35319324
- DOI: 10.1080/10408398.2022.2054934
3 Insights on
- Low evidence
Lactiplantibacillus Plantarum CCFM8724 Reduces the Amounts of Oral Pathogens and Alters the Oral Microbiota in Children With Dental Caries: a Randomized, Double-Blind, Placebo-Controlled Trial.
- 2022-03-21
- RCT
- Journal of the American Nutrition Association 42(4)
- - Qiuxiang Zhang
  - Baokun Shan
  - Xian Xu
  - Bingyong Mao
  - Xin Tang
  - Jianxin Zhao
  - Hao Zhang
  - Shumao Cui
  - Wei Chen
- PubMed: 35512770
- DOI: 10.1080/07315724.2022.2043200
2 Insights on
- Altered Oral Microbiota
- Reduced Oral Pathogen Growth
- High evidence
Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women.
- 2022-03-20
- RCT
- International journal of food sciences and nutrition 73(6)
- - Cíntia Tomaz Sant'Ana
  - Ariane Dias de Amorim
  - Ana Paula Gava
  - Carla Mora Aguilar
  - Nayana Garcia Silva
  - Líllian Duarte Machado
  - Mirelle Lomar Viana
  - Daniela da Silva Oliveira
  - Pollyanna Ibrahim Silva
  - Neuza Maria Brunoro Costa
  - André Gustavo Vasconcelos Costa
- PubMed: 35311432
- DOI: 10.1080/09637486.2022.2052820
5 Insights on
- High evidence
Nasal administration of a probiotic assemblage in allergic rhinitis: A randomised placebo-controlled crossover trial.
- 2022-03-19
- RCT · n = 24
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 52(6)
- - Anders Mårtensson
  - Franziska U Nordström
  - Charlotte Cervin-Hoberg
  - Malin Lindstedt
  - Christina Sakellariou
  - Anders Cervin
  - Lennart Greiff
- PubMed: 35075723
- DOI: 10.1111/cea.14098
2 Insights on
- Reduced Nasal Inflammation
- Reduced Nasal Colonization
- High evidence
Oral administration of Lactobacillus delbrueckii enhances intestinal immunity through inducing dendritic cell activation in suckling piglets.
- 2022-03-17
- Clinical Trial
- Food & Function 13(5)
- - Wei Peng
  - Yinghui Li
  - Guan Yang
  - Jie-Lin Duan
  - Lingyuan Yang
  - Li-Xiang Chen
  - Shuling Hou
  - Xingguo Huang
- PubMed: 35166282
- DOI: 10.1039/d1fo03864h
9 Insights on
- Low evidence
- Animal Study
Intestinal Mucosal Immunity-Mediated Modulation of the Gut Microbiome by Oral Delivery of Enterococcus faecium Against Salmonella Enteritidis Pathogenesis in a Laying Hen Model
- 2022-03-15
- RCT · n = 400
- Frontiers in Immunology 13
- - Shimeng Huang
  - Xiao Rong
  - Meiling Liu
  - Z. Liang
  - Y. Geng
  - Xinyue Wang
  - Jianyun Zhang
  - C. Ji
  - Lihong Zhao
  - Qiugang Ma
- PubMed: 35371085
- DOI: 10.3389/fimmu.2022.853954
7 Insights on
- Low evidence
- Animal Study
Engineered Probiotic Lactococcus lactis for Lycopene Production against ROS Stress in Intestinal Epithelial Cells.
- 2022-03-15
- ACS Synthetic Biology 11(4)
- - Jiapeng Wu
  - Xingfang Tian
  - Xiaoning Xu
  - X. Gu
  - J. Kong
  - T. Guo
- PubMed: 35289165
- DOI: 10.1021/acssynbio.1c00639
2 Insights on
- Improved Cell Survival Rates
- Reduced Oxidative Stress in Intestinal Epithelial Cells
- Low evidence
Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis.
- 2022-03-15
- Clinical Trial
- Food & Function 13(5)
- - Pei Li
  - Guoping Chen
  - Jiaxian Zhang
  - Chaoying Pei
  - Ying Chen
  - Jing Gong
  - S. Deng
  - Kaiwei Cai
  - Haiyan Li
  - Dawei Wang
  - Baochun Shen
  - Zhiyong Xie
  - Q. Liao
- PubMed: 35195119
- DOI: 10.1039/d1fo03360c
13 Insights on
- Low evidence
- Animal Study
Lactiplantibacillus plantarum DMDL 9010 alleviates dextran sodium sulfate (DSS)-induced colitis and behavioral disorders by facilitating microbiota-gut-brain axis balance.
- 2022-03-14
- Clinical Trial
- Food & Function 13(1)
- - Yan‐yan Huang
  - Yanan Wu
  - Xiang-ze Jia
  - Jin Lin
  - Lanlan Xiao
  - Dong‐mei Liu
  - Ming-Hua Liang
- PubMed: 34913458
- DOI: 10.1039/d1fo02938j
6 Insights on
- Low evidence
- Animal Study
Saccharomyces boulardii alleviates DSS-induced intestinal barrier dysfunction and inflammation in humanized mice.
- 2022-03-14
- Clinical Trial
- Food & Function 13(1)
- - Bei Li
  - Haibo Zhang
  - Linlin Shi
  - Rong Li
  - Yanan Luo
  - Yun Deng
  - Shihan Li
  - Ruizhen Li
  - Zhi Liu
- PubMed: 34878454
- DOI: 10.1039/d1fo02752b
3 Insights on
- Low evidence
- Animal Study
Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions
- 2022-03-11
- Clinical Trial
- Frontiers in Nutrition 9
- - Mengyao Lu
  - Jin Sun
  - Yuning Zhao
  - Haowen Zhang
  - Xinyue Li
  - Jingbo Zhou
  - Hongyang Dang
  - Jidong Zhang
  - Wenjing Huang
  - Ce Qi
  - Duo Li
- PubMed: 35369106
- DOI: 10.3389/fnut.2022.851541
6 Insights on
- Low evidence
- Animal Study
Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study.
- 2022-03-11
- RCT · n = 22
- Breast care (Basel, Switzerland) 12(5)
- - Julian Marschalek
  - Alex Farr
  - Marie-Louise Marschalek
  - Konrad J Domig
  - Wolfgang Kneifel
  - Christian F Singer
  - Herbert Kiss
  - Ljubomir Petricevic
- PubMed: 29234255
- DOI: 10.1159/000478994
1 Insight on
- Improved Vaginal Microbiota
- High evidence
Fermentation of Soybean Meal with Lactobacillus acidophilus Allows Greater Inclusion of Vegetable Protein in the Diet and Can Reduce Vibrionacea in the Intestine of the South American Catfish (Rhamdia quelen)
- 2022-03-09
- RCT · n = 140
- Animals 12(6)
- - Nandara Soares de Oliveira
  - N. Ha
  - Larissa da Cunha
  - Luiz Augusto Cipriani
  - A. T. Neto
  - E. Skoronski
  - E. Gisbert
  - Thiago El Hadi Perez Fabregat
- PubMed: 35327087
- DOI: 10.3390/ani12060690
1 Insight on
- Reduced Intestinal Pathogenic Bacteria
- Low evidence
- Rigorous Journal
- Animal Study
Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice
- 2022-03-08
- Clinical Trial
- Gut Microbes 14(1)
- - Shilong Zhang
  - Bing Han
  - Yu-qin Mao
  - Zheng-yan Zhang
  - Zhan-ming Li
  - Chao‐Yue Kong
  - You Wu
  - Guoqiang Chen
  - Li‐Shun Wang
- PubMed: 35259052
- DOI: 10.1080/19490976.2022.2046246
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Assessment of the Effects of the Synbiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Oligofructose-Enriched Inulin Against Digestive Bacterial Infections in a Piglet Model
- 2022-03-08
- Clinical Trial · n = 168
- Frontiers in Microbiology 13
- - A. Rodríguez-Sorrento
  - L. Castillejos
  - Paola López-Colom
  - G. Cifuentes-Orjuela
  - J. A. Moreno-Muñoz
  - S. Martín-Orúe
- PubMed: 35350617
- DOI: 10.3389/fmicb.2022.831737
1 Insight on
- Increased Intestinal T-Cell Count
- Low evidence
- Animal Study
Investigating the effect of quadruple therapy with Saccharomyces boulardii or Lactobacillus reuteri strain (DSMZ 17648) supplements on eradication of Helicobacter pylori and treatments adverse effects: a double-blind placebo-controlled randomized clinical trial.
- 2022-03-07
- RCT · n = 156
- BMC gastroenterology 22(1)
- - Nooshin Naghibzadeh
  - Fatemeh Salmani
  - Samira Nomiri
  - Tahmine Tavakoli
- PubMed: 35255819
- DOI: 10.1186/s12876-022-02187-z
6 Insights on
- High evidence
- Large Human Trial
The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial
- 2022-03-07
- RCT · n = 31
- Nutrients 14(5)
- - K. Babina
  - Dilara Salikhova
  - M. Polyakova
  - Oxana A. Svitich
  - R. Samoylikov
  - S. A. Ahmad El-Abed
  - A. Zaytsev
  - N. Novozhilova
- PubMed: 35268099
- DOI: 10.3390/nu14051124
6 Insights on
- High evidence
Overview of the Importance of Biotics in Gut Barrier Integrity.
- 2022-03-07
- Review
- International journal of molecular sciences 23(5)
- - Aleksandra Maria Kocot
  - Elżbieta Jarocka-Cyrta
  - Natalia Drabińska
- PubMed: 35270039
- DOI: 10.3390/ijms23052896
1 Insight on
- Improved Gut Barrier Function
- Low evidence
- Rigorous Journal
- Animal Study
Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly.
- 2022-03-07
- RCT
- Food & function 13(5)
- - Michio Hashimoto
  - Kentaro Matsuzaki
  - Koji Maruyama
  - Shahdat Hossain
  - Eri Sumiyoshi
  - Harumi Wakatsuki
  - Setsushi Kato
  - Miho Ohno
  - Yoko Tanabe
  - Yoko Kuroda
  - Shuhei Yamaguchi
  - Koji Kajima
  - Yasushi Ohizumi
  - Osamu Shido
- PubMed: 35171190
- DOI: 10.1039/d1fo03508h
1 Insight on
- Improved Cognitive Function
- High evidence
- Rigorous Journal
Epithelial Heat Shock Proteins Mediate the Protective Effects of Limosilactobacillus reuteri in Dextran Sulfate Sodium-Induced Colitis
- 2022-03-07
- RCT
- Frontiers in Immunology 13
- - Hao-Yu Liu
  - Fang Gu
  - C-H Zhu
  - Lijuan Yuan
  - Chuyang Zhu
  - M. Zhu
  - Jiacheng Yao
  - Ping Hu
  - Yunzeng Zhang
  - J. Dicksved
  - Wen-hua Bao
  - Demin Cai
- PubMed: 35320932
- DOI: 10.3389/fimmu.2022.865982
8 Insights on
- Low evidence
- Animal Study
Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.
- 2022-03-04
- Systematic Review
- Frontiers in nutrition 9
- - Yahui Fan
  - Mingxu Wang
  - Zhaofang Li
  - Hong Jiang
  - Jia Shi
  - Xin Shi
  - Sijiao Liu
  - Jinping Zhao
  - Liyun Kong
  - Wei Zhang
  - Le Ma
- PubMed: 35308286
- DOI: 10.3389/fnut.2022.847421
4 Insights on
- High evidence
The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.
- 2022-03-03
- Meta-Analysis · n = 4,865
- Journal of clinical laboratory analysis 36(4)
- - Marzie Mahdizade Ari
  - Samane Teymouri
  - Tayebeh Fazlalian
  - Parisa Asadollahi
  - Roghayeh Afifirad
  - Mohammad Sabaghan
  - Fateme Valizadeh
  - Roya Ghanavati
  - Atieh Darbandi
- PubMed: 35243684
- DOI: 10.1002/jcla.24326
1 Insight on
- Reduced Prevalence of Gestational Diabetes Mellitus
- High evidence
Effects of Synbiotic Preparation Containing Lactobacillus gasseri BNR17 on Body Fat in Obese Dogs: A Pilot Study
- 2022-03-03
- Clinical Trial
- Animals 12(5)
- - Han-Joon Lee
  - Jae Hyoung Cho
  - W. Cho
  - Seong-Ho Gang
  - Seung‐Hwan Park
  - B. Jung
  - H. Kim
  - K. Song
- PubMed: 35268209
- DOI: 10.3390/ani12050642
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Topical Probiotics: More Than a Skin Deep.
- 2022-03-03
- Review
- Pharmaceutics 14(3)
- - Mohammed Habeebuddin
  - Ranjith Kumar Karnati
  - Predeepkumar Narayanappa Shiroorkar
  - Sreeharsha Nagaraja
  - Syed Mohammed Basheeruddin Asdaq
  - Md Khalid Anwer
  - Santosh Fattepur
- PubMed: 35335933
- DOI: 10.3390/pharmaceutics14030557
1 Insight on
- Improved Skin Health
- Low evidence
Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells
- 2022-03-02
- Frontiers in Cellular and Infection Microbiology 12
- - Jiawei Liu
  - Xiaowei Feng
  - Botong Li
  - Yan Sun
  - Tianxiong Jin
  - M. Feng
  - Yaodi Ni
  - Mingchao Liu
- PubMed: 35310848
- DOI: 10.3389/fcimb.2022.809674
2 Insights on
- Reduced Inflammatory Response
- Reduced Inflammation
- Low evidence
Lactobacillus casei modulates inflammatory cytokines and metabolites during tuberculosis treatment: A post hoc randomized controlled trial.
- 2022-03-01
- RCT · n = 47
- Asia Pacific journal of clinical nutrition 31(1)
- - Lan Jiang
  - Jinyu Wang
  - Lei Xu
  - Jing Cai
  - Shanliang Zhao
  - Aiguo Ma
- PubMed: 35357105
- DOI: 10.6133/apjcn.202203_31(1).0008
4 Insights on
- High evidence