December 2018 Supplement Research Papers

• December 4

  • Protective Effect of Lactobacillus diolivorans 1Z, Isolated From Brazilian Kefir, Against Salmonella enterica Serovar Typhimurium in Experimental Murine Models

    • 2018-12-04
    • Clinical Trial
    • Frontiers in Microbiology 9
    • • Mário Abatemarco Júnior
      • S. Sandes
      • M. F. Ricci
      • R. Arantes
      • Á. Nunes
      • J. Nicoli
      • E. Neumann

    • PubMed: 30564201
    • DOI: 10.3389/fmicb.2018.02856

    6 Insights on

    • Reduced Fecal Salmonella Bacteria
    • Increased Intestinal IgA Levels
    • Increased Survival After Salmonella Typhimurium Infection
    • Reduced Ileum Mucosa Damage
    • Reduced Salmonella Translocation to Liver
    • Modified Hepatic Inflammatory Cell Pattern

    • Low evidence
    • Animal Study
• December 6

  • Potential Properties of Lactobacillus plantarum F-10 as a Bio-control Strategy for Wound Infections

    • 2018-12-06
    • Probiotics and Antimicrobial Proteins 11(4)
    • • Tugce Onbas
      • O. Osmanagaoglu
      • F. Kiran

    • PubMed: 30523603
    • DOI: 10.1007/s12602-018-9486-8

    3 Insights on

    • Increased Antioxidant Activity
    • Reduced Pathogen Growth
    • Reduced Virulence Factors

    • Low evidence
• December 7

  • Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects.

    • 2018-12-07
    • RCT · n = 38
    • Beneficial Microbes 9(6)
    • • T. Inoue
      • Y. Kobayashi
      • N. Mori
      • M. Sakagawa
      • J.‐Z. Xiao
      • Toshio Moritani
      • Naoki Sakane
      • N. Nagai

    • PubMed: 30198326
    • DOI: 10.3920/BM2017.0193

    5 Insights on

    • Reduced Body Mass Index
    • Improved Bowel Movement Frequency
    • Improved Cognitive Function
    • Reduced Anxiety Scores
    • Reduced Depression and Anxiety Scores

    • High evidence

  • Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults.

    • 2018-12-07
    • RCT · n = 241
    • Beneficial Microbes 9(6)
    • • M. Murata
      • J. Kondo
      • N. Iwabuchi
      • S. Takahashi
      • K. Yamauchi
      • F. Abe
      • K. Miura

    • PubMed: 30099891
    • DOI: 10.3920/BM2017.0197

    7 Insights on

    • Improved Positive Mood States
    • Improved Resistance to Common Cold
    • Maintained Positive Mood Under Stress
    • Improved Resistance to Infections
    • Reduced Incidence of Common Cold
    • Improved Positive Mood Under Stress
    • Reduced Common Cold Incidence in Susceptible Populations

    • High evidence

  • Lactobacillus paracasei K5 displays adhesion, anti-proliferative activity and apoptotic effects in human colon cancer cells.

    • 2018-12-07
    • Beneficial Microbes 9(6)
    • • P. Chondrou
      • A. Karapetsas
      • D. Kiousi
      • D. Tsela
      • A. Tiptiri-Kourpeti
      • I. Anestopoulos
      • I. Kotsianidis
      • E. Bezirtzoglou
      • Aglaia Pappa
      • A. Galanis

    • PubMed: 30353740
    • DOI: 10.3920/BM2017.0183

    3 Insights on

    • Induced Apoptosis
    • Improved Cell Adhesion
    • Enhanced Adhesion to Colon Cells

    • Low evidence
• December 8

  • Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures

    • 2018-12-08
    • Nutrients 10(12)
    • • A. Sandberg
      • G. Önning
      • N. Engström
      • Nathalie Scheers

    • PubMed: 30544799
    • DOI: 10.3390/nu10121949

    2 Insights on

    • Elevated Ferric Iron Levels
    • Increased Ferric Reductase DCYTB Activity

    • Moderate evidence
• December 11

  • Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 mitigate alcoholic steatosis in mice by inhibiting LPS-mediated NF-κB activation through restoration of the disturbed gut microbiota.

    • 2018-12-11
    • Clinical Trial
    • Food & Function 9(8)
    • • Won-Gyeong Kim
      • Hye-In Kim
      • E. Kwon
      • M. Han
      • Dong-Hyun Kim

    • PubMed: 30010169
    • DOI: 10.1039/c8fo00252e

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Liver Damage

    • Low evidence
    • Animal Study

  • Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats

    • 2018-12-11
    • RCT
    • International Microbiology 22(3)
    • • Ghazaleh Mohammadi
      • L. Dargahi
      • T. Naserpour
      • Y. Mirzanejad
      • S. Alizadeh
      • A. Peymani
      • Marjan Nassiri-Asl

    • PubMed: 30810993
    • DOI: 10.1007/s10123-018-00051-3

    2 Insights on

    • Reduced Hippocampal Apoptosis
    • Reduced Caspase-3 Activity

    • Low evidence
    • Animal Study
• December 18

  • Effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier function, and the expression of NOD-like receptors in weaned piglets

    • 2018-12-18
    • RCT · n = 16
    • PeerJ 6
    • • Shiqiong Wang
      • Haihua Li
      • C. Du
      • Qian Liu
      • Dongji Yang
      • Longbin Chen
      • Qi Zhu
      • Zhixiang Wang

    • PubMed: 30588399
    • DOI: 10.7717/peerj.6060

    5 Insights on

    • Improved Average Daily Gain
    • Reduced Serum Diamine Oxidase Activity
    • Reduced Expression of Caspase-1 in Ileum
    • Reduced IL-1β Expression in Ileum
    • Reduced IL-18 Expression in Ileum

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Milk fat protects Bifidobacterium animalis subsp. lactis Bb-12 from in vitro gastrointestinal stress in potentially synbiotic table spreads.

    • 2018-12-18
    • Food & Function 9(8)
    • • Clara Simone Dos Santos
      • C. H. B. de Souza
      • Marina Padilha
      • L. A. Gioielli
      • J. Ract
      • S. Saad

    • PubMed: 30027199
    • DOI: 10.1039/c8fo00506k

    2 Insights on

    • Improved Gastrointestinal Survival
    • Enhanced Gastrointestinal Survival

    • Low evidence
• December 21

  • A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in Bifidobacterium bifidum

    • 2018-12-21
    • Frontiers in Microbiology 9
    • • A. Mauras
      • F. Chain
      • Aurélien Faucheux
      • P. Ruffié
      • Sophie Gontier
      • B. Ryffel
      • M. Butel
      • P. Langella
      • L. Bermúdez-Humarán
      • A. Waligora-Dupriet

    • PubMed: 30622516
    • DOI: 10.3389/fmicb.2018.03075

    1 Insight on

    • Reduced Low-grade Intestinal Inflammation

    • Low evidence

  • Effects of Saccharomyces Cerevisiae Fermentation Products on the Microbial Community throughout the Gastrointestinal Tract of Calves

    • 2018-12-21
    • RCT · n = 15
    • Animals 9(1)
    • • Z. Cao
      • Jianxin Xiao
      • G. M. Alugongo
      • S. Ji
      • Zhaohai Wu
      • S. Dong
      • Sheng-li Li
      • I. Yoon
      • R. Chung

    • PubMed: 30577678
    • DOI: 10.3390/ani9010004

    2 Insights on

    • Increased Microbial Richness in the Large Intestine
    • Colonization of Fibrolytic Bacteria

    • Low evidence
    • Rigorous Journal
    • Animal Study
• December 22

  • A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period

    • 2018-12-22
    • Clinical Trial
    • Gut Microbes 10(4)
    • • Michael J Davoren
      • Jared Liu
      • Jocelyn Castellanos
      • Norma I Rodríguez-Malavé
      • R. Schiestl

    • PubMed: 30580660
    • DOI: 10.1080/19490976.2018.1547612

    7 Insights on

    • Improved Gut Microbial Persistence
    • Reduced Inflammation Levels
    • Reduced Pathogen Growth
    • Reduced Genotoxicity
    • Increased Acid Resistance
    • Reduced Enteropathogen Activity
    • Increased Microbial Viability in Human Gut

    • High evidence
• December 24

  • Enhanced Antioxidant Activity for Apple Juice Fermented with Lactobacillus plantarum ATCC14917.

    • 2018-12-24
    • Molecules (Basel, Switzerland) 24(1)
    • • Zhongxi Li
      • Jing Teng
      • Yilu Lyu
      • Xiaoqian Hu
      • Yueliang Zhao
      • Mingfu Wang

    • PubMed: 30586844
    • DOI: 10.3390/molecules24010051

    2 Insights on

    • Increased Antioxidant Activity
    • Reduced Oxidative Stress

    • Low evidence
    • Highly Cited
    • Animal Study
• December 26

  • Isolation of immune-regulatory Tetragenococcus halophilus from miso

    • 2018-12-26
    • PLOS ONE 13(12)
    • • T. Kumazawa
      • A. Nishimura
      • Noriyuki Asai
      • T. Adachi

    • PubMed: 30586377
    • DOI: 10.1371/journal.pone.0208821

    2 Insights on

    • Increased IgA Production by PPs
    • Increased OVA-specific IgG Levels Upon Immunization

    • Low evidence
    • Rigorous Journal
• Undated – 8 supplement studies

  • Probiotics Streptococcus salivarius 24SMB and Streptococcus oralis 89a interfere with biofilm formation of pathogens of the upper respiratory tract

    • 2018-12
    • BMC Infectious Diseases 18(1)
    • • Alessandro Bidossi
      • R. De Grandi
      • Marco Toscano
      • M. Bottagisio
      • E. De Vecchi
      • M. Gelardi
      • L. Drago

    • PubMed: 30545317
    • DOI: 10.1186/s12879-018-3576-9

    1 Insight on

    • Reduced Acute Otitis Media

    • Low evidence
    • Rigorous Journal

  • Inhibition of Aeromonas hydrophila‐induced intestinal inflammation and mucosal barrier function damage in crucian carp by oral administration of Lactococcus lactis

    • 2018-12
    • Fish & Shellfish Immunology 83
    • • Yuhao Dong
      • Yuanyuan Yang
      • Jin Liu
      • Furqan Awan
      • Chengping Lu
      • Yongjie Liu

    • PubMed: 30236608
    • DOI: 10.1016/j.fsi.2018.09.041

    5 Insights on

    • Increased PMN Cell Phagocytic Capacity
    • Reduced Inflammatory Response
    • Increased Superoxide Dismutase Activity
    • Maintained Intestinal Villi Integrity
    • Reduced Colonization of Aeromonas Hydrophila in the Intestine

    • Low evidence

  • Effect of Lactobacillus Rhamnosus on serum uremic toxins (phenol and P-Cresol) in hemodialysis patients: A double blind randomized clinical trial.

    • 2018-12
    • RCT · n = 42
    • Clinical Nutrition ESPEN 28
    • • F. Eidi
      • Fatemeh Poor-Reza Gholi
      • A. Ostadrahimi
      • N. Dalili
      • F. Samadian
      • A. Barzegari

    • PubMed: 30390875
    • DOI: 10.1016/j.clnesp.2018.08.010

    1 Insight on

    • Reduced Uremic Toxins Levels

    • High evidence

  • Effects of Lactobacillus acidophilus LA-3 on physicochemical and sensory parameters of açaí and mango based smoothies and its survival following simulated gastrointestinal conditions.

    • 2018-12
    • Food Research International 114
    • • W. A. Luciano
      • Thais Costa Matte
      • Isabella Araújo Portela
      • Lorena Lucena de Medeiros
      • Marcos dos Santos Lima
      • J. F. Maciel
      • E. L. de Souza
      • Estefânia F Garcia
      • M. Magnani

    • PubMed: 30361012
    • DOI: 10.1016/j.foodres.2018.08.005

    3 Insights on

    • Improved Survival of Probiotic Bacteria
    • Improved Quality of Probiotic Food Products
    • Enhanced Sensory Perception

    • Low evidence

  • Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose-induced oxidation in male Kuming mice.

    • 2018-12
    • Journal of Dairy Science 101(12)
    • • Huayi Suo
      • Shanchun Liu
      • Jian Li
      • Yangping Ding
      • Hongwei Wang
      • Yu Zhang
      • Xin Zhao
      • Jia-Le Song

    • PubMed: 30292551
    • DOI: 10.3168/jds.2018-14758

    4 Insights on

    • Increased Superoxide Dismutase Levels
    • Increased Antioxidant Capacity
    • Increased Glutathione Peroxidase Levels
    • Reduced Malondialdehyde Generation

    • Low evidence
    • Rigorous Journal

  • Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA-mediated phosphorylation of hormone-sensitive lipase and ERK-mediated downregulation of perilipin in 3T3-L1 adipocytes

    • 2018-12
    • BMC Complementary and Alternative Medicine 18(1)
    • • M. Ge
      • Rui Guo
      • Hai-xia Lou
      • Wen Zhang

    • PubMed: 30526586
    • DOI: 10.1186/s12906-018-2389-0

    3 Insights on

    • Increased Lipolysis Activity
    • Reduced Intracellular Triglyceride Levels
    • Increased Hormone-Sensitive Lipase Activity

    • Low evidence
    • Rigorous Journal

  • Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota.

    • 2019
    • Clinical Trial
    • Food & Function 10(11)
    • • Peijun Tian
      • Renying Zou
      • Linhong Song
      • Xu Zhang
      • Bin Jiang
      • Gang Wang
      • Yuan-Kun Lee
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen

    • PubMed: 31687714
    • DOI: 10.1039/c9fo01630a

    16 Insights on

    • Improved Gut Microbiota Diversity
    • Increased Butyrate Levels
    • Reduced Depressive Behavior
    • Increased Serum BDNF Levels
    • Increased Serotonin Levels
    • Improved Emotional Behavior
    • Enhanced Brain-Derived Neurotrophic Factor Levels
    • Reduced HPA Axis Hyperactivity
    • Improved Gut Microbiome Diversity
    • Increased BDNF Levels in the Prefrontal Cortex
    • Improved Regulation of HPA Axis
    • Increased Brain-Derived Neurotrophic Factor Levels
    • Reduced Peripheral Inflammation
    • Increased Serotonin Production
    • Reduced Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis
    • Improved Peripheral Inflammation

    • Low evidence
    • Animal Study

  • Influence of Dehydrated Wheat/Rice Cereal Matrices on Probiotic Activity of Bifidobacterium animalis ssp. lactis BB-12®§

    • 2019
    • Food technology and biotechnology 57(2)
    • • A. Leboš-Pavunc
      • Lenkica Penava
      • Jasmina Ranilović
      • Jasna Novak
      • M. Banić
      • Katarina Butorac
      • Emilija Petrović
      • V. Mihaljević-Herman
      • K. Bendelja
      • Ana Savić-Mlakar
      • K. Durgo
      • B. Kos
      • J. Šušković

    • PubMed: 31537964
    • DOI: 10.17113/ftb.57.02.19.6142

    3 Insights on

    • Increased Antagonistic Activity Against Undesirable Microorganisms
    • Enhanced Probiotic Activity
    • Improved Antagonistic Activity Against Undesirable Microorganisms

    • Low evidence