February 2020 Supplement Research Papers

• February 1

  • Lactobacillus rhamnosus Granules Dose-Dependently Balance Intestinal Microbiome Disorders and Ameliorate Chronic Alcohol-Induced Liver Injury.

    • 2020-02-01
    • Clinical Trial
    • Journal of Medicinal Food 23(2)
    • • Zelin Gu
      • Yanfeng Wu
      • Yu Wang
      • Haiyue Sun
      • Ying You
      • Chunhong Piao
      • Junmei Liu
      • Yuhua Wang

    • PubMed: 31747353
    • DOI: 10.1089/jmf.2018.4357

    5 Insights on

    • Improved Chronic Alcohol-Induced Liver Injury
    • Reduced Gram-Negative Bacteria Count
    • Reduced Gram-Negative Bacteria Levels
    • Improved Alcohol-induced Liver Injury
    • Prevention of Liver Steatosis

    • Moderate evidence

  • Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis.

    • 2020-02-01
    • Meta-Analysis
    • Journal of women's health (2002) 29(2)
    • • Soo Liang Ooi
      • Stephanie Watts
      • Rhett McClean
      • Sok Cheon Pak

    • PubMed: 31464546
    • DOI: 10.1089/jwh.2019.7770

    2 Insights on

    • Reduced Breast Pain Intensity
    • Reduced Prolactin Level

    • High evidence
• February 5

  • Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei

    • 2020-02-05
    • Clinical Trial
    • Cancers 12(2)
    • • Georgios Aindelis
      • A. Tiptiri-Kourpeti
      • E. Lampri
      • K. Spyridopoulou
      • E. Lamprianidou
      • I. Kotsianidis
      • P. Ypsilantis
      • Aglaia Pappa
      • K. Chlichlia

    • PubMed: 32033490
    • DOI: 10.3390/cancers12020368

    5 Insights on

    • Enhanced Natural Killer Cell Tumoricidal Activity
    • Reduced Tumor Growth
    • Enhanced Interferon Gamma Production
    • Enhanced CD8+ T Cell Infiltration
    • Induction of Th1 Immune Response

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotic properties of a phytase producing Pediococcus acidilactici strain SMVDUDB2 isolated from traditional fermented cheese product, Kalarei

    • 2020-02-05
    • Scientific Reports 10(1)
    • • D. Bhagat
      • Neelu Raina
      • Amit Kumar
      • M. Katoch
      • Y. Khajuria
      • P. Slathia
      • Preeti Sharma

    • PubMed: 32024895
    • DOI: 10.1038/s41598-020-58676-2

    2 Insights on

    • Enhanced Antimicrobial Resistance
    • Improved Surface Properties for Reduced Microbial Colonization

    • Low evidence
    • Rigorous Journal

  • Preparation and characterization of selenium enriched-Bifidobacterium longum DD98, and its repairing effects on antibiotic-induced intestinal dysbacteriosis in mice.

    • 2020-02-05
    • Clinical Trial
    • Food & Function 10(8)
    • • Hui Zhu
      • Yan Zhou
      • Yan Qi
      • R. Ji
      • Jun-Liang Zhang
      • Zhixiang Qian
      • Chunzhen Wu
      • Jun Tan
      • L. Shao
      • Daijie Chen

    • PubMed: 31343650
    • DOI: 10.1039/c9fo00960d

    2 Insights on

    • Regulated Intestinal Microbiota
    • Repaired Colon Tissue

    • Low evidence
    • Animal Study

  • Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition

    • 2020-02-05
    • Clinical Trial
    • Pediatric Research 88(3)
    • • P. Poinsot
      • A. Penhoat
      • Mélanie Mitchell
      • V. Sauvinet
      • Laure Meiller
      • C. Louche-Pélissier
      • E. Meugnier
      • M. Ruiz
      • M. Schwarzer
      • M. Michalski
      • F. Leulier
      • N. Peretti

    • PubMed: 32023624
    • DOI: 10.1038/s41390-020-0774-0

    2 Insights on

    • Accelerated Immune Response Maturation
    • Improved Growth

    • Low evidence
    • Rigorous Journal
    • Animal Study
• February 7

  • In vitro inhibitory effect of two commercial probiotics on chromogenic actinomycetes

    • 2020-02-07
    • European Archives of Paediatric Dentistry 21(6)
    • • Emanuela Gobbi
      • M. A. D. Francesco
      • G. Piccinelli
      • Arnaldo Caruso
      • E. Bardellini
      • A. Majorana

    • PubMed: 32034698
    • DOI: 10.1007/s40368-020-00512-2

    1 Insight on

    • Reduced Microorganism Growth Associated with Black Tooth Stains

    • Low evidence
• February 10

  • Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge

    • 2020-02-10
    • RCT · n = 36
    • Oxidative Medicine and Cellular Longevity 2020
    • • Fengming Chen
      • Houjun Wang
      • Jiayi Chen
      • Yang Liu
      • Wei Wen
      • Yinghui Li
      • Xingguo Huang

    • PubMed: 32104535
    • DOI: 10.1155/2020/6028606

    5 Insights on

    • Improved Intestinal Barrier Function
    • Improved Intestinal Morphology
    • Reduced Inflammatory Response
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Antioxidant Capacity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• February 11

  • Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice.

    • 2020-02-11
    • Clinical Trial
    • Food & Function 10(9)
    • • Fenfen Yan
      • Na Li
      • Jialu Shi
      • Huizhen Li
      • Yingxue Yue
      • Wenshu Jiao
      • Nana Wang
      • Yue Song
      • G. Huo
      • Bailiang Li

    • PubMed: 31461095
    • DOI: 10.1039/c9fo01062a

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Inflammatory Response
    • Reduced Inflammation Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Epithelial Barrier Function
    • Restored Gut Microbiota Structure

    • Low evidence
    • Highly Cited
    • Animal Study

  • Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells

    • 2020-02-11
    • PLOS ONE 15(2)
    • • Narges Dargahi
      • Joshua C. Johnson
      • V. Apostolopoulos

    • PubMed: 32045425
    • DOI: 10.1371/journal.pone.0228531

    11 Insights on

    • Enhanced Immune System Function
    • Reduced Inflammatory Response
    • Reduced Inflammatory Markers
    • Increased Immune Factor Levels
    • Enhanced Immune Function
    • Reduced Proinflammatory Mediators
    • Modulated Immune Response
    • Increased Immune Marker Levels
    • Reduced Inflammatory Immune Mediators
    • Improved Immune System Modulation
    • Modulated Immune System

    • Low evidence
    • Rigorous Journal

  • Potential of Inactivated Bifidobacterium Strain in Attenuating Benzo(A)Pyrene Exposure-Induced Damage in Colon Epithelial Cells In Vitro

    • 2020-02-11
    • Toxics 8(1)
    • • Mengfan Xu
      • L. Fu
      • Junwen Zhang
      • Tao Wang
      • Junfeng Fan
      • B. Zhu
      • P. Dziugan
      • Bolin Zhang
      • Hongfei Zhao

    • PubMed: 32053893
    • DOI: 10.3390/toxics8010012

    5 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Apoptosis of Colon Epithelial Cells
    • Reduced Cytotoxicity of BaP
    • Reduced Apoptosis Due to Carcinogens
    • Increased Binding of Carcinogenic Compounds

    • Low evidence
• February 12

  • Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial.

    • 2020-02-12
    • RCT · n = 45
    • The Turkish Journal of Gastroenterology 30(3)
    • • İlkay Yılmaz
      • M. E. Dolar
      • H. Ozpinar

    • PubMed: 30662004
    • DOI: 10.5152/TJG.2018.18227

    10 Insights on

    • Improved Gut Microbiota
    • Reduced Bloating
    • Improved Quality of Life
    • Reduced Inflammatory Markers in Crohn's Disease
    • Increased Hemoglobin Levels
    • Improved Quality of Life in Individuals with Crohn's Disease
    • Reduced C-Reactive Protein Levels
    • Increased Lactobacillus Bacterial Load
    • Reduced Erythrocyte Sedimentation Rate
    • Improved Feeling of Well-being

    • High evidence
    • Highly Cited

  • Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients

    • 2020-02-12
    • Clinical Trial
    • European Journal of Clinical Investigation 50(3)
    • • L. Bonfrate
      • D. D. Di Palo
      • G. Celano
      • A. Albert
      • Paola Vitellio
      • M. De Angelis
      • M. Gobbetti
      • P. Portincasa

    • PubMed: 31960952
    • DOI: 10.1111/eci.13201

    7 Insights on

    • Improved Stool Consistency
    • Reduced Bloating
    • Reduced Abdominal Pain
    • Reduced Colonic Permeability
    • Improved Irritable Bowel Syndrome Symptoms
    • Enhanced Beneficial Metabolite Production
    • Improved Intestinal Epithelial Permeability

    • High evidence
    • Rigorous Journal
• February 14

  • In Vitro Antimicrobial Activity of Piper retrofractum Fruit Extracts against Microbial Pathogens Causing Infections in Human and Animals

    • 2020-02-14
    • International Journal of Microbiology 2020
    • • W. Panphut
      • T. Budsabun
      • P. Sangsuriya

    • PubMed: 32148509
    • DOI: 10.1155/2020/5638961

    1 Insight on

    • Reduced Pathogenic Microorganism Activity

    • Low evidence
• February 15

  • Strain-Specific Probiotic Properties of Bifidobacteria and Lactobacilli for the Prevention of Diarrhea Caused by Rotavirus in a Preclinical Model

    • 2020-02-15
    • Clinical Trial
    • Nutrients 12(2)
    • • Ignasi Azagra-Boronat
      • M. Massot-Cladera
      • K. Knipping
      • J. Garssen
      • Kaouther Ben Amor
      • J. Knol
      • À. Franch
      • M. Castell
      • M. J. Rodríguez-Lagunas
      • F. Pérez-Cano

    • PubMed: 32075234
    • DOI: 10.3390/nu12020498

    2 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Viral Load

    • Low evidence
    • Animal Study
• February 17

  • Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases

    • 2020-02-17
    • Clinical Trial
    • European Journal of Nutrition 59(8)
    • • Tanvi Shinde
      • A. P. Perera
      • R. Vemuri
      • Shakuntla V Gondalia
      • D. Beale
      • A. Karpe
      • Sonia Shastri
      • Waheedha Basheer
      • Benjamin Southam
      • R. Eri
      • R. Stanley

    • PubMed: 32067099
    • DOI: 10.1007/s00394-020-02200-9

    1 Insight on

    • Reduced IL-1β Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The Effect of Lactobacillus Fermentum ME-3 Treatment on Glycation and Diabetes Complications.

    • 2020-02-17
    • Clinical Trial
    • Molecular Nutrition & Food Research 64(6)
    • • Axel Guilbaud
      • M. Howsam
      • C. Niquet-Leridon
      • Florian Delguste
      • M. Frémont
      • S. Lestavel
      • P. Maboudou
      • A. Garat
      • S. Schraen
      • B. Onraed
      • B. Foligné
      • E. Boulanger
      • F. Tessier

    • PubMed: 31991062
    • DOI: 10.1002/mnfr.201901018

    8 Insights on

    • Improved Glucose Tolerance
    • Reduced Hepatic Steatosis
    • Reduced Weight Gain
    • Reduced Renal FL-furosine Levels
    • Reduced Renal Free-CML
    • Reduced Pulmonary Free-CML
    • Improved Plasma Lipid Levels
    • Reduced Glycation End Product Accumulation

    • Low evidence
    • Rigorous Journal
    • Animal Study
• February 19

  • Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer's disease model and alleviated neurodegeneration in the eye.

    • 2020-02-19
    • Clinical Trial
    • Beneficial Microbes 11(1)
    • • F. Tan
      • G. Liu
      • S. A. Lau
      • M. Jaafar
      • Y. Park
      • G. Azzam
      • Y. Li
      • M. Liong

    • PubMed: 32066253
    • DOI: 10.3920/bm2019.0086

    2 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Neurodegeneration Symptoms

    • Low evidence
    • Animal Study

  • Treatment with Bifidobacterium longum 51A attenuates intestinal damage and inflammatory response in experimental colitis.

    • 2020-02-19
    • Beneficial Microbes 11(1)
    • • F. A. Abrantes
      • B. B. Nascimento
      • M. E. Andrade
      • P. A. V. de Barros
      • C. T. Cartelle
      • F. S. Martins
      • J. Nicoli
      • R. Arantes
      • S. Generoso
      • S. O. Fernandes
      • V. Cardoso

    • PubMed: 32066260
    • DOI: 10.3920/bm2019.0098

    6 Insights on

    • Reduced Intestinal Permeability
    • Reduced Inflammatory Response
    • Reduced Myeloperoxidase Levels
    • Reduced Interleukin-1β Levels
    • Reduced Eosinophil Peroxidase Levels
    • Reduced Severity of Colon Lesions

    • Low evidence

  • Effects of Bifidobacterium animalis subsp. lactis HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis.

    • 2020-02-19
    • Beneficial Microbes 11(1)
    • • R. S. Cardoso
      • M. Messora
      • P. Silva
      • L. F. Oliveira
      • C. Leite-Panissi
      • S. Salvador
      • R. Casarin
      • A. B. Novaes
      • D. Palioto
      • F. Furlaneto

    • PubMed: 32066256
    • DOI: 10.3920/bm2019.0038

    11 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Proinflammatory Mediators
    • Reduced Alveolar Bone Resorption
    • Elevated Interleukin-17 Levels
    • Stabilized Connective Tissue Attachment Levels
    • No Change in Interleukin-10 Levels
    • Reduced Anti-citrullinated Protein Antibodies Levels
    • Increased Proportion of Aerobic and Anaerobic Bacteria
    • Increased IL-17 Levels
    • Increased Aerobic to Anaerobic Bacteria Ratio

    • Low evidence

  • Intravaginal administration of gelatine capsules containing freeze-dried autochthonous lactobacilli: a double-blind, randomised clinical trial of safety.

    • 2020-02-19
    • RCT
    • Beneficial Microbes 11(1)
    • • P. R. De Gregorio
      • N. C. Maldonado
      • E. V. Pingitore
      • M. C. L. Terraf
      • M. S. J. Tomás
      • C. S. de Ruiz
      • V. Santos
      • B. Wiese
      • E. Bru
      • M. C. Paiz
      • M. Reina
      • D. E. Schujman
      • M. Nader-Macías

    • PubMed: 32066254
    • DOI: 10.3920/bm2019.0081

    5 Insights on

    • Absence of Severe Adverse Events
    • Reduced Nugent Score
    • Increased Cultivable Lactobacilli
    • No Change in Nugent Score
    • Reduced Leukocyte Count

    • High evidence
• February 22

  • Daily Intake of Paraprobiotic Lactobacillus amylovorus CP1563 Improves Pre-Obese Conditions and Affects the Gut Microbial Community in Healthy Pre-Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

    • 2020-02-22
    • RCT · n = 159
    • Microorganisms 8(2)
    • • Tomonori Sugawara
      • D. Sawada
      • S. Yanagihara
      • Yumeko Aoki
      • Isao Takehara
      • H. Sugahara
      • Tatsuhiko Hirota
      • Yasunori Nakamura
      • Susumu Ishikawa

    • PubMed: 32098338
    • DOI: 10.3390/microorganisms8020304

    2 Insights on

    • Reduced Abdominal Fat
    • Altered Gut Microbial Community

    • High evidence
    • Rigorous Journal

  • Oral Intake of Lactobacilli Can Be Helpful in Symptomatic Bacterial Vaginosis: A Randomized Clinical Study

    • 2020-02-22
    • RCT · n = 166
    • Journal of Lower Genital Tract Disease 24(3)
    • • Halyna Reznichenko
      • N. Henyk
      • V. Maliuk
      • Tetyana Khyzhnyak
      • Yevhenia Tynna
      • Ihor Filipiuk
      • N. Veresniuk
      • Larysa Zubrytska
      • J. Quintens
      • K. Richir
      • S. Gerasymov

    • PubMed: 32091443
    • DOI: 10.1097/LGT.0000000000000518

    2 Insights on

    • Reduced Recurrence of Bacterial Vaginosis
    • Increased Survival Without Bacterial Vaginosis

    • High evidence
• February 26

  • Clostridium butyricum Ameliorates Salmonella Enteritis Induced Inflammation by Enhancing and Improving Immunity of the Intestinal Epithelial Barrier at the Intestinal Mucosal Level

    • 2020-02-26
    • Clinical Trial
    • Frontiers in Microbiology 11
    • • Xiaonan Zhao
      • Jie Yang
      • Zijing Ju
      • Jianmin Wu
      • Lili Wang
      • Hai Lin
      • Shuhong Sun

    • PubMed: 32180765
    • DOI: 10.3389/fmicb.2020.00299

    2 Insights on

    • Reduced Th2 Cytokine Levels
    • Reduced Intestinal Oxidative Damage

    • Low evidence
    • Animal Study

  • Comparative Genomics of Pediococcus pentosaceus Isolated From Different Niches Reveals Genetic Diversity in Carbohydrate Metabolism and Immune System

    • 2020-02-26
    • Frontiers in Microbiology 11
    • • Jie Jiang
      • Bo Yang
      • R. Ross
      • C. Stanton
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen

    • PubMed: 32174896
    • DOI: 10.3389/fmicb.2020.00253

    4 Insights on

    • Reduced Obesity
    • Reduced Inflammation Levels
    • Reduced Hepatic Fat Accumulation
    • Reduced Encephalopathy

    • Low evidence

  • Consumption of Lactobacillus reuteri-containing lozenges improves periodontal health in navy sailors at sea: a randomized controlled trial.

    • 2020-02-26
    • RCT · n = 72
    • Journal of Periodontology 91(10)
    • • U. Schlagenhauf
      • Juliane Rehder
      • G. Gelbrich
      • Y. Jockel-Schneider

    • PubMed: 32017092
    • DOI: 10.1002/JPER.19-0393

    1 Insight on

    • Improved Periodontal Health

    • High evidence
• February 28

  • Lactobacillus fermentum CECT5716 Supplementation in Rats during Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota

    • 2020-02-28
    • Clinical Trial
    • Cells 9(3)
    • • Ignasi Azagra-Boronat
      • A. Tres
      • M. Massot-Cladera
      • À. Franch
      • M. Castell
      • F. Guardiola
      • F. Pérez-Cano
      • M. J. Rodríguez-Lagunas

    • PubMed: 32121244
    • DOI: 10.3390/cells9030575

    7 Insights on

    • Improved Immune Function
    • Improved Lipid Profile
    • Modulated Gut Microbiota
    • Improved Immune System in Mothers
    • Changed Maternal Plasma Fatty Acids
    • Modulated Immune Function in Offspring
    • Altered Fatty Acid Profile in Offspring

    • Low evidence
    • Animal Study
• February 29

  • Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.

    • 2020-02-29
    • Drug Discoveries & Therapeutics 14(1)
    • • Yasuhiko Matsumoto
      • Miki Takahashi
      • K. Sekimizu

    • PubMed: 32147629
    • DOI: 10.5582/ddt.2020.01002

    2 Insights on

    • Reduced Hyperglycemic Response
    • Reduced Glucose Uptake

    • Low evidence
• Undated – 6 supplement studies

  • Physicochemical, bioactive and rheological properties of an exopolysaccharide produced by a probiotic Pediococcus pentosaceus M41.

    • 2020-02
    • Carbohydrate Polymers 229
    • • M. Ayyash
      • B. Abu-Jdayil
      • A. Olaimat
      • G. Esposito
      • P. Itsaranuwat
      • T. Osaili
      • R. Obaid
      • Jaleel Kizhakkayil
      • Shaoquan Liu

    • PubMed: 31826478
    • DOI: 10.1016/j.carbpol.2019.115462

    5 Insights on

    • Reduced α-Glucosidase Activity
    • Improved Antioxidant Capacity
    • Increased Antioxidant Capacity
    • Inhibited α-Amylase Activity
    • Reduced Alpha-Amylase Activity

    • Low evidence
    • Highly Cited

  • Ameliorative effects of Lactobacillus plantarum L-137 on Nile tilapia (Oreochromis niloticus) exposed to deltamethrin toxicity in rearing water.

    • 2020-02
    • RCT
    • Aquatic Toxicology 219
    • • M. Dawood
      • Eman M. Moustafa
      • Mahmoud S. Gewaily
      • Safaa E. Abdo
      • Marwa F. Abdel-Kader
      • Moustafa S. SaadAllah
      • A. Hamouda

    • PubMed: 31838306
    • DOI: 10.1016/j.aquatox.2019.105377

    5 Insights on

    • Improved Immune Function
    • Improved Blood Biochemical Markers
    • Improved Histopathological Protection
    • Improved Antioxidant Defense
    • Improved Resistance to Environmental Toxin-Induced Liver Damage

    • High evidence

  • The effects of dietary Bacillus subtilis supplementation, as an alternative to antibiotics, on growth performance, intestinal immunity, and epithelial barrier integrity in broiler chickens infected with Eimeria maxima

    • 2020-02
    • RCT · n = 196
    • Poultry Science 99(2)
    • • I. Park
      • Youngsub Lee
      • D. Goo
      • N. Zimmerman
      • Alexandra H. Smith
      • T. Rehberger
      • H. Lillehoj

    • PubMed: 32036975
    • DOI: 10.1016/j.psj.2019.12.002

    7 Insights on

    • Increased Body Weight
    • Improved Growth Performance
    • Reduced Inflammation Levels
    • Enhanced Intestinal Immunity
    • Reduced Intestinal Lesion Scores
    • Increased Expression of Junctional Adhesion Molecule 2
    • Improved Epithelial Barrier Integrity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lactobacillus plantarum CBT LP3 ameliorates colitis via modulating T cells in mice.

    • 2020-02
    • RCT · n = 3
    • International Journal of Medical Microbiology 310(2)
    • • D. H. Kim
      • Soochan Kim
      • Jae Bum Ahn
      • J. H. Kim
      • H. Ma
      • D. H. Seo
      • X. Che
      • K. Park
      • J. Jeon
      • Sang Yong Kim
      • Hansook Lee
      • Jae-Young Lee
      • T. Kim
      • W. Kim
      • Seung Won Kim
      • J. Cheon

    • PubMed: 32007342
    • DOI: 10.1016/j.ijmm.2020.151391

    14 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Colitis Severity
    • Regulated Immune Response
    • Reduced Ulcerative Colitis Symptoms
    • Reduced Colitis Symptoms
    • Reduced Inflammation Levels
    • Improved Colitis Symptoms
    • Restored Goblet Cell Count
    • Increased Regulatory T Cell Count
    • Reduced Disease Activity Index (DAI) Levels
    • Improved Immune Regulation
    • Reduced Disease Activity in Colitis
    • Increased Regulatory T Cell Induction
    • Restored Goblet Cell Function

    • Low evidence
    • Animal Study

  • GH36 α-galactosidase from Lactobacillus plantarum WCFS1 synthesize Gal-α-1,6 linked prebiotic α-galactooligosaccharide by transglycosylation.

    • 2020-02
    • International Journal of Biological Macromolecules 144
    • • Deepesh Panwar
      • A. Shubhashini
      • S. Chaudhari
      • K. H. Prashanth
      • M. Kapoor
      • M. Kapoor

    • PubMed: 31816385
    • DOI: 10.1016/j.ijbiomac.2019.12.032

    1 Insight on

    • Enhanced Probiotic Bacteria Count

    • Low evidence

  • Safety evaluation of Bacillus coagulans SNZ 1969 in Wistar rats.

    • 2020-02
    • Clinical Trial · n = 6
    • Regulatory Toxicology and Pharmacology 110
    • • A. Metlakunta
      • R. J. Soman

    • PubMed: 31751640
    • DOI: 10.1016/j.yrtph.2019.104538

    3 Insights on

    • Absence of Adverse Effects
    • No Adverse Health Effects
    • Increased Oral Toxicity Threshold

    • Low evidence
    • Animal Study