November 2020 Supplement Research Papers

• November 1

  • The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease.

    • 2020-11-01
    • Review
    • Microorganisms 8(11)
    • • Spase Stojanov
      • Aleš Berlec
      • Borut Štrukelj

    • PubMed: 33139627
    • DOI: 10.3390/microorganisms8111715

    5 Insights on

    • Reduced Obesity
    • Improved Gut Microbiota Balance
    • Reduced Inflammation
    • Restored Gut Microbiome Balance
    • Reduced Incidence of Inflammatory Bowel Diseases

    • Moderate evidence
    • Highly Cited
• November 4

  • Novel Strategies for Efficient Production and Delivery of Live Biotherapeutics and Biotechnological Uses of Lactococcus lactis: The Lactic Acid Bacterium Model

    • 2020-11-04
    • Frontiers in Bioengineering and Biotechnology 8
    • • L. M. Tavares
      • L. D. de Jesus
      • T. F. da Silva
      • F. A. L. Barroso
      • V. L. Batista
      • N. D. Coelho-Rocha
      • V. Azevedo
      • M. M. Drumond
      • Pamela Mancha-Agresti

    • PubMed: 33251190
    • DOI: 10.3389/fbioe.2020.517166

    3 Insights on

    • Prevention of Intestinal Infections
    • Reduced Incidence of Inflammatory Bowel Diseases
    • Prevention of Autoimmune Disorders

    • Low evidence
• November 9

  • Streptococcus Thermophilus UASt-09 Upregulates Goblet Cell Activity in Colonic Epithelial Cells to a Greater Degree than other Probiotic Strains

    • 2020-11-09
    • Microorganisms 8(11)
    • • M. Shastri
      • W. C. Chong
      • R. Vemuri
      • C. Martoni
      • S. Adhikari
      • Harinder Bhullar
      • D. Kunde
      • S. Tristram
      • R. Eri

    • PubMed: 33182355
    • DOI: 10.3390/microorganisms8111758

    2 Insights on

    • Improved Intestinal Barrier Function
    • Improved Gastrointestinal Health

    • Low evidence
    • Rigorous Journal

  • Lacticaseibacillus casei in Diet of Juvenile Convict Cichlid Fish (Amatitlania nigrofasciata): Evaluating Growth Performance, Digestive Enzyme Activities, Immune Responses, and Stress Resistance

    • 2020-11-09
    • RCT · n = 24
    • Probiotics and Antimicrobial Proteins 13(3)
    • • H. Mohammadiazarm
      • M. Maniat

    • PubMed: 33169342
    • DOI: 10.1007/s12602-020-09718-8

    4 Insights on

    • Improved Growth Performance
    • Improved Gut Health
    • Enhanced Immune Response
    • Enhanced Digestive Enzyme Activity

    • Low evidence
    • Animal Study
• November 10

  • Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study.

    • 2020-11-10
    • RCT
    • Amino acids 52(11-12)
    • • Debi Ann Abraham
      • Udayakumar Narasimhan
      • Senta Christy
      • Rajanandh Muhasaparur Ganesan

    • PubMed: 33170378
    • DOI: 10.1007/s00726-020-02909-1

    4 Insights on

    • Reduced Gastrointestinal Symptom Severity
    • Reduced Autism Rating Scale Score
    • Reduced Autism Treatment Evaluation Checklist Score
    • Reduced Sleep Disturbance Score

    • High evidence
• November 12

  • In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12

    • 2020-11-12
    • Probiotics and Antimicrobial Proteins 13(3)
    • • Tzu Yu Chen
      • J. Hale
      • J. Tagg
      • Rohit Jain
      • Abigail L. Voss
      • N. Mills
      • E. Best
      • D. S. Stevenson
      • Philip A. Bird
      • T. Walls

    • PubMed: 33179212
    • DOI: 10.1007/s12602-020-09719-7

    3 Insights on

    • Reduced Pathogen Growth
    • Reduced Acute Otitis Media
    • Inhibition of Otitis Media Pathogens Growth

    • Low evidence
• November 15

  • Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults.

    • 2020-11-15
    • RCT
    • Beneficial microbes 11(7)
    • • R E Trotter
      • A R Vazquez
      • D S Grubb
      • K E Freedman
      • L E Grabos
      • S Jones
      • C L Gentile
      • C L Melby
      • S A Johnson
      • T L Weir

    • PubMed: 33161737
    • DOI: 10.3920/bm2020.0039

    4 Insights on

    • Reduced LDL Cholesterol
    • Reduced Non-HDL Cholesterol
    • Improved Vascular Endothelial Function
    • Reduced Total Cholesterol

    • High evidence
    • Rigorous Journal

  • Lacticaseibacillus rhamnosus GG inhibits infection of human keratinocytes by Staphylococcus aureus through mechanisms involving cell surface molecules and pH reduction.

    • 2020-11-15
    • Beneficial Microbes 11(7)
    • • I. Spacova
      • C. O'Neill
      • S. Lebeer

    • PubMed: 33084369
    • DOI: 10.3920/BM2020.0075

    3 Insights on

    • Reduced Staphylococcus aureus Growth
    • Reduced Staphylococcus Aureus Infection
    • Reduced TLR Inflammatory Activation

    • Low evidence

  • Daily intake of probiotic strain Bacillus subtilis DE111 supports a healthy microbiome in children attending day-care.

    • 2020-11-15
    • RCT
    • Beneficial Microbes 11(7)
    • • A. Paytuví-Gallart
      • W. Sanseverino
      • A. Winger

    • PubMed: 33161736
    • DOI: 10.3920/BM2020.0022

    4 Insights on

    • Improved Gut Microbiome Diversity
    • Improved Alpha Diversity of Intestinal Microbiota
    • Increased Anti-Inflammatory Bacteria Abundance
    • Reduced Abundance of Pro-inflammatory Bacteria

    • High evidence

  • Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults

    • 2020-11-15
    • RCT
    • Beneficial Microbes 11(7)
    • • Roxanne E. Trotter
      • Allegra R. Vazquez
      • Diana S. Grubb
      • Kimberley E. Freedman
      • Lauren E Grabos
      • S. Jones
      • Christopher L. Gentile
      • Christopher L. Melby
      • Sarah A. Johnson
      • Tiffany L. Weir

    • PubMed: 33161737
    • DOI: 10.3920/BM2020.0039

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced LDL Cholesterol
    • Reduced Non-HDL Cholesterol
    • Improved Vascular Endothelial Function
    • Reduced Non-High-Density Lipoprotein Cholesterol
    • Reduced Total Cholesterol

    • High evidence

  • Probiotics diminish the post-operatory pain following mandibular third molar extraction: a randomised double-blind controlled trial (pilot study).

    • 2020-11-15
    • RCT · n = 38
    • Beneficial Microbes 11(7)
    • • E. Ferrés-Amat
      • Jordi Espadaler Mazo
      • J. Calvo-Guirado
      • E. Ferrés-Amat
      • J. Mareque-Bueno
      • A. Salavert
      • M. Aguiló-García
      • J. Moreno-Centeno
      • E. Ferrés-Padró

    • PubMed: 33124895
    • DOI: 10.3920/BM2020.0090

    2 Insights on

    • Reduced Postoperative Pain
    • Reduced Eating Difficulties

    • High evidence

  • Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice.

    • 2020-11-15
    • Clinical Trial
    • Beneficial Microbes 11(7)
    • • T. Yin
      • S. Bayanjargal
      • B. Fang
      • C. Inaba
      • M. Mutoh
      • T. Kawahara
      • S. Tanaka
      • J. Watanabe

    • PubMed: 33045842
    • DOI: 10.3920/BM2020.0009

    3 Insights on

    • Reduced Hepatic Steatosis
    • Reduced Visceral Fat Accumulation
    • Partial Restoration of Intestinal Microbiota

    • Low evidence
    • Animal Study
• November 17

  • PROFAST: A Randomized Trial Assessing the Effects of Intermittent Fasting and Lacticaseibacillus rhamnosus Probiotic among People with Prediabetes

    • 2020-11-17
    • RCT · n = 33
    • Nutrients 12(11)
    • • A. Tay
      • Hannah Pringle
      • Elise Penning
      • L. Plank
      • R. Murphy

    • PubMed: 33212907
    • DOI: 10.3390/nu12113530

    4 Insights on

    • Improved Body Weight
    • Improved Hemoglobin A1c Levels
    • Improved Social Functioning
    • Improved Mental Health

    • High evidence
• November 18

  • Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected Gastric Epithelial Cells

    • 2020-11-18
    • Probiotics and Antimicrobial Proteins 13(3)
    • • M. Yarmohammadi
      • A. Yadegar
      • M. Ebrahimi
      • M. Zali

    • PubMed: 33206342
    • DOI: 10.1007/s12602-020-09721-z

    7 Insights on

    • Reduced Inflammatory Response
    • Reduced IL-8 Production in Gastric Epithelial Cells
    • Reduced Inflammation Levels
    • Reduced IL-8 Production
    • Reduced Inflammation
    • Reduced Inflammatory Response to Helicobacter pylori
    • Reduced Expression of Inflammation-Related Genes

    • Low evidence
• November 19

  • Complete Genome Sequences of Six Lactobacilli Isolated from American Quarter Horses.

    • 2020-11-19
    • Microbiology resource announcements 9(47)
    • • Rachael I Meinders
      • Mary Mendoza
      • Allison N Dickey
      • Elizabeth H Scholl
      • Hosni M Hassan

    • PubMed: 33214299
    • DOI: 10.1128/mra.00997-20

    2 Insights on

    • No Human Health Outcome Reported
    • Genome Sequencing / Genome Characterization

    • Low evidence
• November 23

  • Synthesis and Catalytic Application of Silver Nanoparticles Supported on Lactobacillus kefiri S-Layer Proteins.

    • 2020-11-23
    • Nanomaterials (Basel, Switzerland) 10(11)
    • • Patricia A Bolla
      • Sofía Huggias
      • María A Serradell
      • José F Ruggera
      • Mónica L Casella

    • PubMed: 33238585
    • DOI: 10.3390/nano10112322

    1 Insight on

    • Catalytic Conversion of p-Nitrophenol to p-Aminophenol

    • Low evidence
• November 25

  • Lactobacillus helveticus SBT2171 Alleviates Perennial Allergic Rhinitis in Japanese Adults by Suppressing Eosinophils: A Randomized, Double-Blind, Placebo-Controlled Study

    • 2020-11-25
    • RCT · n = 200
    • Nutrients 12(12)
    • • M. Yamashita
      • M. Miyoshi
      • M. Iwai
      • Ryuji Takeda
      • Takahiro Ono
      • T. Kabuki

    • PubMed: 33255731
    • DOI: 10.3390/nu12123620

    8 Insights on

    • Reduced Allergic Symptoms
    • Improved Nasal Symptoms in Perennial Allergic Rhinitis
    • Reduced Eosinophil Count
    • Reduced Nasal Congestion
    • Reduced Nasal Symptoms
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Reduced Symptoms of Perennial Allergic Rhinitis
    • Reduced Nasal Stuffiness

    • High evidence
• November 26

  • The effect of Pediococcus acidilactici on mucosal immune responses, growth, and reproductive performance in zebrafish (Danio rerio)

    • 2020-11-26
    • RCT
    • Fish Physiology and Biochemistry 47(1)
    • • M. M. Arani
      • A. Salati
      • S. Keyvanshokooh
      • O. Safari

    • PubMed: 33242190
    • DOI: 10.1007/s10695-020-00903-8

    14 Insights on

    • Improved Gastrointestinal Health
    • Improved Intestinal Mucosal Immunity
    • Improved Intestinal Function
    • Improved Gut Health
    • Improved Growth Rate
    • Enhanced Mucosal Immune Function
    • Enhanced Alkaline Phosphatase Activity
    • Enhanced Mucosal Immune Response
    • Elevated Alkaline Phosphatase Levels
    • Improved Intestinal Villus Morphology
    • Improved Productive Performance
    • Increased Alkaline Phosphatase Activity in Skin Mucus
    • Improved Growth Indices
    • Improved Reproductive Health

    • Low evidence
    • Animal Study
• November 30

  • Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice

    • 2020-11-30
    • Clinical Trial
    • Nutrients 12(12)
    • • Sung-Min Won
      • Siyu Chen
      • Seo Yeon Lee
      • Kyung Eun Lee
      • K. Park
      • J. Yoon

    • PubMed: 33266101
    • DOI: 10.3390/nu12123703

    7 Insights on

    • Improved Blood Glucose Levels
    • Improved Energy Levels
    • Reduced Epididymal Fat Mass
    • Reduced Weight Gain
    • Increased Abundance of Beneficial Microbes
    • Increased Butyrate Production
    • Reduced Total Blood Cholesterol

    • Low evidence
    • Animal Study
• Undated – 8 supplement studies

  • Probiotic characterization of Pediococcus strains isolated from Iranian cereal-dairy fermented product: Interaction with pathogenic bacteria and the enteric cell line Caco-2.

    • 2020-11
    • Journal of Bioscience and Bioengineering 130(5)
    • • A. Vasiee
      • F. Falah
      • B. A. Behbahani
      • Farideh Tabatabaee-Yazdi

    • PubMed: 32753308
    • DOI: 10.1016/j.jbiosc.2020.07.002

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Increased Antioxidant Activity
    • Reduced Pathogen Growth
    • Improved Cholesterol Levels
    • Improved Gastric Tolerance
    • Increased Cell Adhesion
    • Reduced Pathogenic Bacterial Growth

    • Low evidence

  • Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice.

    • 2020-11
    • RCT
    • International Immunopharmacology 88
    • • Miao Liu
      • Wenjie Xie
      • X. Wan
      • T. Deng

    • PubMed: 32771947
    • DOI: 10.1016/j.intimp.2020.106862

    4 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Risk of Colorectal Cancer
    • Reduced Severity of Acute Colitis
    • Reduced COX-2 Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effects of Probiotic (Bacillus subtilis) Supplementation During Offseason Resistance Training in Female Division I Athletes.

    • 2020-11
    • RCT · n = 23
    • Journal of Strength and Conditioning Research 34(11)
    • • Jeremy C Toohey
      • Jeremy R. Townsend
      • Sean B Johnson
      • Ann M. Toy
      • William C. Vantrease
      • David Bender
      • Chelsea C Crimi
      • Kathleen L. Stowers
      • M. D. Ruiz
      • Trisha A. VanDusseldorp
      • Y. Feito
      • G. Mangine

    • PubMed: 33105368
    • DOI: 10.1519/JSC.0000000000002675

    4 Insights on

    • Reduced Body Fat Percentage
    • Improved Body Composition
    • Improved Strength Performance
    • Improved Vertical Jump Performance

    • High evidence

  • Effect of Bacillus subtilis on growth performance, bone mineralization, and bacterial population of broilers fed with different protein sources

    • 2020-11
    • RCT · n = 40
    • Poultry Science 99(11)
    • • G. Ciurescu
      • M. Dumitru
      • A. Gheorghe
      • A. Untea
      • R. Drăghici

    • PubMed: 33142513
    • DOI: 10.1016/j.psj.2020.08.075

    4 Insights on

    • Reduced Abdominal Fat
    • Improved Body Weight
    • Reduced Pathogenic Bacterial Populations
    • Increased Tibia Phosphorus Concentration

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

    • 2020-11
    • RCT · n = 120
    • Neurobiology of Stress 13
    • • E. Patterson
      • Síle M. Griffin
      • A. Ibarra
      • E. Ellsiepen
      • J. Hellhammer

    • PubMed: 33385020
    • DOI: 10.1016/j.ynstr.2020.100277

    10 Insights on

    • Reduced Perceived Stress
    • Reduced Exhaustion During Stress Test
    • Normalized Cortisol Levels
    • Absence of Severe Adverse Events
    • Reduced Stress Response
    • Normalized Evening Cortisol Levels in Low Chronic Stress Participants
    • Reduced Exhaustion
    • Improved Perceived Health
    • Improved Sleep-Related Recovery in Participants with High Chronic Stress
    • Increased Heart Rate Response to Stress

    • High evidence

  • Synergistic effects of the early administration of Lactobacillus kefiranofaciens DN1 and Kluyveromyces marxianus KU140723-05 on the inhibition of Salmonella Enteritidis colonization in young chickens

    • 2020-11
    • RCT · n = 108
    • Poultry Science 99(11)
    • • Dongryeoul Bae
      • Dong‐Hyeon Kim
      • Jung-Whan Chon
      • K. Song
      • K. Seo

    • PubMed: 33142518
    • DOI: 10.1016/j.psj.2020.07.032

    2 Insights on

    • Reduced Salmonella enteritidis Colonization
    • Prolonged Inhibition of SE Colonization

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Milk fermented with Lactobacillus rhamnosus R0011 induces a regulatory cytokine profile in LPS-challenged U937 and THP-1 macrophages

    • 2020-11
    • Current Research in Food Science 3
    • • M. Jeffrey
      • H. Jones Taggart
      • J. Strap
      • Gibran Edun
      • J. Green-Johnson

    • PubMed: 32914120
    • DOI: 10.1016/j.crfs.2020.02.002

    4 Insights on

    • Increased IL-10 Production
    • Increased Interleukin-1 Receptor Antagonist Production
    • Increased Expression of CD206
    • Increased Interleukin-10 Production

    • Low evidence

  • Evaluation of the fate of Lactobacillus crispatus BC4, carried in Squacquerone cheese, throughout the simulator of the human intestinal microbial ecosystem (SHIME).

    • 2020-11
    • Food Research International 137
    • • F. Patrignani
      • C. Parolin
      • M. D’Alessandro
      • L. Siroli
      • B. Vitali
      • R. Lanciotti

    • PubMed: 33233191
    • DOI: 10.1016/j.foodres.2020.109580

    7 Insights on

    • Improved Gastrointestinal Survival
    • Improved Survival Through Gastric Conditions
    • Increased Colon Cancer Survival Rate
    • Increased Metabolic Activity in the Colon
    • Increased SCFA Production
    • Enhanced Digestive Process Survival
    • Reduced Lactate Conversion

    • Low evidence