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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of L-carnosine and its zinc complex (Polaprezinc) on pressure ulcer healing.
- 2013-07-08
- Clinical Trial · n = 18
- Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 28(5)
- - Kensaku Sakae
  - Toshihiko Agata
  - Ryoichi Kamide
  - Hiroyuki Yanagisawa
- PubMed: 23835365
- DOI: 10.1177/0884533613493333
1 Insight on
- Reduced Pressure Ulcer Severity
- Moderate evidence
Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial.
- 2013-07-01
- RCT · n = 127
- The Journal of Clinical Endocrinology & Metabolism 98(7)
- - M. Jones
  - C. Martoni
  - S. Prakash
- PubMed: 23609838
- DOI: 10.1210/jc.2012-4262
1 Insight on
- Increased Circulating 25-Hydroxyvitamin D Levels
- High evidence
- Highly Cited
- Rigorous Journal
Lactobacillus brevis G‐101 ameliorates colitis in mice by inhibiting NF‐κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2‐like macrophages
- 2013-07-01
- Clinical Trial
- Journal of Applied Microbiology 115(3)
- - Se-Eun Jang
  - S. Hyam
  - M. Han
  - S. Kim
  - B.G. Lee
  - Dong-Hyun Kim
- PubMed: 23742179
- DOI: 10.1111/jam.12273
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effects of Bacillus subtilis natto on milk production, rumen fermentation and ruminal microbiome of dairy cows.
- 2013-06-19
- RCT · n = 36
- Animal 7(2)
- - P. Sun
  - J. Q. Wang
  - L. F. Deng
- PubMed: 23031615
- DOI: 10.1017/S1751731112001188
8 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Persistence of the Oral Probiotic Streptococcus salivarius M18 Is Dose Dependent and Megaplasmid Transfer Can Augment Their Bacteriocin Production and Adhesion Characteristics
- 2013-06-13
- Clinical Trial · n = 75
- PLoS ONE 8(6)
- - J. Burton
  - P. Wescombe
  - Jean M. Macklaim
  - M. Chai
  - K. Macdonald
  - J. Hale
  - J. Tagg
  - G. Reid
  - G. Gloor
  - P. Cadieux
- PubMed: 23785463
- DOI: 10.1371/journal.pone.0065991
7 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Efficacy of Bacillus clausii strain UBBC-07 in the treatment of patients suffering from acute diarrhoea.
- 2013-06-01
- Beneficial Microbes 4(2)
- - M. Sudha
  - S. Bhonagiri
  - M. Asin Kumar
- PubMed: 23443952
- DOI: 10.3920/BM2012.0034
8 Insights on
- Low evidence
Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial.
- 2013-06-01
- RCT · n = 100
- Journal of Medical Microbiology 62(6)
- - J. Burton
  - B. Drummond
  - C. Chilcott
  - J. Tagg
  - W. Thomson
  - J. Hale
  - P. Wescombe
- PubMed: 23449874
- DOI: 10.1099/jmm.0.056663-0
6 Insights on
- High evidence
- Highly Cited
Atopic dermatitis‐mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi
- 2013-05-16
- Clinical Trial
- Journal of Applied Microbiology 115(2)
- - J. Kim
  - B. Park
  - Hyejin Park
  - Yong-Ha Park
  - B-O Kim
  - S. Pyo
- PubMed: 23607518
- DOI: 10.1111/jam.12229
11 Insights on
- Low evidence
- Animal Study
Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04
- 2013-05-10
- BMC Genomics 14(1)
- - J. Andersen
  - R. Barrangou
  - M. A. Hachem
  - S. Lahtinen
  - Y. Goh
  - B. Svensson
  - T. Klaenhammer
- PubMed: 23663691
- DOI: 10.1186/1471-2164-14-312
2 Insights on
- Improved Gastrointestinal Health
- Improved Immune Function
- Low evidence
- Rigorous Journal
Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus
- 2013-05-09
- Archives of Pharmacal Research 36(12)
- - Do Kyung Lee
  - J. Kang
  - H. Shin
  - I. Park
  - N. Ha
- PubMed: 23657805
- DOI: 10.1007/s12272-013-0141-3
2 Insights on
- Inhibited Hepatitis B Virus Replication
- Reduced Extracellular HBsAg Levels
- Low evidence
Oral evening primrose oil and borage oil for eczema.
- 2013-04-30
- Meta-Analysis · n = 1,596
- The Cochrane database of systematic reviews 2020(12)
- - Joel T M Bamford
  - Sujoy Ray
  - Alfred Musekiwa
  - Christel van Gool
  - Rosemary Humphreys
  - Edzard Ernst
- PubMed: 23633319
- DOI: 10.1002/14651858.cd004416.pub2
3 Insights on
- High evidence
Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells
- 2013-04-30
- PLoS ONE 8(4)
- - Jesper A. B. Strickertsson
  - C. Desler
  - Tomas Martin-Bertelsen
  - Ana Manuel Dantas Machado
  - T. Wadstrom
  - O. Winther
  - L. Rasmussen
  - L. Friis-Hansen
- PubMed: 23646188
- DOI: 10.1371/journal.pone.0063147
3 Insights on
- Low evidence
- Rigorous Journal
Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial
- 2013-04-25
- RCT · n = 210
- British Journal of Nutrition 110(9)
- - Y. Kadooka
  - Masao Sato
  - A. Ogawa
  - M. Miyoshi
  - H. Uenishi
  - Hitomi Ogawa
  - Ken Ikuyama
  - M. Kagoshima
  - T. Tsuchida
- PubMed: 23614897
- DOI: 10.1017/S0007114513001037
9 Insights on
- High evidence
- Highly Cited
Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus L-92 accompanied by the activation of innate immunity
- 2013-04-18
- British Journal of Nutrition 110(10)
- - Hiroaki Goto
  - Atsuhiro Sagitani
  - Nobuhisa Ashida
  - S. Kato
  - Tatsuhiko Hirota
  - T. Shinoda
  - N. Yamamoto
- PubMed: 23594927
- DOI: 10.1017/S0007114513001104
3 Insights on
- High evidence
- Highly Cited
Effect of Lactobacillus gasseri BNR17 on Overweight and Obese Adults: A Randomized, Double-Blind Clinical Trial
- 2013-04-08
- RCT · n = 62
- Korean Journal of Family Medicine 34(2)
- - Seung-Pil Jung
  - Keun-Mi Lee
  - Ji-hee Kang
  - S. Yun
  - Han-Oh Park
  - Yong Moon
  - Jong-Yeon Kim
- PubMed: 23560206
- DOI: 10.4082/kjfm.2013.34.2.80
5 Insights on
- High evidence
- Highly Cited
Necrotising pneumonia caused by Lactococcus lactis cremoris.
- 2013-04-01
- Case Report
- The International Journal of Tuberculosis and Lung Disease 17(4)
- - Buchelli-Ramirez Hl
  - C. Álvarez-Álvarez
  - S. Rojo-Alba
  - M. García-Clemente
  - R. Cimadevilla-Suárez
  - A. Pando-Sandoval
  - P. Casàn-Clará
- PubMed: 23485391
- DOI: 10.5588/ijtld.12.0620
1 Insight on
- Occurrence of Necrotising Pneumonia
- Low evidence
Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in Diet-Induced Obese Mice Is Associated with Gut Microbial Changes and Reduction in Obesity
- 2013-03-21
- RCT · n = 27
- PLoS ONE 8(3)
- - D. Park
  - Y. Ahn
  - Sehoon Park
  - C. Huh
  - Sae-Rom Yoo
  - R. Yu
  - Mi-Kyung Sung
  - R. McGregor
  - Myung‐Sook Choi
- PubMed: 23555678
- DOI: 10.1371/journal.pone.0059470
4 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates.
- 2013-03-11
- Clinical Trial
- British Journal of Nutrition 110(7)
- - Marie C. Lewis
  - D. Patel
  - Jenny Fowler
  - S. Duncker
  - A. Zuercher
  - A. Mercenier
  - M. Bailey
- PubMed: 23473077
- DOI: 10.1017/S0007114513000251
3 Insights on
- Low evidence
- Animal Study
Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome.
- 2013-03-04
- RCT · n = 214
- World Journal of Gastroenterology 18(30)
- - P. Ducrotte
  - P. Sawant
  - V. Jayanthi
- PubMed: 22912552
- DOI: 10.3748/wjg.v18.i30.4012
12 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
The effectiveness of oral goat colostrum in the treatment of patients with type 2 diabetes mellitus: our preliminary experience.
- 2013-03-01
- Clinical Trial · n = 27
- La Clinica terapeutica 164(2)
- - M A Guaragna
  - M Albanesi
  - S Stefani
  - A Pasqualone
  - A Angelini
  - S Alfieri
  - S Paparo Barbaro
- PubMed: 23698202
- DOI: 10.7417/ct.2013.1527
2 Insights on
- Increased Colonic Mucosal Glutathione S-Transferase Levels
- Reduced Insulin Dosage
- Moderate evidence
454 Pyrosequencing Analysis on Faecal Samples from a Randomized DBPC Trial of Colicky Infants Treated with Lactobacillus reuteri DSM 17938
- 2013-02-28
- RCT · n = 29
- PLoS ONE 8(2)
- - S. Roos
  - J. Dicksved
  - V. Tarasco
  - E. Locatelli
  - F. Ricceri
  - U. Grandin
  - F. Savino
- PubMed: 23468874
- DOI: 10.1371/journal.pone.0056710
1 Insight on
- Reduced Colic Symptoms
- High evidence
- Highly Cited
- Rigorous Journal
Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment.
- 2013-02-27
- Journal of Infectious Diseases 207(11)
- - Xinglin Zhang
  - J. Top
  - M. de Been
  - Damien Bierschenk
  - Malbert R. C. Rogers
  - M. Leendertse
  - M. Bonten
  - T. van der Poll
  - R. Willems
  - W. van Schaik
- PubMed: 23447698
- DOI: 10.1093/infdis/jit076
1 Insight on
- Reduced Intestinal Colonization
- Moderate evidence
- Highly Cited
- Rigorous Journal
Probiotic as a novel treatment strategy against liver disease.
- 2013-02-25
- Review
- Hepatitis monthly 13(2)
- - Abbas Ali Imani Fooladi
  - Hamideh Mahmoodzadeh Hosseini
  - Mohammad Reza Nourani
  - Soghra Khani
  - Seyed Moayed Alavian
- PubMed: 23610585
- DOI: 10.5812/hepatmon.7521
3 Insights on
- Low evidence
Black cohosh and breast cancer: a systematic review.
- 2013-02-25
- Systematic Review
- Integrative cancer therapies 13(1)
- - Heidi Fritz
  - Dugald Seely
  - Jessie McGowan
  - Becky Skidmore
  - Rochelle Fernandes
  - Deborah A Kennedy
  - Kieran Cooley
  - Raimond Wong
  - Stephen Sagar
  - Lynda G Balneaves
  - Dean Fergusson
- PubMed: 23439657
- DOI: 10.1177/1534735413477191
6 Insights on
- High evidence
A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy.
- 2013-02-23
- RCT · n = 32
- Complementary therapies in medicine 21(3)
- - Samantha Coulson
  - Amanda Rao
  - Shoshannah L Beck
  - Elizabeth Steels
  - Helen Gramotnev
  - Luis Vitetta
- PubMed: 23642948
- DOI: 10.1016/j.ctim.2013.01.007
3 Insights on
- High evidence
Activities of free and encapsulated Lactobacillus acidophilus LA5 or Lactobacillus casei 01 in processed longan juices on exposure to simulated gastrointestinal tract.
- 2013-02-08
- Journal of the Science of Food and Agriculture 93(9)
- - P. Chaikham
  - A. Apichartsrangkoon
  - Srivilai Worametrachanon
  - Wissanee Supraditareporn
  - Ekachai Chokiatirote
  - Tom Van der Wiele
- PubMed: 23401169
- DOI: 10.1002/jsfa.6030
6 Insights on
- Low evidence
The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials.
- 2013-02-08
- Systematic Review
- Journal of dietary supplements 10(1)
- - Igho Onakpoya
  - Lucy Davies
  - Paul Posadzki
  - Edzard Ernst
- PubMed: 23419021
- DOI: 10.3109/19390211.2012.760508
7 Insights on
- High evidence
Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice
- 2013-01-30
- Clinical Trial
- PLoS ONE 8(1)
- - Ji-hee Kang
  - S. Yun
  - Miri Park
  - Jun-Hong Park
  - So-Young Jeong
  - Han-Oh Park
- PubMed: 23382926
- DOI: 10.1371/journal.pone.0054617
7 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Lactobacillus johnsonii inhibits indoleamine 2,3‐dioxygenase and alters tryptophan metabolite levels in BioBreeding rats
- 2013-01-09
- Clinical Trial
- The FASEB Journal 27(4)
- - Ricardo B. Valladares
  - Lora Bojilova
  - Anastasia H. Potts
  - E. Cameron
  - Christopher L. Gardner
  - G. Lorca
  - Claudio F. Gonzalez
- PubMed: 23303207
- DOI: 10.1096/fj.12-223339
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Immune-modulatory effect of probiotic Bifidobacterium lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial
- 2013-01-09
- RCT
- European Journal of Clinical Nutrition 67(2)
- - Anurag Singh
  - Feriel Hacini-Rachinel
  - M. L. Gosoniu
  - T. Bourdeau
  - S. Holvoet
  - Remi Doucet-Ladevèze
  - Maurice Beaumont
  - Annick Mercenier
  - Sophie Nutten
- PubMed: 23299716
- DOI: 10.1038/ejcn.2012.197
2 Insights on
- Reduced Th-2 Cytokine Concentrations
- Reduced Activation of CD63 Expressing Basophils
- High evidence
- Highly Cited
- Rigorous Journal