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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of β-Alanine Supplementation on Subjects Performing High-Intensity Functional Training.
- 2024-07-19
- RCT · n = 27
- Nutrients 16(14)
- - Eduardo Cimadevilla-Fernández-Pola
  - Cristina Martínez-Roldán
  - Jose Luis Maté-Muñoz
  - Jesús Guodemar-Pérez
  - Maria Aránzazu Sánchez-Calabuig
  - Pablo García-Fernández
  - Juan Pablo Hervás-Pérez
  - Juan Hernández-Lougedo
- PubMed: 39064783
- DOI: 10.3390/nu16142340
5 Insights on
- High evidence
- Rigorous Journal
Safety and efficacy of L-Glutamine in reducing the frequency of acute complications among patients with sickle cell disease: A randomized controlled study.
- 2024-07-19
- RCT
- Annals of hematology 103(9)
- - Fatma Soliman Elsayed Ebeid
  - Nihal Hussien Aly
  - Naglaa Mohammed Shaheen
  - Samah Mohammed Ahmed Abdellatif
  - Ahmed Ashraf Mahmoud Okba
  - Nada Ayman Gad
  - Sara Mostafa Makkeyah
- PubMed: 39028356
- DOI: 10.1007/s00277-024-05877-8
3 Insights on
- High evidence
A Three-Month Probiotic (the Streptococcus salivarius M18 Strain) Supplementation Decreases Gingival Bleeding and Plaque Accumulation: A Randomized Clinical Trial.
- 2024-07-18
- RCT · n = 60
- Dentistry journal 12(7)
- - Ksenia Babina
  - Dilara Salikhova
  - Irina Makeeva
  - Alexandr Zaytsev
  - Inna Sokhova
  - Sevil Musaeva
  - Maria Polyakova
  - Nina Novozhilova
- PubMed: 39057009
- DOI: 10.3390/dj12070222
3 Insights on
- High evidence
Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.
- 2024-07-16
- RCT
- Nutrients 16(14)
- - Cindy Bandala
  - Jazmín Carro-Rodríguez
  - Noemí Cárdenas-Rodríguez
  - Itzel Peña-Montero
  - Modesto Gómez-López
  - Ana Paola Hernández-Roldán
  - Juan Carlos Huerta-Cruz
  - Felipe Muñoz-González
  - Iván Ignacio-Mejía
  - Brayan Domínguez
  - Eleazar Lara-Padilla
- PubMed: 39064727
- DOI: 10.3390/nu16142284
7 Insights on
- High evidence
- Rigorous Journal
The Protective Role Antioxidant of Vitamin C in the Prevention of oral Disease: A Scoping Review of Current Literature.
- 2024-07-16
- Systematic Review
- European journal of dentistry 18(04)
- - Alessio Rosa
  - Alberto Maria Pujia
  - Claudio Arcuri
- PubMed: 39013452
- DOI: 10.1055/s-0044-1786845
2 Insights on
- Reduced Gingival Bleeding
- Reduced Alveolar Bone Absorption
- High evidence
Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.
- 2024-07-16
- RCT
- Journal of the International Society of Sports Nutrition 21(1)
- - Nathaniel J Helwig
  - Laura E Schwager
  - Alexander C Berry
  - Anna C Zucker
  - Jacob S Venenga
  - Samantha C Sterbenz
  - Nathaniel D M Jenkins
- PubMed: 39014963
- DOI: 10.1080/15502783.2024.2379424
11 Insights on
- High evidence
Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation.
- 2024-07-16
- Frontiers in immunology 15
- - Mohammad Haque
  - Lauren Kaminsky
  - Raz Abdulqadir
  - Jessica Engers
  - Evgeny Kovtunov
  - Manmeet Rawat
  - Rana Al-Sadi
  - Thomas Y Ma
- PubMed: 39081324
- DOI: 10.3389/fimmu.2024.1348010
1 Insight on
- Reduced Epithelial Permeability
- Low evidence
Kavalactones support motivation to move during intensive training in males preparing for military special operations forces.
- 2024-07-15
- RCT
- Journal of the International Society of Sports Nutrition 21(1)
- - Sheena Y Smith
  - Carlos F Aylwin
  - Tyler F Daniels
  - Jennifer L Greer
  - Laura J Kunces
  - Loukia Lili
  - Stephen M Phipps
  - Caleb M Schmidt
  - Julian C Schmidt
  - Michael A Schmidt
- PubMed: 39010683
- DOI: 10.1080/15502783.2024.2377194
5 Insights on
- High evidence
Efficacy of forskolin as a promising therapy for chronic olfactory dysfunction post COVID-19.
- 2024-07-13
- RCT · n = 285
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 281(11)
- - Mohamed H Abdelazim
  - Faisal Alsenani
  - Mohammed Alnuhait
  - Abdullah S Alshammari
  - Abdullah H Altemani
  - Eyad A Althagafi
  - Dania S Waggas
  - Ahmed H Abdelazim
  - Adnan Alharbi
- PubMed: 39001919
- DOI: 10.1007/s00405-024-08802-x
4 Insights on
- High evidence
- Large Human Trial
The possible short-term of Nigella sativa - L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial.
- 2024-07-12
- RCT · n = 103
- Journal of ovarian research 17(1)
- - Azamsadat Mahmoudian
  - Akram Ashouri
  - Roghaieh Rahmani Bilandi
  - Fatemeh Mohammadzadeh
  - Sareh Dashti
  - Narjes Bahri
- PubMed: 38997723
- DOI: 10.1186/s13048-024-01460-x
11 Insights on
- High evidence
- Large Human Trial
The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies.
- 2024-07-12
- Meta-Analysis · n = 501
- Nutrients 16(14)
- - Maria Moyseos
  - Jenny Michael
  - Nuno Ferreira
  - Antonia Sophocleous
- PubMed: 39064686
- DOI: 10.3390/nu16142243
5 Insights on
- High evidence
- Rigorous Journal
Nutritional Strategies for Optimizing Health, Sports Performance, and Recovery for Female Athletes and Other Physically Active Women: A Systematic Review.
- 2024-07-12
- Systematic Review · n = 1,654
- Nutrition reviews 83(3)
- - Mar Larrosa
  - Angel Gil-Izquierdo
  - Liliana Guadalupe González-Rodríguez
  - María José Muñoz Alférez
  - Alejandro F San Juan
  - Ángela Sánchez-Gómez
  - Natalia Calvo-Ayuso
  - Juan José Ramos-Álvarez
  - Diego Fernández-Lázaro
  - Raúl Lopez-Grueso
  - Inmaculada López-León
  - Javier Moreno-Lara
  - Diego Domínguez-Balmaseda
  - Román Illescas-Quiroga
  - Eduardo Cuenca
  - Teba López
  - Juan José Montoya
  - Daiana Priscila Rodrigues-de-Souza
  - Elena Carrillo-Alvarez
  - Arturo Casado
  - Belén Rodriguez-Doñate
  - Mireia Porta-Oliva
  - Catalina Santiago
  - Támara Iturriaga
  - Beatriz De Lucas
  - Ángela García Solaesa
  - María Del Pilar Montero-López
  - Elvira Benítez De Gracia
  - Pablo Veiga-Herreros
  - Alejandro Muñoz-López
  - Eva Orantes-Gonzalez
  - José Carlos Barbero-Alvarez
  - Ruth Cabeza-Ruiz
  - Ángel Carnero-Diaz
  - Isabel Sospedra
  - Luis Miguel Fernández-Galván
  - José Miguel Martínez-Sanz
  - Francisco Javier Martín-Almena
  - Margarita Pérez
  - Eduardo J Guerra-Hernández
  - Álvaro López-Samanes
  - Antonio Jesús Sánchez-Oliver
  - Raúl Domínguez
- PubMed: 38994896
- DOI: 10.1093/nutrit/nuae082
2 Insights on
- Increased Muscle Protein Anabolism
- Enhanced Performance
- High evidence
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies.
- 2024-07-12
- Review
- Theranostics 14(10)
- - Jiayao Chen
  - Zhuowen Hao
  - Hanke Li
  - Jianping Wang
  - Tianhong Chen
  - Ying Wang
  - Guang Shi
  - Junwu Wang
  - Zepu Wang
  - Zheyuan Zhang
  - Jingfeng Li
- PubMed: 38994021
- DOI: 10.7150/thno.96516
2 Insights on
- Osteoporosis Treatment Strategy
- Improved Bone Regeneration
- Low evidence
The Role of Lactobacillus plantarum in Reducing Obesity and Inflammation: A Meta-Analysis.
- 2024-07-11
- Meta-Analysis
- International journal of molecular sciences 25(14)
- - Chen-Pi Li
  - Chin-Chang Chen
  - Yao Hsiao
  - Chieh-Hsin Kao
  - Chin-Chu Chen
  - Hao-Jan Yang
  - Ru-Yin Tsai
- PubMed: 39062848
- DOI: 10.3390/ijms25147608
5 Insights on
- High evidence
- Rigorous Journal
Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study.
- 2024-07-10
- RCT
- Nutrients 16(14)
- - Beyda Beteri
  - Monica Barone
  - Silvia Turroni
  - Patrizia Brigidi
  - George Tzortzis
  - Jelena Vulevic
  - Karol Sekulic
  - Diana-Elena Motei
  - Adele Costabile
- PubMed: 39064648
- DOI: 10.3390/nu16142205
2 Insights on
- Reduced Hemoglobin A1c
- Improved Fasting Plasma Glucose
- High evidence
- Rigorous Journal
The effect of Lactobacillus reuteri on pulmonary function test and growth of cystic fibrosis patients.
- 2024-07-10
- RCT · n = 40
- Journal of the science of food and agriculture 104(14)
- - Seyed Ahmad Tabatabaii
  - Ghamartaj Khanbabaee
  - Saeed Sadr
  - Nazanin Farahbakhsh
  - Seyedeh Zalfa Modarresi
  - Matin Pourghasem
  - Mahmoud Hajipour
- PubMed: 38982876
- DOI: 10.1002/jsfa.13732
10 Insights on
- High evidence
Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis.
- 2024-07-09
- RCT · n = 47
- BMC infectious diseases 24(1)
- - Rasha Eletreby
  - Aisha Elsharkawy
  - Rahma Mohamed
  - Mai Hamed
  - Eman Kamal Ibrahim
  - Rabab Fouad
- PubMed: 38982373
- DOI: 10.1186/s12879-024-09367-0
7 Insights on
- High evidence
Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Individuals with Type 2 Diabetes.
- 2024-07-09
- RCT
- Nutrients 16(14)
- - David J Mela
  - Marjan Alssema
  - Harry Hiemstra
  - Anne-Roos Hoogenraad
  - Tanvi Kadam
- PubMed: 39064619
- DOI: 10.3390/nu16142177
2 Insights on
- Reduced Postprandial Glucose
- Reduced Postprandial Insulin Response
- High evidence
- Rigorous Journal
Impact of L-theanine and L-tyrosine on markers of stress and cognitive performance in response to a virtual reality based active shooter training drill.
- 2024-07-08
- RCT · n = 28
- Stress (Amsterdam, Netherlands) 27(1)
- - Matthew J McAllister
  - M Hunter Martaindale
  - Courtney C Dillard
  - Rory McCullough
- PubMed: 38975711
- DOI: 10.1080/10253890.2024.2375588
5 Insights on
- High evidence
Research Progress on the Correlation of Atopic Dermatitis with Gut Microbiota.
- 2024-07-08
- Review
- Clinical, cosmetic and investigational dermatology 17
- - Qiuyu Mao
  - Xinyi Wang
  - Haibin Cai
  - Jingyi Yang
  - Yiwen Zhang
  - Wei Min
  - Qihong Qian
  - Yibin Zeng
- PubMed: 39006130
- DOI: 10.2147/ccid.s442551
1 Insight on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study.
- 2024-07-08
- RCT · n = 13
- Journal of pediatric gastroenterology and nutrition 79(3)
- - P Babu Balagopal
  - Rohit Kohli
  - Vikas Uppal
  - Lauren Averill
  - Chetan Shah
  - Katherine McGoogan
  - Matthew Di Guglielmo
  - Michael Goran
  - Md Jobayer Hossain
- PubMed: 38973318
- DOI: 10.1002/jpn3.12312
4 Insights on
- High evidence
Production, Purification, and Characterization of a Novel Exopolysaccharide from Probiotic Lactobacillus amylovorus: MTCC 8129.
- 2024-07-05
- Indian journal of microbiology 64(3)
- - Janani Murugu
  - Rajnish Narayanan
- PubMed: 39282197
- DOI: 10.1007/s12088-024-01346-y
3 Insights on
- Low evidence
The effect of Cuminum cyminum on the return of bowel motility after abdominal surgery: a triple-blind randomized clinical trial.
- 2024-07-04
- RCT · n = 74
- BMC complementary medicine and therapies 24(1)
- - Esmaeili Abdar Amin
  - Elahabadi Ismail
  - Raeiszadeh Mahboobeh
  - Sadeghi Tabandeh
- PubMed: 38965524
- DOI: 10.1186/s12906-024-04530-1
6 Insights on
- High evidence
Systematic review of pharmacological, complementary, and alternative therapies for the prevention of calcium oxalate stones.
- 2024-07-04
- Review
- Asian journal of urology 12(2)
- - Christopher Y Z Lo
  - Qian Hui Khor
  - Victor A Abdullatif
  - Cesar Delgado
  - Yadong Lu
  - Jonathan Katz
  - Roger L Sur
- PubMed: 40458577
- DOI: 10.1016/j.ajur.2024.04.006
2 Insights on
- Reduced Uric Acid Levels
- Reduced Stone Formation
- Low evidence
Viability-PCR for the selective detection of Lactobacillus acidophilus and Bifidobacterium bifidum in live bacteria-containing products.
- 2024-07-03
- Frontiers in microbiology 15
- - Stefania Catone
  - Serena Iannantuono
  - Domenico Genovese
  - Christina Von Hunolstein
  - Giovanna Franciosa
- PubMed: 39021625
- DOI: 10.3389/fmicb.2024.1400529
1 Insight on
- Increased Probiotic Bacterial Count
- Low evidence
Panax notoginseng: Pharmacological Aspects and Toxicological Issues.
- 2024-07-02
- Review
- Nutrients 16(13)
- - Cesare Mancuso
- PubMed: 38999868
- DOI: 10.3390/nu16132120
1 Insight on
- Improved Cardiac Function
- Moderate evidence
- Rigorous Journal
The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
- 2024-07-02
- Systematic Review
- Nutrients 16(13)
- - Youhe Wu
  - Yuetong Li
  - Qi Zheng
  - Lanjuan Li
- PubMed: 38999862
- DOI: 10.3390/nu16132114
1 Insight on
- Improved IBS Symptom Score
- High evidence
- Rigorous Journal
Intestinal microbiota imbalance resulted by anti-Toxoplasma gondii immune responses aggravate gut and brain injury.
- 2024-07-02
- Parasites & vectors 17(1)
- - Jiating Chen
  - Chi Zhang
  - Zihan Yang
  - Weiling Wu
  - Weihao Zou
  - Zixuan Xin
  - Shuyu Zheng
  - Runchun Liu
  - Lili Yang
  - Hongjuan Peng
- PubMed: 38956725
- DOI: 10.1186/s13071-024-06349-8
3 Insights on
- Low evidence
- Animal Study
The impact of nimodipine combined with Ginkgo biloba extract on cognitive function and ADL scores in patients with Parkinson's disease: A retrospective study.
- 2024-07-01
- Observational · n = 551
- Medicine 103(29)
- - Lianlian Zhang
  - Hua Sun
  - Zaigang Han
- PubMed: 39029001
- DOI: 10.1097/md.0000000000038720
3 Insights on
- High evidence
The Effects of Vitamin D Supplementation During Pregnancy on Maternal, Neonatal, and Infant Health: A Systematic Review and Meta-analysis.
- 2024-07-01
- Meta-Analysis · n = 9,954
- Nutrition reviews 83(3)
- - Wen-Chien Yang
  - Ramaa Chitale
  - Karen M O'Callaghan
  - Christopher R Sudfeld
  - Emily R Smith
- PubMed: 38950419
- DOI: 10.1093/nutrit/nuae065
6 Insights on
- High evidence