August 2020 Supplement Research Papers

• August 1

  • The effect of myo-inositol, vitamin D3 and melatonin on the oocyte quality and pregnancy in in vitro fertilization: a randomized prospective controlled trial.

    • 2020-08-01
    • RCT · n = 100
    • European review for medical and pharmacological sciences 24(16)
    • • A Wdowiak
      • M Filip

    • PubMed: 32894558
    • DOI: 10.26355/eurrev_202008_22649

    4 Insights on

    • Increased Clinical Pregnancy Rate
    • Improved Pregnancy Outcome
    • Improved Oocyte Quality
    • Improved Gestational Period

    • High evidence
    • Large Human Trial
• August 3

  • Improved metabolic function and cognitive performance in middle-aged adults following a single dose of wild blueberry.

    • 2020-08-03
    • RCT
    • European journal of nutrition 60(3)
    • • Adrian R Whyte
      • Sajida Rahman
      • Lynne Bell
      • Indika Edirisinghe
      • Robert Krikorian
      • Claire M Williams
      • Britt Burton-Freeman

    • PubMed: 32747995
    • DOI: 10.1007/s00394-020-02336-8

    5 Insights on

    • Improved Cognitive Function
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Improved Episodic Memory
    • Reduced Post-meal Glucose

    • High evidence
    • Rigorous Journal

  • Lactobacillus salivarius alleviates inflammation via NF-κB signaling in ETEC K88-induced IPEC-J2 cells

    • 2020-08-03
    • Journal of Animal Science and Biotechnology 11(1)
    • • J. Qiao
      • Zeyang Sun
      • Dong-mei Liang
      • Haihua Li

    • PubMed: 32774852
    • DOI: 10.1186/s40104-020-00488-5

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammation Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Intestinal Cell Integrity

    • Moderate evidence

  • Treating vaginitis with probiotics in non-pregnant females: A systematic review and meta-analysis.

    • 2020-08-03
    • Meta-Analysis · n = 30
    • Experimental and therapeutic medicine 20(4)
    • • Huey-Sheng Jeng
      • Tsong-Rong Yan
      • Jing-Yi Chen

    • PubMed: 32855726
    • DOI: 10.3892/etm.2020.9090

    3 Insights on

    • Restored Vaginal Flora
    • Reduced Vaginitis Recurrence
    • Vaginitis Cure or Remission Rate

    • High evidence

  • Cell-free supernatant of Streptococcus salivarius M18 impairs the pathogenic properties of Pseudomonas aeruginosa and Klebsiella pneumonia

    • 2020-08-03
    • Archives of Microbiology 202(10)
    • • S. Tunçer
      • Sevinç Karaçam

    • PubMed: 32747998
    • DOI: 10.1007/s00203-020-02005-8

    4 Insights on

    • Reduced Pathogen Growth
    • Improved Antibiotic Sensitivity
    • Altered Pathogenic Bacterial Biomolecules
    • Increased Antibiotic Sensitization

    • Low evidence
• August 4

  • Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT.

    • 2020-08-04
    • RCT
    • Scientific reports 10(1)
    • • Chanaka N Kahathuduwa
      • Sarah Wakefield
      • Blake D West
      • Jessica Blume
      • Tharaka L Dassanayake
      • Vajira S Weerasinghe
      • Ann Mastergeorge

    • PubMed: 32753637
    • DOI: 10.1038/s41598-020-70037-7

    2 Insights on

    • Improved Total Cognition Composite
    • Worsened Inhibitory Control

    • High evidence
    • Rigorous Journal
• August 5

  • Probiotic potential of Saccharomyces cerevisiae and Kluyveromyces marxianus isolated from West African spontaneously fermented cereal and milk products

    • 2020-08-05
    • Yeast 37(9-10)
    • • G. Motey
      • Pernille Johansen
      • J. Owusu-Kwarteng
      • L. Ofori
      • K. Obiri-Danso
      • H. Siegumfeldt
      • N. Larsen
      • L. Jespersen

    • PubMed: 32678933
    • DOI: 10.1002/yea.3513

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence
• August 6

  • Recent advances in clinical probiotic research for sport.

    • 2020-08-06
    • Review
    • Current opinion in clinical nutrition and metabolic care 23(6)
    • • Ralf Jäger
      • Alex E Mohr
      • Jamie N Pugh

    • PubMed: 32769404
    • DOI: 10.1097/mco.0000000000000686

    5 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Function
    • Improved Energy Metabolism
    • Improved Gastrointestinal Function
    • Improved Nutrient Absorption and Metabolism

    • Low evidence

  • Randomised, double-blind, placebo-controlled trial of oral probiotic Streptococcus salivarius M18 on head and neck cancer patients post-radiotherapy: a pilot study

    • 2020-08-06
    • RCT · n = 13
    • Scientific Reports 10(1)
    • • A. Vesty
      • K. Gear
      • Sharon Boutell
      • Michael W Taylor
      • R. Douglas
      • K. Biswas

    • PubMed: 32764634
    • DOI: 10.1038/s41598-020-70024-y

    3 Insights on

    • Improved Periodontal Health
    • Reduced Oral Pathogenic Bacteria Count
    • No Significant Impact on Bacterial Community Composition or Diversity

    • High evidence
    • Rigorous Journal
• August 9

  • Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD

    • 2020-08-09
    • Clinical Trial
    • Nutrients 12(8)
    • • Tanvi Shinde
      • R. Vemuri
      • Sonia Shastri
      • A. P. Perera
      • Shakuntla V Gondalia
      • D. Beale
      • A. Karpe
      • R. Eri
      • R. Stanley

    • PubMed: 32784883
    • DOI: 10.3390/nu12082380

    3 Insights on

    • Improved Symptoms of Chronic Condition
    • Induced Immunomodulatory Effects
    • Enhanced Immune Profile

    • Low evidence
    • Animal Study
• August 10

  • Effect of dietary supplementation with yeast Saccharomyces cerevisiae on skin, serum and liver of gilthead seabream (Sparus aurata L).

    • 2020-08-10
    • Journal of Fish Biology 97(3)
    • • C. Espinosa
      • M. Esteban

    • PubMed: 32598025
    • DOI: 10.1111/jfb.14449

    3 Insights on

    • Reduced Inflammation Around Wounds
    • Maintained Normal Serum Calcium Levels in Wounded Fish
    • Improved Skin Recovery

    • Low evidence
    • Rigorous Journal
• August 11

  • L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.

    • 2020-08-11
    • RCT
    • Nutritional neuroscience 25(4)
    • • Tharaka L Dassanayake
      • Chanaka N Kahathuduwa
      • Vajira S Weerasinghe

    • PubMed: 32777998
    • DOI: 10.1080/1028415x.2020.1804098

    4 Insights on

    • Improved Attention Span
    • Improved Reaction Time
    • Reduced P3b Latency
    • Reduced P3b Amplitude

    • High evidence

  • Real-Time PCR Assays for the Specific Identification of Probiotic Strains Lactobacillus gasseri BNR17 and Lactobacillus reuteri LRC (NCIMB 30242)

    • 2020-08-11
    • Probiotics and Antimicrobial Proteins 13(3)
    • • H. Shehata
      • S. Ragupathy
      • Shara-Gaye Allen
      • G. Leyer
      • S. Newmaster

    • PubMed: 32780278
    • DOI: 10.1007/s12602-020-09695-y

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• August 12

  • New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response.

    • 2020-08-12
    • Clinical Trial
    • Beneficial Microbes 11(4)
    • • M. Elean
      • L. Albarracín
      • P. G. Cataldo
      • A. Londero
      • H. Kitazawa
      • L. Saavedra
      • J. Villena
      • E. Hebert

    • PubMed: 32755264
    • DOI: 10.3920/bm2019.0198

    8 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Interferon-Gamma Levels
    • Reduced Intestinal Inflammation
    • Elevated Interleukin-10 Levels
    • Enhanced Activation of Peritoneal Macrophages
    • Increased Intestinal IgA Levels
    • Elevated Interferon-β Levels

    • Low evidence
    • Animal Study
• August 14

  • A Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Saccharomyces boulardii in Infants and Children With Acute Diarrhea

    • 2020-08-14
    • RCT · n = 100
    • Pediatric Infectious Disease Journal 39(11)
    • • Florian Mourey
      • Varun P Sureja
      • D. Kheni
      • Parthiv Shah
      • D. Parikh
      • U. Upadhyay
      • M. Satia
      • D. Shah
      • Charlotte Troise
      • A. Decherf

    • PubMed: 32796401
    • DOI: 10.1097/INF.0000000000002849

    2 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Diarrhea Severity

    • High evidence
• August 16

  • Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK

    • 2020-08-16
    • International Journal of Molecular Sciences 21(16)
    • • L. Lew
      • Y. Hor
      • M. Jaafar
      • A. Lau
      • Boon-Kiat Lee
      • L. Chuah
      • K. Yap
      • A. Azlan
      • G. Azzam
      • S. Choi
      • M. Liong

    • PubMed: 32824277
    • DOI: 10.3390/ijms21165872

    3 Insights on

    • Reduced Triglyceride Levels
    • Reduced Hepatic Steatosis
    • Reduced Hepatic Lipid Synthesis

    • Low evidence
• August 17

  • PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota in Healthy Adults

    • 2020-08-17
    • RCT · n = 68
    • Nutrients 12(8)
    • • Diana S. Grubb
      • Scott D. Wrigley
      • Kimberley E. Freedman
      • Yuren Wei
      • Allegra R. Vazquez
      • Roxanne E. Trotter
      • T. Wallace
      • S. Johnson
      • T. Weir

    • PubMed: 32824480
    • DOI: 10.3390/nu12082474

    16 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Gastrointestinal Inflammation
    • Reduced Colon Pain
    • Improved Gastrointestinal Health
    • Reduced Intestinal Inflammation
    • Increased Short-Chain Fatty Acid Production
    • Increased Lactobacillus Population
    • Improved Gut Microbiome Composition
    • Increased Short-Chain Fatty Acid-Producing Microbial Population
    • Increased Lactobacillus Levels
    • Increased Lactobacilli Populations
    • Improved Intestinal Microbial Composition
    • Enhanced Beneficial Gut Microbiota
    • Improved Gut Microbial Population
    • Improved Gastrointestinal Inflammation
    • Improved Colon Pain

    • High evidence

  • The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals.

    • 2020-08-17
    • RCT · n = 101
    • Nutrients 12(8)
    • • Sanne Ahles
      • Yala R Stevens
      • Peter J Joris
      • David Vauzour
      • Jos Adam
      • Eric de Groot
      • Jogchum Plat

    • PubMed: 32824483
    • DOI: 10.3390/nu12082475

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Improved Attention Span
    • Improved Vascular Function
    • Improved Cognitive Flexibility
    • Increased Brain-derived Neurotrophic Factor Level
    • Improved Psychomotor Speed

    • High evidence
    • Large Human Trial
    • Rigorous Journal
• August 18

  • L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety.

    • 2020-08-18
    • RCT
    • Alcohol and alcoholism (Oxford, Oxfordshire) 55(6)
    • • C J Peter Eriksson
      • Markus Metsälä
      • Tommi Möykkynen
      • Heikki Mäkisalo
      • Olli Kärkkäinen
      • Maria Palmén
      • Joonas E Salminen
      • Jussi Kauhanen

    • PubMed: 32808029
    • DOI: 10.1093/alcalc/agaa082

    5 Insights on

    • Reduced Nausea
    • Reduced Anxiety
    • Reduced Stress
    • Reduced Headache
    • Reduced Hangover Symptoms

    • High evidence
• August 19

  • Effects of Beta-Alanine Supplementation on Physical Performance in Aerobic-Anaerobic Transition Zones: A Systematic Review and Meta-Analysis.

    • 2020-08-19
    • Meta-Analysis
    • Nutrients 12(9)
    • • Álvaro Huerta Ojeda
      • Camila Tapia Cerda
      • María Fernanda Poblete Salvatierra
      • Guillermo Barahona-Fuentes
      • Carlos Jorquera Aguilera

    • PubMed: 32824885
    • DOI: 10.3390/nu12092490

    3 Insights on

    • Improved Time-Trial Performance
    • Improved Timed Test Performance
    • Improved Limited Distance Test Performance

    • High evidence
    • Rigorous Journal

  • Characterization of Highly Mucus-Adherent Non-GMO Derivatives of Lacticaseibacillus rhamnosus GG

    • 2020-08-19
    • Frontiers in Bioengineering and Biotechnology 8
    • • Pia Rasinkangas
      • Hanne L. P. Tytgat
      • J. Ritari
      • J. Reunanen
      • S. Salminen
      • A. Palva
      • François P Douillard
      • W. D. de Vos

    • PubMed: 32974330
    • DOI: 10.3389/fbioe.2020.01024

    1 Insight on

    • Reduced Diarrhea Incidence

    • Low evidence
• August 20

  • Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods.

    • 2020-08-20
    • Review
    • Microbial cell factories 19(1)
    • • Basavaprabhu H Nataraj
      • Syed Azmal Ali
      • Pradip V Behare
      • Hariom Yadav

    • PubMed: 32819443
    • DOI: 10.1186/s12934-020-01426-w

    2 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss

    • Moderate evidence
    • Highly Cited
• August 24

  • Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA

    • 2020-08-24
    • Scientific Reports 10(1)
    • • S. Duranti
      • L. Ruiz
      • G. Lugli
      • H. Tamés
      • C. Milani
      • Leonardo Mancabelli
      • Walter Mancino
      • G. Longhi
      • L. Carnevali
      • A. Sgoifo
      • A. Margolles
      • M. Ventura
      • P. Ruas-Madiedo
      • F. Turroni

    • PubMed: 32839473
    • DOI: 10.1038/s41598-020-70986-z

    1 Insight on

    • Increased GABA Production

    • Moderate evidence
    • Highly Cited
    • Rigorous Journal
• August 26

  • The Administration Matrix Modifies the Beneficial Properties of a Probiotic Mix of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5.

    • 2020-08-26
    • Probiotics and antimicrobial proteins 13(2)
    • • Gréta Pápai
      • Edgar Torres-Maravilla
      • Florian Chain
      • Éva Varga-Visi
      • Otília Antal
      • Zoltán Naár
      • Luis G Bermúdez-Humarán
      • Philippe Langella
      • Rebeca Martín

    • PubMed: 32851584
    • DOI: 10.1007/s12602-020-09702-2

    6 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Colitis Severity
    • Improved Colitis Symptoms
    • Reduced Inflammation
    • Improved Gut Barrier Function
    • Reduced IL-8 Secretion

    • Low evidence
    • Rigorous Journal

  • Metabolic and clinical responses to Bunium Persicum (black caraway) supplementation in overweight and obese patients with type 2 diabetes: a double-blind, randomized placebo-controlled clinical trial.

    • 2020-08-26
    • RCT · n = 60
    • Nutrition & metabolism 17(1)
    • • Saber Jafari-Maskouni
      • Mansour Shahraki
      • Milad Daneshi-Maskooni
      • Alireza Dashipour
      • Ali Shamsi-Goushki
      • Zinat Mortazavi

    • PubMed: 32863846
    • DOI: 10.1186/s12986-020-00494-4

    3 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Fasting Blood Glucose Levels

    • High evidence
• August 27

  • What's new in atopic eczema? An analysis of systematic reviews published in 2018. Part 1: prevention and topical therapies.

    • 2020-08-27
    • Systematic Review
    • Clinical and experimental dermatology 45(8)
    • • F Tasker
      • A Brown
      • D J C Grindlay
      • N K Rogers
      • K E Harman

    • PubMed: 32852805
    • DOI: 10.1111/ced.14303

    1 Insight on

    • Reduced Atopic Eczema Risk

    • High evidence
• August 31

  • Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.

    • 2020-08-31
    • Systematic Review
    • Nutrients 12(9)
    • • Ethan Lowry
      • Joanne Marley
      • Joseph G McVeigh
      • Emeir McSorley
      • Philip Allsopp
      • Daniel Kerr

    • PubMed: 32878326
    • DOI: 10.3390/nu12092664

    1 Insight on

    • Reduced Pain

    • High evidence
    • Rigorous Journal
• Undated – 8 supplement studies

  • Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study

    • 2020-08
    • Observational · n = 234
    • Cell Reports Medicine 1(5)
    • • Cristina Alcon-Giner
      • M. Dalby
      • Shabhonam Caim
      • Jennifer Ketskemety
      • A. Shaw
      • K. Sim
      • Melissa A. E. Lawson
      • R. Kiu
      • C. Leclaire
      • Lisa Chalklen
      • M. Kujawska
      • Suparna Mitra
      • Suparna Mitra
      • Fahmina Fardus-Reid
      • Gustav Belteki
      • Katherine McColl
      • J. Swann
      • J. Kroll
      • Paul Clarke
      • Paul Clarke
      • L. Hall

    • PubMed: 32904427
    • DOI: 10.1016/j.xcrm.2020.100077

    5 Insights on

    • Reduced Faecal pH
    • Increased Fecal Acetate Levels
    • Reduced Abundance of Pathobionts
    • Mature Gut Microbiota
    • Bifidobacterium-Dominated Preterm Gut Microbiota

    • High evidence
    • Highly Cited

  • Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials.

    • 2020-08
    • Meta-Analysis
    • Gastroenterology 159(2)
    • • R. Morgan
      • Geoffrey A. Preidis
      • P. Kashyap
      • A. Weizman
      • B. Sadeghirad
      • Yaping Chang
      • I. Flórez
      • F. Foroutan
      • Shaneela Shahid
      • D. Zeraatkar

    • PubMed: 32592699
    • DOI: 10.1053/j.gastro.2020.05.096

    2 Insights on

    • Reduced Hospitalization Duration
    • Reduced Severe Necrotizing Enterocolitis (NEC)

    • High evidence
    • Highly Cited

  • Lactococcus Lactis subsp. cremoris Elicits Protection Against Metabolic Changes Induced by a Western-style Diet.

    • 2020-08
    • Gastroenterology 159(2)
    • • C. Naudin
      • Kristal M. Maner-Smith
      • Joshua A. Owens
      • Grace M. Wynn
      • B. Robinson
      • J. Matthews
      • April R. Reedy
      • L. Luo
      • A. Wolfarth
      • T. Darby
      • E. Ortlund
      • Rheinallt M. Jones

    • PubMed: 32169430
    • DOI: 10.1053/j.gastro.2020.03.010

    7 Insights on

    • Reduced Inflammation Levels
    • Reduced Serum Cholesterol Levels
    • Improved Glucose Tolerance
    • Reduced Serum Total Cholesterol Levels
    • Reduced Hepatic Steatosis
    • Reduced Weight Gain
    • Reduced Hepatic Inflammation

    • Low evidence

  • Evaluation of the antitumor immune responses of probiotic Bifidobacterium bifidum in human papillomavirus-induced tumor model.

    • 2020-08
    • Clinical Trial
    • Microbial Pathogenesis 145
    • • Elahe Abdolalipour
      • Mehran Mahooti
      • A. Salehzadeh
      • A. Torabi
      • S. Mohebbi
      • A. Gorji
      • A. Ghaemi

    • PubMed: 32325236
    • DOI: 10.1016/j.micpath.2020.104207

    4 Insights on

    • Reduced Tumor Growth
    • Increased Lymphocyte Proliferation
    • Enhanced Antitumor Immune Response
    • Enhanced Cytolytic Response of CD8+ T Cells

    • Low evidence
    • Animal Study

  • Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis.

    • 2020-08
    • Meta-Analysis · n = 530
    • Complementary therapies in medicine 52
    • • Mahdieh Golzarand
      • Mahsa Omidian
      • Karamollah Toolabi

    • PubMed: 32951714
    • DOI: 10.1016/j.ctim.2020.102451

    4 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Percentage of Fat Mass

    • High evidence

  • Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions.

    • 2020-08
    • Food Research International 134
    • • A. T. Holkem
      • C. Fávaro-Trindade
      • M. Lacroix

    • PubMed: 32517954
    • DOI: 10.1016/j.foodres.2020.109274

    2 Insights on

    • Increased Anticancer Activity
    • Increased Resistance to Simulated Gastrointestinal Conditions

    • Low evidence

  • Titration of supplemental Bacillus subtilis subsp. subtilis American Type Culture Collection PTA-125135 to broiler chickens fed diets of 2 different metabolizable energy concentrations

    • 2020-08
    • Poultry Science 99(8)
    • • L. Krueger
      • D. Spangler
      • M. Sims

    • PubMed: 32731986
    • DOI: 10.1016/j.psj.2020.04.027

    1 Insight on

    • Increased Mortality Rate

    • Low evidence
    • Rigorous Journal

  • Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle.

    • 2020-08
    • RCT · n = 13
    • Physiological reports 8(15)
    • • Joaquin U Gonzales
      • Stephen M Fischer
      • Arun Maharaj
      • Heather Vellers
      • Todd Anderson
      • Adcharee Karnjanapiboonwong
      • Seenivasan Subbiah
      • J M Kellawan
      • Arturo Figueroa

    • PubMed: 32776464
    • DOI: 10.14814/phy2.14536

    1 Insight on

    • Improved Exercise-Onset Vasodilator Kinetics

    • High evidence