September 2020 Supplement Research Papers

• September 1

  • Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2020-09-01
    • RCT · n = 80
    • Journal of Alzheimer's Disease 77(1)
    • • Jinzhong Xiao
      • N. Katsumata
      • F. Bernier
      • Kazuya Ohno
      • Yuki Yamauchi
      • T. Odamaki
      • K. Yoshikawa
      • Kumie Ito
      • Toshiyuki Kaneko

    • PubMed: 32623402
    • DOI: 10.3233/JAD-200488

    7 Insights on

    • Improved Cognitive Function
    • Improved Delayed Memory
    • Improved JMCIS Score
    • Improved Memory Function
    • Improved Immediate Memory
    • Improved Visuospatial Constructional Skills
    • Improved Cognitive Screen Score

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition - a double-blind, randomized, and placebo-controlled trial.

    • 2020-09-01
    • RCT · n = 21
    • European review for medical and pharmacological sciences 24(18)
    • • K Kaźmierczak-Siedlecka
      • M Folwarski
      • J Ruszkowski
      • K Skonieczna-Żydecka
      • W Szafrański
      • W Makarewicz

    • PubMed: 33015813
    • DOI: 10.26355/eurrev_202009_23059

    6 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Quality of Life
    • Increased Serum Albumin Levels
    • Reduced Vomiting Frequency
    • Reduced Flatulence
    • Reduced Vomiting

    • High evidence

  • Bacillus subtilis: a potential growth promoter in weaned pigs in comparison to carbadox.

    • 2020-09-01
    • RCT
    • Journal of Animal Science 98(9)
    • • Yijie He
      • Kwangwoo Kim
      • Lauren L Kovanda
      • Cynthia N Jinno
      • Minho Song
      • J. Chase
      • Xunde Li
      • B. Tan
      • Yanhong Liu

    • PubMed: 32877510
    • DOI: 10.1093/jas/skaa290

    7 Insights on

    • Increased Body Weight
    • Reduced Inflammatory Response
    • Improved Intestinal Barrier Integrity
    • Improved Average Daily Gain
    • Reduced Diarrhea Frequency
    • Improved Barrier Integrity
    • Reduced White Blood Cell Count

    • High evidence
    • Rigorous Journal
• September 2

  • Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.

    • 2020-09-02
    • Review
    • FEMS microbiology reviews 45(1)
    • • Samira Soltani
      • Riadh Hammami
      • Paul D Cotter
      • Sylvie Rebuffat
      • Laila Ben Said
      • Hélène Gaudreau
      • François Bédard
      • Eric Biron
      • Djamel Drider
      • Ismail Fliss

    • PubMed: 32876664
    • DOI: 10.1093/femsre/fuaa039

    3 Insights on

    • Reduced Gastrointestinal Infections
    • Improved Immune Modulation
    • No Human Health Outcome Reported

    • Moderate evidence
    • Highly Cited
• September 4

  • Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium.

    • 2020-09-04
    • Bioprocess and biosystems engineering 44(2)
    • • Xiao Guo
      • Ailing Guo
      • Erhu Li

    • PubMed: 32888093
    • DOI: 10.1007/s00449-020-02437-y

    2 Insights on

    • Improved Bioavailability of Citrus Flavanone Metabolites
    • Increased Flavanone Metabolism

    • Low evidence
• September 6

  • Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens

    • 2020-09-06
    • RCT · n = 216
    • Animals 10(9)
    • • A. Alaqil
      • A. O. Abbas
      • H. S. El-Beltagi
      • H. A. El-Atty
      • G. Mehaisen
      • E. S. Moustafa

    • PubMed: 32899938
    • DOI: 10.3390/ani10091588

    16 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Stress Hormone Levels
    • Improved Immune Response
    • Enhanced Immune Response
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Plasma Triglycerides
    • Improved Egg Weight
    • Reduced Yolk Cholesterol Content
    • Reduced Liver Cholesterol Levels
    • Reduced Stress Levels
    • Improved Productive Performance
    • Reduced Heterophil-to-Lymphocyte Ratio
    • Increased Antibody Titer
    • Enhanced T- and B-Lymphocyte Proliferation
    • Increased Egg Mass

    • Low evidence
    • Rigorous Journal
    • Animal Study
• September 8

  • Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.

    • 2020-09-08
    • Review
    • Frontiers in physiology 11
    • • Silvia Turroni
      • Marciane Magnani
      • Pukar Kc
      • Philippe Lesnik
      • Hubert Vidal
      • Martina Heer

    • PubMed: 33013480
    • DOI: 10.3389/fphys.2020.553929

    5 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss
    • Reduced Severity of Common Cold Symptoms
    • Reduced Fatigue
    • Improved Menopausal Symptom Relief

    • Low evidence

  • Effect of Bacillus clausii Capsules in Reducing Adverse Effects Associated with Helicobacter pylori Eradication Therapy: A Randomized, Double-Blind, Controlled Trial

    • 2020-09-08
    • RCT
    • Infectious Diseases and Therapy 9(4)
    • • Manuel Plomer
      • Marcos III Perez
      • Dorothea Maren Greifenberg

    • PubMed: 32897519
    • DOI: 10.1007/s40121-020-00333-2

    4 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate
    • Improved Tolerability

    • High evidence
    • Rigorous Journal
• September 10

  • The in vitro Effects of the Probiotic Strain, Lactobacillus casei ZX633 on Gut Microbiota Composition in Infants With Diarrhea

    • 2020-09-10
    • Frontiers in Cellular and Infection Microbiology 10
    • • Xing Wang
      • Miao Zhang
      • Weidong Wang
      • Haoxin Lv
      • Hua Zhang
      • Yuan Liu
      • Zhongfang Tan

    • PubMed: 33072628
    • DOI: 10.3389/fcimb.2020.576185

    5 Insights on

    • Increased Escherichia Coli Levels
    • Increased Propionic Acid Levels
    • Improved Microbial Structures
    • Reduced Abundance of Streptococcus Bacteroides Enterococcus Veillonella
    • Reduced Infant Diarrhea Incidence

    • Low evidence
• September 11

  • Probiotics: A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut-Brain Interaction.

    • 2020-09-11
    • Review
    • Microorganisms 8(9)
    • • Tetsuji Hori
      • Kazunori Matsuda
      • Kenji Oishi

    • PubMed: 32933067
    • DOI: 10.3390/microorganisms8091401

    1 Insight on

    • Transient Colonization of the Human Ileal Microbiota

    • Low evidence

  • Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol

    • 2020-09-11
    • Clinical Trial
    • PLOS ONE 15(9)
    • • Chiyoko Terada-Ikeda
      • M. Kitabatake
      • A. Hiraku
      • Kumiko Kato
      • Satsuki Yasui
      • N. Imakita
      • N. Ouji-Sageshima
      • N. Iwabuchi
      • K. Hamada
      • Toshihiro Ito

    • PubMed: 32915886
    • DOI: 10.1371/journal.pone.0238923

    9 Insights on

    • Reduced Histological Scores
    • Reduced Th2 Cytokine Levels
    • Improved Gut Microbiome Composition
    • Reduced Eosinophils in Bronchoalveolar Lavage Fluid
    • Prevented Allergic Reactions
    • Reduced Allergic Lung Inflammation
    • Reduced Allergic Markers
    • Reduced Eosinophilic Inflammation
    • Reduced Lung Inflammation

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The use of Lactobacillus plantarum 299v (DSM 9843) in cancer patients receiving home enteral nutrition – study protocol for a randomized, double-blind, and placebo-controlled trial

    • 2020-09-11
    • RCT
    • Nutrition Journal 19(1)
    • • Karolina Kaźmierczak-Siedlecka
      • Marcin Folwarski
      • Karolina Skonieczna-Żydecka
      • Jakub Ruszkowski
      • Wojciech Makarewicz

    • PubMed: 32917221
    • DOI: 10.1186/s12937-020-00598-w

    6 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Nutritional Status
    • Improved Quality of Life
    • Improved Enteral Nutrition Tolerance
    • Improved Health-related Quality of Life
    • Prevention of Weight Loss

    • High evidence
• September 14

  • Elderberry Extract Outpatient Influenza Treatment for Emergency Room Patients Ages 5 and Above: a Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2020-09-14
    • RCT · n = 87
    • Journal of general internal medicine 35(11)
    • • Michael Macknin
      • Kathy Wolski
      • Jeffrey Negrey
      • Sharon Mace

    • PubMed: 32929634
    • DOI: 10.1007/s11606-020-06170-w

    2 Insights on

    • Reduced Influenza Symptom Duration
    • Reduced Time to Symptom Resolution

    • High evidence
• September 18

  • Treatments for breast engorgement during lactation.

    • 2020-09-18
    • Systematic Review · n = 2,170
    • The Cochrane database of systematic reviews 2020(9)
    • • Irena Zakarija-Grkovic
      • Fiona Stewart

    • PubMed: 32944940
    • DOI: 10.1002/14651858.cd006946.pub4

    3 Insights on

    • Reduced Breast Pain
    • Reduced Breast Swelling
    • Reduced Breast Engorgement

    • High evidence

  • Oral Administration of Live and Dead Cells of Lactobacillus sakei proBio65 Alleviated Atopic Dermatitis in Children and Adolescents: a Randomized, Double-Blind, and Placebo-Controlled Study

    • 2020-09-18
    • RCT · n = 90
    • Probiotics and Antimicrobial Proteins 13(2)
    • • I. Rather
      • Byung-Chun Kim
      • L. Lew
      • S. Cha
      • Jong Hwan Lee
      • Gyeong-Jun Nam
      • R. Majumder
      • Jeongheui Lim
      • S. Lim
      • Y. Seo
      • Yong-Ha Park

    • PubMed: 32949011
    • DOI: 10.1007/s12602-020-09654-7

    4 Insights on

    • Reduced SCORAD Index
    • Improved Skin Barrier Function
    • Reduced Atopic Dermatitis Severity
    • Increased Skin Sebum Production

    • High evidence
• September 22

  • Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients

    • 2020-09-22
    • RCT · n = 30
    • PLOS ONE 15(9)
    • • M. Invernici
      • F. Furlaneto
      • S. Salvador
      • A. Ouwehand
      • S. Salminen
      • Anastasia Mantziari
      • G. Vinderola
      • E. Ervolino
      • S. Santana
      • P. Silva
      • M. Messora

    • PubMed: 32960889
    • DOI: 10.1371/journal.pone.0238425

    13 Insights on

    • Reduced Gingival Bleeding
    • Improved Periodontal Health
    • Reduced Plaque Accumulation
    • Improved Immunological Response in Gingival Tissues
    • Reduced Pathogen Adhesion to Buccal Epithelial Cells
    • Reduced Pathogen Adhesion
    • Improved Immunocompetence of Gingival Tissues
    • Reduced Periodontopathogen Activity
    • Increased Expression of Beta-Defensin 3
    • Reduced Periodontal Pathogens
    • Reduced Porphyromonas Gingivalis Adhesion to Buccal Epithelial Cells
    • Reduced Plaque Index
    • Reduced Gingivalis Adhesion

    • High evidence
    • Rigorous Journal
• September 24

  • Lactobacillus delbrueckii subsp. bulgaricus KLDS 1.0207 Exerts Antimicrobial and Cytotoxic Effects in vitro and Improves Blood Biochemical Parameters in vivo Against Notable Foodborne Pathogens

    • 2020-09-24
    • Frontiers in Microbiology 11
    • • S. Evivie
      • Amro Abdelazez
      • Bailiang Li
      • Shi-juan Lu
      • Fei Liu
      • G. Huo

    • PubMed: 33072056
    • DOI: 10.3389/fmicb.2020.583070

    14 Insights on

    • Improved Weight Management
    • Reduced Inflammation Levels
    • Reduced Pathogen Growth
    • Improved Biochemical Parameters
    • Improved Lipid Levels
    • Improved Cholesterol Levels
    • Normalized Serum Lipid Levels
    • Reduced Pathogen Activity
    • Prevention of Weight Loss
    • Increased Survival in Acidic Environment
    • Reduced Inflammatory Activities
    • Enhanced Viability in Acidic Conditions
    • Improved Cholesterol Regulation
    • Restored HDL Levels

    • Low evidence

  • Effect of Limosilactobacillus reuteri LRE02-Lacticaseibacillus rhamnosus LR04 Combination on Antibiotic-Associated Diarrhea in a Pediatric Population: A National Survey.

    • 2020-09-24
    • Observational
    • Journal of clinical medicine 9(10)
    • • Lorenzo Drago
      • Gabriele Meroni
      • Antonio Chiaretti
      • Nicola Laforgia
      • Salvatore Cucchiara
      • Maria Elisabetta Baldassarre
      • On Behalf Of The Surveyflor Group

    • PubMed: 32987822
    • DOI: 10.3390/jcm9103080

    2 Insights on

    • Improved Stool Consistency
    • Reduced Antibiotic-Associated Diarrhea

    • Low evidence
• September 27

  • Capsicum annuum (hot pepper): An ancient Latin-American crop with outstanding bioactive compounds and nutraceutical potential. A review.

    • 2020-09-27
    • Comprehensive Reviews in Food Science and Food Safety 19(6)
    • • T. Hernández-Pérez
      • M. Gómez-García
      • M. E. Valverde
      • O. Paredes-López

    • PubMed: 33337034
    • DOI: 10.1111/1541-4337.12634

    5 Insights on

    • Reduced Body Weight
    • Increased Antioxidant Capacity
    • Enhanced Antimicrobial Capacity
    • Enhanced Anticancer Capacity
    • Increased Analgesic Capacity

    • Low evidence
    • Highly Cited
• September 28

  • Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial

    • 2020-09-28
    • RCT · n = 37
    • Nutrients 12(10)
    • • A. G. Contreras
      • Edgar M Vásquez Garibay
      • C. A. S. Ramírez
      • Mary Fafutis Morris
      • Vidal Delgado Rizo

    • PubMed: 32998471
    • DOI: 10.3390/nu12102971

    3 Insights on

    • Reduced Faecal pH
    • Improved Stool Characteristics
    • Increased Fecal Lactobacillus reuteri Concentration

    • High evidence

  • Effect of probiotics Lactobacillus paracasei GKS6, L. plantarum GKM3, and L. rhamnosus GKLC1 on alleviating alcohol-induced alcoholic liver disease in a mouse model.

    • 2020-09-28
    • Clinical Trial · n = 6
    • Nutrition research and practice 14(4)
    • • You-Shan Tsai
      • Shih-Wei Lin
      • Yen-Lien Chen
      • Chin-Chu Chen

    • PubMed: 32765811
    • DOI: 10.4162/nrp.2020.14.4.299

    5 Insights on

    • Reduced Hepatic Fat Accumulation
    • Reduced Liver Fat
    • Reduced Alcohol-Induced Liver Injury
    • Reduced Gastric Tissue Damage
    • Improved Alcohol-induced Liver Injury

    • Moderate evidence

  • Bifidobacterium bifidum G9-1 ameliorates soft feces induced by metformin without affecting its antihyperglycemic action

    • 2020-09-28
    • Clinical Trial
    • Bioscience of Microbiota, Food and Health 39(3)
    • • Yutaka Makizaki
      • Ayako Maeda
      • Miyuki Yamamoto
      • Saya Tamura
      • Yoshiki Tanaka
      • Shunji Nakajima
      • H. Ohno

    • PubMed: 32775133
    • DOI: 10.12938/bmfh.2019-022

    2 Insights on

    • Reduced Occurrence of Soft Stools
    • Stable Antihyperglycemic Effect

    • High evidence
    • Rigorous Journal

  • A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

    • 2020-09-28
    • RCT · n = 27
    • Bioscience of Microbiota, Food and Health 39(1)
    • • Y. Gotoh
      • Fumio Nanba
      • Nobuhiko Shioya
      • Haruhi Sugimura
      • Toshio Suzuki

    • PubMed: 32010540
    • DOI: 10.12938/bmfh.19-009

    3 Insights on

    • Improved Bowel Movement Frequency
    • Increased Bowel Movement Frequency
    • Increased Stool Volume

    • High evidence
• September 29

  • Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial.

    • 2020-09-29
    • RCT · n = 256
    • Journal of Food Biochemistry 44(11)
    • • Wei Jing
      • Qingbin Liu
      • Wei Wang

    • PubMed: 32996156
    • DOI: 10.1111/jfbc.13489

    16 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Allergic Symptoms
    • Enhanced Anti-inflammatory Response
    • Improved Gut Microbiome Composition
    • Increased Probiotic Genus Proportion
    • Reduced Proportion of Pathogenic Genus
    • Reduced Serum Immunoglobulin E Levels
    • Elevated Serum IgG2 Levels
    • Reduced Allergic Scores
    • Reduced Proportion of Pathogenic Genera
    • Reduced Incidence of Milk Allergy
    • Reduced Milk Protein Allergy Symptoms
    • Improved Secondary Outcomes
    • Increased Serum IgG2 Levels
    • Reduced Serum IgE Levels
    • Increased Immunoglobulin G2 Levels

    • High evidence

  • Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial.

    • 2020-09-29
    • RCT
    • Scientific reports 10(1)
    • • Anne-Sophie Alvarez
      • Julien Tap
      • Isabelle Chambaud
      • Stéphanie Cools-Portier
      • Laurent Quinquis
      • Pierre Bourlioux
      • Philippe Marteau
      • Eric Guillemard
      • Juergen Schrezenmeir
      • Muriel Derrien

    • PubMed: 32994487
    • DOI: 10.1038/s41598-020-72161-w

    3 Insights on

    • Increased Persistence of Probiotics in Fecal Matter
    • No Significant Safety Parameter Changes
    • Maintained Gut Microbiota Diversity

    • High evidence
    • Rigorous Journal
• September 30

  • Effect of Bifidobacterium animalis ssp. lactis GCL2505 on visceral fat accumulation in healthy Japanese adults: a randomized controlled trial

    • 2020-09-30
    • RCT · n = 137
    • Bioscience of Microbiota, Food and Health 35(4)
    • • Shota Takahashi
      • D. Anzawa
      • K. Takami
      • Akihiro Ishizuka
      • Takashi Mawatari
      • Kohei Kamikado
      • Haruhi Sugimura
      • Tomohiko Nishijima

    • PubMed: 27867803
    • DOI: 10.12938/bmfh.2016-002

    6 Insights on

    • Reduced Visceral Fat
    • Increased Gut Bifidobacteria
    • Increased Fecal Bifidobacteria Levels
    • Reduced Visceral Fat Mass
    • Increased Fecal Bifidobacteria
    • Reduced Abdominal Visceral Fat

    • High evidence
    • Rigorous Journal

  • A double blind, placebo-controlled, randomized clinical trial that breast milk derived-Lactobacillus gasseri BNR17 mitigated diarrhea-dominant irritable bowel syndrome

    • 2020-09-30
    • RCT · n = 24
    • Journal of Clinical Biochemistry and Nutrition 62(2)
    • • S. Shin
      • Yoon Mi Choi
      • W. Kim
      • S. Hong
      • Jong‐Min Park
      • Joohee Kim
      • O. Kwon
      • E. Lee
      • K. Hahm

    • PubMed: 29610559
    • DOI: 10.3164/jcbn.17-73

    12 Insights on

    • Improved Bowel Movement Frequency
    • Improved Quality of Life
    • Reduced Abdominal Pain
    • Increased Beneficial Gut Microbiota
    • Reduced Diarrhea Symptoms
    • Reduced Abdominal Distension
    • Enhanced Beneficial Gut Microbiota
    • Reduced Colonic Transit Time
    • Corrected Rapid Colon Transit Pattern
    • Reduced Daily Life Disturbance
    • Reduced Defecation Frequency
    • Corrected Rapid Colon Transit Time

    • High evidence
    • Rigorous Journal

  • Postbiotics against Pathogens Commonly Involved in Pediatric Infectious Diseases.

    • 2020-09-30
    • Review
    • Microorganisms 8(10)
    • • Anastasia Mantziari
      • Seppo Salminen
      • Hania Szajewska
      • Jeadran Nevardo Malagón-Rojas

    • PubMed: 33008065
    • DOI: 10.3390/microorganisms8101510

    2 Insights on

    • Improved Intestinal Barrier Integrity
    • Reduced Risk of Infection

    • Low evidence

  • Effects of intake of Lactobacillus casei subsp. casei 327 on skin conditions: a randomized, double-blind, placebo-controlled, parallel-group study in women

    • 2020-09-30
    • RCT · n = 64
    • Bioscience of Microbiota, Food and Health 36(3)
    • • Yuhi Saito
      • Toshihiro Mihara
      • Kentaro Maruyama
      • Jiro Saito
      • Masumi Ikeda
      • A. Tomonaga
      • T. Kumagai

    • PubMed: 28748132
    • DOI: 10.12938/bmfh.16-031

    3 Insights on

    • Improved Skin Barrier Function
    • Reduced Skin Flakiness
    • Confirmed Safety of Treatment

    • High evidence
• Undated – 4 supplement studies

  • Lactobacillus gasseri JM1 with potential probiotic characteristics alleviates inflammatory response by activating the PI3K/Akt signaling pathway in vitro.

    • 2020-09
    • Journal of Dairy Science 103(9)
    • • Linlin Sun
      • Wenli Tian
      • Xiaojie Guo
      • Yu Zhang
      • Xinyu Liu
      • Xuesong Li
      • Yazhen Tian
      • C. Man
      • Yujun Jiang

    • PubMed: 32600763
    • DOI: 10.3168/jds.2020-18187

    2 Insights on

    • Reduced Inflammatory Response
    • Enhanced Anti-inflammatory Response

    • Low evidence
    • Rigorous Journal

  • Probiotic potentials of Pediococuss acidilactici isolated from wara; A Nigerian unripened soft cheese

    • 2020-09
    • Heliyon 6(9)
    • • Temidayo Emmanuel Olajugbagbe
      • Oluwatosin Esther Elugbadebo
      • B. O. Omafuvbe

    • PubMed: 32984599
    • DOI: 10.1016/j.heliyon.2020.e04889

    4 Insights on

    • Increased Inhibition of Pathogenic Bacteria
    • Enhanced Antimicrobial Resistance
    • Increased Exopolysaccharide Production
    • Increased Survival in High Osmotic Pressure

    • Low evidence

  • Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary randomized study.

    • 2020-09
    • RCT · n = 190
    • Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(5)
    • • Victoria Sanborn
      • M. Azcarate-Peril
      • J. Gunstad

    • PubMed: 32570015
    • DOI: 10.1016/j.dsx.2020.05.034

    2 Insights on

    • Regulated Blood Glucose Levels
    • Stabilized Hemoglobin A1c Level

    • High evidence

  • l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2020-09
    • RCT · n = 120
    • The Journal of nutrition 150(9)
    • • Ikuko Sasahara
      • Akiko Yamamoto
      • Masamichi Takeshita
      • Yasuyo Suga
      • Katsuya Suzuki
      • Natsumi Nishikata
      • Michihiro Takada
      • Masaki Hashimoto
      • Tomoyuki Mine
      • Yasuo Kobuna
      • Kenji Nagao

    • PubMed: 32520991
    • DOI: 10.1093/jn/nxaa156

    5 Insights on

    • Reduced Low Back Pain
    • Reduced Knee Pain
    • Reduced Worst Pain
    • Reduced Average Pain
    • Reduced Pain During Movement

    • High evidence
    • Large Human Trial