November 2023 Supplement Research Papers

• November 1

  • Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients.

    • 2023-11-01
    • RCT
    • Canadian journal of physiology and pharmacology 101(11)
    • • Esraa Habiba
      • Samia Ali
      • Yehia Ghanem
      • Ola Sharaki
      • Wafaa Hewedy

    • PubMed: 37721213
    • DOI: 10.1139/cjpp-2022-0359

    3 Insights on

    • Reduced Nuclear Factor-κB Level
    • Reduced Platelet Aggregation
    • Reduced Platelet Calcium Content

    • High evidence
• November 2

  • Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial.

    • 2023-11-02
    • RCT · n = 827
    • JAMA network open 6(11)
    • • Suvi Sarlin
      • Ulla Koskela
      • Minna Honkila
      • Paula A Tähtinen
      • Tytti Pokka
      • Marjo Renko
      • Terhi Tapiainen

    • PubMed: 37917062
    • DOI: 10.1001/jamanetworkopen.2023.40608

    2 Insights on

    • Reduced Acute Otitis Media Requiring Antimicrobial Therapy
    • Increased Time to First Acute Otitis Media Episode

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Rhizospheric Bacillus spp. Exhibit Miticidal Efficacy against Oligonychus coffeae (Acari: Tetranychidae) of Tea.

    • 2023-11-02
    • Microorganisms 11(11)
    • • Popy Bora
      • Sukanya Gogoi
      • Mukund Vinayak Deshpande
      • Pankaj Garg
      • Rana P Bhuyan
      • Nilofar Altaf
      • Nikita Saha
      • Sapna Mayuri Borah
      • Mousumi Phukon
      • Nabajit Tanti
      • Bishal Saikia
      • Shenaz Sultana Ahmed
      • Sanjib Ranjan Borah
      • Ashish Dutta
      • Bidyut Kumar Sarmah

    • PubMed: 38004703
    • DOI: 10.3390/microorganisms11112691

    1 Insight on

    • Reduced Red Spider Mite Mortality

    • Low evidence

  • Identification and evaluation of probiotic potential of Bifidobacterium breve AHC3 isolated from chicken intestines and its effect on necrotizing enterocolitis (NEC) in newborn SD rats.

    • 2023-11-02
    • Clinical Trial
    • PloS one 18(11)
    • • Xiaopei Lin
      • Changjun Wu

    • PubMed: 37917716
    • DOI: 10.1371/journal.pone.0287799

    2 Insights on

    • Reduced Intestinal Inflammation
    • Reduced Inducible Nitric Oxide Synthase Expression in Intestinal Tissue

    • Moderate evidence
• November 3

  • Limosilactobacillus reuteri BIO7251 administration improves metabolic phenotype in obese mice fed a high fat diet: an inter-organ crosstalk between gut, adipose tissue and nervous system.

    • 2023-11-03
    • Clinical Trial
    • International Journal of Food Sciences and Nutrition 75(1)
    • • A. Abot
      • Nicolas Pomié
      • Gwendoline Astre
      • Fety Jaomanjaka
      • Pierre Marchand
      • Patrice D. Cani
      • Nathalie Roudier
      • C. Knauf

    • PubMed: 37921224
    • DOI: 10.1080/09637486.2023.2276672

    5 Insights on

    • Reduced Body Weight
    • Improved Glucose Tolerance
    • Reduced Food Intake
    • Reduced Subcutaneous Fat Mass
    • Reduced Glucose Absorption

    • Low evidence
    • Animal Study
• November 5

  • The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review.

    • 2023-11-05
    • Systematic Review
    • Nutrients 15(21)
    • • Simon Paquette
      • Sean C Thomas
      • Krishnan Venkataraman
      • Vasu D Appanna
      • Sujeenthar Tharmalingam

    • PubMed: 37960343
    • DOI: 10.3390/nu15214690

    1 Insight on

    • Improved Glycemia

    • High evidence
    • Rigorous Journal
• November 6

  • Randomised clinical trial: efficacy and safety of H. pylori eradication treatment with and without Saccharomyces boulardii supplementation.

    • 2023-11-06
    • RCT · n = 404
    • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 33(3)
    • • Olga Sjomina
      • Inese Poļaka
      • Jekaterina Suhorukova
      • Reinis Vangravs
      • Sergejs Paršutins
      • Viktoria Knaze
      • Jin Young Park
      • Rolando Herrero
      • Raul Murillo
      • Mārcis Leja

    • PubMed: 37942999
    • DOI: 10.1097/cej.0000000000000858

    2 Insights on

    • Increased Helicobacter pylori Eradication Rate
    • Reduced Diarrhea

    • High evidence
    • Large Human Trial
• November 8

  • Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males.

    • 2023-11-08
    • RCT
    • Nutrients 15(22)
    • • Deepti Nayyar
      • Xu Yan
      • Guoqin Xu
      • Min Shi
      • Andrew P Garnham
      • Michael L Mathai
      • Andrew J McAinch

    • PubMed: 38004115
    • DOI: 10.3390/nu15224721

    4 Insights on

    • Reduced Uric Acid Levels
    • Reduced Blood Glucose Levels
    • Improved Time-Trial Performance
    • Improved Muscle Oxygen Flux

    • High evidence
    • Rigorous Journal

  • Effects of dietary nitrate and vitamin C co-ingestion on blood pressure and hand-grip strength in young adults.

    • 2023-11-08
    • RCT
    • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 94(5-6)
    • • Eazaz Lbban
      • Alex Macey
      • Joshua Rundle
      • Ammar Ashor
      • Iskandar Idris
      • Mario Siervo

    • PubMed: 37938096
    • DOI: 10.1024/0300-9831/a000799

    4 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Improved Handgrip Strength
    • Reduced 8-Isoprostane Level

    • High evidence
• November 9

  • Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics.

    • 2023-11-09
    • International microbiology : the official journal of the Spanish Society for Microbiology 27(3)
    • • Yao Dong
      • Mei Han
      • Teng Fei
      • Huan Liu
      • Zhonghui Gai

    • PubMed: 37946011
    • DOI: 10.1007/s10123-023-00446-x

    3 Insights on

    • Improved Gut Microbiota
    • Enhanced Probiotic Growth
    • Increased Bifidobacteria Growth

    • Low evidence
• November 12

  • Safety assesment of Bacillus clausii UBBC07, a spore forming probiotic

    • 2023-11-12
    • Clinical Trial
    • Toxicology Reports 4
    • • S. Lakshmi
      • N. Jayanthi
      • M. Saravanan
      • M. Ratna

    • PubMed: 28959626
    • DOI: 10.1016/j.toxrep.2016.12.004

    4 Insights on

    • Ensured Safety for Human Consumption
    • Improved Safety Profile
    • Increased Antimicrobial Resistance
    • Absence of Toxin Genes

    • Low evidence
    • Animal Study
• November 13

  • Effect of Virgin Coconut Oil Supplementation on Cognition of Individuals with Mild-to-Moderate Alzheimer's Disease in Sri Lanka (VCO-AD Study): A Randomized Placebo-Controlled Trial.

    • 2023-11-13
    • RCT
    • Journal of Alzheimer's disease : JAD 96(3)
    • • Malika G Fernando
      • Renuka Silva
      • W M A D Binosha Fernando
      • H Asita de Silva
      • A Rajitha Wickremasinghe
      • Asoka S Dissanayake
      • Hamid R Sohrabi
      • Ralph N Martins
      • Shehan S Williams

    • PubMed: 37980665
    • DOI: 10.3233/jad-230670

    5 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Improved Cognitive Function
    • Reduced Hemoglobin A1c
    • Improved Mini-Mental State Examination Score
    • Improved Clock Drawing Test Score

    • High evidence

  • The Use of Microbial Modifying Therapies to Prevent Psoriasis Exacerbation and Associated Cardiovascular Comorbidity.

    • 2023-11-13
    • Review
    • Inflammation 47(1)
    • • Eva Reali
      • Cristiana Caliceti
      • Antonello Lorenzini
      • Paola Rizzo

    • PubMed: 37953417
    • DOI: 10.1007/s10753-023-01915-1

    1 Insight on

    • Reduced Psoriasis Inflammation

    • Low evidence
• November 14

  • Systematic review and network meta-analysis of efficacy and safety of interventions for preventing anti-tuberculosis drug induced liver injury.

    • 2023-11-14
    • Systematic Review · n = 3,423
    • Scientific reports 13(1)
    • • Pattaraporn Akkahadsee
      • Ratree Sawangjit
      • Panumart Phumart
      • Nathorn Chaiyakunapruk
      • Duangkamon Sakloetsakun

    • PubMed: 37963954
    • DOI: 10.1038/s41598-023-46565-3

    1 Insight on

    • Reduced Anti-Tuberculosis Drug Induced Liver Injury

    • High evidence
    • Rigorous Journal

  • Probiotics for infantile colic: Is there evidence beyond doubt? A meta-analysis and systematic review.

    • 2023-11-14
    • Meta-Analysis
    • Acta paediatrica (Oslo, Norway : 1992) 113(2)
    • • Sáskia Ribeiro Vaz
      • Marise Helena Tofoli
      • Melissa Ameloti Gomes Avelino
      • Paulo Sérgio Sucasas da Costa

    • PubMed: 37962097
    • DOI: 10.1111/apa.17036

    1 Insight on

    • Reduced Crying Time

    • High evidence

  • Long-Term Bovine Colostrum Supplementation in Football Players.

    • 2023-11-14
    • RCT
    • Nutrients 15(22)
    • • Mirosława Cieślicka
      • Błażej Stankiewicz
      • Radosław Muszkieta
      • Małgorzata Tafil-Klawe
      • Jacek Klawe
      • Anna Skarpańska-Stejnborn
      • Joanna Ostapiuk-Karolczuk

    • PubMed: 38004173
    • DOI: 10.3390/nu15224779

    5 Insights on

    • Reduced Inflammatory Markers
    • Increased Immunoglobulin G Levels
    • Improved Athletic Performance
    • Improved Iron Homeostasis
    • Improved Hormonal Response

    • High evidence
    • Rigorous Journal

  • The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and meta-analysis of randomized clinical trials.

    • 2023-11-14
    • Meta-Analysis · n = 17
    • Phytotherapy research : PTR 38(2)
    • • Felipe Mendes Delpino
      • Francine Silva Dos Santos
      • Thaynã Ramos Flores
      • Henrique S Cerqueira
      • Heitor O Santos
      • Heitor O Santos

    • PubMed: 37963472
    • DOI: 10.1002/ptr.8069

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence
• November 15

  • Efficacy and safety of vitamin D supplementation on psoriasis: A systematic review and meta-analysis.

    • 2023-11-15
    • Meta-Analysis · n = 333
    • PloS one 18(11)
    • • Qianqian Dai
      • Yanfeng Zhang
      • Qian Liu
      • Chijin Zhang

    • PubMed: 37967075
    • DOI: 10.1371/journal.pone.0294239

    7 Insights on

    • Reduced C-Reactive Protein Levels
    • Improved Dermatology Life Quality Index
    • Improved Psoriasis Severity
    • Reduced Psoriasis Area and Severity Index
    • Improved Psoriasis Area and Severity Index
    • Improved Psoriasis Disability Index
    • Reduced C-reactive Protein Level

    • High evidence
• November 18

  • Effect of Mangifera Indica (Mango) on Dental Caries: A Systematic Review.

    • 2023-11-18
    • Review · n = 130
    • Nutrition and metabolic insights 16
    • • Yasaman Salimi
      • Narges Tavahodi
      • Hamed Taheri
      • Maryam Masoudi
      • Matin Safari Modaber
      • Nozhan Azimi
      • Mohammed Namiq Amin
      • Mobina Bagharianlemraski
      • Reza Namadkolahi
      • Mozhgan Khorami
      • Mehrnaz Salahi
      • Pouyan Razavi
      • Parisa Behshood
      • Seyed Ali Mosaddad
      • Niloofar Deravi

    • PubMed: 38024868
    • DOI: 10.1177/11786388231204200

    2 Insights on

    • Reduced Mutans Streptococcus Counts
    • Increased Salivary pH

    • High evidence
• November 19

  • Carnosine Did Not Affect Vascular and Metabolic Outcomes in Patients with Prediabetes and Type 2 Diabetes: A 14-Week Randomized Controlled Trial.

    • 2023-11-19
    • RCT · n = 49
    • Nutrients 15(22)
    • • Saeede Saadati
      • James Cameron
      • Kirthi Menon
      • Alexander Hodge
      • Zhong X Lu
      • Maximilian de Courten
      • Jack Feehan
      • Barbora de Courten

    • PubMed: 38004228
    • DOI: 10.3390/nu15224835

    12 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Liver Enzyme Levels
    • Reduced Blood Cholesterol
    • Improved Vascular Endothelial Function
    • Reduced Arterial Stiffness
    • Increased HDL Cholesterol
    • Improved Renal Function
    • Reduced Heart Rate
    • Reduced Peripheral Blood Pressure
    • Reduced Central Blood Pressure
    • Reduced Liver Stiffness

    • High evidence
    • Rigorous Journal
• November 20

  • The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.

    • 2023-11-20
    • RCT
    • Nutrients 15(22)
    • • Sarah Docherty
      • Faye L Doughty
      • Ellen F Smith

    • PubMed: 38004235
    • DOI: 10.3390/nu15224842

    2 Insights on

    • Improved Cognitive Function
    • Reduced Subjective Stress

    • High evidence
    • Rigorous Journal
• November 22

  • A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome.

    • 2023-11-22
    • Review · n = 1,738
    • Nutrients 15(23)
    • • Marion Mackonochie
      • Ana Rodriguez-Mateos
      • Simon Mills
      • Vivien Rolfe

    • PubMed: 38068725
    • DOI: 10.3390/nu15234867

    3 Insights on

    • Reduced Inflammatory Markers
    • Reduced Blood Lipid Levels
    • Reduced Blood Glucose Levels

    • High evidence
    • Rigorous Journal
• November 23

  • Supplementation with postbiotic from Bifidobacterium Breve BB091109 improves inflammatory status and endocrine function in healthy females: a randomized, double-blind, placebo-controlled, parallel-groups study

    • 2023-11-23
    • RCT
    • Frontiers in Microbiology 14
    • • Diana Elena Motei
      • Beyda Beteri
      • Piril Hepsomali
      • G. Tzortzis
      • J. Vulevic
      • Adele Costabile

    • PubMed: 38075921
    • DOI: 10.3389/fmicb.2023.1273861

    2 Insights on

    • Reduced Inflammation Levels
    • Improved Endocrine Function

    • High evidence
• November 27

  • Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study.

    • 2023-11-27
    • Observational
    • Medicina (Kaunas, Lithuania) 59(12)
    • • Delia Colombo
      • Corinna Rigoni
      • Alessandra Cantù
      • Antonello Carnevali
      • Rossella Filippetti
      • Tiziana Franco
      • Alessandra Grassi
      • Camilla Loi
      • Annamaria Mazzotta
      • Ivona Patroi
      • Beatrice Raone
      • Marco Andrea Tomassini
      • Angela Amoruso
      • Marco Pane
      • Giovanni Damiani

    • PubMed: 38138183
    • DOI: 10.3390/medicina59122080

    2 Insights on

    • Reduced Eczema Severity
    • Reduced Pruritus

    • Low evidence

  • Effect of systemic administration of Bifidobacterium animalis subsp. lactis HN019 on apical periodontitis.

    • 2023-11-27
    • Brazilian oral research 37
    • • Lisa Danielly Curcino Araujo
      • Raquel Assed Bezerra Segato
      • Thaís de Paula Colen Reis
      • Sérgio Luis de Souza Salvador
      • Flávia Aparecida Chaves Furlaneto
      • Michel Reis Messora
      • Paulo Nelson-Filho
      • Lana Kei Yamamoto de Almeida
      • Marília Pacífico Lucisano
      • Clara Marina Pereira Cavalcanti Silva
      • Léa Assed Bezerra da Silva

    • PubMed: 37970935
    • DOI: 10.1590/1807-3107bor-2023.vol37.0115

    1 Insight on

    • Improved Apical Periodontitis Histological Status

    • Low evidence
    • Animal Study

  • The effect of chamomile consumption on glycemic markers in humans and animals: a systematic review and meta-analysis.

    • 2023-11-27
    • Review
    • Journal of diabetes and metabolic disorders 23(1)
    • • Camellia Akhgarjand
      • Jalal Moludi
      • Sara Ebrahimi-Mousavi
      • Amir Bagheri
      • Narges Ghorbani Bavani
      • Mohammad Taghi Beigmohammadi
      • Mahsa Malekahmadi

    • PubMed: 38932814
    • DOI: 10.1007/s40200-023-01345-8

    2 Insights on

    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels

    • Low evidence
• November 28

  • An overview of fermentation in the food industry - looking back from a new perspective.

    • 2023-11-28
    • Review
    • Bioresources and bioprocessing 10(1)
    • • Shahida Anusha Siddiqui
      • Zeki Erol
      • Jerina Rugji
      • Fulya Taşçı
      • Hatice Ahu Kahraman
      • Valeria Toppi
      • Laura Musa
      • Giacomo Di Giacinto
      • Nur Alim Bahmid
      • Mohammad Mehdizadeh
      • Roberto Castro-Muñoz

    • PubMed: 38647968
    • DOI: 10.1186/s40643-023-00702-y

    5 Insights on

    • Improved Gut Microbiota Composition
    • Improved Skin Hydration
    • Improved Gut Health
    • Reduced Skin Flakiness
    • Reduced Non-Communicable Disease Risk

    • Low evidence
• November 29

  • Effect of Gut Microbiota on Blood Cholesterol: A Review on Mechanisms.

    • 2023-11-29
    • Review
    • Foods (Basel, Switzerland) 12(23)
    • • Chuanling Deng
      • Jingjin Pan
      • Hanyue Zhu
      • Zhen-Yu Chen

    • PubMed: 38231771
    • DOI: 10.3390/foods12234308

    3 Insights on

    • Improved Lipid Metabolism
    • Reduced Blood Cholesterol
    • Improved Cholesterol Levels

    • Low evidence

  • Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review.

    • 2023-11-29
    • Review · n = 881
    • JMIR dermatology 6
    • • Isaac Weber
      • Emily Woolhiser
      • Noah Keime
      • Margaret Wasvary
      • Madeline J Adelman
      • Torunn E Sivesind
      • Robert P Dellavalle

    • PubMed: 38019566
    • DOI: 10.2196/40857

    1 Insight on

    • Improved Atopic Dermatitis Symptoms

    • High evidence
• November 30

  • Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli.

    • 2023-11-30
    • Microorganisms 11(12)
    • • Mark Rawling
      • Marion Schiavone
      • Amélie Mugnier
      • Eric Leclercq
      • Daniel Merrifield
      • Andrew Foey
      • Emmanuelle Apper

    • PubMed: 38138044
    • DOI: 10.3390/microorganisms11122900

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence
• Undated – 4 supplement studies

  • Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.

    • 2023-11
    • Meta-Analysis · n = 7,000
    • Gastroenterology 165(5)
    • • Vivek C Goodoory
      • Mais Khasawneh
      • Christopher J Black
      • Eamonn M M Quigley
      • Paul Moayyedi
      • Alexander C Ford

    • PubMed: 37541528
    • DOI: 10.1053/j.gastro.2023.07.018

    1 Insight on

    • Reduced Irritable Bowel Syndrome Symptoms

    • High evidence
    • Rigorous Journal

  • Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.

    • 2023-11
    • RCT · n = 30
    • Complementary therapies in clinical practice 53
    • • Sayeh Mottaghi
      • Hassan Abbaszadeh

    • PubMed: 37832335
    • DOI: 10.1016/j.ctcp.2023.101804

    11 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Improved Iron Levels
    • Increased Hemoglobin Levels
    • Reduced Alanine Transaminase Level
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Improved Glutathione Level
    • Reduced Aspartate Aminotransferase Level
    • Reduced Malondialdehyde Level
    • Reduced Ferritin Level
    • Increased Total Iron Binding Capacity
    • Improved Superoxide Dismutase Activity

    • High evidence

  • How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?

    • 2023-11
    • Review
    • BMJ oncology 2(1)
    • • Fatima Asim
      • Lowenna Clarke
      • Elizabeth Donnelly
      • Fouzia Rahana Jamal
      • Lucrezia Maria Piccicacchi
      • Mahanoor Qadir
      • Nain Tara Raja
      • Cyrus Samadi
      • Chee Kin Then
      • Anne E Kiltie

    • PubMed: 39886510
    • DOI: 10.1136/bmjonc-2023-000107

    1 Insight on

    • Relieved Intestinal Impairments

    • Low evidence

  • N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial.

    • 2023-11
    • RCT
    • Reviews on recent clinical trials 18(4)
    • • Bijan Heidari
      • Zeinab-Alsadat Seyedian
      • Maryam Mehrpooya
      • Davoud Ahmadimoghaddam
      • Mahtabalsadat Mirjalili
      • Masood Ghiasian

    • PubMed: 37779397
    • DOI: 10.2174/0115748871250545230919055109

    4 Insights on

    • Reduced Pain Severity
    • Reduced Pain-Related Disability
    • Improved Global Symptom
    • Improved Global Improvement of Symptoms (Clinician-Rated)

    • High evidence