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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum
- 2019-08-27
- RCT
- PeerJ 7
- - Md Javed Foysal
  - T. Nguyen
  - Md. Reaz Chaklader
  - M. Siddik
  - C. Tay
  - R. Fotedar
  - S. Gupta
- PubMed: 31523510
- DOI: 10.7717/peerj.7553
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome.
- 2019-08-21
- Review
- Frontiers in microbiology 10
- - Yu Gu
  - Guoqiong Zhou
  - Xiali Qin
  - Shumin Huang
  - Bangmao Wang
  - Hailong Cao
- PubMed: 31497000
- DOI: 10.3389/fmicb.2019.01894
1 Insight on
- Improved Irritable Bowel Syndrome Symptoms
- Low evidence
Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88
- 2019-08-21
- RCT · n = 96
- Journal of Animal Science and Biotechnology 10(1)
- - X. Peng
  - Ru Wang
  - Liang Hu
  - Qiang Zhou
  - Yang Liu
  - Min Yang
  - Z. Fang
  - Yan Lin
  - Shengyu Xu
  - B. Feng
  - Jian Li
  - Xuemei Jiang
  - Y. Zhuo
  - Hua Li
  - De Wu
  - L. Che
- PubMed: 31452881
- DOI: 10.1186/s40104-019-0376-z
4 Insights on
- Low evidence
- Animal Study
The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study.
- 2019-08-21
- RCT
- Nutrients 11(9)
- - Krzysztof Durkalec-Michalski
  - Krzysztof Kusy
  - Monika Ciekot-Sołtysiak
  - Jacek Zieliński
- PubMed: 31438535
- DOI: 10.3390/nu11091961
3 Insights on
- High evidence
- Rigorous Journal
Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults
- 2019-08-21
- RCT · n = 289
- Scientific Reports 9(1)
- - R. Madempudi
  - J. Ahire
  - J. Neelamraju
  - A. Tripathi
  - S. Nanal
- PubMed: 31434935
- DOI: 10.1038/s41598-019-48554-x
4 Insights on
- High evidence
- Rigorous Journal
Colonization of Germ-Free Piglets with Commensal Lactobacillus amylovorus, Lactobacillus mucosae, and Probiotic E. coli Nissle 1917 and Their Interference with Salmonella Typhimurium
- 2019-08-20
- Clinical Trial
- Microorganisms 7(8)
- - I. Splichal
  - S. Donovan
  - Zdislava Splichalova
  - Vera Neuzil Bunesova
  - E. Vlková
  - Vera Jenistova
  - J. Killer
  - R. Svejstil
  - E. Skřivanová
  - A. Splichalova
- PubMed: 31434337
- DOI: 10.3390/microorganisms7080273
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial.
- 2019-08-19
- RCT · n = 120
- PloS one 14(8)
- - Barbara Troesch
  - Johann Demmelmair
  - Martina Gimpfl
  - Christina Hecht
  - Goran Lakovic
  - Robert Roehle
  - Ljilja Sipka
  - Branka Trisic
  - Milica Vusurovic
  - Rotraut Schoop
  - Sznezana Zdjelar
  - Berthold Koletzko
- PubMed: 31425504
- DOI: 10.1371/journal.pone.0216790
11 Insights on
- High evidence
- Large Human Trial
Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- 2019-08-16
- RCT · n = 78
- Nutrients 11(8)
- - Å. Håkansson
  - Carin Andrén Aronsson
  - C. Brundin
  - E. Oscarsson
  - G. Molin
  - D. Agardh
- PubMed: 31426299
- DOI: 10.3390/nu11081925
12 Insights on
- High evidence
An In Vitro Enrichment Strategy for Formulating Synergistic Synbiotics.
- 2019-08-15
- Applied and environmental microbiology 85(16)
- - Car Reen Kok
  - David Fabian Gomez Quintero
  - Clement Niyirora
  - Devin Rose
  - Amanda Li
  - Robert Hutkins
- PubMed: 31201276
- DOI: 10.1128/aem.01073-19
1 Insight on
- Improved Gut Microbiome Establishment
- Low evidence
- Rigorous Journal
Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis
- 2019-08-14
- Meta-Analysis
- Helicobacter 24(5)
- - Ben‐Gang Zhou
  - Lingxiao Chen
  - Bohua Li
  - Lin-Yan Wan
  - Yao-Wei Ai
- PubMed: 31414551
- DOI: 10.1111/hel.12651
7 Insights on
- High evidence
Effects of oligosaccharides on the growth and stress tolerance of Lactobacillus plantarum ZLP001 in vitro, and the potential synbiotic effects of L. plantarum ZLP001 and fructo-oligosaccharide in post-weaning piglets.
- 2019-08-14
- RCT
- Journal of Animal Science 97(11)
- - Jing Wang
  - Sixin Wang
  - Hui Liu
  - Dongyan Zhang
  - Yamin Wang
  - H. Ji
- PubMed: 31410455
- DOI: 10.1093/jas/skz254
3 Insights on
- High evidence
- Rigorous Journal
Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.
- 2019-08-14
- RCT
- Journal of orthopaedic surgery and research 14(1)
- - Chunhua Zhang
  - Sujuan Xue
  - Yong Wang
  - Dan Yu
  - Limei Hua
  - Chunhua Guo
  - Dawei Wang
  - Min Lei
- PubMed: 31412879
- DOI: 10.1186/s13018-019-1310-y
5 Insights on
- High evidence
Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial.
- 2019-08-13
- RCT
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 34(11)
- - Mary Sharpe
  - Vibhuti Shah
  - Tatiana Freire-Lizama
  - Elizabeth C Cates
  - Kory McGrath
  - Iuliana David
  - Sara Cowan
  - Janaya Letkeman
  - Emily Stewart-Wilson
- PubMed: 31362572
- DOI: 10.1080/14767058.2019.1650907
2 Insights on
- Reduced Vaginal Group B Streptococcus Colonization
- No Documented Adverse Effects
- High evidence
The Application of Lactobacillus reuteri CCM 8617 and Flaxseed Positively Improved the Health of Mice Challenged with Enterotoxigenic E. coli O149:F4
- 2019-08-13
- RCT · n = 60
- Probiotics and Antimicrobial Proteins 12(3)
- - Z. Andrejčáková
  - D. Sopková
  - R. Vlčková
  - Z. Hertelyová
  - S. Gancarčíková
  - R. Nemcová
- PubMed: 31410766
- DOI: 10.1007/s12602-019-09578-x
4 Insights on
- Low evidence
- Animal Study
Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study
- 2019-08-10
- RCT · n = 60
- Nutrients 11(8)
- - K. Nishida
  - D. Sawada
  - Y. Kuwano
  - Hiroki Tanaka
  - K. Rokutan
- PubMed: 31405122
- DOI: 10.3390/nu11081859
10 Insights on
- High evidence
- Highly Cited
Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.
- 2019-08-10
- International journal of molecular sciences 20(16)
- - Ghalia Khoder
  - Farah Al-Yassir
  - Asma Al Menhali
  - Prashanth Saseedharan
  - Subi Sugathan
  - Catherine Tomasetto
  - Sherif M Karam
- PubMed: 31405107
- DOI: 10.3390/ijms20163901
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial
- 2019-08-08
- RCT · n = 23
- Journal of Applied Oral Science 27
- - Oda Yuki
  - Chiaki Furutani
  - Yuika Mizota
  - Atsuko Wakita
  - Sumiyo Mimura
  - T. Kihara
  - M. Ohara
  - Yoshiyuki Okada
  - M. Okada
  - H. Nikawa
- PubMed: 31365710
- DOI: 10.1590/1678-7757-2018-0564
2 Insights on
- Reduced Probing Depth
- Reduced PMA Index
- High evidence
Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.
- 2019-08-06
- Clinical Trial
- Food & Function 10(3)
- - Q. Zhai
  - Yang Liu
  - Chen Wang
  - DingWu Qu
  - Jianxin Zhao
  - Hao Zhang
  - F. Tian
  - Wei Chen
- PubMed: 30768114
- DOI: 10.1039/c8fo02554a
2 Insights on
- Increased Fecal Bile Acid Levels
- Increased Lead Excretion
- Low evidence
- Animal Study
A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation.
- 2019-08-05
- RCT · n = 8
- Food & Function 10(3)
- - Shuang Yan
  - Bo Yang
  - Jichun Zhao
  - Jianxin Zhao
  - C. Stanton
  - R. P. Ross
  - Hao Zhang
  - Wei Chen
- PubMed: 30806428
- DOI: 10.1039/c9fo00014c
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease.
- 2019-08-05
- Review
- Nutrients 11(8)
- - Eirini Dimidi
  - Selina Rose Cox
  - Megan Rossi
  - Kevin Whelan
- PubMed: 31387262
- DOI: 10.3390/nu11081806
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Recent advances in dairy goat products.
- 2019-08-01
- Review
- Asian-Australasian Journal of Animal Sciences. 32(8)
- - Lucia Sepe
  - Anastasio Argüello
- PubMed: 31357271
- DOI: 10.5713/ajas.19.0487
2 Insights on
- Increased Antioxidant Activity
- Improved Overall Health
- Low evidence
Improvement of cognitive functions by oral intake of Hericium erinaceus.
- 2019-08-01
- RCT
- Biomedical research (Tokyo, Japan) 40(4)
- - Yuusuke Saitsu
  - Akemi Nishide
  - Kenji Kikushima
  - Kuniyoshi Shimizu
  - Koichiro Ohnuki
- PubMed: 31413233
- DOI: 10.2220/biomedres.40.125
3 Insights on
- High evidence
Lactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study
- 2019-07-31
- RCT · n = 53
- Nutrients 11(8)
- - C. Tenorio-Jiménez
  - M. Martínez-Ramírez
  - I. Del Castillo-Codes
  - C. Arraiza-Irigoyen
  - M. Tercero-Lozano
  - José Camacho
  - N. Chueca
  - Federico García
  - J. Olza
  - J. Plaza-Díaz
  - L. Fontana
  - M. Olivares
  - Á. Gil
  - C. Gómez-Llorente
- PubMed: 31370223
- DOI: 10.3390/nu11081761
7 Insights on
- High evidence
Gut Dysbiosis and the Intestinal Microbiome: Streptococcus thermophilus a Key Probiotic for Reducing Uremia
- 2019-07-31
- Review
- Microorganisms 7(8)
- - L. Vitetta
  - H. Llewellyn
  - D. Oldfield
- PubMed: 31370220
- DOI: 10.3390/microorganisms7080228
2 Insights on
- Reduced Uremic Toxins Levels
- Reduced Mucosal Pro-Inflammatory Activity
- Moderate evidence
- Rigorous Journal
The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis.
- 2019-07-31
- Meta-Analysis
- Journal of complementary & integrative medicine 17(1)
- - Sanaz Mollazadeh
  - Mojgan Mirghafourvand
  - Nafiseh Ghassab Abdollahi
- PubMed: 31369395
- DOI: 10.1515/jcim-2018-0053
3 Insights on
- High evidence
Lactobacilli Isolated From Wild Boar (Sus scrofa) Antagonize Mycobacterium bovis Bacille Calmette-Guerin (BCG) in a Species-Dependent Manner.
- 2019-07-30
- Frontiers in microbiology 10
- - Maria Bravo
  - Theo Combes
  - Fernando O Martinez
  - Rosario Cerrato
  - Joaquín Rey
  - Waldo Garcia-Jimenez
  - Pedro Fernandez-Llario
  - David Risco
  - Jorge Gutierrez-Merino
- PubMed: 31417502
- DOI: 10.3389/fmicb.2019.01663
4 Insights on
- Low evidence
Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short‐chain fatty acids metabolism and GPR41/43 expression in β‐lactoglobulin–sensitized mice
- 2019-07-29
- Clinical Trial
- Microbiology and Immunology 63(8)
- - Jun-Juan Wang
  - Qi-Min Zhang
  - Wei-wei Ni
  - Xin Zhang
  - Ying Li
  - Ai-Li Li
  - P. Du
  - Chun Li
  - Su-Su Yu
- PubMed: 31218724
- DOI: 10.1111/1348-0421.12723
4 Insights on
- Low evidence
- Animal Study
Update on the treatment of vitamin B6 dependent epilepsies.
- 2019-07-29
- Review
- Expert review of neurotherapeutics 19(11)
- - Mario Mastrangelo
  - Serena Cesario
- PubMed: 31340680
- DOI: 10.1080/14737175.2019.1648212
1 Insight on
- Reduced Seizure Frequency
- Low evidence
Lactobacillus plantarum L‐137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice
- 2019-07-29
- Clinical Trial
- Microbiology and Immunology 63(9)
- - Hiroko Nakai
  - Y. Hirose
  - S. Murosaki
  - Y. Yoshikai
- PubMed: 31273816
- DOI: 10.1111/1348-0421.12725
5 Insights on
- Low evidence
- Animal Study
Effects of Streptococcus salivarius K12 with nystatin on oral candidiasis - RCT.
- 2019-07-26
- RCT · n = 56
- Oral Diseases 25(6)
- - Li-Jie Hu
  - Qinghua Mao
  - Peiru Zhou
  - Xin Lv
  - H. Hua
  - Zhimin Yan
- PubMed: 31177581
- DOI: 10.1111/odi.13142
5 Insights on
- High evidence