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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Impact of L-carnitine supplementation on post-transplant outcomes in liver transplant candidates with sarcopenia: A randomized controlled open-label trial.
- 2025-12
- RCT · n = 18
- Clinical nutrition ESPEN 70
- - Marwa Abd El-Razek Salama
  - Elham Ahmed Hassan
  - Nahed A Makhlouf
- PubMed: 40962224
- DOI: 10.1016/j.clnesp.2025.09.008
2 Insights on
- Increased Platelet Count
- Reduced Mortality Risk
- High evidence
Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis.
- 2025-12
- Meta-Analysis · n = 2,465
- Multiple sclerosis and related disorders 104
- - Patrick J Gaffney
  - Rajesh K Gupta
- PubMed: 41124782
- DOI: 10.1016/j.msard.2025.106797
4 Insights on
- High evidence
Selenium status and supplementation in thyroid disorders: A narrative review of current evidence.
- 2025-12
- Review
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 92
- - Ye Htut Linn
  - Sohail Aziz
  - Shiueh Lian Mok
- PubMed: 41206976
- DOI: 10.1016/j.jtemb.2025.127799
5 Insights on
- Low evidence
Infant gut microbiota and functional foods: Opportunities for early health intervention.
- 2025-12
- Review
- Clinical nutrition ESPEN 70
- - Pourandokht Gholamipour-Shirazi
  - Azarmidokht Gholamipour-Shirazi
- PubMed: 41197774
- DOI: 10.1016/j.clnesp.2025.10.032
1 Insight on
- Reduced Incidence of Atopic Dermatitis
- Low evidence
Different oligosaccharides and sodium caseinate glycosylated conjugates for the microencapsulation of Lactobacillus fermentum to improve stability and cholesterol-lowering activity.
- 2025-12
- International journal of biological macromolecules 334
- - Chenglong Lv
  - Xiangfei Li
  - Jie Liu
  - Jiayan Gu
  - Fei Gao
  - Jing Sun
  - Xinyi Pang
  - Yingjian Lu
- PubMed: 41271046
- DOI: 10.1016/j.ijbiomac.2025.149167
2 Insights on
- Improved Cholesterol Levels
- Improved Gastrointestinal Survival
- Low evidence
- Animal Study
The Effect of Ginger and Mint on Postoperative Nausea and Vomiting in Patients Undergoing Total Thyroidectomy.
- 2025-12
- RCT
- Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 40(6)
- - Sona Pashaei
  - Nuray Akyüz
  - Yeliz Emine Ersoy
- PubMed: 40856681
- DOI: 10.1016/j.jopan.2025.02.004
3 Insights on
- High evidence
Novel Application of Oral Postbiotics for Skin Condition in Healthy Middle-Aged Women: A Randomized, Double-Blind, and Placebo-Controlled Study.
- 2025-12
- RCT · n = 60
- Journal of cosmetic dermatology 24(12)
- - Jinko Sawashita
  - Shinichi Honda
  - Yuji Tominaga
  - Namiko Tomatsu
  - Jordi Espadaler-Mazo
  - Takahiro Ueda
- PubMed: 41414786
- DOI: 10.1111/jocd.70617
7 Insights on
- High evidence
Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.
- 2025-12
- Review
- International wound journal 22(12)
- - Seyedeh-Sara Hashemi
  - Alireza Rafati
  - Shahin Roohinejad
  - Fatemeh Yaghoobi
  - Alireza Salehi
- PubMed: 41381406
- DOI: 10.1111/iwj.70799
5 Insights on
- Low evidence
Species-level enumeration of low-concentration lactic acid bacteria in breast milk.
- 2025-12
- Food chemistry. Molecular sciences 11
- - Yue Sun
  - Qiming Li
  - Mengling Hu
  - You Wu
  - Yunchao Wa
  - Hai Lu
  - Shilong Jiang
  - Hui Wang
  - Qiaosi Wei
  - Yujun Huang
  - Ruixia Gu
  - Chenchen Zhang
- PubMed: 40678022
- DOI: 10.1016/j.fochms.2025.100269
3 Insights on
- Low evidence
The effects of Bifidobacterium animalis subsp. lactis BLa80 on glycemic control and gut microbiota in patients with T2DM: a randomized, double-blind, placebo-controlled trial.
- 2025-12
- RCT · n = 80
- Journal of diabetes and its complications 39(12)
- - Chao Zhao
  - Xin Lu
  - Xiaoling Deng
  - Wenbo Xia
  - Tingting Sun
  - Di Huo
  - Lili Shi
- PubMed: 41110348
- DOI: 10.1016/j.jdiacomp.2025.109195
3 Insights on
- High evidence
Psyllium supplementation and lipid profiles: systematic review and dose-response meta-analysis of randomized controlled trials.
- 2025-12
- Review · n = 2,049
- Genes & nutrition 20(1)
- - Zeinab Gholami
  - Zamzam Paknahad
- PubMed: 41366295
- DOI: 10.1186/s12263-025-00786-5
1 Insight on
- Reduced Blood Cholesterol
- High evidence
Surface modification of probiotics at single-cell resolution: Strategies, applications, and future directions in inflammatory bowel disease.
- 2025-12
- Review
- Materials today. Bio 35
- - Li Peng
  - Xinyu Wang
  - Yafen Wang
  - Jueshuo Guo
  - Jianhong Yang
- PubMed: 41281648
- DOI: 10.1016/j.mtbio.2025.102485
4 Insights on
- Low evidence
Spatiotemporal dynamics of mucosa-associated Lactobacillus along the small intestine and its response to 2'-fucosyllactose and galacto-oligosaccharides in piglets.
- 2025-12
- RCT
- Animal nutrition (Zhongguo xu mu shou yi xue hui) 23
- - Wenlu Fan
  - Chunlong Mu
  - Xuan Li
  - Yanan Zhang
  - Kaifan Yu
  - Yong Su
  - Weiyun Zhu
- PubMed: 41321508
- DOI: 10.1016/j.aninu.2025.04.015
1 Insight on
- Increased Ileal Mucosal Colonization of Lactobacillus amylovorus
- High evidence
Safety and efficacy of a feed additive consisting of viable cells of Lactobacillus acidophilusCNCM I-3231, Ligilactobacillus salivariusCNCM I-3233, Lactiplantibacillus plantarumCNCM I-3232, Lacticaseibacillus rhamnosusCNCM I-4427, and Bifidobacterium animalis subsp. lactis CNCM I-3993 (FlorEquilibre® Chien) for dogs (Wamine SAS).
- 2025-12
- Review
- EFSA journal. European Food Safety Authority 23(12)
- - Roberto Edoardo Villa
  - Giovanna Azimonti
  - Eleftherios Bonos
  - Henrik Christensen
  - Mojca Durjava
  - Birgit Dusemund
  - Ronette Gehring
  - Boet Glandorf
  - Maryline Kouba
  - Marta López-Alonso
  - Francesca Marcon
  - Carlo Nebbia
  - Alena Pechová
  - Miguel Prieto-Maradona
  - Ilen Röhe
  - Katerina Theodoridou
  - Giovanna Martelli
  - Baltasar Mayo
  - Maria Saarela
  - Montserrat Anguita
  - Nicole Bozzi Cionci
  - Rosella Brozzi
  - Matteo L Innocenti
  - Jordi Ortuño
- PubMed: 41377166
- DOI: 10.2903/j.efsa.2025.9794
2 Insights on
- Safety Concern in Target Species
- No Conclusive Efficacy
- Low evidence
Probiotics and Their Antimicrobial Metabolites: A Collegial Strategy for Food Bio-Preservation - A Review.
- 2025-12
- Review
- Food science & nutrition 13(12)
- - Lingling Wang
  - Shuanshan Ren
  - Atique Ahmed Behan
  - Muhammad Asif Arain
  - Nissar Ahmed Ujjan
  - Dequan Zeng
  - Yufeng Li
  - Xingming Ma
- PubMed: 41356233
- DOI: 10.1002/fsn3.71318
6 Insights on
- Low evidence
Spirulina's impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT.
- 2025-11
- Meta-Analysis
- Complementary therapies in medicine 94
- - Hamidreza Shiri
  - Ali Akbar Soleimani
  - Behnam Omidi Sarajar
  - Abdolkarim Talebi Taheri
  - Fataneh Esmaeili
  - Mohammad Hadi Nematollahi
  - Mahmood Alizadeh Sani
- PubMed: 40953712
- DOI: 10.1016/j.ctim.2025.103242
15 Insights on
- High evidence
Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model.
- 2025-11
- Microbial pathogenesis 208
- - Xiangmin Dong
  - Shengyi Han
  - Hua Zha
  - Lanjuan Li
- PubMed: 40849096
- DOI: 10.1016/j.micpath.2025.108002
3 Insights on
- Low evidence
- Animal Study
Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy.
- 2025-11
- Bioactive materials 53
- - Yi Wang
  - Yansheng Qu
  - Xiangmei Liu
  - Jin Huang
  - Congyang Mao
  - Chaofeng Wang
  - Shengli Zhu
  - Yufeng Zheng
  - Zhaoyang Li
  - Zhenduo Cui
  - Hui Jiang
  - Yang Lv
  - Jie Shen
  - Shuilin Wu
- PubMed: 40688024
- DOI: 10.1016/j.bioactmat.2025.07.004
2 Insights on
- Reduced Periodontal Inflammation
- Improved Oral Microbial Balance
- Low evidence
Examining the effect of L-theanine on sleep: a systematic review of dietary supplementation trials.
- 2025-11
- Systematic Review
- Nutritional neuroscience 29(2)
- - Jack Cotter
  - Charlotte E Caddick
  - Jessica L Harper
  - James K Ebajemito
- PubMed: 41176609
- DOI: 10.1080/1028415x.2025.2556925
6 Insights on
- High evidence
Acute effects of cocoa flavanols on cognitive control and response inhibition.
- 2025-11
- RCT
- Nutrition (Burbank, Los Angeles County, Calif.) 139
- - Ahmet Altinok
  - Monica Moruzzi
  - Elkan G Akyürek
- PubMed: 40614481
- DOI: 10.1016/j.nut.2025.112860
8 Insights on
- High evidence
The Effects of Peppermint on Menstrual Disorders: A Systematic Review of Randomized Controlled Trials.
- 2025-11
- Review · n = 499
- Iranian journal of nursing and midwifery research 30(6)
- - Yegane Lagzian
  - Fariba Askari
  - Rahele Mehrabi
- PubMed: 41311590
- DOI: 10.4103/ijnmr.ijnmr_283_23
3 Insights on
- High evidence
Emerging Nonthermal Technologies for the Production of Postbiotics.
- 2025-11
- Review
- Comprehensive reviews in food science and food safety 24(6)
- - Rohit Thirumdas
  - Priti Mudgil
- PubMed: 41273201
- DOI: 10.1111/1541-4337.70335
3 Insights on
- Low evidence
Impact of ginger supplementation on obesity indices and Adipokine profiles in adults: A GRADE-based systematic review and dose-response meta-analysis of randomized controlled trials.
- 2025-11
- Meta-Analysis
- Complementary therapies in medicine 94
- - Shrin Rjabi
  - Seyed Sina Seyedhatami
  - Maede Makhtoomi
  - Mohammad Reza Ahmadi
  - Saeede Alimohamadi
  - Ehsan Aliabadi
  - Soroush Talakesh
  - Mehran Nouri
  - Behzad Zamani
  - Moein Askarpour
- PubMed: 41101746
- DOI: 10.1016/j.ctim.2025.103260
6 Insights on
- High evidence
Genomic mechanisms underlying the adaptation of Anaerobutyricum species to the human host.
- 2025-11
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 135
- - Chaoyang Gu
  - Dezhong Wang
  - Kai Han
  - Jiarui Li
  - Liang Chen
  - Qinghui Zhuang
  - Tingzhu Yao
  - HengKun Wei
  - Jinglin Yue
  - Mingxi Hua
  - Chen Chen
- PubMed: 41109491
- DOI: 10.1016/j.meegid.2025.105844
1 Insight on
- Not Reported
- Low evidence
The effects of whole foods and dietary patterns on flow-mediated dilation: a systematic review and meta-analysis of randomized controlled trials.
- 2025-11
- Meta-Analysis
- The American journal of clinical nutrition 122(5)
- - Nina M Trinquet
  - Nicole J Kellow
  - Rafika Eviana
  - Gary Williamson
  - Aimee L Dordevic
- PubMed: 40972869
- DOI: 10.1016/j.ajcnut.2025.09.020
1 Insight on
- Improved Flow-Mediated Dilation
- High evidence
A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in older adults.
- 2025-11
- Meta-Analysis
- Experimental gerontology 211
- - Mohadeseh Ostovar
  - Mohammad Hamed Khademizadeh
  - Foroogh Namjoyan
  - Asma Kazemi
  - Sina Vakili
  - Seyed Hamdollah Mosavat
  - Mohsen Mohit
  - Mohammad Hashem Hashempur
- PubMed: 41057090
- DOI: 10.1016/j.exger.2025.112919
1 Insight on
- Improved Sleep Quality
- High evidence
Probiotic supplementation attenuates dental pain and inhibits pain-induced cognitive impairment in male rats.
- 2025-11
- RCT · n = 8
- Archives of oral biology 179
- - Pegah Abazari-Bozhgani
  - Saeed Esmaeili-Mahani
  - Mehdi Abbasnejad
  - Maryam Raoof
  - Frank Lobbezoo
- PubMed: 40902425
- DOI: 10.1016/j.archoralbio.2025.106382
2 Insights on
- Improved Cognitive Function
- Reduced Oral Pain
- Low evidence
- Animal Study
Gut Virome: What's the Role in Irritable Bowel Syndrome?
- 2025-11
- Review
- Reviews in medical virology 35(6)
- - Francesco Rettura
  - Christian Lambiase
  - Andrea Bottari
  - Fabio Filippini
  - Luca Giacomelli
  - Mauro Pistello
  - Massimo Bellini
- PubMed: 41296916
- DOI: 10.1002/rmv.70080
1 Insight on
- Improved Irritable Bowel Syndrome Symptoms
- Low evidence
Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial.
- 2025-11
- RCT
- Current drug research reviews 17(3)
- - Mahsa Rouhi
  - Mohammad Bagher Hossieni
  - Laleh Khodaie
  - Sakineh Mohammad-Alizadeh-Charandabi
  - Mojgan Mirghafourvand
- PubMed: 41239794
- DOI: 10.2174/0125899775313919240822102906
4 Insights on
- High evidence
Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial.
- 2025-11
- RCT · n = 442
- The American journal of clinical nutrition 122(5)
- - Xiaoran Liu
  - Frank M Sacks
  - Todd Beck
  - Christy C Tangney
  - Walter C Willett
  - Hussein Yassine
  - Klodian Dhana
  - Neelum T Aggarwal
  - Kumar B Rajan
  - Lisa L Barnes
- PubMed: 40876538
- DOI: 10.1016/j.ajcnut.2025.08.012
1 Insight on
- Improved Global Cognition
- High evidence
- Large Human Trial