May 2018 Supplement Research Papers

• May 2

  • Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial

    • 2018-05-02
    • RCT · n = 341
    • Pediatric Research 83(6)
    • • J. Escribano
      • N. Ferré
      • M. Gispert-Llauradó
      • V. Luque
      • C. Rubio-Torrents
      • M. Zaragoza-Jordana
      • I. Polanco
      • F. Codoñer
      • E. Chenoll
      • M. Morera
      • J. A. Moreno-Muñoz
      • M. Rivero
      • R. Closa-Monasterolo

    • PubMed: 29538368
    • DOI: 10.1038/pr.2018.34

    7 Insights on

    • Reduced Stool Frequency
    • Reduced Diarrhea Incidence
    • Increased Constipation Risk
    • Reduced Incidence of Constipation
    • No Significant Change in Gastrointestinal Symptoms
    • Reduced Constipation Prevalence
    • No Impact on Digestive Symptoms, Growth, or Formula Intake

    • High evidence
    • Large Human Trial
    • Rigorous Journal
• May 10

  • Effect of Dietary Probiotic Lactobacillus helveticus on Growth Performance, Antioxidant Levels, and Absorption of Essential Trace Elements in Goldfish (Carassius auratus)

    • 2018-05-10
    • Probiotics and Antimicrobial Proteins 11(2)
    • • J. Ahire
      • J. Ahire
      • Narendra U. Mokashe
      • B. Chaudhari

    • PubMed: 29748780
    • DOI: 10.1007/s12602-018-9428-5

    4 Insights on

    • Increased Body Weight
    • Reduced Colitis-Related Mortality
    • Elevated Antioxidant Levels
    • Improved Absorption of Essential Trace Elements

    • Low evidence
• May 13

  • Consumption of Probiotic Lactobacillus fermentum MTCC: 5898-Fermented Milk Attenuates Dyslipidemia, Oxidative Stress, and Inflammation in Male Rats Fed on Cholesterol-Enriched Diet

    • 2018-05-13
    • Probiotics and Antimicrobial Proteins 11(2)
    • • R. Yadav
      • S. H. Khan
      • S. Mada
      • S. Meena
      • R. Kapila
      • S. Kapila

    • PubMed: 29754388
    • DOI: 10.1007/s12602-018-9429-4

    9 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Serum Triacylglycerols
    • Reduced Risk of Coronary Heart Disease
    • Reduced Serum Total Cholesterol Levels
    • Reduced Atherogenic Index
    • Reduced Lipid Peroxidation
    • Improved Antioxidative Enzyme Activities
    • Reduced Hepatic Lipid Levels
    • Increased High-Density Lipoprotein Cholesterol

    • Low evidence
• May 15

  • Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice

    • 2018-05-15
    • Clinical Trial
    • International Immunology 30(7)
    • • Yuki Usui
      • Y. Kimura
      • T. Satoh
      • Naoki Takemura
      • Yasuo Ouchi
      • Hiroko Ohmiya
      • Kyosuke Kobayashi
      • Hiromi Suzuki
      • Satomi Koyama
      • S. Hagiwara
      • Hirotoshi Tanaka
      • S. Imoto
      • G. Eberl
      • Y. Asami
      • K. Fujimoto
      • S. Uematsu

    • PubMed: 29767727
    • DOI: 10.1093/intimm/dxy035

    1 Insight on

    • Enhanced Immune Function

    • Low evidence
    • Animal Study
• May 17

  • Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model

    • 2018-05-17
    • Clinical Trial
    • Frontiers in Microbiology 9
    • • I. Rather
      • V. Bajpai
      • Y. Huh
      • Young‐Kyu Han
      • E. Bhat
      • Jeongheui Lim
      • W. Paek
      • Yong-Ha Park

    • PubMed: 29867905
    • DOI: 10.3389/fmicb.2018.01021

    2 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Psoriasis Symptoms

    • Low evidence
    • Animal Study

  • Review of Saccharomyces boulardii as a treatment option in IBD

    • 2018-05-17
    • Systematic Review
    • Immunopharmacology and Immunotoxicology 40(6)
    • • K. Sivananthan
      • A. Petersen

    • PubMed: 29771163
    • DOI: 10.1080/08923973.2018.1469143

    2 Insights on

    • Reduced IBD Symptoms
    • No Effect in Crohn's Disease Cases

    • High evidence
• May 21

  • The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study

    • 2018-05-21
    • RCT · n = 116
    • Digestion 96(2)
    • • Toshihiro Ohtsu
      • A. Takagi
      • N. Uemura
      • Kazuhiko Inoue
      • H. Sekino
      • A. Kawashima
      • M. Uchida
      • Y. Koga

    • PubMed: 28768250
    • DOI: 10.1159/000479000

    2 Insights on

    • Improved Functional Dyspepsia Symptoms
    • Improved Overall Gastric Symptoms

    • High evidence
• May 24

  • Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors.

    • 2018-05-24
    • Clinical Trial
    • Digestive diseases and sciences 63(11)
    • • Mariko Hojo
      • Takashi Asahara
      • Akihito Nagahara
      • Tsutomu Takeda
      • Kohei Matsumoto
      • Hiroya Ueyama
      • Kenshi Matsumoto
      • Daisuke Asaoka
      • Takuya Takahashi
      • Koji Nomoto
      • Yuichiro Yamashiro
      • Sumio Watanabe

    • PubMed: 29796911
    • DOI: 10.1007/s10620-018-5122-4

    1 Insight on

    • No Significant Change in Blood Bacterial Detection

    • High evidence
    • Rigorous Journal

  • Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival

    • 2018-05-24
    • Frontiers in Nutrition 5
    • • M. Casanova
      • J. Azevedo-Silva
      • L. Rodrigues
      • A. Preto

    • PubMed: 29881727
    • DOI: 10.3389/fnut.2018.00044

    2 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Reduced Cancer Risk

    • Low evidence
• May 25

  • Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome.

    • 2018-05-25
    • Scientific reports 8(1)
    • • Ayako Uchinaka
      • Naoki Azuma
      • Hisashi Mizumoto
      • Shiho Nakano
      • Moeko Minamiya
      • Mamoru Yoneda
      • Kiyoshi Aoyama
      • Yuki Komatsu
      • Yuichiro Yamada
      • Toyoaki Murohara
      • Kohzo Nagata

    • PubMed: 29802339
    • DOI: 10.1038/s41598-018-26588-x

    5 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Inflammation in Adipose Tissue
    • Improved Insulin Resistance
    • Increased Proportion of Intestinal Regulatory T Cells
    • Improved Diastolic Function

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 31

  • The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice.

    • 2018-05-31
    • Clinical Trial
    • Food & Function 8(11)
    • • Jiaming Liu
      • Ya-Fen Fu
      • Hao Zhang
      • Jindan Wang
      • Jing Zhu
      • Yaqi Wang
      • Yuegui Guo
      • Guocan Wang
      • Tianqi Xu
      • M. Chu
      • Fangyan Wang

    • PubMed: 28933492
    • DOI: 10.1039/c7fo00355b

    6 Insights on

    • Reduced Colitis-Related Mortality
    • Increased Antioxidant Activity
    • Reduced Serum Malondialdehyde Levels
    • Reduced Inflammation
    • Increased NRF2 Levels
    • Elevated IL-10 Levels

    • Low evidence
    • Animal Study
• Undated – 6 supplement studies

  • Effects of dietary Lactobacillus rhamnosus JCM1136 and Lactococcus lactis subsp. lactis JCM5805 on the growth, intestinal microbiota, morphology, immune response and disease resistance of juvenile Nile tilapia, Oreochromis niloticus

    • 2018-05
    • RCT
    • Fish & Shellfish Immunology 76
    • • Y. Xia
      • Mai-xin Lu
      • Gang Chen
      • Jianmeng Cao
      • F. Gao
      • Miao Wang
      • Zhigang Liu
      • Defeng Zhang
      • Huaping Zhu
      • Mengmeng Yi

    • PubMed: 29550602
    • DOI: 10.1016/j.fsi.2018.03.020

    14 Insights on

    • Improved Gut Microbiota
    • Improved Intestinal Morphology
    • Improved Immune Response
    • Reduced Potential Pathogenic Bacteria
    • Enhanced Disease Resistance
    • Improved Growth Rate
    • Improved Gut Morphology
    • Reduced Pathogenic Bacteria Levels
    • Improved Fish Growth
    • Reduced Potential Pathogens
    • Reduced Pathogenic Bacteria in Gut
    • Increased Survival Against Pathogens
    • Increased Gut Microvilli Length
    • Enhanced Gut Probiotic Bacteria Propagation

    • High evidence
    • Highly Cited

  • Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2018-05
    • RCT · n = 90
    • Journal of Medicinal Food 21(5)
    • • Joohee Kim
      • J. Yun
      • M. K. Kim
      • O. Kwon
      • B. Cho

    • PubMed: 29688793
    • DOI: 10.1089/jmf.2017.3937

    12 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Visceral Fat
    • Reduced Body Weight
    • Reduced Hip Circumference
    • Reduced Waist-to-Hip Ratio
    • Reduced Body Fat Mass
    • Reduced Visceral Fat Mass
    • Unchanged Biochemical Parameters
    • Increased Lean Body Mass
    • Reduced Abdominal Adipose Tissue Area
    • Reduced Biochemical Parameter Level

    • High evidence
    • Highly Cited

  • Effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: A pilot randomized clinical trial

    • 2018-05
    • RCT · n = 40
    • United European Gastroenterology Journal 6(4)
    • • C. Cremon
      • S. Guglielmetti
      • G. Gargari
      • Valentina Taverniti
      • A. Castellazzi
      • C. Valsecchi
      • C. Tagliacarne
      • W. Fiore
      • M. Bellini
      • L. Bertani
      • D. Gambaccini
      • M. Cicala
      • B. Germanà
      • M. Vecchi
      • I. Pagano
      • M. Barbaro
      • L. Bellacosa
      • V. Stanghellini
      • G. Barbara

    • PubMed: 29881616
    • DOI: 10.1177/2050640617736478

    7 Insights on

    • Reduced Ruminococcus Abundance
    • Reduced Interleukin-15 Levels
    • No Improvement in IBS Symptoms
    • Increased Short Chain Fatty Acids
    • Increased Short Chain Fatty Acids (SCFAs) Levels
    • Reduced Pro-Inflammatory Cytokine Interleukin-15 Levels
    • Increased SCFA Butyrate Levels

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Potential of Lactobacillus plantarum ZDY2013 and Bifidobacterium bifidum WBIN03 in relieving colitis by gut microbiota, immune, and anti-oxidative stress.

    • 2018-05
    • Clinical Trial
    • Canadian Journal of Microbiology 64(5)
    • • Yuanyuan Wang
      • Yilin Guo
      • Hui Chen
      • Hua Wei
      • C. Wan

    • PubMed: 29401402
    • DOI: 10.1139/cjm-2017-0716

    4 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Pro-inflammatory Cytokine Release
    • Elevated Antioxidant Levels
    • Reduced Ulcerative Colitis Symptoms

    • Low evidence
    • Animal Study

  • Lack of efficacy of Lactobacillus GG in reducing pulmonary exacerbations and hospital admissions in children with cystic fibrosis: A randomised placebo controlled trial.

    • 2018-05
    • RCT · n = 95
    • Journal of Cystic Fibrosis 17(3)
    • • E. Bruzzese
      • V. Raia
      • Eliana Ruberto
      • R. Scotto
      • A. Giannattasio
      • D. Bruzzese
      • M. C. Cavicchi
      • M. Francalanci
      • C. Colombo
      • N. Faelli
      • V. Daccò
      • G. Magazzù
      • S. Costa
      • V. Lucidi
      • F. Majo
      • A. Guarino

    • PubMed: 29128317
    • DOI: 10.1016/j.jcf.2017.10.014

    6 Insights on

    • Improved Nutritional Status
    • Reduced Pulmonary Exacerbations
    • Reduced Hospitalisation
    • Improved Pulmonary Function
    • Increased Incidence of Pulmonary Exacerbations
    • Increased Hospital Admissions

    • High evidence

  • Use of Streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects.

    • 2018-05
    • Observational · n = 133
    • Minerva Pediatrics 70(3)
    • • F. Di Pierro
      • P. Risso
      • E. Poggi
      • A. Timitilli
      • Sara Bolloli
      • Maurizio Bruno
      • Egidio Caneva
      • R. Campus
      • A. Giannattasio

    • PubMed: 29322750
    • DOI: 10.23736/S0026-4946.18.05182-4

    2 Insights on

    • Reduced Acute Otitis Media
    • Reduced Incidence of Pharyngotonsillitis

    • High evidence