February 2019 Supplement Research Papers

• February 1

  • Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    • 2019-02-01
    • RCT · n = 100
    • Nutrients 11(2)
    • • Yun-Ha Hwang
      • Shinwon Park
      • J. Paik
      • S. Chae
      • Dong-Hyun Kim
      • Doc-Gyun Jeong
      • Eunji Ha
      • Myeongju Kim
      • Gahae Hong
      • Soo-Hyun Park
      • Su-Jin Jung
      • Sang-Min Lee
      • Kyu-Heum Na
      • Jungyoon Kim
      • Young-Chul Chung

    • PubMed: 30717153
    • DOI: 10.3390/nu11020305

    3 Insights on

    • Improved Cognitive Function
    • Increased Serum BDNF Levels
    • Safe Drug Administration

    • High evidence
    • Highly Cited
• February 5

  • Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets

    • 2019-02-05
    • Clinical Trial
    • Frontiers in Microbiology 10
    • • Tianwei Wang
      • Kunling Teng
      • Yayong Liu
      • Weixiong Shi
      • Jie Zhang
      • Enqiu Dong
      • Xin Zhang
      • Yong Tao
      • Jin Zhong

    • PubMed: 30804899
    • DOI: 10.3389/fmicb.2019.00090

    10 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate
    • Increased Beneficial Gut Microbiota
    • Improved Growth Rate
    • Improved Intestinal Health
    • Enhanced Beneficial Gut Microbiota
    • Increased Colonic SCFA Levels
    • Increased Gut Beneficial Microbes
    • Enhanced Intestinal Microbiota Maturation
    • Enhanced Gut Microbiota Maturation

    • Low evidence
    • Highly Cited
    • Animal Study
• February 7

  • The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes

    • 2019-02-07
    • RCT
    • Nutrients 11(2)
    • • Wen-Ching Huang
      • C. Wei
      • Chi-Chang Huang
      • Wen‐Lin Chen
      • Hui-Yu Huang

    • PubMed: 30736479
    • DOI: 10.3390/nu11020353

    4 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Inflammation Levels
    • Improved Exercise Performance
    • Elevated Plasma-Branched Chain Amino Acids

    • High evidence
    • Highly Cited
• February 8

  • Spores of Bacillus coagulans GBI-30, 6086 show high germination, survival and enzyme activity in a dynamic, computer-controlled in vitro model of the gastrointestinal tract.

    • 2019-02-08
    • Beneficial Microbes 10(1)
    • • D. Keller
      • Sanne Verbruggen
      • H. Cash
      • S. Farmer
      • Koen Venema

    • PubMed: 30694101
    • DOI: 10.3920/BM2018.0037

    7 Insights on

    • Increased Survival Rate
    • Improved Digestive Function
    • Germination of Probiotics in Small Intestine
    • Improved Metabolic Activity of Bacillus coagulans
    • Increased Germination Rate
    • Increased Metabolic Activity
    • Increased Gut Microbial Growth

    • Low evidence
• February 11

  • Lactobacillus sakei Alleviates High‐Fat‐Diet‐Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota‐Mediated NF‐&kgr;B Activation

    • 2019-02-11
    • Clinical Trial
    • Molecular Nutrition & Food Research 63(6)
    • • H. Jang
      • Sang-Kap Han
      • Jeon-Kyung Kim
      • Seong‐Jun Oh
      • Hwan Jang
      • Dong-Hyun Kim

    • PubMed: 30636176
    • DOI: 10.1002/mnfr.201800978

    5 Insights on

    • Reduced Gastrointestinal Inflammation
    • Reduced Colitis-Related Mortality
    • Reduced Obesity
    • Reduced Anxiety
    • Reduced Obesity Indicators

    • Low evidence
    • Animal Study
• February 12

  • Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain

    • 2019-02-12
    • Clinical Trial · n = 61
    • Nutrients 11(2)
    • • Nívia Cárdenas
      • V. Martín
      • Rebeca Arroyo
      • M. López
      • M. Carrera
      • C. Badiola
      • E. Jiménez
      • J. M. Rodríguez

    • PubMed: 30759799
    • DOI: 10.3390/nu11020376

    1 Insight on

    • Reduced Acute Otitis Media

    • High evidence
• February 15

  • Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis: a randomized placebo-controlled clinical study

    • 2019-02-15
    • RCT · n = 41
    • European Archives of Oto-Rhino-Laryngology 276(3)
    • • C. Andaloro
      • M. Santagati
      • S. Stefani
      • I. La Mantia

    • PubMed: 30767047
    • DOI: 10.1007/s00405-019-05346-3

    5 Insights on

    • Improved Quality of Life
    • Reduced Antibiotic Usage
    • Reduced GABHS Infection Frequency
    • Reduced GABHS Infection Duration
    • Reduced School Absence Days

    • High evidence
    • Rigorous Journal
• February 16

  • Effects of a Saccharomyces cerevisiae fermentation product on fecal characteristics, nutrient digestibility, fecal fermentative end-products, fecal microbial populations, immune function, and diet palatability in adult dogs1.

    • 2019-02-16
    • RCT
    • Journal of Animal Science 97(4)
    • • Ching-Yen Lin
      • Celeste Alexander
      • A. Steelman
      • C. Warzecha
      • M. D. de Godoy
      • K. Swanson

    • PubMed: 30770927
    • DOI: 10.1093/jas/skz064

    6 Insights on

    • Increased Gut Bifidobacteria
    • Reduced Fusobacterium Abundance
    • Reduced Total White Blood Cell Counts
    • Decreased TNF-α Production in Immune Cells
    • Elevated Serum IgE Levels
    • Increased Preference for SCFP-Containing Diet

    • High evidence
    • Rigorous Journal
• February 20

  • Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.

    • 2019-02-20
    • BMC complementary and alternative medicine 19(1)
    • • Jong-Min Lim
      • Chang-Hyun Song
      • Su-Jin Park
      • Dong-Chan Park
      • Go-Woon Jung
      • Hyung-Rae Cho
      • Khawaja Muhammad Imran Bashir
      • Sae Kwang Ku
      • Jae-Suk Choi

    • PubMed: 30786935
    • DOI: 10.1186/s12906-019-2457-0

    6 Insights on

    • Reduced Inflammation
    • Improved Antioxidant Defense
    • Reduced Mucosal Damage
    • Reduced Gastric Ulcer Area
    • Reduced Gastric Inflammation
    • Improved Gastric Mucosal Protection

    • Low evidence
    • Animal Study
• February 22

  • Nutraceutical approach for the management of cardiovascular risk – a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study

    • 2019-02-22
    • RCT
    • Nutrition Journal 18(1)
    • • M. Ruscica
      • C. Pavanello
      • S. Gandini
      • C. Macchi
      • M. Botta
      • Daria Dall’Orto
      • M. Del Puppo
      • M. Bertolotti
      • R. Bosisio
      • Giuliana Mombelli
      • C. Sirtori
      • L. Calabresi
      • P. Magni

    • PubMed: 30795775
    • DOI: 10.1186/s12937-019-0438-2

    6 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Non-HDL Cholesterol
    • Reduced Total Cholesterol
    • Reduced Apolipoprotein B Levels
    • Reduced Lathosterol to Total Cholesterol Ratio

    • High evidence

  • Supplementation of a Lactobacillus acidophilus fermentation product can attenuate the acute phase response following a lipopolysaccharide challenge in weaned pigs.

    • 2019-02-22
    • RCT
    • Animal 13(1)
    • • N. B. Sanchez
      • J. Carroll
      • P. R. Broadway
      • B. Bass
      • Jason W. Frank

    • PubMed: 29921343
    • DOI: 10.1017/S1751731118001222

    4 Insights on

    • Reduced Acute Phase Response
    • Reduced Increase in Intraoperative Temperature
    • Reduced Cortisol Levels
    • Altered Pro-Inflammatory Cytokine Levels

    • High evidence
    • Rigorous Journal
• Undated – 12 supplement studies

  • Exopolysaccharides production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12: Optimization of fermentation variables and characterization of structure and bioactivities.

    • 2019-02
    • International Journal of Biological Macromolecules 123
    • • S. Amiri
      • Reza Rezaei Mokarram
      • M. Sowti Khiabani
      • Mahmoud Rezazadeh Bari
      • Mohammad Alizadeh Khaledabad

    • PubMed: 30447370
    • DOI: 10.1016/j.ijbiomac.2018.11.084

    3 Insights on

    • Increased Antioxidant Activity
    • Improved Thermal Stability of Exopolysaccharides
    • Reduced Power

    • Low evidence
    • Highly Cited

  • Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study.

    • 2019-02
    • Journal of Affective Disorders 245
    • • R. Okubo
      • Minori Koga
      • N. Katsumata
      • T. Odamaki
      • Shiina Matsuyama
      • Matsuhiko Oka
      • H. Narita
      • N. Hashimoto
      • I. Kusumi
      • Jinzhong Xiao
      • Y. Matsuoka

    • PubMed: 30423465
    • DOI: 10.1016/j.jad.2018.11.011

    8 Insights on

    • Reduced Anxiety Levels
    • Reduced Depression Symptoms
    • Reduced Anxiety Symptoms
    • Enhanced Immune Response
    • Improved Anxiety Symptoms
    • Modulated Immune Response
    • Improved Depressive Symptoms
    • Altered Expression of Immune Products

    • Moderate evidence
    • Highly Cited
    • Rigorous Journal

  • L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-κB pathways.

    • 2019-02
    • RCT · n = 65
    • Toxicology and applied pharmacology 365
    • • Rana Yehia
      • Samira Saleh
      • Hanan El Abhar
      • Amr S Saad
      • Mona Schaalan

    • PubMed: 30592963
    • DOI: 10.1016/j.taap.2018.12.015

    7 Insights on

    • Reduced Caspase-3 Activity
    • Reduced Malondialdehyde Level
    • Reduced Peripheral Neuropathy Grade
    • Reduced NF-κB Level
    • Reduced Nuclear Factor Kappa-B Level
    • Reduced Tumor Necrosis Factor-alpha Level
    • Increased Nrf2 Level

    • High evidence

  • Effects of dietary supplementation with Clostridium butyricum on laying performance, egg quality, serum parameters, and cecal microflora of laying hens in the late phase of production

    • 2019-02
    • RCT · n = 960
    • Poultry Science 98(2)
    • • H. Zhan
      • X. Dong
      • L. Li
      • Y. X. Zheng
      • Y. Gong
      • X. Zou

    • PubMed: 30285187
    • DOI: 10.3382/ps/pey436

    4 Insights on

    • Improved Immune Function
    • Improved Blood Parameters
    • Improved Laying Performance
    • Improved Antioxidative Capacity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model.

    • 2019-02
    • Clinical Trial
    • Journal of Dairy Science 102(2)
    • • M. Niibo
      • Bungo Shirouchi
      • Minami Umegatani
      • Yukiko Morita
      • A. Ogawa
      • F. Sakai
      • Y. Kadooka
      • Masao Sato

    • PubMed: 30471910
    • DOI: 10.3168/jds.2018-15203

    2 Insights on

    • Improved Insulin Sensitivity
    • Improved Insulin Secretion

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets

    • 2019-02
    • RCT · n = 24
    • Journal of Zhejiang University-SCIENCE B 20(2)
    • • Yang Wang
      • L. Gong
      • Yan-ping Wu
      • Z. Cui
      • Yong-qiang Wang
      • Yi Huang
      • Xiao-ping Zhang
      • Wei-fen Li

    • PubMed: 30666850
    • DOI: 10.1631/jzus.B1800022

    14 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate
    • Improved Intestinal Mucosal Immunity
    • Increased Weaning Weight
    • Increased Jejunal Permeability
    • Improved Immunologic Barrier Function
    • Improved Average Daily Gain
    • Increased Barrier-Preserving Protein Levels
    • Improved Daily Weight Gain
    • Improved Intestinal Immune Barrier
    • Improved Gut Permeability
    • Improved Jejunal Permeability
    • Improved Intestinal Immune Response

    • Low evidence
    • Animal Study

  • Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine

    • 2019-02
    • Clinical Trial
    • iScience 12
    • • T. Darby
      • Joshua A. Owens
      • B. Saeedi
      • L. Luo
      • J. Matthews
      • B. Robinson
      • C. Naudin
      • Rheinallt M. Jones

    • PubMed: 30739017
    • DOI: 10.1016/j.isci.2019.01.030

    11 Insights on

    • Reduced Gut Inflammation
    • Reduced Inflammatory Injury
    • Reduced Ileum Inflammation
    • Protection Against Gut Tissue Damage
    • Reduced Gastric Tissue Damage
    • Reduced Colitis Inflammation
    • Reduced Injury-Induced Gut Inflammation
    • Reduced Radiological Damage in the Gut
    • Reduced Intestinal Tissue Damage
    • Increased Cytoprotection Against Tissue Damage
    • Protection Against Radiological Damage

    • Low evidence
    • Animal Study

  • Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.

    • 2019-02
    • Archives of Oral Biology 98
    • • T. Higuchi
      • N. Suzuki
      • S. Nakaya
      • Sami Omagari
      • M. Yoneda
      • T. Hanioka
      • T. Hirofuji

    • PubMed: 30530235
    • DOI: 10.1016/j.archoralbio.2018.11.027

    4 Insights on

    • Reduced Growth of Streptococcus mutans
    • Inhibition of Glucan Production by Streptococcus mutans
    • Reduced Growth of Porphyromonas gingivalis
    • Enhanced Inhibition of Porphyromonas Gingivalis with EGCg

    • Low evidence

  • In vitro and in vivo resistance of Lactobacillus rhamnosus GG carried by a mixed pineapple (Ananas comosus L. Merril) and jussara (Euterpe edulis Martius) juice to the gastrointestinal tract.

    • 2019-02
    • Clinical Trial
    • Food Research International 116
    • • Renata Cristina de Almeida Bianchini Campos
      • E. Martins
      • Bruno de Andrade Pires
      • Maria do Carmo Gouveia Pelúzio
      • A. N. da Rocha Campos
      • A. M. Ramos
      • Bruno Ricardo de Castro Leite Júnior
      • Aurélia Dornelas de Oliveira Martins
      • Roselir Ribeiro da Silva
      • M. L. Martins

    • PubMed: 30716912
    • DOI: 10.1016/j.foodres.2018.10.012

    2 Insights on

    • Reduced LDL Cholesterol
    • Improved Gastrointestinal Resistance

    • Low evidence
    • Animal Study

  • Lactobacillus rhamnosus GG modulates gastrointestinal absorption, excretion patterns, and toxicity in Holstein calves fed a single dose of aflatoxin B1.

    • 2019-02
    • RCT
    • Journal of Dairy Science 102(2)
    • • L. Y. Zhang
      • S. Liu
      • X. Zhao
      • N. Wang
      • X. Jiang
      • H. Xin
      • Y. Zhang

    • PubMed: 30594375
    • DOI: 10.3168/jds.2018-15444

    3 Insights on

    • Reduced Hepatotoxicity
    • Reduced Absorption of AFB1
    • Increased Fecal Excretion

    • High evidence
    • Rigorous Journal

  • Evaluation of protective effect of Lactobacillus acidophilus La-5 on toxicity and colonization of Clostridium difficile in human epithelial cells in vitro.

    • 2019-02
    • Anaerobe 55
    • • A. Najarian
      • S. Sharif
      • M. Griffiths

    • PubMed: 30576791
    • DOI: 10.1016/j.anaerobe.2018.12.004

    2 Insights on

    • Reduced Clostridium difficile Cytotoxicity
    • Reduced Clostridium Difficile Adherence

    • Low evidence

  • Effect of Tribulus terrestris L. on sperm parameters in men with idiopathic infertility: A systematic review.

    • 2019-02
    • Systematic Review
    • Complementary therapies in medicine 42
    • • Sima Sanagoo
      • Behnaz Sadeghzadeh Oskouei
      • Nafiseh Gassab Abdollahi
      • Hanieh Salehi-Pourmehr
      • Nazanin Hazhir
      • Azizeh Farshbaf-Khalili

    • PubMed: 30670288
    • DOI: 10.1016/j.ctim.2018.09.015

    4 Insights on

    • Improved Sperm Count
    • Improved Sperm Morphology
    • Improved Sperm Motility
    • Improved Sperm Quality

    • High evidence